The Experts below are selected from a list of 1776 Experts worldwide ranked by ideXlab platform
Jan Ravkilde - One of the best experts on this subject based on the ideXlab platform.
-
graft patency after off pump coronary artery bypass surgery is inferior even with identical Heparinization protocols results from the danish on pump versus off pump randomization study doors
The Journal of Thoracic and Cardiovascular Surgery, 2014Co-Authors: Kim Christian Houlind, Morten Fengergron, Susanne Juel Holme, Bo Juel Kjeldsen, Susanne Norgaard Madsen, Bodil Steen Rasmussen, Mogens Harrits Jepsen, Jan RavkildeAbstract:Objective To determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same Heparinization protocol. Methods In a randomized, controlled, multicenter trial, 900 patients more than 70 years of age received either on-pump or off-pump coronary artery bypass surgery. Heparin was given to achieve an activated clotting time of 400 seconds before arteriotomy in both groups. After the procedure, protamine sulfate was given to revert the activated clotting time to less than 120 seconds. Coronary angiography was performed 6 months after the operation and graft patency was assessed by independent blinded observers. Results A total of 481 patients underwent angiography. In the off-pump group, 561 (79%) of 710 grafts were open, 65 (9%) were stenotic, and 84 (12%) were occluded. In the on-pump group, 549 (86%) of 650 grafts were open, 38 (5%) were stenotic, and 63 (9%) were occluded. The difference between the proportion of open grafts was statistically significant in favor of on-pump surgery ( P = .01). The proportion of open left internal thoracic artery grafts was 95% in both groups. Perioperative use of intracoronary shunts did not increase the risk of stenosis of the coronary artery distal to the anastomosis. Conclusions Despite comparable Heparinization, graft patency after off-pump surgery was inferior to that after on-pump surgery.
Kim Christian Houlind - One of the best experts on this subject based on the ideXlab platform.
-
graft patency after off pump coronary artery bypass surgery is inferior even with identical Heparinization protocols results from the danish on pump versus off pump randomization study doors
The Journal of Thoracic and Cardiovascular Surgery, 2014Co-Authors: Kim Christian Houlind, Morten Fengergron, Susanne Juel Holme, Bo Juel Kjeldsen, Susanne Norgaard Madsen, Bodil Steen Rasmussen, Mogens Harrits Jepsen, Jan RavkildeAbstract:Objective To determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same Heparinization protocol. Methods In a randomized, controlled, multicenter trial, 900 patients more than 70 years of age received either on-pump or off-pump coronary artery bypass surgery. Heparin was given to achieve an activated clotting time of 400 seconds before arteriotomy in both groups. After the procedure, protamine sulfate was given to revert the activated clotting time to less than 120 seconds. Coronary angiography was performed 6 months after the operation and graft patency was assessed by independent blinded observers. Results A total of 481 patients underwent angiography. In the off-pump group, 561 (79%) of 710 grafts were open, 65 (9%) were stenotic, and 84 (12%) were occluded. In the on-pump group, 549 (86%) of 650 grafts were open, 38 (5%) were stenotic, and 63 (9%) were occluded. The difference between the proportion of open grafts was statistically significant in favor of on-pump surgery ( P = .01). The proportion of open left internal thoracic artery grafts was 95% in both groups. Perioperative use of intracoronary shunts did not increase the risk of stenosis of the coronary artery distal to the anastomosis. Conclusions Despite comparable Heparinization, graft patency after off-pump surgery was inferior to that after on-pump surgery.
Yizao Wan - One of the best experts on this subject based on the ideXlab platform.
