The Experts below are selected from a list of 201 Experts worldwide ranked by ideXlab platform
José Gonçalves Pereira Filho - One of the best experts on this subject based on the ideXlab platform.
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an ontology based application in Heart Electrophysiology representation reasoning and visualization on the web
ACM Symposium on Applied Computing, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Computational technologies have been increasingly explored to make biomedical knowledge and data more accessible for human understanding, comparison, analysis and communication. In this context, ontology has been recognized in the bioinformatics literature as a suitable technique for advancing knowledge and data representations in Biomedicine. Moreover, automated reasoning and visualization mechanisms can favor in providing support for human comprehensibility as well as in dealing with the complexity inherent to this domain. This paper elaborates on the application of ontology for Heart Electrophysiology representation, reasoning and visualization on the web. The ontology-based application we propose can be used to offer support for interactive learning in Heart Electrophysiology.
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SAC - An ontology-based application in Heart Electrophysiology: representation, reasoning and visualization on the web
Proceedings of the 2009 ACM symposium on Applied Computing - SAC '09, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Computational technologies have been increasingly explored to make biomedical knowledge and data more accessible for human understanding, comparison, analysis and communication. In this context, ontology has been recognized in the bioinformatics literature as a suitable technique for advancing knowledge and data representations in Biomedicine. Moreover, automated reasoning and visualization mechanisms can favor in providing support for human comprehensibility as well as in dealing with the complexity inherent to this domain. This paper elaborates on the application of ontology for Heart Electrophysiology representation, reasoning and visualization on the web. The ontology-based application we propose can be used to offer support for interactive learning in Heart Electrophysiology.
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Using a lightweight ontology of Heart Electrophysiology in an interactive web application
Companion Proceedings of the XIV Brazilian Symposium on Multimedia and the Web - WebMedia '08, 2008Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Biomedical knowledge and data have been increasingly more explored by computer programs in providing support for human visualization of biomedical phenomena. Use scenarios of such graphical simulations range from physician's decision support to aid-learning in medical sciences. The knowledge and data representation often plays a prominent role in such biomedical applications. In this sense, this paper introduces the use of a lightweight ontology of Heart Electrophysiology in an interactive web application. We reflect on this ontology-based application to highlight some benefits achieved with a representation based on a combination of the semantic web languages OWL DL and SWRL. The application can be used to offer support for interactive learning in Heart Electrophysiology.
B. Wojcik - One of the best experts on this subject based on the ideXlab platform.
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Changes in ECG and enzyme activity in rat Heart after myocardial infarction: effect of TPP and MnCl_2
Journal of Physiology and Biochemistry, 2008Co-Authors: Adam Tylicki, Jan Czerniecki, A. Godlewska, M. Kieliszek, T. Zebrowski, T. Bielawski, B. WojcikAbstract:Tras infarto de miocardio, es de gran importancia el mantenimiento de un adecuado nivel energético. El catión Mn^2+ y la tiamina pirofosfato (TPP) afectan positivamente la actividad de los complejos piruvato deshidrogenasa (PDH) y 2-oxoglutarato deshidrogenasa (OGDH), con importante papel en el ciclo de Krebs. Asi, se ha estudiado el efecto del MnCl_2 (10 mg/kg) y la TPP (20 mg/kg), 4 inyecciones cada 12 h, sobre la actividad PDH, OGDH, lactato deshidrogenasa (LDH) y malato deshidrogenasa (MDH), tanto en ratas sanas como tras infarto de miocardio. Además se ha analizado el ECG de ratas sanas tras tratamiento con MnCl_2 y TPP. Los resultados muestran descenso en la actividad OGDH y MDH en ratas que han sufrido infarto respecto de sus controles. En ratas sanas, el MnCl_2 incrementa la actividad OGDH y, tanto MnCl_2 como TPP, incrementan la actividad PDH, Los datos electrocardiográficos muestran un ligero acortamiento del intervalo QT, con incremento de la frecuencia cardiaca tras el tratamiento con MnCl_2. La TPP causa sólo alargamiento del intervalo QT. Los resultados sugieren una posible aplicación potencial del MnCl_2 durante el período de convalecencia posterior al infarto