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Tobias Reichenbach - One of the best experts on this subject based on the ideXlab platform.
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Predicted motion of the reticular lamina for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) A small value of the Deiter’s Cell extensibility Δ leads to a large reticular-lamina displacement. At a critical extensibility ΔC ≈ 1.2 (dashed strip) the displacement vanishes. The critical extensibility ΔC varies slightly with the outer hair Cell contraction ϵ. (B) The Deiter’s Cell extensibility Δ strongly influences the relation between reticular-lamina displacement (dashed) and Hensen-Cell motion (solid) for the model parameter Γ = 0.1 as identified from comparison with experiments. The Hensen-Cell motion for the model parameter Δ = 1.15 (red) is in very good qualitative agreement with experimental results of in vitro Hensen Cell motion under applied current [20, 34]. Both the motion of the Hensen Cells and of the reticular lamina depends nonlinearly on the contraction ϵ of the outer hair Cells, and this nonlinearity is particularly pronounced for a Deiter’s Cell extensibility Δ close to the critical value ΔC. (C) The nonlinear dependence in the reticular-lamina motion DRL on the contraction of the outer hair Cells ϵ implies that the absolute value of the derivative of DRL with respect to the contraction ϵ varies with ϵ. The relative change is particularly strong for a large extensibility Δ of the Deiter’s Cells, which has important functional implications.
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Predicted motion of the Hensen Cells for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) We characterize the motion of the Hensen Cells through the radial and vertical displacements of two points on the top and on the side of the Hensen-Cell contour (red stars). (B) The motion pattern predicted by our model through comparison with experimental data involves large displacement of the Hensen Cells as well as of the base of the outer hair Cells way from the basilar membrane upon outer hair Cell contraction. The basilar membrane is assumed to be fixed. (C-F) Vertical and radial displacement of the two points on the Hensen-Cell contour for a hair-Cell contraction ϵ = 0.005 and different choices of the mode parameters Δ and Γ. The parameter values that are identified as biologically realistic through comparison with experimental data are indicated through an asterisk and are used in (B). (C) The top of the organ consistently moves away from the basilar membrane when the outer hair Cells contract. (D) The radial displacement of the upper point shows a more complex behaviour: both motion towards and away from the stria vascularis can occur under outer hair Cell contraction, depending on the values of the model parameters. (E-F) The direction of both the vertical and the radial motion of the lateral point depend on the values of the model parameters as well. However, this motion was not experimentally accessible.
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Direction of motion of the Hensen Cells.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) Confocal microscopy shows the motion of the reticular lamina when a negative externally-applied current is switched to a positive current of equal magnitude, causing contraction of the outer hair Cells. The green arrows show the displacement for the first and third row of outer hair Cells (the displacement of the second row was similar to the first row). A pivot point emerges between the second and third row of outer hair Cells: the first and second row move towards the basilar membrane whereas the third row moves away from it, following the displacement of the Hensen Cells [20]. (B) Direction of displacement of the third row of outer hair Cells. In this angle histogram, 0° corresponds to motion directed to the right in the image shown in panel A. According to morphometric measurements by Kelly, the basilar membrane is inclined by 37.26° on average with respect to the reticular lamina (dashed line) [42]. Our own measurements from anatomical 3D-reconstructions indicate that this inclination is slightly, but significantly, larger in the undamaged organ of Corti of our in vitro cochlear preparation (42.77° ± 6.43°, continuous black line; N = 13, p = 0.009 by two-tailed t-test, t = 3.09, d.f. = 12.). (C) The first row of outer hair Cells (squares) moves only little. The larger displacement of third-row outer hair Cells (circles) mirrors the large displacement of the Hensen Cells. Error bars indicate the standard error of the mean from the different measurements. Data in (A-C) are from 683 measurements from 15 preparations for the first row of outer hair Cells, and from 905 measurements from 18 preparations for the third row of outer hair Cells. (D) The radial component of the Hensen-Cell displacements was measured directly by tilting the preparation with respect to the interferometer beam. Representative data from one preparation show that the largest motion occurs in a direction with a small component towards the modiolus (red) for positive current injections, consistent with the reticular-lamina data shown in (A, B). Consistent results were obtained from four additional preparations.
