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Hsueyin Hsu - One of the best experts on this subject based on the ideXlab platform.

  • comparative study on the immunocompetent activity of three different kinds of peh hue juwa chi cao Hedyotis diffusa h corymbosa and mollugo pentaphylla after sublethal whole body x irradiation
    Phytotherapy Research, 1997
    Co-Authors: Jenqjer Yang, Hsueyin Hsu, Chunching Lin
    Abstract:

    This brief communication describes the immunocompetent activity of the Chinese folk-medicinal herbs, Hedyotis corymbosa, H. diffusa and Mollugo pentaphylla in mice after moderate whole body x-irradiation. These antitumour drugs, given at doses of 500 and 1000 mg/kg/day for 7 consecutive days before x-irradiation protected ICR strain mice from the sublethal effects of radiation at a dose of 4 Gy, especialy for the dose at 1000 mg/kg. Prior administration of H. corymbosa and H. diffusa ameliorated the leukopenia and splenic cellular decrease induced by sublethal irradiation, and slightly increased the immunocompetence of splenic cells after being stimulated by mitogens. However, administration of M. pentaphylla before x-irradiation exerted a less protective effect on ameliorating leukopenia and on splenic cellular immunocompetence. These findings suggest that some types of Peh-Hue-Juwa-Chi-Caoi (PHJCC) may also be effective in the prevention of haematopoietic damage when used in combination with radiotherapy.

  • the possible use of peh hue juwa chi cao as an antitumour agent and radioprotector after therapeutic irradiation
    Phytotherapy Research, 1997
    Co-Authors: Jenqjer Yang, Chunching Lin, Hsueyin Hsu
    Abstract:

    Peh-Hue-Juwa-Chi-Cao is suggested for human use as an antitumour agent. In this study, three different crude drugs that take the same name 'Peh-Hue-Juwa-Chi-Cao', Hedyotis diffusa (HD), Hedyotis colymbosa (HC) and Mollugo pentaphylla (MP), were evaluated for their antitumour activity against malignant implanted subcutaneous tumours. In addition, studies on the protective effect of radiation-induced haematopoietic damage after whole body irradiation were also done. Several experimental approaches were used. In the antitumour study, sarcoma-180 cells were implanted into the femoral part to induce subcutaneous tumours several days later. Combinations of 9.5 Gy x-irradiation with 1000 mg/kg Peh-Hue-Juwa-Chi-Cao was more effective than other treatments. Studies on their radioprotective effects were performed using measurements of the changes of leukocytes and haematocrits after whole-body irradiation. Different sequences of x-irradiation were studied with or without crude drug administration in groups of ICR strain mice which were intraperitoneally injected at a dose of 500 or 1000 mg/kg body weight, 30 min before irradiation. These three kinds of Peh-Hue-Juwa-Chi-Cao, HD, HC and MP all showed the similar antitumour effects on the implanted subcutaneous tumour. Using adequate treatment, HD, HC and MP had significant effects on promoting the recovery of leukocytes from radiation damage. However, HD showed no significant difference on the efficacy of recovery from haematocrit, compared with that of HC.

Jenqjer Yang - One of the best experts on this subject based on the ideXlab platform.

  • comparative study on the immunocompetent activity of three different kinds of peh hue juwa chi cao Hedyotis diffusa h corymbosa and mollugo pentaphylla after sublethal whole body x irradiation
    Phytotherapy Research, 1997
    Co-Authors: Jenqjer Yang, Hsueyin Hsu, Chunching Lin
    Abstract:

    This brief communication describes the immunocompetent activity of the Chinese folk-medicinal herbs, Hedyotis corymbosa, H. diffusa and Mollugo pentaphylla in mice after moderate whole body x-irradiation. These antitumour drugs, given at doses of 500 and 1000 mg/kg/day for 7 consecutive days before x-irradiation protected ICR strain mice from the sublethal effects of radiation at a dose of 4 Gy, especialy for the dose at 1000 mg/kg. Prior administration of H. corymbosa and H. diffusa ameliorated the leukopenia and splenic cellular decrease induced by sublethal irradiation, and slightly increased the immunocompetence of splenic cells after being stimulated by mitogens. However, administration of M. pentaphylla before x-irradiation exerted a less protective effect on ameliorating leukopenia and on splenic cellular immunocompetence. These findings suggest that some types of Peh-Hue-Juwa-Chi-Caoi (PHJCC) may also be effective in the prevention of haematopoietic damage when used in combination with radiotherapy.