de miocardio. Heart infarction is one of the main causes of death in the human population. Assurance of a sufficient level of bioenergetic processes is very important for the Heart after infarction. Mn^2+ as well as thiamine pyrophosphate (TPP) are positive effectors of the pyruvate dehydrogenase complex (PDH) and the 2-oxoglutarate dehydrogenase complex (OGDH), both of which play a very important role in the Krebs cycle. Thus, we have established the effect of MnCl_2 (10mg/kg) and TPP (20mg/kg)-4 injections every 12 h-on the activity of PDH, OGDH, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH). Additionally, we perform an analysis of ECG to affirm the changes in the Heart Electrophysiology of healthy rats after MnCl_2 and TPP treatment. We then analyzed changes in the activity of these enzymes after experimental myocardial infarction in rats. We observed a decrease of OGDH and MDH activity in rat Hearts after infarction in comparison, with sham-operated rats. Treatment of healthy rats with MnCl_2 caused an increase of OGDH activity. Moreover both MnCl_2 and TPP caused an increase of PDH activity and a decrease of MDH activity (TPP revealed a stronger effect). We found no changes in LDH activity. Electrocardiography data showed a slight shortening of the QT interval and an enhanced Heartbeat rate after treatment with MnCl_2. TPP caused only elongation of the QT interval. In conclusion, application of MnCl_2 enhanced the activity of some very important enzymes in the respiration process (PDH and OGDH). This effect, connected with enhanced Heartbeat and a slightly shortened ventricle relaxation, may have potential application during the key period of convalescence following Heart infarction.
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Changes in ECG and enzyme activity in rat Heart after myocardial infarction : effect of TPP and MnCl2
Journal of physiology and biochemistry, 2008Co-Authors: Adam Tylicki, Jan Czerniecki, A. Godlewska, M. Kieliszek, T. Zebrowski, T. Bielawski, B. WojcikAbstract:Heart infarction is one of the main causes of death in the human population. Assurance of a sufficient level of bioenergetic processes is very important for the Heart after infarction. Mn2+ as well as thiamine pyrophosphate (TPP) are positive effectors of the pyruvate dehydrogenase complex (PDH) and the 2-oxoglutarate dehydrogenase complex (OGDH), both of which play a very important role in the Krebs cycle. Thus, we have established the effect of MnCl2 (10mg/kg) and TPP (20mg/kg)-4 injections every 12 h-on the activity of PDH, OGDH, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH). Additionally, we perform an analysis of ECG to affirm the changes in the Heart Electrophysiology of healthy rats after MnCl2 and TPP treatment. We then analyzed changes in the activity of these enzymes after experimental myocardial infarction in rats. We observed a decrease of OGDH and MDH activity in rat Hearts after infarction in comparison, with sham-operated rats. Treatment of healthy rats with MnCl2 caused an increase of OGDH activity. Moreover both MnCl2 and TPP caused an increase of PDH activity and a decrease of MDH activity (TPP revealed a stronger effect). We found no changes in LDH activity. Electrocardiography data showed a slight shortening of the QT interval and an enhanced Heartbeat rate after treatment with MnCl2. TPP caused only elongation of the QT interval. In conclusion, application of MnCl2 enhanced the activity of some very important enzymes in the respiration process (PDH and OGDH). This effect, connected with enhanced Heartbeat and a slightly shortened ventricle relaxation, may have potential application during the key period of convalescence following Heart infarction.
Bernardo Gonçalves - One of the best experts on this subject based on the ideXlab platform.
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An ontological analysis of the electrocardiogram
RECIIS, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo GuizzardiAbstract:Bioinformatics has been a fertile field for the application of the discipline of formal ontology. The principled representation of biomedical entities has increasingly supported biological research, with direct benefits ranging from the reformulation of medical terminologies to the introduction of new perspectives for enhanced models of Electronic Health Records (EHR). This paper introduces an application-independent ontological analysis of the electrocardiogram (ECG) grounded in the Unified Foundational Ontology. With the objective of investigating the phenomena underlying this cardiological exam, we deal with the sub-domains of human Heart Electrophysiology and anatomy. We then outline an ECG Ontology built upon the OBO Relation Ontology. In addition, the domain ontology sketched here takes inspiration both in the Foundational Model of Anatomy and in the Ontology of Functions proposed under the auspices of the General Formal Ontology (GFO) research program.
