The Experts below are selected from a list of 10713 Experts worldwide ranked by ideXlab platform
Liandi Zhang - One of the best experts on this subject based on the ideXlab platform.
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five membered heteroaromatic ring fused pyrimidine derivatives design synthesis and Hedgehog Signaling Pathway inhibition study
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five‐Membered Heteroaromatic Ring Fused‐Pyrimidine Derivatives: Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study.
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and Hedgehog Signaling Pathway inhibition study.
Bioorganic & medicinal chemistry letters, 2014Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines have been identified to be potent inhibitors of Hedgehog Signaling Pathway. The synthesis and SAR of these compounds are described. Among this new series of Hedgehog Signaling Pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for Hedgehog Signaling Pathway inhibitors, deserving more exploration and further investigation.
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Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel Hedgehog Signaling Pathway inhibitors
Medicinal Chemistry Research, 2014Co-Authors: Minhang Xin, Jun Wen, Han Shen, Liandi Zhang, Liu Zhaoyu, Lingfei Cheng, Xinge ZhaoAbstract:A novel series of Hedgehog Signaling Pathway inhibitors were designed by replacing the pyrimidine nucleus of our earlier reported compounds with 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine scaffold. Among this new class of Hedgehog Signaling Pathway inhibitors, compounds 14 and 18 exhibited promising potency in vitro compared to GDC-0449. Compound 18 was advanced to profile its pharmacokinetic characteristics, and showed moderate pharmacokinetic properties in vivo, indicating that the 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine skeleton is a promising scaffold for further exploration as Hedgehog Signaling Pathway inhibitors.
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Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of Hedgehog Signaling Pathway.
Bioorganic & medicinal chemistry letters, 2013Co-Authors: Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Lingfei Cheng, Wei Huang, Wang Mengyu, Liandi ZhangAbstract:A novel series of Hedgehog Signaling Pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
Minhang Xin - One of the best experts on this subject based on the ideXlab platform.
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five membered heteroaromatic ring fused pyrimidine derivatives design synthesis and Hedgehog Signaling Pathway inhibition study
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five‐Membered Heteroaromatic Ring Fused‐Pyrimidine Derivatives: Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study.
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and Hedgehog Signaling Pathway inhibition study.
Bioorganic & medicinal chemistry letters, 2014Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines have been identified to be potent inhibitors of Hedgehog Signaling Pathway. The synthesis and SAR of these compounds are described. Among this new series of Hedgehog Signaling Pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for Hedgehog Signaling Pathway inhibitors, deserving more exploration and further investigation.
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Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel Hedgehog Signaling Pathway inhibitors
Medicinal Chemistry Research, 2014Co-Authors: Minhang Xin, Jun Wen, Han Shen, Liandi Zhang, Liu Zhaoyu, Lingfei Cheng, Xinge ZhaoAbstract:A novel series of Hedgehog Signaling Pathway inhibitors were designed by replacing the pyrimidine nucleus of our earlier reported compounds with 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine scaffold. Among this new class of Hedgehog Signaling Pathway inhibitors, compounds 14 and 18 exhibited promising potency in vitro compared to GDC-0449. Compound 18 was advanced to profile its pharmacokinetic characteristics, and showed moderate pharmacokinetic properties in vivo, indicating that the 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine skeleton is a promising scaffold for further exploration as Hedgehog Signaling Pathway inhibitors.
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Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of Hedgehog Signaling Pathway.
Bioorganic & medicinal chemistry letters, 2013Co-Authors: Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Lingfei Cheng, Wei Huang, Wang Mengyu, Liandi ZhangAbstract:A novel series of Hedgehog Signaling Pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
Xinge Zhao - One of the best experts on this subject based on the ideXlab platform.
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five membered heteroaromatic ring fused pyrimidine derivatives design synthesis and Hedgehog Signaling Pathway inhibition study
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five‐Membered Heteroaromatic Ring Fused‐Pyrimidine Derivatives: Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study.
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and Hedgehog Signaling Pathway inhibition study.
Bioorganic & medicinal chemistry letters, 2014Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines have been identified to be potent inhibitors of Hedgehog Signaling Pathway. The synthesis and SAR of these compounds are described. Among this new series of Hedgehog Signaling Pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for Hedgehog Signaling Pathway inhibitors, deserving more exploration and further investigation.
