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Elaine S Jaffe - One of the best experts on this subject based on the ideXlab platform.
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Comprar Hematopathology (Online And Print) 2nd Ed. | Elaine Sarkin Jaffe | 9780323296137 | Elsevier España
2020Co-Authors: Elaine S Jaffe, Daniel A. Arber, Nancy Lee Harris, Elias Campo, Leticia Quintanilla-martinezAbstract:Tienda online donde Comprar Hematopathology (Online And Print) 2nd Ed. al precio 219,45 € de Elaine Sarkin Jaffe | Nancy Lee Harris | Daniel A. Arber | Elias Campo | Leticia Quintanilla-Martinez, tienda de Libros de Medicina, Libros de Hematologia - Hematopatologia
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comprar Hematopathology online and print 2nd ed elaine sarkin jaffe 9780323296137 elsevier espana
2016Co-Authors: Elaine S Jaffe, Daniel A. Arber, Nancy Lee Harris, Elias Campo, Leticia QuintanillamartinezAbstract:Tienda online donde Comprar Hematopathology (Online And Print) 2nd Ed. al precio 219,45 € de Elaine Sarkin Jaffe | Nancy Lee Harris | Daniel A. Arber | Elias Campo | Leticia Quintanilla-Martinez, tienda de Libros de Medicina, Libros de Hematologia - Hematopatologia
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peripheral t cell and nk cell lymphomas and their mimics taking a step forward report on the lymphoma workshop of the xvith meeting of the european association for haematopathology and the society for Hematopathology
Histopathology, 2014Co-Authors: Ayoma D Attygalle, Jonathan W Said, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Daphne De Jong, Young Hyeh Ko, Wolfram KlapperAbstract:Mature T-cell and T/NK-cell neoplasms are both uncommon and heterogeneous, among the broad category of non-Hodgkin lymphomas. Owing to the lack of specific genetic alterations in the vast majority, most currently defined entities show overlapping morphological and immunophenotypic features, and therefore pose a challenge to the diagnostic pathologist. In the light of recent immunophenotypic, cytogenetic and molecular genetics advances in the field of T-cell and T/NK-cell lymphomas, the focus of the lymphoma workshop of the European Association for Haematopathology/Society for Hematopathology meeting in Lisbon, Portugal, in October 2012 was to refine existing diagnostic criteria and clarify the borders between overlapping entities. The panel reviewed over 200 submitted cases, which were grouped into five categories: (i) angioimmunoblastic T-cell lymphoma and T-follicular-helper-cell-associated lymphomas; (ii) CD30-positive T-cell lymphomas/lymphoproliferative diseases; (iii) extranodal T-cell and NK-cell neoplasms; (iv) EBV-associated T-cell/NK-cell lymphomas/lymphoproliferative diseases; and (v) peripheral T-cell lymphoma, not otherwise specified, post-transplant lymphoproliferative disorders, and mimics. This report summarizes the discussions and conclusions of the workshop, which question current diagnostic criteria and provide recommendations for refining existing classifications.
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Peripheral T‐cell and NK‐cell lymphomas and their mimics; taking a step forward – report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology
Histopathology, 2013Co-Authors: Ayoma D Attygalle, Jonathan W Said, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Daphne De Jong, Young Hyeh Ko, Wolfram KlapperAbstract:Mature T-cell and T/NK-cell neoplasms are both uncommon and heterogeneous, among the broad category of non-Hodgkin lymphomas. Owing to the lack of specific genetic alterations in the vast majority, most currently defined entities show overlapping morphological and immunophenotypic features, and therefore pose a challenge to the diagnostic pathologist. In the light of recent immunophenotypic, cytogenetic and molecular genetics advances in the field of T-cell and T/NK-cell lymphomas, the focus of the lymphoma workshop of the European Association for Haematopathology/Society for Hematopathology meeting in Lisbon, Portugal, in October 2012 was to refine existing diagnostic criteria and clarify the borders between overlapping entities. The panel reviewed over 200 submitted cases, which were grouped into five categories: (i) angioimmunoblastic T-cell lymphoma and T-follicular-helper-cell-associated lymphomas; (ii) CD30-positive T-cell lymphomas/lymphoproliferative diseases; (iii) extranodal T-cell and NK-cell neoplasms; (iv) EBV-associated T-cell/NK-cell lymphomas/lymphoproliferative diseases; and (v) peripheral T-cell lymphoma, not otherwise specified, post-transplant lymphoproliferative disorders, and mimics. This report summarizes the discussions and conclusions of the workshop, which question current diagnostic criteria and provide recommendations for refining existing classifications.