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an ontology based application in Heart Electrophysiology representation reasoning and visualization on the web
ACM Symposium on Applied Computing, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Computational technologies have been increasingly explored to make biomedical knowledge and data more accessible for human understanding, comparison, analysis and communication. In this context, ontology has been recognized in the bioinformatics literature as a suitable technique for advancing knowledge and data representations in Biomedicine. Moreover, automated reasoning and visualization mechanisms can favor in providing support for human comprehensibility as well as in dealing with the complexity inherent to this domain. This paper elaborates on the application of ontology for Heart Electrophysiology representation, reasoning and visualization on the web. The ontology-based application we propose can be used to offer support for interactive learning in Heart Electrophysiology.
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SAC - An ontology-based application in Heart Electrophysiology: representation, reasoning and visualization on the web
Proceedings of the 2009 ACM symposium on Applied Computing - SAC '09, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Computational technologies have been increasingly explored to make biomedical knowledge and data more accessible for human understanding, comparison, analysis and communication. In this context, ontology has been recognized in the bioinformatics literature as a suitable technique for advancing knowledge and data representations in Biomedicine. Moreover, automated reasoning and visualization mechanisms can favor in providing support for human comprehensibility as well as in dealing with the complexity inherent to this domain. This paper elaborates on the application of ontology for Heart Electrophysiology representation, reasoning and visualization on the web. The ontology-based application we propose can be used to offer support for interactive learning in Heart Electrophysiology.
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An Ontological Theory of the Electrocardiogram with Applications
2009Co-Authors: Bernardo GonçalvesAbstract:The fields of Medicaland Bio-informatics are bearing witness of the application of the discipline of Formal Ontology to the representation of biomedical entities and (re-)organization of medical terminologies also in view of advancing electronic health records (EHR). In this context, the electrocardiogram (ECG) defines one of the prominent kinds of biomedical data. As a vital sign, it is an important piece in the composition of the EHR of today, as likely in the EHR of the future. This thesis introduces an ontological analysis of the ECG grounded in the Unified Foundational Ontology (UFO) and axiomatized in First-Order Logic (FOL). With the goal of investigating the phenomena underlying this cardiological exam, we deal with the sub-domains of human Heart Electrophysiology and anatomy. We then outline an ECG ontology meant to represent what the ECG is on both sides of the patient and of the physician. The ontology is implemented in the semantic web technology OWL with its SWRL extension. The ECG Ontology makes use of basic relations standardized in the OBO Relation Ontology for the biomedical domain. In addition, it takes inspiration in the Foundational Model of Anatomy (FMA) and applies the Ontology of Functions (OF). Besides the ECG ontological theory itself, two applications of the ECG Ontology are also presented here. The first one is concerned with the off-line integration of ECG data standards, a relevant endeavor for the progress of Medical Informatics. The second one in turn comprises a reasoning-based web system that can be used to offer support for interactive learning in electrocardiography / Heart Electrophysiology. Overall, we also reflect on the ECG Ontology as well as on its two applications to provide evidence for benefits achieved with the employment of methodological principles in terms of both ontological foundations and ontology engineering in building a domain ontology.
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Using a lightweight ontology of Heart Electrophysiology in an interactive web application
Companion Proceedings of the XIV Brazilian Symposium on Multimedia and the Web - WebMedia '08, 2008Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Biomedical knowledge and data have been increasingly more explored by computer programs in providing support for human visualization of biomedical phenomena. Use scenarios of such graphical simulations range from physician's decision support to aid-learning in medical sciences. The knowledge and data representation often plays a prominent role in such biomedical applications. In this sense, this paper introduces the use of a lightweight ontology of Heart Electrophysiology in an interactive web application. We reflect on this ontology-based application to highlight some benefits achieved with a representation based on a combination of the semantic web languages OWL DL and SWRL. The application can be used to offer support for interactive learning in Heart Electrophysiology.
Adam Tylicki - One of the best experts on this subject based on the ideXlab platform.
