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Frits A.j. Muskiet - One of the best experts on this subject based on the ideXlab platform.
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Predictive Value of Cord Blood Hematological Indices and Hemoglobin Barts for the Detection of Heterozygous α-Thalassemia-2 in an African-Caribbean Population
Clinical chemistry, 1999Co-Authors: Fey P. L. Van Der Dijs, Marcel Volmer, Dieuwke G. Van Gijssel-wiersma, Jan W. Smit, Reind Van Veen, Frits A.j. MuskietAbstract:Background: Cord blood Hemoglobin Barts (HbBarts) and hemocytometric indices may be used for classification of newborns into those without α-thalassemia-2 (αα/αα) and with heterozygous α-thalassemia-2 (-α3.7/αα). We investigated by logistic regression analysis whether the combination of HbBarts and hemocytometric indices improves classification compared with classification based on a single analyte. Methods: HbBarts percentages and hemocytometric indices were determined in cord blood of 208 consecutive newborns in Curacao (Netherlands Antilles). Of these, 157 had αα/αα and 51 had -α3.7/αα, as established by DNA analysis. Results: Between-group differences were significant for erythrocytes, mean cell volume, mean cell Hemoglobin (MCH), mean cell Hemoglobin concentration, platelets, Hemoglobin F (HbF), and HbBarts. The Logit equation of the logistic regression model, using MCH (pg) and HbBarts (%), was: 42.7164 + 5.7916(HbBarts) − 1.3110(MCH). A sensitivity of 100% was reached at a Logit value of −3.70. The corresponding specificity was 62.2%, and the predictive value of a positive test (PV+) was 46.3% (95% confidence interval, 37.0–55.7%). The relative information gains were as follows: 88% for the HbBarts-MCH combination, 26% for MCH (not significant), and 0% for HbBarts compared with the 24.6% -α3.7/αα prevalence. Conclusion: Combined use of cord blood HbBarts and MCH improves classification compared with classification based on single hemocytometric indices.
Fey P. L. Van Der Dijs - One of the best experts on this subject based on the ideXlab platform.
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Predictive Value of Cord Blood Hematological Indices and Hemoglobin Barts for the Detection of Heterozygous α-Thalassemia-2 in an African-Caribbean Population
Clinical chemistry, 1999Co-Authors: Fey P. L. Van Der Dijs, Marcel Volmer, Dieuwke G. Van Gijssel-wiersma, Jan W. Smit, Reind Van Veen, Frits A.j. MuskietAbstract:Background: Cord blood Hemoglobin Barts (HbBarts) and hemocytometric indices may be used for classification of newborns into those without α-thalassemia-2 (αα/αα) and with heterozygous α-thalassemia-2 (-α3.7/αα). We investigated by logistic regression analysis whether the combination of HbBarts and hemocytometric indices improves classification compared with classification based on a single analyte. Methods: HbBarts percentages and hemocytometric indices were determined in cord blood of 208 consecutive newborns in Curacao (Netherlands Antilles). Of these, 157 had αα/αα and 51 had -α3.7/αα, as established by DNA analysis. Results: Between-group differences were significant for erythrocytes, mean cell volume, mean cell Hemoglobin (MCH), mean cell Hemoglobin concentration, platelets, Hemoglobin F (HbF), and HbBarts. The Logit equation of the logistic regression model, using MCH (pg) and HbBarts (%), was: 42.7164 + 5.7916(HbBarts) − 1.3110(MCH). A sensitivity of 100% was reached at a Logit value of −3.70. The corresponding specificity was 62.2%, and the predictive value of a positive test (PV+) was 46.3% (95% confidence interval, 37.0–55.7%). The relative information gains were as follows: 88% for the HbBarts-MCH combination, 26% for MCH (not significant), and 0% for HbBarts compared with the 24.6% -α3.7/αα prevalence. Conclusion: Combined use of cord blood HbBarts and MCH improves classification compared with classification based on single hemocytometric indices.
Reind Van Veen - One of the best experts on this subject based on the ideXlab platform.