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early lesions in lymphoid neoplasia conclusions based on the workshop of the xv meeting of the european association of Hematopathology and the society of Hematopathology in uppsala sweden
Journal of Hematopathology, 2012Co-Authors: Falko Fend, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Andrew Wotherspoon, Philip M Kluin, Isinsu Kuzu, Loann Peterson, Christer SundstromAbstract:The increasing use of immunophenotypic and molecular techniques on lymphoid tissue samples without obvious involvement of malignant lymphoma has resulted in the increased detection of ‘early’ lymphoid proliferations which show some, but not all, of the criteria necessary for a diagnosis of malignant lymphoma. In most instances, these are incidental findings in asymptomatic individuals, and their biological behaviour is uncertain. In order to better characterize these premalignant conditions and to establish diagnostic criteria, a joint workshop of the European Association for Haematopathology and the Society of Hematopathology was held in Uppsala, Sweden, in September 2010. The panel reviewed and discussed more than 130 submitted cases and reached consensus diagnoses. Cases representing the nodal equivalent of monoclonal B cell lymphocytosis were discussed, as well as the ‘in situ’ counterparts of follicular lymphoma (FL) and mantle cell lymphoma, topics that also stimulated discussions concerning the best terminology for these lesions. The workshop also addressed the borderland between reactive hyperplasia and clonal proliferations such as paediatric marginal zone lymphoma and paediatric FL, which may have very limited capacity for progression. Virus-driven lymphoproliferations in the grey zone between reactive lesions and manifest malignant lymphoma were covered. Finally, early manifestations of T cell lymphoma, both nodal and extranodal, and their mimics were addressed. This workshop report summarizes the most important conclusions concerning the diagnostic features, as well as proposals for terminology and classification, of early lymphoproliferations and tries to give some practical guidelines for diagnosis and reporting.
Leticia Quintanillamartinez - One of the best experts on this subject based on the ideXlab platform.
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comprar Hematopathology online and print 2nd ed elaine sarkin jaffe 9780323296137 elsevier espana
2016Co-Authors: Elaine S Jaffe, Daniel A. Arber, Nancy Lee Harris, Elias Campo, Leticia QuintanillamartinezAbstract:Tienda online donde Comprar Hematopathology (Online And Print) 2nd Ed. al precio 219,45 € de Elaine Sarkin Jaffe | Nancy Lee Harris | Daniel A. Arber | Elias Campo | Leticia Quintanilla-Martinez, tienda de Libros de Medicina, Libros de Hematologia - Hematopatologia
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non mycosis fungoides cutaneous t cell lymphomas report of the 2011 society for Hematopathology european association for haematopathology workshop
American Journal of Clinical Pathology, 2013Co-Authors: Leticia Quintanillamartinez, Marsha C Kinney, Steven H Swerdlow, Patty M Jansen, Rein WillemzeAbstract:Primary cutaneous T-cell lymphomas (CTCL) excluding mycosis fungoides (MF) were discussed in 2 sessions of the 2011 Society for Hematopathology/ European Association of Haematopathology Workshop, Los Angeles, CA. Session 2 focused on primary cutaneous CD30+ T-cell lymphoproliferative disorders and their differential diagnosis, including systemic CD30+ T-cell lymphoma secondarily infiltrating the skin. Interesting features like special morphologic variants and atypical phenotypes were presented. In addition, the possibility of rare ALK+ primary cutaneous lymphomas was discussed. Session 3 examined other more uncommon non-MF CTCLs, including subcutaneous panniculitis-like T-cell lymphoma, extranodal NK/T-cell lymphoma, hydroa vacciniforme–like T-cell lymphoma, and rare subtypes of primary cutaneous peripheral T-cell lymphoma, not otherwise specified. In addition, systemic T-cell lymphomas involving the skin secondarily, such as angioimmunoblastic T-cell lymphoma, were included in this session. In this report, novel findings, areas of special interest, and diagnostic challenges emerging from the cases submitted to the workshop will be highlighted. The necessity to integrate histologic, immunophenotypical, genetic, and in particular, clinical data to arrive at the correct diagnosis, and subsequently provide adequate treatment, is emphasized.
