The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Fred Guyer - One of the best experts on this subject based on the ideXlab platform.
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Case report: palmar Herpetic Whitlow and forearm lymphangitis in a 10-year-old female
BMC pediatrics, 2019Co-Authors: Leora Lieberman, Daniel Castro, Avni Bhatt, Fred GuyerAbstract:Herpetic Whitlow is a viral infection caused by the herpes simplex virus (HSV) types 1 or 2, and occurs in the pediatric population primarily on the fingers and toes due to autoinoculation from oral secretions. Because of this cited prevalence, other locations of Herpetic Whitlow may go unrecognized. We present an atypical presentation of palmar Herpetic Whitlow with delayed recognition and associated viral lymphangitis. The patient presented as a transfer from an outside hospital with a progressive, three-day history of a suspected left hand abscess preceded by left hand pain and itching. She was initially evaluated by Orthopedic Surgery, who described an erythematous, edematous, tender, left palmar abscess with associated erythematous streaking up her forearm. The lesion was surgically managed with an incision and drainage. Wound cultures were obtained during which “minimal drainage” was noted. After admission to the General Pediatrics Hospital service, the lesion was noted to appear vesicular and subsequently obtained PCR samples were positive for HSV type 1, confirming her diagnosis of Herpetic Whitlow. Although she remained afebrile with negative wound cultures throughout her hospitalization, a secondary bacterial infection could not be conclusively excluded due to the accompanying lymphangitis. Thus, she was discharged with oral antibiotics and anticipatory guidance of potential recurrence of palmar lesions. Herpetic Whitlow should be included in the differential diagnosis of palmar lesions that appear vesicular or abscess-like to ensure appropriate treatment. Additionally, these palmar lesions may present with associated lymphangitis without evidence of bacterial infection.
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Case report: palmar Herpetic Whitlow and forearm lymphangitis in a 10-year-old female
BMC Pediatrics, 2019Co-Authors: Leora Lieberman, Daniel Castro, Avni Bhatt, Fred GuyerAbstract:Background Herpetic Whitlow is a viral infection caused by the herpes simplex virus (HSV) types 1 or 2, and occurs in the pediatric population primarily on the fingers and toes due to autoinoculation from oral secretions. Because of this cited prevalence, other locations of Herpetic Whitlow may go unrecognized. Case presentation We present an atypical presentation of palmar Herpetic Whitlow with delayed recognition and associated viral lymphangitis. The patient presented as a transfer from an outside hospital with a progressive, three-day history of a suspected left hand abscess preceded by left hand pain and itching. She was initially evaluated by Orthopedic Surgery, who described an erythematous, edematous, tender, left palmar abscess with associated erythematous streaking up her forearm. The lesion was surgically managed with an incision and drainage. Wound cultures were obtained during which “minimal drainage” was noted. After admission to the General Pediatrics Hospital service, the lesion was noted to appear vesicular and subsequently obtained PCR samples were positive for HSV type 1, confirming her diagnosis of Herpetic Whitlow. Although she remained afebrile with negative wound cultures throughout her hospitalization, a secondary bacterial infection could not be conclusively excluded due to the accompanying lymphangitis. Thus, she was discharged with oral antibiotics and anticipatory guidance of potential recurrence of palmar lesions. Conclusions Herpetic Whitlow should be included in the differential diagnosis of palmar lesions that appear vesicular or abscess-like to ensure appropriate treatment. Additionally, these palmar lesions may present with associated lymphangitis without evidence of bacterial infection.
Itzhak Varsano - One of the best experts on this subject based on the ideXlab platform.
