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Andy Sun - One of the best experts on this subject based on the ideXlab platform.

  • Significantly higher frequencies of Hematinic deficiencies and hyperhomocysteinemia in oral precancer patients.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019
    Co-Authors: Fang-yeh Chu, Shih-jung Cheng, Andy Sun, Hsin-ming Chen
    Abstract:

    Background/Purpose Our previous studies found relatively higher frequencies of anemia, Hematinic deficiencies, and hyperhomocysteinemia in patients with different types of oral mucosal diseases. This study evaluated whether patients with oral precancerous lesions (oral precancer patients) had significantly higher frequencies of anemia, Hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects. Methods The complete blood count, serum iron, vitamin B12, folic acid, and homocysteine levels in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects were measured and compared. Results We found significantly lower mean serum iron (for women only), vitamin B12, and folic acid levels and a significantly higher mean serum homocysteine level in oral precancer patients than in healthy control subjects (all P-values   20 cigarettes per day than in 61 smokers consuming ≤ 20 cigarettes per day (P = 0.024), and in 52 betel quid chewers than in 79 non-chewers (P = 0.051). Conclusion There are significantly higher frequencies of anemia, serum vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in oral precancer patients than in healthy control subjects.

  • Atrophic glossitis: Etiology, serum autoantibodies, anemia, Hematinic deficiencies, hyperhomocysteinemia, and management.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • Anemia, Hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients
    Elsevier, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results: Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients. Keywords: Gastric parietal cell antibody, Atrophic glossitis, Anemia, Vitamin B12 deficiency, Hyperhomocysteinemi

  • Significantly higher frequencies of anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients
    Elsevier, 2018
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Background/Purpose: Atrophic glossitis (AG) patients are prone to have anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods: The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results: We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values 

  • Oral lichen planus – Differential diagnoses, serum autoantibodies, Hematinic deficiencies, and management
    Elsevier, 2018
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. OLP more commonly affects buccal mucosa, tongue, and gingiva. It always has a bilateral and symmetric distribution of the oral lesions. Plaque-like and atrophic/erosive OLP may be misdiagnosed as oral leukoplakia and oral erythroleukoplakia, respectively. Our previous study found serum autoantibodies in 195 (60.9%) of the 320 OLP patients. Specific serum anti-nuclear, anti-smooth muscle, anti-mitochondrial, gastric parietal cell, thyroglobulin, and thyroid microsomal autoantibodies are present in 28.1%, 8.4%, 1.6%, 26.3%, 21.3%, and 24.4% of 320 OLP patients, respectively. Furthermore, we also discovered that 21.9%, 13.6%, 7.1%, 0.3%, and 14.8% of 352 OLP patients have hemoglobin, iron, vitamin B12, and folic acid deficiencies, and abnormally high serum homocysteine level, respectively. Therefore, it is very important to examine the serum autoantibody, Hematinic and homocysteine levels in OLP patients before starting the treatments for OLP patients. Because OLP is an immunologically-mediated disease, corticosteroids are the drugs of choice for treatment of OLP. Keywords: Oral lichen planus, Hematinic deficiency, Autoantibody, Gastric parietal cell antibody, Thyroglobulin antibody, Thyroid microsomal antibod

Julia Yu Fong Chang - One of the best experts on this subject based on the ideXlab platform.

  • atrophic glossitis etiology serum autoantibodies anemia Hematinic deficiencies hyperhomocysteinemia and management
    Journal of the Formosan Medical Association, 2020
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • Atrophic glossitis: Etiology, serum autoantibodies, anemia, Hematinic deficiencies, hyperhomocysteinemia, and management.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • anemia Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody positive and negative atrophic glossitis patients
    Journal of the Formosan Medical Association, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients.

  • Anemia, Hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients
    Elsevier, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results: Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients. Keywords: Gastric parietal cell antibody, Atrophic glossitis, Anemia, Vitamin B12 deficiency, Hyperhomocysteinemi

  • significantly higher frequencies of anemia Hematinic deficiencies hyperhomocysteinemia and serum gastric parietal cell antibody positivity in atrophic glossitis patients
    Journal of the Formosan Medical Association, 2018
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Atrophic glossitis (AG) patients are prone to have anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values  Conclusion There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients.

Chun-pin Chiang - One of the best experts on this subject based on the ideXlab platform.

  • atrophic glossitis etiology serum autoantibodies anemia Hematinic deficiencies hyperhomocysteinemia and management
    Journal of the Formosan Medical Association, 2020
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • Atrophic glossitis: Etiology, serum autoantibodies, anemia, Hematinic deficiencies, hyperhomocysteinemia, and management.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • anemia Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody positive and negative atrophic glossitis patients
    Journal of the Formosan Medical Association, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients.