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cutaneous b cell lymphoproliferative disorders report of the 2011 society for Hematopathology european association for haematopathology workshop
American Journal of Clinical Pathology, 2013Co-Authors: Steven H Swerdlow, Rein Willemze, Leticia Quintanillamartinez, Marsha C KinneyAbstract:The diagnosis and classification of the cutaneous B-cell lymphomas can be quite a challenge, with a definitive diagnosis sometimes being elusive, even when an extensive workup has been performed. Distinction of benign from neoplastic disorders can be difficult, with some hyperplasias mimicking lymphomas and vice versa. There are only a limited number of skin-specific B-cell lymphomas, including primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type. Cutaneous marginal zone lymphomas have distinctive features but are classified with the other mucosa-associated lymphoid tissue lymphomas. It is important, however, to also remember that many other B-cell lymphomas/ plasma cell neoplasms can primarily, or more often secondarily, involve the skin. Some may mimic one of the skin-specific lymphomas but have very different clinical implications. Iatrogenic and senescent immunodeficiency-associated lymphoproliferative disorders that are often Epstein-Barr virus (EBV) positive can also primarily involve the skin, including cases also known as EBV-positive mucocutaneous ulcer. Diagnosing a cutaneous B-cell lymphoma is a 3-step process, often with major challenges at all stages. In most cases, a biopsy demonstrates a variably dense nonepidermotropic, superficial, and deep lymphoplasmacytic infiltrate. The first step then is to determine if the infiltrate is benign or malignant; the second is to decide if it is a B-cell, T-/natural killer (NK)–cell, or other type of neoplasm; and the final step is to classify the B-cell lymphoma. The first step can be particularly problematic, because some benign infiltrates can be very extensive, resemble a lymphoma morphologically in many ways (as discussed by Sarantopoulos et al 1 in this issue of the Journal), and even have monoclonal immunoglobulin gene rearrangements. 2,3 Conversely, some lymphomas closely resemble a reactive proliferation with only a few neoplastic cells and a prominent reactive B-cell component that can include follicles and polyclonal plasma cells. The second step in distinguishing the lineage of the neoplasm is often straightforward based on the morphologic appearance and phenotypic studies, but in some cases, this can also be a major problem. As with the better-known T-cell–rich large B-cell lymphomas, many cutaneous marginal zone lymphomas (MZLs) also have numerous T cells and conversely, some cutaneous T-cell lymphomas, specifically primary cutaneous CD4+ small-medium T-cell lymphoma (which, in most cases, may not be a lymphoma at all, as discussed
Jonathan W Said - One of the best experts on this subject based on the ideXlab platform.
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peripheral t cell and nk cell lymphomas and their mimics taking a step forward report on the lymphoma workshop of the xvith meeting of the european association for haematopathology and the society for Hematopathology
Histopathology, 2014Co-Authors: Ayoma D Attygalle, Jonathan W Said, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Daphne De Jong, Young Hyeh Ko, Wolfram KlapperAbstract:Mature T-cell and T/NK-cell neoplasms are both uncommon and heterogeneous, among the broad category of non-Hodgkin lymphomas. Owing to the lack of specific genetic alterations in the vast majority, most currently defined entities show overlapping morphological and immunophenotypic features, and therefore pose a challenge to the diagnostic pathologist. In the light of recent immunophenotypic, cytogenetic and molecular genetics advances in the field of T-cell and T/NK-cell lymphomas, the focus of the lymphoma workshop of the European Association for Haematopathology/Society for Hematopathology meeting in Lisbon, Portugal, in October 2012 was to refine existing diagnostic criteria and clarify the borders between overlapping entities. The panel reviewed over 200 submitted cases, which were grouped into five categories: (i) angioimmunoblastic T-cell lymphoma and T-follicular-helper-cell-associated lymphomas; (ii) CD30-positive T-cell lymphomas/lymphoproliferative diseases; (iii) extranodal T-cell and NK-cell neoplasms; (iv) EBV-associated T-cell/NK-cell lymphomas/lymphoproliferative diseases; and (v) peripheral T-cell lymphoma, not otherwise specified, post-transplant lymphoproliferative disorders, and mimics. This report summarizes the discussions and conclusions of the workshop, which question current diagnostic criteria and provide recommendations for refining existing classifications.