Nikola Ciganović - One of the best experts on this subject based on the ideXlab platform.
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Predicted motion of the reticular lamina for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) A small value of the Deiter’s Cell extensibility Δ leads to a large reticular-lamina displacement. At a critical extensibility ΔC ≈ 1.2 (dashed strip) the displacement vanishes. The critical extensibility ΔC varies slightly with the outer hair Cell contraction ϵ. (B) The Deiter’s Cell extensibility Δ strongly influences the relation between reticular-lamina displacement (dashed) and Hensen-Cell motion (solid) for the model parameter Γ = 0.1 as identified from comparison with experiments. The Hensen-Cell motion for the model parameter Δ = 1.15 (red) is in very good qualitative agreement with experimental results of in vitro Hensen Cell motion under applied current [20, 34]. Both the motion of the Hensen Cells and of the reticular lamina depends nonlinearly on the contraction ϵ of the outer hair Cells, and this nonlinearity is particularly pronounced for a Deiter’s Cell extensibility Δ close to the critical value ΔC. (C) The nonlinear dependence in the reticular-lamina motion DRL on the contraction of the outer hair Cells ϵ implies that the absolute value of the derivative of DRL with respect to the contraction ϵ varies with ϵ. The relative change is particularly strong for a large extensibility Δ of the Deiter’s Cells, which has important functional implications.
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Predicted motion of the Hensen Cells for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) We characterize the motion of the Hensen Cells through the radial and vertical displacements of two points on the top and on the side of the Hensen-Cell contour (red stars). (B) The motion pattern predicted by our model through comparison with experimental data involves large displacement of the Hensen Cells as well as of the base of the outer hair Cells way from the basilar membrane upon outer hair Cell contraction. The basilar membrane is assumed to be fixed. (C-F) Vertical and radial displacement of the two points on the Hensen-Cell contour for a hair-Cell contraction ϵ = 0.005 and different choices of the mode parameters Δ and Γ. The parameter values that are identified as biologically realistic through comparison with experimental data are indicated through an asterisk and are used in (B). (C) The top of the organ consistently moves away from the basilar membrane when the outer hair Cells contract. (D) The radial displacement of the upper point shows a more complex behaviour: both motion towards and away from the stria vascularis can occur under outer hair Cell contraction, depending on the values of the model parameters. (E-F) The direction of both the vertical and the radial motion of the lateral point depend on the values of the model parameters as well. However, this motion was not experimentally accessible.
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Direction of motion of the Hensen Cells.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) Confocal microscopy shows the motion of the reticular lamina when a negative externally-applied current is switched to a positive current of equal magnitude, causing contraction of the outer hair Cells. The green arrows show the displacement for the first and third row of outer hair Cells (the displacement of the second row was similar to the first row). A pivot point emerges between the second and third row of outer hair Cells: the first and second row move towards the basilar membrane whereas the third row moves away from it, following the displacement of the Hensen Cells [20]. (B) Direction of displacement of the third row of outer hair Cells. In this angle histogram, 0° corresponds to motion directed to the right in the image shown in panel A. According to morphometric measurements by Kelly, the basilar membrane is inclined by 37.26° on average with respect to the reticular lamina (dashed line) [42]. Our own measurements from anatomical 3D-reconstructions indicate that this inclination is slightly, but significantly, larger in the undamaged organ of Corti of our in vitro cochlear preparation (42.77° ± 6.43°, continuous black line; N = 13, p = 0.009 by two-tailed t-test, t = 3.09, d.f. = 12.). (C) The first row of outer hair Cells (squares) moves only little. The larger displacement of third-row outer hair Cells (circles) mirrors the large displacement of the Hensen Cells. Error bars indicate the standard error of the mean from the different measurements. Data in (A-C) are from 683 measurements from 15 preparations for the first row of outer hair Cells, and from 905 measurements from 18 preparations for the third row of outer hair Cells. (D) The radial component of the Hensen-Cell displacements was measured directly by tilting the preparation with respect to the interferometer beam. Representative data from one preparation show that the largest motion occurs in a direction with a small component towards the modiolus (red) for positive current injections, consistent with the reticular-lamina data shown in (A, B). Consistent results were obtained from four additional preparations.
Rebecca L. Warren - One of the best experts on this subject based on the ideXlab platform.
