The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
Antonella Rotola - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2020Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is\ud still debated. Peripheral blood mononuclear cells from MS patients and controls\ud were treated with CpG sequences and infected in vitro with HSV-1. Samples were\ud analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation\ud and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted \ud an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients:\ud TLR9 pathways did not show defects while NK cells presented decreased\ud degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. \ud CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell \ud activation. These data suggest potential implications for viral pathogenesis of\ud MS
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2013Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64] Roberta Rizzo, Valentina Gentili , Ilaria Casetta, Elisabetta Caselli , Riccardo De Gennaro, Enrico Granieri , Enzo Cassai , Dario Di Luca, Antonella Rotola⁎ a Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy b Section of Neurology, Department of Medical and Surgical Disciplines, University of Ferrara, Italy
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Altered natural killer cells' response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression
Journal of Neuroimmunology, 2012Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Abstract The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is still debated. Peripheral blood mononuclear cells from MS patients and controls were treated with CpG sequences and infected in vitro with HSV-1. Samples were analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients: TLR9 pathways did not show defects while NK cells presented decreased degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell activation. These data suggest potential implications for viral pathogenesis of MS.
Roberta Rizzo - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2020Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is\ud still debated. Peripheral blood mononuclear cells from MS patients and controls\ud were treated with CpG sequences and infected in vitro with HSV-1. Samples were\ud analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation\ud and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted \ud an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients:\ud TLR9 pathways did not show defects while NK cells presented decreased\ud degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. \ud CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell \ud activation. These data suggest potential implications for viral pathogenesis of\ud MS
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2013Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64] Roberta Rizzo, Valentina Gentili , Ilaria Casetta, Elisabetta Caselli , Riccardo De Gennaro, Enrico Granieri , Enzo Cassai , Dario Di Luca, Antonella Rotola⁎ a Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy b Section of Neurology, Department of Medical and Surgical Disciplines, University of Ferrara, Italy
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Altered natural killer cells' response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression
Journal of Neuroimmunology, 2012Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Abstract The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is still debated. Peripheral blood mononuclear cells from MS patients and controls were treated with CpG sequences and infected in vitro with HSV-1. Samples were analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients: TLR9 pathways did not show defects while NK cells presented decreased degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell activation. These data suggest potential implications for viral pathogenesis of MS.
Tao Peng - One of the best experts on this subject based on the ideXlab platform.
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immune surveillance by cd8αα skin resident t cells in human Herpes Virus Infection
Nature, 2013Co-Authors: Tao Peng, Christine Johnston, Khamsone Phasouk, Angela S Kask, Alexis Klock, Kurt Diem, David M Koelle, Anna Wald, Harlan RobinsAbstract:Herpes simplex Virus 2-infected individuals are shown to have skin-tissue-resident CD8αα+ T cells that persist at the portal of Virus release in genital skin and mucosa, possess oligoclonal T-cell-receptor-β CDR3 sequences that are stable over time, and express gene signatures of antiviral and cytolytic function indicative of viral-specific immune surveillance. Using Herpes simplex Virus 2 (HSV-2) as a model pathogen, Jia Zhu et al. demonstrate that a unique subset of tissue-resident CD8+ T cells persists in the genital mucosa. In HSV-2-infected individuals, Virus-specific and clonally related CD8αα+ T cells — rather than conventional CD8αβ+ T cells — are the predominant tissue-resident memory cells localized to the source of HSV-2 release, where they contribute to immune surveillance. These findings suggest that vaccines or immunotherapeutic approaches that increase the number and density of tissue-resident CD8αα+ cells may enhance control of not only HSV-2 but of other genital tract Infections, such as HIV. Most Herpes simplex Virus 2 (HSV-2) reactivations in humans are subclinical and associated with rapid expansion and containment of Virus. Previous studies have shown that CD8+ T cells persist in genital skin and mucosa at the dermal–epidermal junction (DEJ)—the portal of neuronal release of reactivating Virus—for prolonged time periods after Herpes lesions are cleared1,2. The phenotype and function of this persistent CD8+ T-cell population remain unknown. Here, using cell-type-specific laser capture microdissection, transcriptional profiling and T-cell antigen receptor β-chain (TCRβ) genotyping on sequential genital skin biopsies, we show that CD8αα+ T cells are the dominant resident population of DEJ CD8+ T cells that persist at the site of previous HSV-2 reactivation. CD8αα+ T cells located at the DEJ lack chemokine-receptor expression required for lymphocyte egress and recirculation, express gene signatures of T-cell activation and antiviral activity, and produce cytolytic granules during clinical and virological quiescent time periods. Sequencing of the TCR β-chain repertoire reveals that the DEJ CD8αα+ T cells are oligoclonal with diverse usage of TCR variable-β genes, which differ from those commonly described for mucosa-associated invariant T cells and natural killer T cells. Dominant clonotypes are shown to overlap among multiple recurrences over a period of two-and-a-half years. Episodes of rapid asymptomatic HSV-2 containment were also associated with a high CD8 effector-to-target ratio and focal enrichment of CD8αα+ T cells. These studies indicate that DEJ CD8αα+ T cells are tissue-resident cells that seem to have a fundamental role in immune surveillance and in initial containment of HSV-2 reactivation in human peripheral tissue. Elicitation of CD8αα+ T cells may be a critical component for developing effective vaccines against skin and mucosal Infections.