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Peripheral T‐cell and NK‐cell lymphomas and their mimics; taking a step forward – report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology
Histopathology, 2013Co-Authors: Ayoma D Attygalle, Jonathan W Said, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Daphne De Jong, Young Hyeh Ko, Wolfram KlapperAbstract:Mature T-cell and T/NK-cell neoplasms are both uncommon and heterogeneous, among the broad category of non-Hodgkin lymphomas. Owing to the lack of specific genetic alterations in the vast majority, most currently defined entities show overlapping morphological and immunophenotypic features, and therefore pose a challenge to the diagnostic pathologist. In the light of recent immunophenotypic, cytogenetic and molecular genetics advances in the field of T-cell and T/NK-cell lymphomas, the focus of the lymphoma workshop of the European Association for Haematopathology/Society for Hematopathology meeting in Lisbon, Portugal, in October 2012 was to refine existing diagnostic criteria and clarify the borders between overlapping entities. The panel reviewed over 200 submitted cases, which were grouped into five categories: (i) angioimmunoblastic T-cell lymphoma and T-follicular-helper-cell-associated lymphomas; (ii) CD30-positive T-cell lymphomas/lymphoproliferative diseases; (iii) extranodal T-cell and NK-cell neoplasms; (iv) EBV-associated T-cell/NK-cell lymphomas/lymphoproliferative diseases; and (v) peripheral T-cell lymphoma, not otherwise specified, post-transplant lymphoproliferative disorders, and mimics. This report summarizes the discussions and conclusions of the workshop, which question current diagnostic criteria and provide recommendations for refining existing classifications.
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mycosis fungoides report of the 2011 society for Hematopathology european association for haematopathology workshop
American Journal of Clinical Pathology, 2013Co-Authors: Sophie X Song, Rein Willemze, Steven H Swerdlow, Marsha C Kinney, Jonathan W SaidAbstract:: Session 1 of the 2011 Workshop of the Society for Hematopathology and European Association for Haematopathology focused on mycosis fungoides (MF), the most common cutaneous lymphoma. The 62 cases in this case group demonstrated a wide spectrum of clinicopathologic features, including those seen in typical cases as well as those, by contrast, with atypical clinical history, morphology, immunophenotype, and/or genotype. Of the 62 cases, 27 (44%) were presented at the workshop and highlighted diagnostic challenges plus related issues. This report summarizes the approach recommended for making a confident diagnosis of MF and its clinically significant variants; emphasizes pitfalls in evaluating early MF, assessing nodal involvement, and diagnosing transformed MF; and discusses the relationship between MF and primary cutaneous CD30+ T-cell lymphoproliferative disorders. Last, Sezary syndrome is discussed, with concentration on those features distinct from MF.
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mimics of cutaneous lymphoma report of the 2011 society for Hematopathology european association for haematopathology workshop
American Journal of Clinical Pathology, 2013Co-Authors: George P Sarantopoulos, Rein Willemze, Steven H Swerdlow, Marsha C Kinney, Jonathan W Said, Beth Palla, Scott W BinderAbstract:The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lymphoid hyperplasia, cutaneous drug reactions, lupus-associated panniculitis, pityriasis lichenoides, hypereosinophilic syndrome, histiocytic necrotizing lymphadenitis, traumatic ulcerative granuloma with stromal eosinophils, and pigmented purpuric dermatosis, as well as a brief review of the pertinent literature and discussion of submitted conference cases. For the pathologist, it is important to be aware of diagnostic pitfalls as well as the limitations of ancillary testing (eg, clonality studies). Finally, correlation with total clinical information, good communication with clinical colleagues, close clinical follow-up with rebiopsy, and prudent use of laboratory studies are vital and will likely offer the best path toward a correct diagnosis.
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Mycosis fungoides: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.
American Journal of Clinical Pathology, 2013Co-Authors: Sophie X Song, Rein Willemze, Steven H Swerdlow, Marsha C Kinney, Jonathan W SaidAbstract:: Session 1 of the 2011 Workshop of the Society for Hematopathology and European Association for Haematopathology focused on mycosis fungoides (MF), the most common cutaneous lymphoma. The 62 cases in this case group demonstrated a wide spectrum of clinicopathologic features, including those seen in typical cases as well as those, by contrast, with atypical clinical history, morphology, immunophenotype, and/or genotype. Of the 62 cases, 27 (44%) were presented at the workshop and highlighted diagnostic challenges plus related issues. This report summarizes the approach recommended for making a confident diagnosis of MF and its clinically significant variants; emphasizes pitfalls in evaluating early MF, assessing nodal involvement, and diagnosing transformed MF; and discusses the relationship between MF and primary cutaneous CD30+ T-cell lymphoproliferative disorders. Last, Sezary syndrome is discussed, with concentration on those features distinct from MF.
Wolfram Klapper - One of the best experts on this subject based on the ideXlab platform.
