The Experts below are selected from a list of 3675 Experts worldwide ranked by ideXlab platform

Mauri A. Kostiainen - One of the best experts on this subject based on the ideXlab platform.

  • virus encapsulated dna origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracel...

  • Virus-encapsulated DNA origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intraCellular reactions by origami-based templates.

Joona Mikkilä - One of the best experts on this subject based on the ideXlab platform.

  • virus encapsulated dna origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracel...

  • Virus-encapsulated DNA origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intraCellular reactions by origami-based templates.

Elina H. Niemelä - One of the best experts on this subject based on the ideXlab platform.

  • virus encapsulated dna origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracel...

  • Virus-encapsulated DNA origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intraCellular reactions by origami-based templates.

Päivi Törmä - One of the best experts on this subject based on the ideXlab platform.

  • virus encapsulated dna origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracel...

  • Virus-encapsulated DNA origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intraCellular reactions by origami-based templates.

Veikko Linko - One of the best experts on this subject based on the ideXlab platform.

  • virus encapsulated dna origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracel...

  • Virus-encapsulated DNA origami nanostructures for Cellular delivery
    Nano Letters, 2014
    Co-Authors: Joona Mikkilä, Antti Pekka Eskelinen, Elina H. Niemelä, Päivi Törmä, Veikko Linko, Mikko J Frilander, Mauri A. Kostiainen
    Abstract:

    DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing Cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 Cell Line indicate that protein coating improves Cellular attachment and delivery of origamis into the Cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intraCellular reactions by origami-based templates.