The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Gregor B. E. Jemec - One of the best experts on this subject based on the ideXlab platform.
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Diagnosing Hidradenitis Suppurativa.
Dermatologic Clinics, 2016Co-Authors: Jean Revuz, Gregor B. E. JemecAbstract:Three diagnostic criteria must be met for Hidradenitis suppurativa: typical lesions, occurrence in one or more of the predilection areas, and that it is chronic and/or recurrent. Several outcome measures are used, including patient-reported pain and itch scales, Dermatology Life Quality Index, and Skindex. Hidradenitis suppurativa is associated with significant comorbidities that must be addressed in the evaluation of the patients.
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Psychosocial impact of Hidradenitis suppurativa: a qualitative study.
Acta Dermato Venereologica, 2011Co-Authors: Solveig Esmann, Gregor B. E. JemecAbstract:Hidradenitis suppurativa influences patients' lives in many ways. It is therefore necessary to focus on the effects of the disease on daily life in order better to define patient-related outcomes in Hidradenitis suppurativa studies. Interviews were conducted with 12 patients with Hidradenitis suppurativa. Initial single interviews were followed by semi-structured and structured qualitative focus group interviews in order to improve the richness of the data and obtain in-depth understanding of the impact of the topics. Important topics were found to relate to aspects of interpersonal contact, especially in relation to smell and appearance, various emotional reactions, and feelings of lack of control. It was found that Hidradenitis suppurativa has a great emotional impact on patients and promotes isolation due to fear of stigmatization. Shame and irritation are frequent and relate to smell, scars, itching and pain. Quality of life is adversely affected and professional support is needed.
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Hidradenitis suppurativa and Crohn's disease: two cases that support an association.
Acta dermatovenerologica Alpina Pannonica et Adriatica, 2010Co-Authors: Shiva Yazdanyar, I.m. Miller, Gregor B. E. JemecAbstract:An association between Crohn's disease and Hidradenitis suppurativa has been suggested. The presence of Crohn's disease generally precedes the diagnosis of Hidradenitis suppurativa. We present two new cases in which Hidradenitis lesions developed before Crohn's disease, suggesting an overlap and supporting an association. Furthermore, in one of these cases, treatment with infliximab resulted in marked improvement in both the Crohn's disease and Hidradenitis suppurativa.
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Prevalence of Hidradenitis suppurativa in Denmark
Ugeskrift for laeger, 1998Co-Authors: Gregor B. E. Jemec, M. Heidenheim, Niels Henrik NielsenAbstract:The morbidity of Hidradenitis suppurativa can be considerable, but little is known about its epidemiology. Our purpose was to describe the one-year and point prevalences of Hidradenitis suppurative and its potential precursor lesions. We obtained the histories and examined an unselected sample (599 persons) of the general population (one-year prevalence), and we performed physical examination for a consecutive sample of 507 persons undergoing screening for sexually transmitted diseases (point prevalence). The point prevalence was 4.1% (95% confidence interval [CI] = 3.0-6.0) on the basis of objective findings. The one-year prevalence of Hidradenitis was 1.0% (CI = 0.4-2.2) on the basis of subject recollection only. The patients in the sample on which the point prevalence is based were younger than those in the unselected sample of the general population (p < 0.001). Hidradenitis was significantly more common in women (p = 0.037), which may result from a female preponderance of genitofemoral lesions (odds ratio [OR] = 5.4; CI = 1.5-19.3). No sex difference was found in the prevalence of axillary lesions. Hidradenitis suppurativa is significantly more common than hitherto estimated. A female preponderance of patients is confirmed, except for patients with axillary lesions. Additional longitudinal studies are necessary to assess the importance of potential precursor lesions such as non-inflamed nodules or comedones.