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Predictive Value of Cord Blood Hematological Indices and Hemoglobin Barts for the Detection of Heterozygous α-Thalassemia-2 in an African-Caribbean Population
Clinical chemistry, 1999Co-Authors: Fey P. L. Van Der Dijs, Marcel Volmer, Dieuwke G. Van Gijssel-wiersma, Jan W. Smit, Reind Van Veen, Frits A.j. MuskietAbstract:Background: Cord blood Hemoglobin Barts (HbBarts) and hemocytometric indices may be used for classification of newborns into those without α-thalassemia-2 (αα/αα) and with heterozygous α-thalassemia-2 (-α3.7/αα). We investigated by logistic regression analysis whether the combination of HbBarts and hemocytometric indices improves classification compared with classification based on a single analyte. Methods: HbBarts percentages and hemocytometric indices were determined in cord blood of 208 consecutive newborns in Curacao (Netherlands Antilles). Of these, 157 had αα/αα and 51 had -α3.7/αα, as established by DNA analysis. Results: Between-group differences were significant for erythrocytes, mean cell volume, mean cell Hemoglobin (MCH), mean cell Hemoglobin concentration, platelets, Hemoglobin F (HbF), and HbBarts. The Logit equation of the logistic regression model, using MCH (pg) and HbBarts (%), was: 42.7164 + 5.7916(HbBarts) − 1.3110(MCH). A sensitivity of 100% was reached at a Logit value of −3.70. The corresponding specificity was 62.2%, and the predictive value of a positive test (PV+) was 46.3% (95% confidence interval, 37.0–55.7%). The relative information gains were as follows: 88% for the HbBarts-MCH combination, 26% for MCH (not significant), and 0% for HbBarts compared with the 24.6% -α3.7/αα prevalence. Conclusion: Combined use of cord blood HbBarts and MCH improves classification compared with classification based on single hemocytometric indices.
Jan W. Smit - One of the best experts on this subject based on the ideXlab platform.
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Predictive Value of Cord Blood Hematological Indices and Hemoglobin Barts for the Detection of Heterozygous α-Thalassemia-2 in an African-Caribbean Population
Clinical chemistry, 1999Co-Authors: Fey P. L. Van Der Dijs, Marcel Volmer, Dieuwke G. Van Gijssel-wiersma, Jan W. Smit, Reind Van Veen, Frits A.j. MuskietAbstract:Background: Cord blood Hemoglobin Barts (HbBarts) and hemocytometric indices may be used for classification of newborns into those without α-thalassemia-2 (αα/αα) and with heterozygous α-thalassemia-2 (-α3.7/αα). We investigated by logistic regression analysis whether the combination of HbBarts and hemocytometric indices improves classification compared with classification based on a single analyte. Methods: HbBarts percentages and hemocytometric indices were determined in cord blood of 208 consecutive newborns in Curacao (Netherlands Antilles). Of these, 157 had αα/αα and 51 had -α3.7/αα, as established by DNA analysis. Results: Between-group differences were significant for erythrocytes, mean cell volume, mean cell Hemoglobin (MCH), mean cell Hemoglobin concentration, platelets, Hemoglobin F (HbF), and HbBarts. The Logit equation of the logistic regression model, using MCH (pg) and HbBarts (%), was: 42.7164 + 5.7916(HbBarts) − 1.3110(MCH). A sensitivity of 100% was reached at a Logit value of −3.70. The corresponding specificity was 62.2%, and the predictive value of a positive test (PV+) was 46.3% (95% confidence interval, 37.0–55.7%). The relative information gains were as follows: 88% for the HbBarts-MCH combination, 26% for MCH (not significant), and 0% for HbBarts compared with the 24.6% -α3.7/αα prevalence. Conclusion: Combined use of cord blood HbBarts and MCH improves classification compared with classification based on single hemocytometric indices.
Dieuwke G. Van Gijssel-wiersma - One of the best experts on this subject based on the ideXlab platform.
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Predictive Value of Cord Blood Hematological Indices and Hemoglobin Barts for the Detection of Heterozygous α-Thalassemia-2 in an African-Caribbean Population
Clinical chemistry, 1999Co-Authors: Fey P. L. Van Der Dijs, Marcel Volmer, Dieuwke G. Van Gijssel-wiersma, Jan W. Smit, Reind Van Veen, Frits A.j. MuskietAbstract:Background: Cord blood Hemoglobin Barts (HbBarts) and hemocytometric indices may be used for classification of newborns into those without α-thalassemia-2 (αα/αα) and with heterozygous α-thalassemia-2 (-α3.7/αα). We investigated by logistic regression analysis whether the combination of HbBarts and hemocytometric indices improves classification compared with classification based on a single analyte. Methods: HbBarts percentages and hemocytometric indices were determined in cord blood of 208 consecutive newborns in Curacao (Netherlands Antilles). Of these, 157 had αα/αα and 51 had -α3.7/αα, as established by DNA analysis. Results: Between-group differences were significant for erythrocytes, mean cell volume, mean cell Hemoglobin (MCH), mean cell Hemoglobin concentration, platelets, Hemoglobin F (HbF), and HbBarts. The Logit equation of the logistic regression model, using MCH (pg) and HbBarts (%), was: 42.7164 + 5.7916(HbBarts) − 1.3110(MCH). A sensitivity of 100% was reached at a Logit value of −3.70. The corresponding specificity was 62.2%, and the predictive value of a positive test (PV+) was 46.3% (95% confidence interval, 37.0–55.7%). The relative information gains were as follows: 88% for the HbBarts-MCH combination, 26% for MCH (not significant), and 0% for HbBarts compared with the 24.6% -α3.7/αα prevalence. Conclusion: Combined use of cord blood HbBarts and MCH improves classification compared with classification based on single hemocytometric indices.