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Changes in ECG and enzyme activity in rat Heart after myocardial infarction: effect of TPP and MnCl_2
Journal of Physiology and Biochemistry, 2008Co-Authors: Adam Tylicki, Jan Czerniecki, A. Godlewska, M. Kieliszek, T. Zebrowski, T. Bielawski, B. WojcikAbstract:Tras infarto de miocardio, es de gran importancia el mantenimiento de un adecuado nivel energético. El catión Mn^2+ y la tiamina pirofosfato (TPP) afectan positivamente la actividad de los complejos piruvato deshidrogenasa (PDH) y 2-oxoglutarato deshidrogenasa (OGDH), con importante papel en el ciclo de Krebs. Asi, se ha estudiado el efecto del MnCl_2 (10 mg/kg) y la TPP (20 mg/kg), 4 inyecciones cada 12 h, sobre la actividad PDH, OGDH, lactato deshidrogenasa (LDH) y malato deshidrogenasa (MDH), tanto en ratas sanas como tras infarto de miocardio. Además se ha analizado el ECG de ratas sanas tras tratamiento con MnCl_2 y TPP. Los resultados muestran descenso en la actividad OGDH y MDH en ratas que han sufrido infarto respecto de sus controles. En ratas sanas, el MnCl_2 incrementa la actividad OGDH y, tanto MnCl_2 como TPP, incrementan la actividad PDH, Los datos electrocardiográficos muestran un ligero acortamiento del intervalo QT, con incremento de la frecuencia cardiaca tras el tratamiento con MnCl_2. La TPP causa sólo alargamiento del intervalo QT. Los resultados sugieren una posible aplicación potencial del MnCl_2 durante el período de convalecencia posterior al infarto de miocardio. Heart infarction is one of the main causes of death in the human population. Assurance of a sufficient level of bioenergetic processes is very important for the Heart after infarction. Mn^2+ as well as thiamine pyrophosphate (TPP) are positive effectors of the pyruvate dehydrogenase complex (PDH) and the 2-oxoglutarate dehydrogenase complex (OGDH), both of which play a very important role in the Krebs cycle. Thus, we have established the effect of MnCl_2 (10mg/kg) and TPP (20mg/kg)-4 injections every 12 h-on the activity of PDH, OGDH, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH). Additionally, we perform an analysis of ECG to affirm the changes in the Heart Electrophysiology of healthy rats after MnCl_2 and TPP treatment. We then analyzed changes in the activity of these enzymes after experimental myocardial infarction in rats. We observed a decrease of OGDH and MDH activity in rat Hearts after infarction in comparison, with sham-operated rats. Treatment of healthy rats with MnCl_2 caused an increase of OGDH activity. Moreover both MnCl_2 and TPP caused an increase of PDH activity and a decrease of MDH activity (TPP revealed a stronger effect). We found no changes in LDH activity. Electrocardiography data showed a slight shortening of the QT interval and an enhanced Heartbeat rate after treatment with MnCl_2. TPP caused only elongation of the QT interval. In conclusion, application of MnCl_2 enhanced the activity of some very important enzymes in the respiration process (PDH and OGDH). This effect, connected with enhanced Heartbeat and a slightly shortened ventricle relaxation, may have potential application during the key period of convalescence following Heart infarction.
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Changes in ECG and enzyme activity in rat Heart after myocardial infarction : effect of TPP and MnCl2
Journal of physiology and biochemistry, 2008Co-Authors: Adam Tylicki, Jan Czerniecki, A. Godlewska, M. Kieliszek, T. Zebrowski, T. Bielawski, B. WojcikAbstract:Heart infarction is one of the main causes of death in the human population. Assurance of a sufficient level of bioenergetic processes is very important for the Heart after infarction. Mn2+ as well as thiamine pyrophosphate (TPP) are positive effectors of the pyruvate dehydrogenase complex (PDH) and the 2-oxoglutarate dehydrogenase complex (OGDH), both of which play a very important role in the Krebs cycle. Thus, we have established the effect of MnCl2 (10mg/kg) and TPP (20mg/kg)-4 injections every 12 h-on the activity of PDH, OGDH, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH). Additionally, we perform an analysis of ECG to affirm the changes in the Heart Electrophysiology of healthy rats after MnCl2 and TPP treatment. We then analyzed changes in the activity of these enzymes after experimental myocardial infarction in rats. We observed a decrease of OGDH and MDH activity in rat Hearts after infarction in comparison, with sham-operated rats. Treatment of healthy rats with MnCl2 caused an increase of OGDH activity. Moreover both MnCl2 and TPP caused an increase of PDH activity and a decrease of MDH activity (TPP revealed a stronger effect). We found no changes in LDH activity. Electrocardiography data showed a slight shortening of the QT interval and an enhanced Heartbeat rate after treatment with MnCl2. TPP caused only elongation of the QT interval. In conclusion, application of MnCl2 enhanced the activity of some very important enzymes in the respiration process (PDH and OGDH). This effect, connected with enhanced Heartbeat and a slightly shortened ventricle relaxation, may have potential application during the key period of convalescence following Heart infarction.