  • the possible use of peh hue juwa chi cao as an antitumour agent and radioprotector after therapeutic irradiation
    Phytotherapy Research, 1997
    Co-Authors: Jenqjer Yang, Chunching Lin, Hsueyin Hsu
    Abstract:

    Peh-Hue-Juwa-Chi-Cao is suggested for human use as an antitumour agent. In this study, three different crude drugs that take the same name 'Peh-Hue-Juwa-Chi-Cao', Hedyotis diffusa (HD), Hedyotis colymbosa (HC) and Mollugo pentaphylla (MP), were evaluated for their antitumour activity against malignant implanted subcutaneous tumours. In addition, studies on the protective effect of radiation-induced haematopoietic damage after whole body irradiation were also done. Several experimental approaches were used. In the antitumour study, sarcoma-180 cells were implanted into the femoral part to induce subcutaneous tumours several days later. Combinations of 9.5 Gy x-irradiation with 1000 mg/kg Peh-Hue-Juwa-Chi-Cao was more effective than other treatments. Studies on their radioprotective effects were performed using measurements of the changes of leukocytes and haematocrits after whole-body irradiation. Different sequences of x-irradiation were studied with or without crude drug administration in groups of ICR strain mice which were intraperitoneally injected at a dose of 500 or 1000 mg/kg body weight, 30 min before irradiation. These three kinds of Peh-Hue-Juwa-Chi-Cao, HD, HC and MP all showed the similar antitumour effects on the implanted subcutaneous tumour. Using adequate treatment, HD, HC and MP had significant effects on promoting the recovery of leukocytes from radiation damage. However, HD showed no significant difference on the efficacy of recovery from haematocrit, compared with that of HC.

Chunching Lin - One of the best experts on this subject based on the ideXlab platform.

  • comparative study on the immunocompetent activity of three different kinds of peh hue juwa chi cao Hedyotis diffusa h corymbosa and mollugo pentaphylla after sublethal whole body x irradiation
    Phytotherapy Research, 1997
    Co-Authors: Jenqjer Yang, Hsueyin Hsu, Chunching Lin
    Abstract:

    This brief communication describes the immunocompetent activity of the Chinese folk-medicinal herbs, Hedyotis corymbosa, H. diffusa and Mollugo pentaphylla in mice after moderate whole body x-irradiation. These antitumour drugs, given at doses of 500 and 1000 mg/kg/day for 7 consecutive days before x-irradiation protected ICR strain mice from the sublethal effects of radiation at a dose of 4 Gy, especialy for the dose at 1000 mg/kg. Prior administration of H. corymbosa and H. diffusa ameliorated the leukopenia and splenic cellular decrease induced by sublethal irradiation, and slightly increased the immunocompetence of splenic cells after being stimulated by mitogens. However, administration of M. pentaphylla before x-irradiation exerted a less protective effect on ameliorating leukopenia and on splenic cellular immunocompetence. These findings suggest that some types of Peh-Hue-Juwa-Chi-Caoi (PHJCC) may also be effective in the prevention of haematopoietic damage when used in combination with radiotherapy.

  • the possible use of peh hue juwa chi cao as an antitumour agent and radioprotector after therapeutic irradiation
    Phytotherapy Research, 1997
    Co-Authors: Jenqjer Yang, Chunching Lin, Hsueyin Hsu
    Abstract:

    Peh-Hue-Juwa-Chi-Cao is suggested for human use as an antitumour agent. In this study, three different crude drugs that take the same name 'Peh-Hue-Juwa-Chi-Cao', Hedyotis diffusa (HD), Hedyotis colymbosa (HC) and Mollugo pentaphylla (MP), were evaluated for their antitumour activity against malignant implanted subcutaneous tumours. In addition, studies on the protective effect of radiation-induced haematopoietic damage after whole body irradiation were also done. Several experimental approaches were used. In the antitumour study, sarcoma-180 cells were implanted into the femoral part to induce subcutaneous tumours several days later. Combinations of 9.5 Gy x-irradiation with 1000 mg/kg Peh-Hue-Juwa-Chi-Cao was more effective than other treatments. Studies on their radioprotective effects were performed using measurements of the changes of leukocytes and haematocrits after whole-body irradiation. Different sequences of x-irradiation were studied with or without crude drug administration in groups of ICR strain mice which were intraperitoneally injected at a dose of 500 or 1000 mg/kg body weight, 30 min before irradiation. These three kinds of Peh-Hue-Juwa-Chi-Cao, HD, HC and MP all showed the similar antitumour effects on the implanted subcutaneous tumour. Using adequate treatment, HD, HC and MP had significant effects on promoting the recovery of leukocytes from radiation damage. However, HD showed no significant difference on the efficacy of recovery from haematocrit, compared with that of HC.

Jinping Liu - One of the best experts on this subject based on the ideXlab platform.

  • discovery of the potential biomarkers for discrimination between Hedyotis diffusa and Hedyotis corymbosa by uplc qtof ms metabolome analysis
    Molecules, 2018
    Co-Authors: Yaru Wang, Cuizhu Wang, Hongqiang Lin, Yunhe Liu, Yan Zhao, Jinping Liu
    Abstract:

    Hedyotis diffuse Willd. (HD) and Hedyotis corymbosa (L.) Lam. (HC), two closely related species of the same genus, are both used for health benefits and disease prevention in China. HC is also indiscriminately sold as HD in the wholesale chain and food markets. This confusion has led to a growing concern about their identification and quality evaluation. In order to further understand the molecular diversification between them, we focus on the screening of chemical components and the analysis of non-targeted metabolites. In this study, UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analyses were used to profile them. Firstly, a total of 113 compounds, including 80 shared chemical constituents of the two plants, were identified from HC and HD by using the UNIFI platform. Secondly, the differences between two herbs were highlighted with the comparative analysis. As a result, a total of 33 robust biomarkers enabling the differentiation were discovered by using multivariate statistical analyses. For HC, there were 18 potential biomarkers (either the contents were much greater than in HD or being detected only in HC) including three iridoids, eight flavonoids, two tannins, two ketones, one alcohol and two monoterpenes. For HD, there were15 potential biomarkers (either the contents were much greater than in HC or being detected only in HD) including two iridoids, eight flavonoids, one tannin, one ketone, and three anthraquinones. With a comprehensive consideration of the contents or the MS responses of the chemical composition, Hedycoryside A and B, detected only in HC, could be used for rapid identification of HC. The compounds 1,3-dihydroxy-2-methylanthraquinone and 2-hydroxy-3-methylanthraquinone, detected only in HD, could be used for rapid identification of that plant. The systematic comparison of similarities and differences between two confusing Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances. HC should not be used as the substitute of HD.

  • Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
    'MDPI AG', 2018
    Co-Authors: Yaru Wang, Cuizhu Wang, Hongqiang Lin, Yunhe Liu, Yan Zhao, Jinping Liu
    Abstract:

    Hedyotis diffuse Willd. (HD) and Hedyotis corymbosa (L.) Lam. (HC), two closely related species of the same genus, are both used for health benefits and disease prevention in China. HC is also indiscriminately sold as HD in the wholesale chain and food markets. This confusion has led to a growing concern about their identification and quality evaluation. In order to further understand the molecular diversification between them, we focus on the screening of chemical components and the analysis of non-targeted metabolites. In this study, UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analyses were used to profile them. Firstly, a total of 113 compounds, including 80 shared chemical constituents of the two plants, were identified from HC and HD by using the UNIFI platform. Secondly, the differences between two herbs were highlighted with the comparative analysis. As a result, a total of 33 robust biomarkers enabling the differentiation were discovered by using multivariate statistical analyses. For HC, there were 18 potential biomarkers (either the contents were much greater than in HD or being detected only in HC) including three iridoids, eight flavonoids, two tannins, two ketones, one alcohol and two monoterpenes. For HD, there were15 potential biomarkers (either the contents were much greater than in HC or being detected only in HD) including two iridoids, eight flavonoids, one tannin, one ketone, and three anthraquinones. With a comprehensive consideration of the contents or the MS responses of the chemical composition, Hedycoryside A and B, detected only in HC, could be used for rapid identification of HC. The compounds 1,3-dihydroxy-2-methylanthraquinone and 2-hydroxy-3-methylanthraquinone, detected only in HD, could be used for rapid identification of that plant. The systematic comparison of similarities and differences between two confusing Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances. HC should not be used as the substitute of HD

Yaru Wang - One of the best experts on this subject based on the ideXlab platform.

