The Experts below are selected from a list of 9702 Experts worldwide ranked by ideXlab platform
Katherine E Yutzey - One of the best experts on this subject based on the ideXlab platform.
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calcineurin signaling and nfat activation in cardiovascular and skeletal muscle development
Developmental Biology, 2004Co-Authors: Robert A Schulz, Katherine E YutzeyAbstract:Calcineurin signaling has been implicated in a broad spectrum of developmental processes in a variety of organ systems. Calcineurin is a calmodulin-dependent, calcium-activated protein phosphatase composed of catalytic and regulatory subunits. The serine/threonine-specific phosphatase functions within a signal transduction pathway that regulates gene expression and biological responses in many developmentally important cell types. Calcineurin signaling was first defined in T lymphocytes as a regulator of nuclear factor of activated T cells (NFAT) transcription factor nuclear translocation and activation. Recent studies have demonstrated the vital nature of calcium/calcineurin/NFAT signaling in cardiovascular and skeletal muscle development in vertebrates. Inhibition, mutation, or forced expression of calcineurin pathway genes result in defects or alterations in cardiomyocyte maturation, Heart valve formation, vascular development, skeletal muscle differentiation and fiber-type switching, and cardiac and skeletal muscle hypertrophy. Conserved calcineurin genes are found in invertebrates such as Drosophila and Caenorhabditis elegans, and genetic studies have demonstrated specific myogenic functions for the phosphatase in their development. The ability to investigate calcineurin signaling pathways in vertebrates and model genetic organisms provides a great potential to more fully comprehend the functions of calcineurin and its interacting genes in Heart, Blood Vessel, and muscle development.
Nengsheng Pai - One of the best experts on this subject based on the ideXlab platform.
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bifurcation and nonlinear dynamic analysis of Heart Blood Vessel system
International Conference on Mechatronics and Automation, 2012Co-Authors: Chengchi Wang, Mingjyi Jang, Nengsheng PaiAbstract:Many studies have been shown and focused that variation of the quantity of vasoconstriction and Blood pressure will cause the nonlinear chaotic behaviors in the Heart Blood Vessel system and then induce the cardiovascular effect. Due to this kind of non-periodic motion is random and difficult to control, it is important to analyze and understand the status of dynamic system under different parametric conditions. In this paper, the differential transformation method is used to investigate the governing equations of system, and the dynamic behavior is characterized by reference to bifurcation diagrams, phase portraits, power spectra, and Poincare map produced. The results indicate that the system behavior is significantly dependent on the magnitude of the vibrational amplitude. Specifically, the motion changes from T-periodic to 2T-periodic, then from 4T-periodic to 8-periodic, and finally to chaotic motion with windows of periodic motion as the vibrational amplitude is increased from 0.3 to 0.6. The results can be used as the basis for subsequent development of the control system design, and also reduced the possibility of cardiopathy.
Robert A Schulz - One of the best experts on this subject based on the ideXlab platform.
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calcineurin signaling and nfat activation in cardiovascular and skeletal muscle development
Developmental Biology, 2004Co-Authors: Robert A Schulz, Katherine E YutzeyAbstract:Calcineurin signaling has been implicated in a broad spectrum of developmental processes in a variety of organ systems. Calcineurin is a calmodulin-dependent, calcium-activated protein phosphatase composed of catalytic and regulatory subunits. The serine/threonine-specific phosphatase functions within a signal transduction pathway that regulates gene expression and biological responses in many developmentally important cell types. Calcineurin signaling was first defined in T lymphocytes as a regulator of nuclear factor of activated T cells (NFAT) transcription factor nuclear translocation and activation. Recent studies have demonstrated the vital nature of calcium/calcineurin/NFAT signaling in cardiovascular and skeletal muscle development in vertebrates. Inhibition, mutation, or forced expression of calcineurin pathway genes result in defects or alterations in cardiomyocyte maturation, Heart valve formation, vascular development, skeletal muscle differentiation and fiber-type switching, and cardiac and skeletal muscle hypertrophy. Conserved calcineurin genes are found in invertebrates such as Drosophila and Caenorhabditis elegans, and genetic studies have demonstrated specific myogenic functions for the phosphatase in their development. The ability to investigate calcineurin signaling pathways in vertebrates and model genetic organisms provides a great potential to more fully comprehend the functions of calcineurin and its interacting genes in Heart, Blood Vessel, and muscle development.
Chengchi Wang - One of the best experts on this subject based on the ideXlab platform.
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bifurcation and nonlinear dynamic analysis of Heart Blood Vessel system
International Conference on Mechatronics and Automation, 2012Co-Authors: Chengchi Wang, Mingjyi Jang, Nengsheng PaiAbstract:Many studies have been shown and focused that variation of the quantity of vasoconstriction and Blood pressure will cause the nonlinear chaotic behaviors in the Heart Blood Vessel system and then induce the cardiovascular effect. Due to this kind of non-periodic motion is random and difficult to control, it is important to analyze and understand the status of dynamic system under different parametric conditions. In this paper, the differential transformation method is used to investigate the governing equations of system, and the dynamic behavior is characterized by reference to bifurcation diagrams, phase portraits, power spectra, and Poincare map produced. The results indicate that the system behavior is significantly dependent on the magnitude of the vibrational amplitude. Specifically, the motion changes from T-periodic to 2T-periodic, then from 4T-periodic to 8-periodic, and finally to chaotic motion with windows of periodic motion as the vibrational amplitude is increased from 0.3 to 0.6. The results can be used as the basis for subsequent development of the control system design, and also reduced the possibility of cardiopathy.
Mingjyi Jang - One of the best experts on this subject based on the ideXlab platform.
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bifurcation and nonlinear dynamic analysis of Heart Blood Vessel system
International Conference on Mechatronics and Automation, 2012Co-Authors: Chengchi Wang, Mingjyi Jang, Nengsheng PaiAbstract:Many studies have been shown and focused that variation of the quantity of vasoconstriction and Blood pressure will cause the nonlinear chaotic behaviors in the Heart Blood Vessel system and then induce the cardiovascular effect. Due to this kind of non-periodic motion is random and difficult to control, it is important to analyze and understand the status of dynamic system under different parametric conditions. In this paper, the differential transformation method is used to investigate the governing equations of system, and the dynamic behavior is characterized by reference to bifurcation diagrams, phase portraits, power spectra, and Poincare map produced. The results indicate that the system behavior is significantly dependent on the magnitude of the vibrational amplitude. Specifically, the motion changes from T-periodic to 2T-periodic, then from 4T-periodic to 8-periodic, and finally to chaotic motion with windows of periodic motion as the vibrational amplitude is increased from 0.3 to 0.6. The results can be used as the basis for subsequent development of the control system design, and also reduced the possibility of cardiopathy.
