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Chaoran Zhang - One of the best experts on this subject based on the ideXlab platform.

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M Labetoulle - One of the best experts on this subject based on the ideXlab platform.

  • persistent impairment of quality of life in patients with Herpes Simplex Keratitis
    Ophthalmology, 2017
    Co-Authors: Clotilde Reynaud, Antoine Rousseau, G Kaswin, M Mgarrech, E Barreau, M Labetoulle
    Abstract:

    Purpose To evaluate the quality of life (QoL) in patients with quiescent Herpes Simplex Keratitis compared with control patients without ocular Herpes. Design Prospective, case-control study. Participants Thirty-three patients with a unilateral and relapsing Herpes Simplex Keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were age and gender matched. Methods Three previously validated QoL questionnaires were used in this study: the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25), Glaucoma Quality of Life 17 (Glau-QoL17) questionnaire, and Ocular Surface Disease Quality of Life (OSD-QoL) questionnaire. Each questionnaire covered various aspects of the disease. Main Outcome Measures The outcomes of the 3 questionnaires were compared between groups. For the HSK group, the results were correlated to the clinical findings and the history of herpetic disease. Results The mean total questionnaire scores of the 3 QoL questionnaires were significantly lower in the HSK group compared with controls (NEI VFQ-25: 70.5±3.8 vs. 91.1±0.8, P P P Conclusions Even during a quiescent phase of the disease, unilateral and relapsing HSK significantly impairs the QoL of patients to a similar level as most sight-threatening diseases. The decrease of VA has the greatest overall effect, but other factors also significantly affect QoL, such as the frequency of relapses.

  • Persistent Impairment of Quality of Life in Patients with Herpes Simplex Keratitis.
    Ophthalmology, 2016
    Co-Authors: Clotilde Reynaud, Antoine Rousseau, G Kaswin, E Barreau, M. M’garrech, M Labetoulle
    Abstract:

    To evaluate the quality of life (QoL) in patients with quiescent Herpes Simplex Keratitis compared with control patients without ocular Herpes. Prospective, case-control study. Thirty-three patients with a unilateral and relapsing Herpes Simplex Keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were age and gender matched. Three previously validated QoL questionnaires were used in this study: the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25), Glaucoma Quality of Life 17 (Glau-QoL17) questionnaire, and Ocular Surface Disease Quality of Life (OSD-QoL) questionnaire. Each questionnaire covered various aspects of the disease. The outcomes of the 3 questionnaires were compared between groups. For the HSK group, the results were correlated to the clinical findings and the history of herpetic disease. The mean total questionnaire scores of the 3 QoL questionnaires were significantly lower in the HSK group compared with controls (NEI VFQ-25: 70.5±3.8 vs. 91.1±0.8, P < 0.0001; Glau-QoL17: 68.2±3.1 vs. 87.9±1.0, P < 0.0001; and OSD-QoL: 65.4±2.9 vs. 93.1±0.6, P < 0.0001, respectively). In the HSK group, the level of visual acuity (VA) in the affected eye had the greatest impact on QoL, inducing lower QoL results related to "general vision," "distance activities," "dependency," "peripheral vision," "self-image," "daily living," and "driving" dimensions. Decreased VA in the unaffected eye also negatively affected "self-image" and "driving" results. Patients with frequent HSK relapses had lower QoL related to "ocular pain" and "acknowledgement." Even during a quiescent phase of the disease, unilateral and relapsing HSK significantly impairs the QoL of patients to a similar level as most sight-threatening diseases. The decrease of VA has the greatest overall effect, but other factors also significantly affect QoL, such as the frequency of relapses. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Zhu-jian Wang - One of the best experts on this subject based on the ideXlab platform.

C. Stephen Foster - One of the best experts on this subject based on the ideXlab platform.

  • A prospective randomized trial of oral acyclovir after penetrating keratoplasty for Herpes Simplex Keratitis.
    Cornea, 1994
    Co-Authors: Neal P. Barney, C. Stephen Foster
    Abstract:

    Corneal graft survival in 13 patients (14 eyes) receiving oral acyclovir after penetrating keratoplasty for Herpes Simplex Keratitis was compared with that in nine patients (nine eyes) who underwent penetrating keratoplasty for Herpes Simplex Keratitis without postoperative acyclovir. Mean age, duration of disease, and time of follow-up did not differ in the two groups. There were no recurrences of Herpes Simplex Keratitis in any patient receiving acyclovir during a mean follow-up of 16.5 months compared with a 44% (four of nine) recurrence rate in patients without acyclovir during a mean follow-up of 20.6 months (p < 0.01). Graft failure occurred in 14% (2 of 14) of acyclovir treatment eyes compared with 56% (five of nine) without acyclovir. Long-term prophylactic oral acyclovir significantly decreased the recurrence of Herpes Simplex Keratitis and reduced corneal graft failure in patients who had a history of recurrent Herpes Simplex Keratitis and who had undergone penetrating keratoplasty.

  • Systemic acyclovir and penetrating keratoplasty for Herpes Simplex Keratitis.
    Documenta ophthalmologica. Advances in ophthalmology, 1992
    Co-Authors: C. Stephen Foster, Neal P. Barney
    Abstract:

    Corneal graft survival in 13 patients (14 eyes) receiving oral acyclovir following corneal transplantation for Herpes Simplex Keratitis was compared to that in nine patients (9 eyes) who underwent penetrating keratoplasty for Herpes Simplex Keratitis without receiving postoperative acyclovir. Mean age, duration of disease, and time of follow-up did not differ in the two groups. There were no recurrences of Herpes Simplex Keratitis in any patient receiving acyclovir during a mean follow-up of 16.5 months compared to a 44% (4/9) recurrence rate in patients without acyclovir during a mean follow-up of 20.6 months (p < 0.01). Graft failure occurred in 14% (2/14) of acyclovir treatment eyes and in 56% (5/9) of the grafts in patients not receiving acyclovir. Long term prophylactic oral acyclovir significantly decreased the recurrence of Herpes Simplex Keratitis and reduced corneal graft failure in patients with a history of recurrent Herpes Simplex Keratitis who underwent corneal transplantation.