  • Anemia, Hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients
    Elsevier, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results: Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients. Keywords: Gastric parietal cell antibody, Atrophic glossitis, Anemia, Vitamin B12 deficiency, Hyperhomocysteinemi

  • significantly higher frequencies of anemia Hematinic deficiencies hyperhomocysteinemia and serum gastric parietal cell antibody positivity in atrophic glossitis patients
    Journal of the Formosan Medical Association, 2018
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Atrophic glossitis (AG) patients are prone to have anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values  Conclusion There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients.

Yi-ping Wang - One of the best experts on this subject based on the ideXlab platform.

  • atrophic glossitis etiology serum autoantibodies anemia Hematinic deficiencies hyperhomocysteinemia and management
    Journal of the Formosan Medical Association, 2020
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • Atrophic glossitis: Etiology, serum autoantibodies, anemia, Hematinic deficiencies, hyperhomocysteinemia, and management.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • anemia Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody positive and negative atrophic glossitis patients
    Journal of the Formosan Medical Association, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients.

  • Anemia, Hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients
    Elsevier, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Andy Sun
    Abstract:

    Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results: Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients. Keywords: Gastric parietal cell antibody, Atrophic glossitis, Anemia, Vitamin B12 deficiency, Hyperhomocysteinemi

  • significantly higher frequencies of anemia Hematinic deficiencies hyperhomocysteinemia and serum gastric parietal cell antibody positivity in atrophic glossitis patients
    Journal of the Formosan Medical Association, 2018
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Atrophic glossitis (AG) patients are prone to have anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values  Conclusion There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients.

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  • atrophic glossitis etiology serum autoantibodies anemia Hematinic deficiencies hyperhomocysteinemia and management
    Journal of the Formosan Medical Association, 2020
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Atrophic glossitis (AG) is characterized by the partial or complete absence of filiform papillae on the dorsal surface of the tongue. AG may reflect the significant deficiencies of some major nutrients including riboflavin, niacin, pyridoxine, vitamin B12, folic acid, iron, zinc, and vitamin E. Moreover, protein-calorie malnutrition, candidiasis, Helicobacter pylori colonization, xerostomia, and diabetes mellitus are also the etiologies of AG. Our previous study found the serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 26.7%, 28.4%, and 29.8% of 1064 AG patients, respectively. We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 19.0%, 16.9%, 5.3%, 2.3%, and 11.9% of 1064 AG patients, respectively. Moreover, GPCA-positive AG patients tended to have relatively higher frequencies of hemoglobin, iron, and vitamin B12 deficiencies and hyperhomocysteinemia than GPCA-negative AG patients. Supplementations with vitamin BC capsules plus corresponding deficient Hematinics for those AG patients with Hematinic deficiencies can achieve complete remission of oral symptoms and AG in some AG patients. Therefore, it is very important to examine the complete blood count, serum Hematinic, homocysteine, and autoantibody levels in AG patients before we start to offer treatments for AG patients.

  • anemia Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody positive and negative atrophic glossitis patients
    Journal of the Formosan Medical Association, 2019
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion The disease of AG itself is a significant factor causing anemia, Hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients.

  • significantly higher frequencies of anemia Hematinic deficiencies hyperhomocysteinemia and serum gastric parietal cell antibody positivity in atrophic glossitis patients
    Journal of the Formosan Medical Association, 2018
    Co-Authors: Chun-pin Chiang, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Yangche Wu
    Abstract:

    Background/Purpose Atrophic glossitis (AG) patients are prone to have anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, Hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values  Conclusion There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients.

  • Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis
    Journal of the Formosan Medical Association, 2016
    Co-Authors: Yangche Wu, Yi-ping Wang, Julia Yu Fong Chang, Yuhsueh Wu, Hsin-ming Chen
    Abstract:

    Background/Purpose Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG−/RAS patients) had anemia and Hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and Hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Results Both AG+/RAS and AG−/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Moreover, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG−/RAS patients. Of 69 anemia AG+/RAS patients, 30 (43.5%) had normocytic anemia and 23 (33.3%) had iron deficiency anemia. Of 38 anemia AG−/RAS patients, 26 (68.4%) had normocytic anemia and 5 (13.2%) had iron deficiency anemia. Conclusion We conclude that some of AG+/RAS or AG−/RAS patients do have anemia and Hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG−/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and Hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively.