The Experts below are selected from a list of 1092 Experts worldwide ranked by ideXlab platform
Qing Zhao - One of the best experts on this subject based on the ideXlab platform.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2021Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambiguously established by means of extensive spectroscopic data (IR, UV, HRMS, and NMR) and electronic circular dichroism (ECD) calculations. This is the first report of naturally occurring labdane-type hexanorditerpenoid. Compound 1 was proved to have moderate cytotoxicity against XWLC-05 cell line with an IC50 value of 53.6 μM.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2019Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambigu...
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hedychins a and b 6 7 dinorlabdane diterpenoids with a peroxide bridge from Hedychium forrestii
Organic Letters, 2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively.
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Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii
2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively
Haiyang Liu - One of the best experts on this subject based on the ideXlab platform.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2021Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambiguously established by means of extensive spectroscopic data (IR, UV, HRMS, and NMR) and electronic circular dichroism (ECD) calculations. This is the first report of naturally occurring labdane-type hexanorditerpenoid. Compound 1 was proved to have moderate cytotoxicity against XWLC-05 cell line with an IC50 value of 53.6 μM.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2019Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambigu...
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hedychins a and b 6 7 dinorlabdane diterpenoids with a peroxide bridge from Hedychium forrestii
Organic Letters, 2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively.
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Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii
2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively
Xujie Qin - One of the best experts on this subject based on the ideXlab platform.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2021Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambiguously established by means of extensive spectroscopic data (IR, UV, HRMS, and NMR) and electronic circular dichroism (ECD) calculations. This is the first report of naturally occurring labdane-type hexanorditerpenoid. Compound 1 was proved to have moderate cytotoxicity against XWLC-05 cell line with an IC50 value of 53.6 μM.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2019Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambigu...
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hedychins a and b 6 7 dinorlabdane diterpenoids with a peroxide bridge from Hedychium forrestii
Organic Letters, 2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively.
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Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii
2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively
Jiejie Gao - One of the best experts on this subject based on the ideXlab platform.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2021Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambiguously established by means of extensive spectroscopic data (IR, UV, HRMS, and NMR) and electronic circular dichroism (ECD) calculations. This is the first report of naturally occurring labdane-type hexanorditerpenoid. Compound 1 was proved to have moderate cytotoxicity against XWLC-05 cell line with an IC50 value of 53.6 μM.
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new diterpenoids from the rhizomes of Hedychium forrestii
Natural Product Research, 2019Co-Authors: Wenhui Wang, Jiejie Gao, Xiaofei Zuo, Xujie Qin, Haiyang Liu, Qing ZhaoAbstract:A novel hexanorditerpenoid, hedychin C (1), and a new diterpenoid, hedychin D (2), were isolated from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unambigu...
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hedychins a and b 6 7 dinorlabdane diterpenoids with a peroxide bridge from Hedychium forrestii
Organic Letters, 2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively.
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Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii
2018Co-Authors: Qing Zhao, Jiejie Gao, Xujie Qin, Xiaojiang Hao, Haiyang LiuAbstract:Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC50 values of 8.0 and 19.7 μM, respectively
Madhusudana J Rao - One of the best experts on this subject based on the ideXlab platform.
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phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity
Bioorganic & Medicinal Chemistry Letters, 2009Co-Authors: Prabhakar P Reddy, B S Sastry, Madhusudana J Rao, Ranga R Rao, J Shashidhar, Suresh K BabuAbstract:A comprehensive reinvestigation of chemical constituents from the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpene (1, 2), together with six known compounds (3-8). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature. In addition, all the isolates were tested for their cytotoxicity against the THP-1 (human acute monocytic leukemia), HL-60 (human promyelocytic leukemia), A-375 (human malignant melanoma) and A-549 (human lung carcinoma) cancerous cell lines.
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new labdane diterpenes as intestinal α glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum ham ex smith rhizomes
Bioorganic & Medicinal Chemistry Letters, 2009Co-Authors: Prabhakar P Reddy, Ashok K Tiwari, Ranga R Rao, K Madhusudhana, Rama Subba V Rao, Amtul Z Ali, Suresh K Babu, Madhusudana J RaoAbstract:Abstract Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4–9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal α-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal α-glucosidase inhibitory potential.
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two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum
Bioorganic & Medicinal Chemistry Letters, 2009Co-Authors: Prabhakar P Reddy, Ranga R Rao, Suresh K Babu, K Rekha, J Shashidhar, G Shashikiran, Vijaya V Lakshmi, Madhusudana J RaoAbstract:Phytochemical investigation of CHCl3 extract of the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpenes, compounds 1 and 2 along with five known compounds (3–7). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against the Colo-205 (Colo-cancer), A-431 (skin cancer), MCF-7 (breast cancer), A-549 (lung cancer) and Chinese hamster ovary cells (CHO). Two new compounds 1 and 2 were shown good cytotoxic activity.
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a new convenient method for quantitative analysis of hedychenone an anti inflammatory compound in the rhizomes of Hedychium spicatum buch hem
Jpc-journal of Planar Chromatography-modern Tlc, 2007Co-Authors: P V Srinivas, Sekar Anubala, V U M Sarma, B S Sastry, Madhusudana J RaoAbstract:Plants of the Hedychium genus are perennial rhizomatus plants belonging to the Zingiberaceae family. Extracts of Zingiberacaea have long been used in traditional medicine. A simple, precise, and convenient HPTLC method has been established for analysis of hedychenone, the major marker compound extracted from the rhizomes of Hedychium spicatum (Buch-Hem). Chromatography was performed on silica gel 60F 254 plates with ethyl acetate-hexane, 20 + 80 ( v/v ), as mobile phase. Detection and quantification were performed densitometrically at λ max = 254 nm with hedychenone as external standard. The method is characterized by high sensitivity and linearity over a wide range of concentrations.