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Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel Hedgehog Signaling Pathway inhibitors
Medicinal Chemistry Research, 2014Co-Authors: Minhang Xin, Jun Wen, Han Shen, Liandi Zhang, Liu Zhaoyu, Lingfei Cheng, Xinge ZhaoAbstract:A novel series of Hedgehog Signaling Pathway inhibitors were designed by replacing the pyrimidine nucleus of our earlier reported compounds with 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine scaffold. Among this new class of Hedgehog Signaling Pathway inhibitors, compounds 14 and 18 exhibited promising potency in vitro compared to GDC-0449. Compound 18 was advanced to profile its pharmacokinetic characteristics, and showed moderate pharmacokinetic properties in vivo, indicating that the 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine skeleton is a promising scaffold for further exploration as Hedgehog Signaling Pathway inhibitors.
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Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of Hedgehog Signaling Pathway.
Bioorganic & medicinal chemistry letters, 2013Co-Authors: Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Lingfei Cheng, Wei Huang, Wang Mengyu, Liandi ZhangAbstract:A novel series of Hedgehog Signaling Pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
Jun Wen - One of the best experts on this subject based on the ideXlab platform.
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five membered heteroaromatic ring fused pyrimidine derivatives design synthesis and Hedgehog Signaling Pathway inhibition study
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five‐Membered Heteroaromatic Ring Fused‐Pyrimidine Derivatives: Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study.
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and Hedgehog Signaling Pathway inhibition study.
Bioorganic & medicinal chemistry letters, 2014Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines have been identified to be potent inhibitors of Hedgehog Signaling Pathway. The synthesis and SAR of these compounds are described. Among this new series of Hedgehog Signaling Pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for Hedgehog Signaling Pathway inhibitors, deserving more exploration and further investigation.
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Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel Hedgehog Signaling Pathway inhibitors
Medicinal Chemistry Research, 2014Co-Authors: Minhang Xin, Jun Wen, Han Shen, Liandi Zhang, Liu Zhaoyu, Lingfei Cheng, Xinge ZhaoAbstract:A novel series of Hedgehog Signaling Pathway inhibitors were designed by replacing the pyrimidine nucleus of our earlier reported compounds with 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine scaffold. Among this new class of Hedgehog Signaling Pathway inhibitors, compounds 14 and 18 exhibited promising potency in vitro compared to GDC-0449. Compound 18 was advanced to profile its pharmacokinetic characteristics, and showed moderate pharmacokinetic properties in vivo, indicating that the 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine skeleton is a promising scaffold for further exploration as Hedgehog Signaling Pathway inhibitors.
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Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of Hedgehog Signaling Pathway.
Bioorganic & medicinal chemistry letters, 2013Co-Authors: Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Lingfei Cheng, Wei Huang, Wang Mengyu, Liandi ZhangAbstract:A novel series of Hedgehog Signaling Pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
Han Shen - One of the best experts on this subject based on the ideXlab platform.
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five membered heteroaromatic ring fused pyrimidine derivatives design synthesis and Hedgehog Signaling Pathway inhibition study
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five‐Membered Heteroaromatic Ring Fused‐Pyrimidine Derivatives: Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study.
ChemInform, 2015Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:Among the new pyrimidine derivatives, compounds (I) are the most potent Hedgehog Signaling Pathway inhibitors.
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Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and Hedgehog Signaling Pathway inhibition study.
Bioorganic & medicinal chemistry letters, 2014Co-Authors: Liandi Zhang, Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Ping WeiAbstract:A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines have been identified to be potent inhibitors of Hedgehog Signaling Pathway. The synthesis and SAR of these compounds are described. Among this new series of Hedgehog Signaling Pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for Hedgehog Signaling Pathway inhibitors, deserving more exploration and further investigation.
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Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel Hedgehog Signaling Pathway inhibitors
Medicinal Chemistry Research, 2014Co-Authors: Minhang Xin, Jun Wen, Han Shen, Liandi Zhang, Liu Zhaoyu, Lingfei Cheng, Xinge ZhaoAbstract:A novel series of Hedgehog Signaling Pathway inhibitors were designed by replacing the pyrimidine nucleus of our earlier reported compounds with 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine scaffold. Among this new class of Hedgehog Signaling Pathway inhibitors, compounds 14 and 18 exhibited promising potency in vitro compared to GDC-0449. Compound 18 was advanced to profile its pharmacokinetic characteristics, and showed moderate pharmacokinetic properties in vivo, indicating that the 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine skeleton is a promising scaffold for further exploration as Hedgehog Signaling Pathway inhibitors.
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Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of Hedgehog Signaling Pathway.
Bioorganic & medicinal chemistry letters, 2013Co-Authors: Minhang Xin, Jun Wen, Feng Tang, Han Shen, Xinge Zhao, Lingfei Cheng, Wei Huang, Wang Mengyu, Liandi ZhangAbstract:A novel series of Hedgehog Signaling Pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.