-
Heparinization and hybridization of electrospun tubular graft for improved endothelialization and anticoagulation
Materials Science and Engineering: C, 2021Co-Authors: Quanchao Zhang, Xiangbo Zhu, Honglin Luo, Miguel Gama, Mengxia Peng, Xiaoyan Deng, Yizao WanAbstract:Constructing biomimetic structure and immobilizing antithrombus factors are two effective methods to ensure rapid endothelialization and long-term anticoagulation for small-diameter vascular grafts. However, few literatures are available regarding simultaneous implementation of these two strategies. Herein, a nano-micro-fibrous biomimetic graft with a heparin coating was prepared via a step-by-step in situ biosynthesis method to improve potential endothelialization and anticoagulation. The 4-mm-diameter tubular graft consists of electrospun cellulose acetate (CA) microfibers and entangled bacterial nanocellulose (BNC) nanofibers with heparin coating on dual fibers. The hybridized and heparinized graft possesses suitable pore structure that facilitates endothelia cells adhesion and proliferation but prevents infiltration of fibrous tissue and blood leakage. In addition, it shows higher mechanical properties than those of bare CA and hybridized CA/BNC grafts, which match well with native blood vessels. Moreover, this dually modified graft exhibits improved blood compatibility and endothelialization over the counterparts without hybridization or Heparinization according to the testing results of platelet adhesion, cell morphology, and protein expression of von Willebrand Factor. This novel graft with dual modifications shows promising as a new small-diameter vascular graft. This study provides a guidance for promoting endothelialization and blood compatibility by dual modifications of biomimetic structure and immobilized bioactive molecules.
Susanne Juel Holme - One of the best experts on this subject based on the ideXlab platform.
-
graft patency after off pump coronary artery bypass surgery is inferior even with identical Heparinization protocols results from the danish on pump versus off pump randomization study doors
The Journal of Thoracic and Cardiovascular Surgery, 2014Co-Authors: Kim Christian Houlind, Morten Fengergron, Susanne Juel Holme, Bo Juel Kjeldsen, Susanne Norgaard Madsen, Bodil Steen Rasmussen, Mogens Harrits Jepsen, Jan RavkildeAbstract:Objective To determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same Heparinization protocol. Methods In a randomized, controlled, multicenter trial, 900 patients more than 70 years of age received either on-pump or off-pump coronary artery bypass surgery. Heparin was given to achieve an activated clotting time of 400 seconds before arteriotomy in both groups. After the procedure, protamine sulfate was given to revert the activated clotting time to less than 120 seconds. Coronary angiography was performed 6 months after the operation and graft patency was assessed by independent blinded observers. Results A total of 481 patients underwent angiography. In the off-pump group, 561 (79%) of 710 grafts were open, 65 (9%) were stenotic, and 84 (12%) were occluded. In the on-pump group, 549 (86%) of 650 grafts were open, 38 (5%) were stenotic, and 63 (9%) were occluded. The difference between the proportion of open grafts was statistically significant in favor of on-pump surgery ( P = .01). The proportion of open left internal thoracic artery grafts was 95% in both groups. Perioperative use of intracoronary shunts did not increase the risk of stenosis of the coronary artery distal to the anastomosis. Conclusions Despite comparable Heparinization, graft patency after off-pump surgery was inferior to that after on-pump surgery.
Morten Fengergron - One of the best experts on this subject based on the ideXlab platform.
-
graft patency after off pump coronary artery bypass surgery is inferior even with identical Heparinization protocols results from the danish on pump versus off pump randomization study doors
The Journal of Thoracic and Cardiovascular Surgery, 2014Co-Authors: Kim Christian Houlind, Morten Fengergron, Susanne Juel Holme, Bo Juel Kjeldsen, Susanne Norgaard Madsen, Bodil Steen Rasmussen, Mogens Harrits Jepsen, Jan RavkildeAbstract:Objective To determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same Heparinization protocol. Methods In a randomized, controlled, multicenter trial, 900 patients more than 70 years of age received either on-pump or off-pump coronary artery bypass surgery. Heparin was given to achieve an activated clotting time of 400 seconds before arteriotomy in both groups. After the procedure, protamine sulfate was given to revert the activated clotting time to less than 120 seconds. Coronary angiography was performed 6 months after the operation and graft patency was assessed by independent blinded observers. Results A total of 481 patients underwent angiography. In the off-pump group, 561 (79%) of 710 grafts were open, 65 (9%) were stenotic, and 84 (12%) were occluded. In the on-pump group, 549 (86%) of 650 grafts were open, 38 (5%) were stenotic, and 63 (9%) were occluded. The difference between the proportion of open grafts was statistically significant in favor of on-pump surgery ( P = .01). The proportion of open left internal thoracic artery grafts was 95% in both groups. Perioperative use of intracoronary shunts did not increase the risk of stenosis of the coronary artery distal to the anastomosis. Conclusions Despite comparable Heparinization, graft patency after off-pump surgery was inferior to that after on-pump surgery.