The Experts below are selected from a list of 2061 Experts worldwide ranked by ideXlab platform
Wei Sun - One of the best experts on this subject based on the ideXlab platform.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
Andrés Caballero - One of the best experts on this subject based on the ideXlab platform.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
Wenbin Mao - One of the best experts on this subject based on the ideXlab platform.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
Charles Primiano - One of the best experts on this subject based on the ideXlab platform.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
Sabet Hashim - One of the best experts on this subject based on the ideXlab platform.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Author Correction: New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2019Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid–structure interaction computational modeling
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Raymond Mckay, Charles Primiano, Sabet Hashim, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
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New insights into mitral Heart Valve Prolapse after chordae rupture through fluid-structure interaction computational modeling.
Scientific Reports, 2018Co-Authors: Andrés Caballero, Wenbin Mao, Charles Primiano, Sabet Hashim, Raymond G. Mckay, Wei SunAbstract:Mitral Valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall. Chordae rupture disrupts the link between the MV and the left ventricle (LV), causing mitral regurgitation (MR), the most common valvular disease. In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left Heart (LH) dynamics and severity of MR. A control and seven chordae rupture LH models were developed to simulate a pathological process in which minimal chordae rupture precedes more extensive chordae rupture. Different non-eccentric and eccentric regurgitant jets were identified during systole. Cardiac efficiency was evaluated by the ratio of external stroke work. MV structural results showed that basal/strut chordae were the major load-bearing chordae. An increased number of ruptured chordae resulted in reduced basal/strut tension, but increased marginal/intermediate load. Chordae rupture in a specific scallop did not necessarily involve an increase in the stress of the entire Prolapsed leaflet. This work represents a further step towards patient-specific modeling of pathological LH dynamics, and has the potential to improve our understanding of the biomechanical mechanisms and treatment of primary MR.