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Primary herpes simplex virus type 1 gingivostomatitis in pediatric personnel
Infection, 1997Co-Authors: J. Amir, R. Kleper, H. A. Cohen, Moshe Nussinovitch, Itzhak VarsanoAbstract:Herpetic gingivostomatitis is common in young children, but primary oral infection has also been described in adults. Herpetic Whitlow as an occupational hazard of medical personnel has been well documented. Four cases of primary Herpetic gingivostomatitis are reported in two pediatricians and two pediatric nurses who contracted the infection in their fourth decade of life. All suffered from sore throat and fever as presenting symptoms. Correct diagnosis was delayed for 4–5 days. In conclusion, pediatric personnel with pharyngitis and a negative history of Herpetic gingivostomatitis or herpes labialis should bear the possibility of oral HSV infection in mind. Early diagnosis is essential to prevent the spread of the infection to their patients.
J. Amir - One of the best experts on this subject based on the ideXlab platform.
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Herpetic Whitlow Infection in a General Pediatrician - An Occupational Hazard
Infection, 2002Co-Authors: Y. Avitzur, J. AmirAbstract:Herpetic Whitlow is a well-known occupational hazard for medical staff. It has been reported to affect mainly workers in intensive care units who come into close contact with oral secretions. We report Herpetic Whitlow infection in a general pediatrician in order to increase the awareness to this infectious occupational hazard that might occur in any health care worker who deals with oral secretions. A 35-year-old male general pediatrician sustained a minor knife cut in his finger and 5 days later he developed Herpetic Whitlow. He was treated with acyclovir with gradual improvement. We review the clinical course, complications and treatment of Herpetic Whitlow. The source of the infection in the present case was unknown, but it probably derived from oral secretions of children with unrecognized infection. Simple measures like wearing gloves during oral examination will avoid unnecessary morbidity in medical staff.
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Primary herpes simplex virus type 1 gingivostomatitis in pediatric personnel
Infection, 1997Co-Authors: J. Amir, R. Kleper, H. A. Cohen, Moshe Nussinovitch, Itzhak VarsanoAbstract:Herpetic gingivostomatitis is common in young children, but primary oral infection has also been described in adults. Herpetic Whitlow as an occupational hazard of medical personnel has been well documented. Four cases of primary Herpetic gingivostomatitis are reported in two pediatricians and two pediatric nurses who contracted the infection in their fourth decade of life. All suffered from sore throat and fever as presenting symptoms. Correct diagnosis was delayed for 4–5 days. In conclusion, pediatric personnel with pharyngitis and a negative history of Herpetic gingivostomatitis or herpes labialis should bear the possibility of oral HSV infection in mind. Early diagnosis is essential to prevent the spread of the infection to their patients.
Leora Lieberman - One of the best experts on this subject based on the ideXlab platform.
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Case report: palmar Herpetic Whitlow and forearm lymphangitis in a 10-year-old female
BMC pediatrics, 2019Co-Authors: Leora Lieberman, Daniel Castro, Avni Bhatt, Fred GuyerAbstract:Herpetic Whitlow is a viral infection caused by the herpes simplex virus (HSV) types 1 or 2, and occurs in the pediatric population primarily on the fingers and toes due to autoinoculation from oral secretions. Because of this cited prevalence, other locations of Herpetic Whitlow may go unrecognized. We present an atypical presentation of palmar Herpetic Whitlow with delayed recognition and associated viral lymphangitis. The patient presented as a transfer from an outside hospital with a progressive, three-day history of a suspected left hand abscess preceded by left hand pain and itching. She was initially evaluated by Orthopedic Surgery, who described an erythematous, edematous, tender, left palmar abscess with associated erythematous streaking up her forearm. The lesion was surgically managed with an incision and drainage. Wound cultures were obtained during which “minimal drainage” was noted. After admission to the General Pediatrics Hospital service, the lesion was noted to appear vesicular and subsequently obtained PCR samples were positive for HSV type 1, confirming her diagnosis of Herpetic Whitlow. Although she remained afebrile with negative wound cultures throughout her hospitalization, a secondary bacterial infection could not be conclusively excluded due to the accompanying lymphangitis. Thus, she was discharged with oral antibiotics and anticipatory guidance of potential recurrence of palmar lesions. Herpetic Whitlow should be included in the differential diagnosis of palmar lesions that appear vesicular or abscess-like to ensure appropriate treatment. Additionally, these palmar lesions may present with associated lymphangitis without evidence of bacterial infection.