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peripheral t cell and nk cell lymphomas and their mimics taking a step forward report on the lymphoma workshop of the xvith meeting of the european association for haematopathology and the society for Hematopathology
Histopathology, 2014Co-Authors: Ayoma D Attygalle, Jonathan W Said, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Daphne De Jong, Young Hyeh Ko, Wolfram KlapperAbstract:Mature T-cell and T/NK-cell neoplasms are both uncommon and heterogeneous, among the broad category of non-Hodgkin lymphomas. Owing to the lack of specific genetic alterations in the vast majority, most currently defined entities show overlapping morphological and immunophenotypic features, and therefore pose a challenge to the diagnostic pathologist. In the light of recent immunophenotypic, cytogenetic and molecular genetics advances in the field of T-cell and T/NK-cell lymphomas, the focus of the lymphoma workshop of the European Association for Haematopathology/Society for Hematopathology meeting in Lisbon, Portugal, in October 2012 was to refine existing diagnostic criteria and clarify the borders between overlapping entities. The panel reviewed over 200 submitted cases, which were grouped into five categories: (i) angioimmunoblastic T-cell lymphoma and T-follicular-helper-cell-associated lymphomas; (ii) CD30-positive T-cell lymphomas/lymphoproliferative diseases; (iii) extranodal T-cell and NK-cell neoplasms; (iv) EBV-associated T-cell/NK-cell lymphomas/lymphoproliferative diseases; and (v) peripheral T-cell lymphoma, not otherwise specified, post-transplant lymphoproliferative disorders, and mimics. This report summarizes the discussions and conclusions of the workshop, which question current diagnostic criteria and provide recommendations for refining existing classifications.
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Peripheral T‐cell and NK‐cell lymphomas and their mimics; taking a step forward – report on the lymphoma workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology
Histopathology, 2013Co-Authors: Ayoma D Attygalle, Jonathan W Said, Jose Cabecadas, Philippe Gaulard, Elaine S Jaffe, Daphne De Jong, Young Hyeh Ko, Wolfram KlapperAbstract:Mature T-cell and T/NK-cell neoplasms are both uncommon and heterogeneous, among the broad category of non-Hodgkin lymphomas. Owing to the lack of specific genetic alterations in the vast majority, most currently defined entities show overlapping morphological and immunophenotypic features, and therefore pose a challenge to the diagnostic pathologist. In the light of recent immunophenotypic, cytogenetic and molecular genetics advances in the field of T-cell and T/NK-cell lymphomas, the focus of the lymphoma workshop of the European Association for Haematopathology/Society for Hematopathology meeting in Lisbon, Portugal, in October 2012 was to refine existing diagnostic criteria and clarify the borders between overlapping entities. The panel reviewed over 200 submitted cases, which were grouped into five categories: (i) angioimmunoblastic T-cell lymphoma and T-follicular-helper-cell-associated lymphomas; (ii) CD30-positive T-cell lymphomas/lymphoproliferative diseases; (iii) extranodal T-cell and NK-cell neoplasms; (iv) EBV-associated T-cell/NK-cell lymphomas/lymphoproliferative diseases; and (v) peripheral T-cell lymphoma, not otherwise specified, post-transplant lymphoproliferative disorders, and mimics. This report summarizes the discussions and conclusions of the workshop, which question current diagnostic criteria and provide recommendations for refining existing classifications.
Steven H Swerdlow - One of the best experts on this subject based on the ideXlab platform.
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molecular and cytogenetic education in Hematopathology fellowship
American Journal of Clinical Pathology, 2019Co-Authors: Lorinda Soma, Steven H Swerdlow, Rose C Beck, Dan Jones, Alexandra E Kovach, Alexa J Siddon, Sarah E Gibson, David Wu, James R Cook, Sonam PrakashAbstract:OBJECTIVES: Given the increased complexity of molecular and cytogenetic testing (MOL-CG), the Society for Hematopathology Education Committee (SH-EC) was interested in determining what the current expectations are for MOL-CG education in Hematopathology (HP) fellowship training. METHODS: The SH-EC sent a questionnaire to HP fellowship program directors (HP-PDs) covering MOL-CG training curricula, test menus, faculty background, teaching, and sign-out roles. These findings were explored via a panel-based discussion at the 2018 SH-EC meeting for HP-PDs. RESULTS: HP fellows are expected to understand basic principles, nomenclature, and indications for and limitations of testing. Interpretation of common assays is within that scope, but not necessarily proficiency in technical troubleshooting of testing or analysis of complex raw data. CONCLUSIONS: The consensus was that HP fellows should understand the components of MOL-CG testing necessary to incorporate those results into an accurate, clinically relevant, and integrated HP report.