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Predicted motion of the reticular lamina for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) A small value of the Deiter’s Cell extensibility Δ leads to a large reticular-lamina displacement. At a critical extensibility ΔC ≈ 1.2 (dashed strip) the displacement vanishes. The critical extensibility ΔC varies slightly with the outer hair Cell contraction ϵ. (B) The Deiter’s Cell extensibility Δ strongly influences the relation between reticular-lamina displacement (dashed) and Hensen-Cell motion (solid) for the model parameter Γ = 0.1 as identified from comparison with experiments. The Hensen-Cell motion for the model parameter Δ = 1.15 (red) is in very good qualitative agreement with experimental results of in vitro Hensen Cell motion under applied current [20, 34]. Both the motion of the Hensen Cells and of the reticular lamina depends nonlinearly on the contraction ϵ of the outer hair Cells, and this nonlinearity is particularly pronounced for a Deiter’s Cell extensibility Δ close to the critical value ΔC. (C) The nonlinear dependence in the reticular-lamina motion DRL on the contraction of the outer hair Cells ϵ implies that the absolute value of the derivative of DRL with respect to the contraction ϵ varies with ϵ. The relative change is particularly strong for a large extensibility Δ of the Deiter’s Cells, which has important functional implications.
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Predicted motion of the Hensen Cells for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) We characterize the motion of the Hensen Cells through the radial and vertical displacements of two points on the top and on the side of the Hensen-Cell contour (red stars). (B) The motion pattern predicted by our model through comparison with experimental data involves large displacement of the Hensen Cells as well as of the base of the outer hair Cells way from the basilar membrane upon outer hair Cell contraction. The basilar membrane is assumed to be fixed. (C-F) Vertical and radial displacement of the two points on the Hensen-Cell contour for a hair-Cell contraction ϵ = 0.005 and different choices of the mode parameters Δ and Γ. The parameter values that are identified as biologically realistic through comparison with experimental data are indicated through an asterisk and are used in (B). (C) The top of the organ consistently moves away from the basilar membrane when the outer hair Cells contract. (D) The radial displacement of the upper point shows a more complex behaviour: both motion towards and away from the stria vascularis can occur under outer hair Cell contraction, depending on the values of the model parameters. (E-F) The direction of both the vertical and the radial motion of the lateral point depend on the values of the model parameters as well. However, this motion was not experimentally accessible.
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Direction of motion of the Hensen Cells.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) Confocal microscopy shows the motion of the reticular lamina when a negative externally-applied current is switched to a positive current of equal magnitude, causing contraction of the outer hair Cells. The green arrows show the displacement for the first and third row of outer hair Cells (the displacement of the second row was similar to the first row). A pivot point emerges between the second and third row of outer hair Cells: the first and second row move towards the basilar membrane whereas the third row moves away from it, following the displacement of the Hensen Cells [20]. (B) Direction of displacement of the third row of outer hair Cells. In this angle histogram, 0° corresponds to motion directed to the right in the image shown in panel A. According to morphometric measurements by Kelly, the basilar membrane is inclined by 37.26° on average with respect to the reticular lamina (dashed line) [42]. Our own measurements from anatomical 3D-reconstructions indicate that this inclination is slightly, but significantly, larger in the undamaged organ of Corti of our in vitro cochlear preparation (42.77° ± 6.43°, continuous black line; N = 13, p = 0.009 by two-tailed t-test, t = 3.09, d.f. = 12.). (C) The first row of outer hair Cells (squares) moves only little. The larger displacement of third-row outer hair Cells (circles) mirrors the large displacement of the Hensen Cells. Error bars indicate the standard error of the mean from the different measurements. Data in (A-C) are from 683 measurements from 15 preparations for the first row of outer hair Cells, and from 905 measurements from 18 preparations for the third row of outer hair Cells. (D) The radial component of the Hensen-Cell displacements was measured directly by tilting the preparation with respect to the interferometer beam. Representative data from one preparation show that the largest motion occurs in a direction with a small component towards the modiolus (red) for positive current injections, consistent with the reticular-lamina data shown in (A, B). Consistent results were obtained from four additional preparations.
Batu Keçeli - One of the best experts on this subject based on the ideXlab platform.