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Case report: palmar Herpetic Whitlow and forearm lymphangitis in a 10-year-old female
BMC Pediatrics, 2019Co-Authors: Leora Lieberman, Daniel Castro, Avni Bhatt, Fred GuyerAbstract:Background Herpetic Whitlow is a viral infection caused by the herpes simplex virus (HSV) types 1 or 2, and occurs in the pediatric population primarily on the fingers and toes due to autoinoculation from oral secretions. Because of this cited prevalence, other locations of Herpetic Whitlow may go unrecognized. Case presentation We present an atypical presentation of palmar Herpetic Whitlow with delayed recognition and associated viral lymphangitis. The patient presented as a transfer from an outside hospital with a progressive, three-day history of a suspected left hand abscess preceded by left hand pain and itching. She was initially evaluated by Orthopedic Surgery, who described an erythematous, edematous, tender, left palmar abscess with associated erythematous streaking up her forearm. The lesion was surgically managed with an incision and drainage. Wound cultures were obtained during which “minimal drainage” was noted. After admission to the General Pediatrics Hospital service, the lesion was noted to appear vesicular and subsequently obtained PCR samples were positive for HSV type 1, confirming her diagnosis of Herpetic Whitlow. Although she remained afebrile with negative wound cultures throughout her hospitalization, a secondary bacterial infection could not be conclusively excluded due to the accompanying lymphangitis. Thus, she was discharged with oral antibiotics and anticipatory guidance of potential recurrence of palmar lesions. Conclusions Herpetic Whitlow should be included in the differential diagnosis of palmar lesions that appear vesicular or abscess-like to ensure appropriate treatment. Additionally, these palmar lesions may present with associated lymphangitis without evidence of bacterial infection.
Kimiyasu Shiraki - One of the best experts on this subject based on the ideXlab platform.
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Genital herpes due to acyclovir-sensitive herpes simplex virus caused secondary and recurrent Herpetic Whitlows due to thymidine kinase-deficient/temperature-sensitive virus
Journal of medical virology, 2007Co-Authors: Yuka Shimada, Kazuhiko Takehara, Mikiko Suzuki, Fumiaki Shirasaki, Eriko Saito, Kana Sogo, Minoru Hasegawa, Jurairatana Phromjai, Tatsuya Chuhjo, Kimiyasu ShirakiAbstract:Herpes simplex virus (HSV)-2 caused a genital ulcer in a 40-year-old allogenic stem cell recipient, and a secondary Herpetic Whitlow appeared during 2 months of acyclovir (ACV) therapy. Both genital ulcer, and Whitlow were cured 3 months later, but 6 months after recovery the Whitlow alone recurred. DNA of the genital, first, and recurrent Whitlow isolates showed similar endonuclease digestion fragment profiles. The genital virus was ACV-sensitive, and the two Whitlow isolates were ACV-resistant/thymidine kinase (TK)-deficient. The TK gene of the Whitlow isolates had the same frame shift from the 274th amino acid and termination at the 347th amino acid due to the deletion of a cytosine at the 819th nucleotide. Because the temperature of the thumb is 33/34 degrees C or lower, the temperature sensitivity of the isolates were compared, and both Whitlow isolates were significantly more temperature-sensitive (ts) at 39 degrees C than the genital isolate. The two Whitlow isolates showed cutaneous pathogenicity in mouse ear pinna but not midflank, while the genital isolate was pathogenic at both sites, suggesting that temperature adaptation was an important element of pathogenicity in the Whitlow. The virus populations of isolates of the genital, and first Whitlow were examined by 31, and 82 clones, respectively, and the clones from genital, and Whitlow isolates were ACV-sensitive, and -resistant, respectively, showing their homogeneity. The acyclovir-sensitive genital lesion had spread as a TK-deficient/ts Herpetic Whitlow during ACV treatment, and an apparently TK-deficient virus adapted to the local temperature might have caused the Whitlow recurrence.