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Diagnosis of malignant lymphomas in 2014
Pathology, 2016Co-Authors: Steven H SwerdlowAbstract:The field of Hematopathology is ever-changing with important new discoveries of biologic and clinical importance. We continue to learn more about the clinical, morphologic, immunophenotypic and molecular/genetic features of the seemingly innumerable types of malignant lymphomas and their benign mimics. These discoveries have very pragmatic implications affecting our daily practice in terms of what we are expected to know about the entities we are attempting to diagnose, as well as providing new tools for our diagnostic armamentarium. To help deal with these challenges as they relate to the diagnosis of lymphoma, six international Hematopathology experts will cover the following topics in this long course: an approach to diagnostic lymph node pathology (JR Cook), small B-cell lymphomas (L Quintanilla-Fend), aggressive B-cell lymphomas (S Pileri), T-cell lymphomas (L de Leval), Hodgkin lymphomas (NL Harris) and lymphoid hyperplasias and their differential diagnosis with lymphomas (JKC Chan). The goal is to provide guidance related to practicing state-of-the-art lymphoma pathology in 2014.
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mycosis fungoides report of the 2011 society for Hematopathology european association for haematopathology workshop
American Journal of Clinical Pathology, 2013Co-Authors: Sophie X Song, Rein Willemze, Steven H Swerdlow, Marsha C Kinney, Jonathan W SaidAbstract:: Session 1 of the 2011 Workshop of the Society for Hematopathology and European Association for Haematopathology focused on mycosis fungoides (MF), the most common cutaneous lymphoma. The 62 cases in this case group demonstrated a wide spectrum of clinicopathologic features, including those seen in typical cases as well as those, by contrast, with atypical clinical history, morphology, immunophenotype, and/or genotype. Of the 62 cases, 27 (44%) were presented at the workshop and highlighted diagnostic challenges plus related issues. This report summarizes the approach recommended for making a confident diagnosis of MF and its clinically significant variants; emphasizes pitfalls in evaluating early MF, assessing nodal involvement, and diagnosing transformed MF; and discusses the relationship between MF and primary cutaneous CD30+ T-cell lymphoproliferative disorders. Last, Sezary syndrome is discussed, with concentration on those features distinct from MF.
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mimics of cutaneous lymphoma report of the 2011 society for Hematopathology european association for haematopathology workshop
American Journal of Clinical Pathology, 2013Co-Authors: George P Sarantopoulos, Rein Willemze, Steven H Swerdlow, Marsha C Kinney, Jonathan W Said, Beth Palla, Scott W BinderAbstract:The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lymphoid hyperplasia, cutaneous drug reactions, lupus-associated panniculitis, pityriasis lichenoides, hypereosinophilic syndrome, histiocytic necrotizing lymphadenitis, traumatic ulcerative granuloma with stromal eosinophils, and pigmented purpuric dermatosis, as well as a brief review of the pertinent literature and discussion of submitted conference cases. For the pathologist, it is important to be aware of diagnostic pitfalls as well as the limitations of ancillary testing (eg, clonality studies). Finally, correlation with total clinical information, good communication with clinical colleagues, close clinical follow-up with rebiopsy, and prudent use of laboratory studies are vital and will likely offer the best path toward a correct diagnosis.
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Mycosis fungoides: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.
American Journal of Clinical Pathology, 2013Co-Authors: Sophie X Song, Rein Willemze, Steven H Swerdlow, Marsha C Kinney, Jonathan W SaidAbstract:: Session 1 of the 2011 Workshop of the Society for Hematopathology and European Association for Haematopathology focused on mycosis fungoides (MF), the most common cutaneous lymphoma. The 62 cases in this case group demonstrated a wide spectrum of clinicopathologic features, including those seen in typical cases as well as those, by contrast, with atypical clinical history, morphology, immunophenotype, and/or genotype. Of the 62 cases, 27 (44%) were presented at the workshop and highlighted diagnostic challenges plus related issues. This report summarizes the approach recommended for making a confident diagnosis of MF and its clinically significant variants; emphasizes pitfalls in evaluating early MF, assessing nodal involvement, and diagnosing transformed MF; and discusses the relationship between MF and primary cutaneous CD30+ T-cell lymphoproliferative disorders. Last, Sezary syndrome is discussed, with concentration on those features distinct from MF.