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Predicted motion of the reticular lamina for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) A small value of the Deiter’s Cell extensibility Δ leads to a large reticular-lamina displacement. At a critical extensibility ΔC ≈ 1.2 (dashed strip) the displacement vanishes. The critical extensibility ΔC varies slightly with the outer hair Cell contraction ϵ. (B) The Deiter’s Cell extensibility Δ strongly influences the relation between reticular-lamina displacement (dashed) and Hensen-Cell motion (solid) for the model parameter Γ = 0.1 as identified from comparison with experiments. The Hensen-Cell motion for the model parameter Δ = 1.15 (red) is in very good qualitative agreement with experimental results of in vitro Hensen Cell motion under applied current [20, 34]. Both the motion of the Hensen Cells and of the reticular lamina depends nonlinearly on the contraction ϵ of the outer hair Cells, and this nonlinearity is particularly pronounced for a Deiter’s Cell extensibility Δ close to the critical value ΔC. (C) The nonlinear dependence in the reticular-lamina motion DRL on the contraction of the outer hair Cells ϵ implies that the absolute value of the derivative of DRL with respect to the contraction ϵ varies with ϵ. The relative change is particularly strong for a large extensibility Δ of the Deiter’s Cells, which has important functional implications.
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Predicted motion of the Hensen Cells for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) We characterize the motion of the Hensen Cells through the radial and vertical displacements of two points on the top and on the side of the Hensen-Cell contour (red stars). (B) The motion pattern predicted by our model through comparison with experimental data involves large displacement of the Hensen Cells as well as of the base of the outer hair Cells way from the basilar membrane upon outer hair Cell contraction. The basilar membrane is assumed to be fixed. (C-F) Vertical and radial displacement of the two points on the Hensen-Cell contour for a hair-Cell contraction ϵ = 0.005 and different choices of the mode parameters Δ and Γ. The parameter values that are identified as biologically realistic through comparison with experimental data are indicated through an asterisk and are used in (B). (C) The top of the organ consistently moves away from the basilar membrane when the outer hair Cells contract. (D) The radial displacement of the upper point shows a more complex behaviour: both motion towards and away from the stria vascularis can occur under outer hair Cell contraction, depending on the values of the model parameters. (E-F) The direction of both the vertical and the radial motion of the lateral point depend on the values of the model parameters as well. However, this motion was not experimentally accessible.
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Direction of motion of the Hensen Cells.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) Confocal microscopy shows the motion of the reticular lamina when a negative externally-applied current is switched to a positive current of equal magnitude, causing contraction of the outer hair Cells. The green arrows show the displacement for the first and third row of outer hair Cells (the displacement of the second row was similar to the first row). A pivot point emerges between the second and third row of outer hair Cells: the first and second row move towards the basilar membrane whereas the third row moves away from it, following the displacement of the Hensen Cells [20]. (B) Direction of displacement of the third row of outer hair Cells. In this angle histogram, 0° corresponds to motion directed to the right in the image shown in panel A. According to morphometric measurements by Kelly, the basilar membrane is inclined by 37.26° on average with respect to the reticular lamina (dashed line) [42]. Our own measurements from anatomical 3D-reconstructions indicate that this inclination is slightly, but significantly, larger in the undamaged organ of Corti of our in vitro cochlear preparation (42.77° ± 6.43°, continuous black line; N = 13, p = 0.009 by two-tailed t-test, t = 3.09, d.f. = 12.). (C) The first row of outer hair Cells (squares) moves only little. The larger displacement of third-row outer hair Cells (circles) mirrors the large displacement of the Hensen Cells. Error bars indicate the standard error of the mean from the different measurements. Data in (A-C) are from 683 measurements from 15 preparations for the first row of outer hair Cells, and from 905 measurements from 18 preparations for the third row of outer hair Cells. (D) The radial component of the Hensen-Cell displacements was measured directly by tilting the preparation with respect to the interferometer beam. Representative data from one preparation show that the largest motion occurs in a direction with a small component towards the modiolus (red) for positive current injections, consistent with the reticular-lamina data shown in (A, B). Consistent results were obtained from four additional preparations.
Stefan Jacob - One of the best experts on this subject based on the ideXlab platform.