Giancarlo Guizzardi - One of the best experts on this subject based on the ideXlab platform.
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An ontological analysis of the electrocardiogram
RECIIS, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo GuizzardiAbstract:Bioinformatics has been a fertile field for the application of the discipline of formal ontology. The principled representation of biomedical entities has increasingly supported biological research, with direct benefits ranging from the reformulation of medical terminologies to the introduction of new perspectives for enhanced models of Electronic Health Records (EHR). This paper introduces an application-independent ontological analysis of the electrocardiogram (ECG) grounded in the Unified Foundational Ontology. With the objective of investigating the phenomena underlying this cardiological exam, we deal with the sub-domains of human Heart Electrophysiology and anatomy. We then outline an ECG Ontology built upon the OBO Relation Ontology. In addition, the domain ontology sketched here takes inspiration both in the Foundational Model of Anatomy and in the Ontology of Functions proposed under the auspices of the General Formal Ontology (GFO) research program.
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an ontology based application in Heart Electrophysiology representation reasoning and visualization on the web
ACM Symposium on Applied Computing, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Computational technologies have been increasingly explored to make biomedical knowledge and data more accessible for human understanding, comparison, analysis and communication. In this context, ontology has been recognized in the bioinformatics literature as a suitable technique for advancing knowledge and data representations in Biomedicine. Moreover, automated reasoning and visualization mechanisms can favor in providing support for human comprehensibility as well as in dealing with the complexity inherent to this domain. This paper elaborates on the application of ontology for Heart Electrophysiology representation, reasoning and visualization on the web. The ontology-based application we propose can be used to offer support for interactive learning in Heart Electrophysiology.
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SAC - An ontology-based application in Heart Electrophysiology: representation, reasoning and visualization on the web
Proceedings of the 2009 ACM symposium on Applied Computing - SAC '09, 2009Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Computational technologies have been increasingly explored to make biomedical knowledge and data more accessible for human understanding, comparison, analysis and communication. In this context, ontology has been recognized in the bioinformatics literature as a suitable technique for advancing knowledge and data representations in Biomedicine. Moreover, automated reasoning and visualization mechanisms can favor in providing support for human comprehensibility as well as in dealing with the complexity inherent to this domain. This paper elaborates on the application of ontology for Heart Electrophysiology representation, reasoning and visualization on the web. The ontology-based application we propose can be used to offer support for interactive learning in Heart Electrophysiology.
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Using a lightweight ontology of Heart Electrophysiology in an interactive web application
Companion Proceedings of the XIV Brazilian Symposium on Multimedia and the Web - WebMedia '08, 2008Co-Authors: Bernardo Gonçalves, Veruska Zamborlini, Giancarlo Guizzardi, José Gonçalves Pereira FilhoAbstract:Biomedical knowledge and data have been increasingly more explored by computer programs in providing support for human visualization of biomedical phenomena. Use scenarios of such graphical simulations range from physician's decision support to aid-learning in medical sciences. The knowledge and data representation often plays a prominent role in such biomedical applications. In this sense, this paper introduces the use of a lightweight ontology of Heart Electrophysiology in an interactive web application. We reflect on this ontology-based application to highlight some benefits achieved with a representation based on a combination of the semantic web languages OWL DL and SWRL. The application can be used to offer support for interactive learning in Heart Electrophysiology.
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Codification and Application of a Well-Founded Heart-ECG Ontology
2007Co-Authors: Veruska Zamborlini, Bernardo Gonçalves, Giancarlo GuizzardiAbstract:Despite the fact that many authors in the literature defend the need of ontologically well-founded languages for ontology representation, this approach has not yet been broadly adopted. We present in this paper a codification of a well-founded Heart-ECG domain ontology in OWL+SWRL. The lightweight ontology produced is then applied to a web environment for Heart Electrophysiology reasoning and visualization. We also reflect on this codification process to argue in favor of the view that two classes of languages are needed for ontology engineering: (i) a theoretically well-founded representation language for creating conceptual domain ontologies; (ii) a lightweight representation language for codifying these conceptual ontologies.