  • discovery of the potential biomarkers for discrimination between Hedyotis diffusa and Hedyotis corymbosa by uplc qtof ms metabolome analysis
    Molecules, 2018
    Co-Authors: Yaru Wang, Cuizhu Wang, Hongqiang Lin, Yunhe Liu, Yan Zhao, Jinping Liu
    Abstract:

    Hedyotis diffuse Willd. (HD) and Hedyotis corymbosa (L.) Lam. (HC), two closely related species of the same genus, are both used for health benefits and disease prevention in China. HC is also indiscriminately sold as HD in the wholesale chain and food markets. This confusion has led to a growing concern about their identification and quality evaluation. In order to further understand the molecular diversification between them, we focus on the screening of chemical components and the analysis of non-targeted metabolites. In this study, UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analyses were used to profile them. Firstly, a total of 113 compounds, including 80 shared chemical constituents of the two plants, were identified from HC and HD by using the UNIFI platform. Secondly, the differences between two herbs were highlighted with the comparative analysis. As a result, a total of 33 robust biomarkers enabling the differentiation were discovered by using multivariate statistical analyses. For HC, there were 18 potential biomarkers (either the contents were much greater than in HD or being detected only in HC) including three iridoids, eight flavonoids, two tannins, two ketones, one alcohol and two monoterpenes. For HD, there were15 potential biomarkers (either the contents were much greater than in HC or being detected only in HD) including two iridoids, eight flavonoids, one tannin, one ketone, and three anthraquinones. With a comprehensive consideration of the contents or the MS responses of the chemical composition, Hedycoryside A and B, detected only in HC, could be used for rapid identification of HC. The compounds 1,3-dihydroxy-2-methylanthraquinone and 2-hydroxy-3-methylanthraquinone, detected only in HD, could be used for rapid identification of that plant. The systematic comparison of similarities and differences between two confusing Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances. HC should not be used as the substitute of HD.

  • Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
    'MDPI AG', 2018
    Co-Authors: Yaru Wang, Cuizhu Wang, Hongqiang Lin, Yunhe Liu, Yan Zhao, Jinping Liu
    Abstract:

    Hedyotis diffuse Willd. (HD) and Hedyotis corymbosa (L.) Lam. (HC), two closely related species of the same genus, are both used for health benefits and disease prevention in China. HC is also indiscriminately sold as HD in the wholesale chain and food markets. This confusion has led to a growing concern about their identification and quality evaluation. In order to further understand the molecular diversification between them, we focus on the screening of chemical components and the analysis of non-targeted metabolites. In this study, UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analyses were used to profile them. Firstly, a total of 113 compounds, including 80 shared chemical constituents of the two plants, were identified from HC and HD by using the UNIFI platform. Secondly, the differences between two herbs were highlighted with the comparative analysis. As a result, a total of 33 robust biomarkers enabling the differentiation were discovered by using multivariate statistical analyses. For HC, there were 18 potential biomarkers (either the contents were much greater than in HD or being detected only in HC) including three iridoids, eight flavonoids, two tannins, two ketones, one alcohol and two monoterpenes. For HD, there were15 potential biomarkers (either the contents were much greater than in HC or being detected only in HD) including two iridoids, eight flavonoids, one tannin, one ketone, and three anthraquinones. With a comprehensive consideration of the contents or the MS responses of the chemical composition, Hedycoryside A and B, detected only in HC, could be used for rapid identification of HC. The compounds 1,3-dihydroxy-2-methylanthraquinone and 2-hydroxy-3-methylanthraquinone, detected only in HD, could be used for rapid identification of that plant. The systematic comparison of similarities and differences between two confusing Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances. HC should not be used as the substitute of HD