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Predicted motion of the reticular lamina for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) A small value of the Deiter’s Cell extensibility Δ leads to a large reticular-lamina displacement. At a critical extensibility ΔC ≈ 1.2 (dashed strip) the displacement vanishes. The critical extensibility ΔC varies slightly with the outer hair Cell contraction ϵ. (B) The Deiter’s Cell extensibility Δ strongly influences the relation between reticular-lamina displacement (dashed) and Hensen-Cell motion (solid) for the model parameter Γ = 0.1 as identified from comparison with experiments. The Hensen-Cell motion for the model parameter Δ = 1.15 (red) is in very good qualitative agreement with experimental results of in vitro Hensen Cell motion under applied current [20, 34]. Both the motion of the Hensen Cells and of the reticular lamina depends nonlinearly on the contraction ϵ of the outer hair Cells, and this nonlinearity is particularly pronounced for a Deiter’s Cell extensibility Δ close to the critical value ΔC. (C) The nonlinear dependence in the reticular-lamina motion DRL on the contraction of the outer hair Cells ϵ implies that the absolute value of the derivative of DRL with respect to the contraction ϵ varies with ϵ. The relative change is particularly strong for a large extensibility Δ of the Deiter’s Cells, which has important functional implications.
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Predicted motion of the Hensen Cells for different parameter values.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) We characterize the motion of the Hensen Cells through the radial and vertical displacements of two points on the top and on the side of the Hensen-Cell contour (red stars). (B) The motion pattern predicted by our model through comparison with experimental data involves large displacement of the Hensen Cells as well as of the base of the outer hair Cells way from the basilar membrane upon outer hair Cell contraction. The basilar membrane is assumed to be fixed. (C-F) Vertical and radial displacement of the two points on the Hensen-Cell contour for a hair-Cell contraction ϵ = 0.005 and different choices of the mode parameters Δ and Γ. The parameter values that are identified as biologically realistic through comparison with experimental data are indicated through an asterisk and are used in (B). (C) The top of the organ consistently moves away from the basilar membrane when the outer hair Cells contract. (D) The radial displacement of the upper point shows a more complex behaviour: both motion towards and away from the stria vascularis can occur under outer hair Cell contraction, depending on the values of the model parameters. (E-F) The direction of both the vertical and the radial motion of the lateral point depend on the values of the model parameters as well. However, this motion was not experimentally accessible.
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Direction of motion of the Hensen Cells.
2018Co-Authors: Nikola Ciganović, Rebecca L. Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias ReichenbachAbstract:(A) Confocal microscopy shows the motion of the reticular lamina when a negative externally-applied current is switched to a positive current of equal magnitude, causing contraction of the outer hair Cells. The green arrows show the displacement for the first and third row of outer hair Cells (the displacement of the second row was similar to the first row). A pivot point emerges between the second and third row of outer hair Cells: the first and second row move towards the basilar membrane whereas the third row moves away from it, following the displacement of the Hensen Cells [20]. (B) Direction of displacement of the third row of outer hair Cells. In this angle histogram, 0° corresponds to motion directed to the right in the image shown in panel A. According to morphometric measurements by Kelly, the basilar membrane is inclined by 37.26° on average with respect to the reticular lamina (dashed line) [42]. Our own measurements from anatomical 3D-reconstructions indicate that this inclination is slightly, but significantly, larger in the undamaged organ of Corti of our in vitro cochlear preparation (42.77° ± 6.43°, continuous black line; N = 13, p = 0.009 by two-tailed t-test, t = 3.09, d.f. = 12.). (C) The first row of outer hair Cells (squares) moves only little. The larger displacement of third-row outer hair Cells (circles) mirrors the large displacement of the Hensen Cells. Error bars indicate the standard error of the mean from the different measurements. Data in (A-C) are from 683 measurements from 15 preparations for the first row of outer hair Cells, and from 905 measurements from 18 preparations for the third row of outer hair Cells. (D) The radial component of the Hensen-Cell displacements was measured directly by tilting the preparation with respect to the interferometer beam. Representative data from one preparation show that the largest motion occurs in a direction with a small component towards the modiolus (red) for positive current injections, consistent with the reticular-lamina data shown in (A, B). Consistent results were obtained from four additional preparations.