Valentina Gentili - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2020Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is\ud still debated. Peripheral blood mononuclear cells from MS patients and controls\ud were treated with CpG sequences and infected in vitro with HSV-1. Samples were\ud analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation\ud and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted \ud an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients:\ud TLR9 pathways did not show defects while NK cells presented decreased\ud degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. \ud CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell \ud activation. These data suggest potential implications for viral pathogenesis of\ud MS
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2013Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64] Roberta Rizzo, Valentina Gentili , Ilaria Casetta, Elisabetta Caselli , Riccardo De Gennaro, Enrico Granieri , Enzo Cassai , Dario Di Luca, Antonella Rotola⁎ a Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy b Section of Neurology, Department of Medical and Surgical Disciplines, University of Ferrara, Italy
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Altered natural killer cells' response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression
Journal of Neuroimmunology, 2012Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Abstract The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is still debated. Peripheral blood mononuclear cells from MS patients and controls were treated with CpG sequences and infected in vitro with HSV-1. Samples were analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients: TLR9 pathways did not show defects while NK cells presented decreased degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell activation. These data suggest potential implications for viral pathogenesis of MS.
Elisabetta Caselli - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2020Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is\ud still debated. Peripheral blood mononuclear cells from MS patients and controls\ud were treated with CpG sequences and infected in vitro with HSV-1. Samples were\ud analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation\ud and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted \ud an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients:\ud TLR9 pathways did not show defects while NK cells presented decreased\ud degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. \ud CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell \ud activation. These data suggest potential implications for viral pathogenesis of\ud MS
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Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64]
Journal of Neuroimmunology, 2013Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Corrigendum to “Altered natural killer cells response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression” [J. Neuroimmunol. 251 (2012) 55–64] Roberta Rizzo, Valentina Gentili , Ilaria Casetta, Elisabetta Caselli , Riccardo De Gennaro, Enrico Granieri , Enzo Cassai , Dario Di Luca, Antonella Rotola⁎ a Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy b Section of Neurology, Department of Medical and Surgical Disciplines, University of Ferrara, Italy
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Altered natural killer cells' response to Herpes Virus Infection in multiple sclerosis involves KIR2DL2 expression
Journal of Neuroimmunology, 2012Co-Authors: Roberta Rizzo, Valentina Gentili, Ilaria Casetta, Elisabetta Caselli, Riccardo De Gennaro, Enrico Granieri, Enzo Cassai, Dario Di Luca, Antonella RotolaAbstract:Abstract The role of Herpes Viruses as potential triggers of multiple sclerosis (MS) is still debated. Peripheral blood mononuclear cells from MS patients and controls were treated with CpG sequences and infected in vitro with HSV-1. Samples were analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted an unexpected sensitivity to Herpes Virus Infection in a subset of MS patients: TLR9 pathways did not show defects while NK cells presented decreased degranulation and cytotoxicity and up-regulated the inhibitory KIR2DL2 receptor. CpG treatment of purified NK cells affected directly KIR2DL2 modulation and cell activation. These data suggest potential implications for viral pathogenesis of MS.