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Ultrasound examination of hair follicles in Hidradenitis suppurativa
Archives of dermatology, 1997Co-Authors: Gregor B. E. Jemec, M. GniadeckaAbstract:Objective: To describe the in vivo skin echostructure, hair follicle shape, and dermal thickness in Hidradenitis suppurativa. Design: Qualitative and quantitative assessment of highfrequency (20-MHz) B-mode ultrasound images of lesional and paralesional skin. Setting: University hospital. Patients: Age- and sex-matched outpatients with Hidradenitis suppurativa (n=15) and healthy control subjects (n=13). Median age was 34 years (range, 31-38). Results: Clinically normal paralesional hair follicles in Hidradenitis have an abnormal shape. The follicles appear to be wider in the deep dermis, the difference being statistically significant in the genitofemoral region (P=.007). Patients with Hidradenitis have larger follicles in the axilla than controls (P=.002). Mature acne and Hidradenitis lesions are indistinguishable, but both are different from epidermal cysts. Mean axillary and genitofemoral skin was significantly thicker in patients than in controls. Conclusions: In vivo ultrasonography shows characteristic differences in the shape of hair follicles in Hidradenitis. The general underlying abnormalities appear to occur in the deep part of the follicle. The mature lesions are indistinguishable from acne, but are clearly different from epidermal cysts. A thickened skin may play a pathogenic role in the development of Hidradenitis. Arch Dermatol. 1997;133:967-970
Christos C. Zouboulis - One of the best experts on this subject based on the ideXlab platform.
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Comorbidities of Hidradenitis suppurativa (acne inversa)
Dermato-Endocrinology, 2010Co-Authors: Sabine Fimmel, Christos C. ZouboulisAbstract:Comorbidities of Hidradenitis suppurativa (acne inversa) were reviewed by extracting original and review publications included in MEDLINE, EMBASE and COCHRANE libraries using the terms "Hidradenitis," "Verneuil" and "acne inversa." Follicular occlusion disorders, inflammatory bowel diseases, especially Crohn's disease, spondylarthropathy, other hyperergic diseases, genetic keratin disorders associated with follicular occlusion and squamous cell carcinoma were the most common Hidradenitis suppurativa comorbid diseases. A first classification of these major comorbidities and their possible genetic background reveals a list of chromosome loci and genes, which could be Hidradenitis suppurativa candidates. Most of these diseases belong to the group of autoinflammatory disorders, where Th17 cell cytokines seem to play a central role.
Nancy B. Esterly - One of the best experts on this subject based on the ideXlab platform.
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Recurrent palmoplantar Hidradenitis in children.
Archives of dermatology, 1995Co-Authors: Linda G. Rabinowitz, Maria Letícia Cintra, Antoinette F. Hood, Nancy B. EsterlyAbstract:Background: There are several reports of tender, erythematous plantar nodules occurring in pediatric patients. Despite similar morphological features, the histologic findings in these lesions have been quite diverse. A new entity calledidiopathic plantar Hidradenitis(also termedneutrophilic eccrine Hidradenitis in children), which is characterized by tender, red nodules on the feet and unique histopathologic features, was recently described. Observations: We describe two children with these unusual cutaneous lesions and histopathologic findings and compare them with patients with idiopathic plantar Hidradenitis. Our patients, in contrast to those with idiopathic plantar Hidradenitis, had involvement of the palms as well as the soles. Both children had self-limited recurrent lesions; in one child, the lesions were associated with low-grade fever. Biopsy specimen findings in both cases demonstrated dense neutrophilic infiltrates localized to the eccrine units. Conclusions: Our patients had clinical and histologic findings similar to those recently reported as idiopathic plantar Hidradenitis (neutrophilic eccrine Hidradenitis in children). Because palms and soles can be affected and the lesions typically recur, we suggest that this condition be referred to asrecurrent palmoplantar Hidradenitis. (Arch Dermatol. 1995;131:817-820)
Maxwell A Fung - One of the best experts on this subject based on the ideXlab platform.
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Infectious eccrine Hidradenitis caused by nocardia
Journal of the American Academy of Dermatology, 2004Co-Authors: Diana D. Antonovich, Adrienne Berke, Jane M. Grant-kels, Maxwell A FungAbstract:Neutrophilic eccrine Hidradenitis is a nonspecific clinical reaction pattern classified as a neutrophilic dermatosis that typically occurs in the setting of chemotherapy for hematologic malignant disease. Neutrophilic eccrine Hidradenitis more rarely has been reported in association with infectious agents, including Serratia, Enterobacter, Staphylococcus, and HIV. We describe the first case of infectious eccrine Hidradenitis occurring in a patient with cutaneous Nocardia infection.
Sabine Fimmel - One of the best experts on this subject based on the ideXlab platform.
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Comorbidities of Hidradenitis suppurativa (acne inversa)
Dermato-Endocrinology, 2010Co-Authors: Sabine Fimmel, Christos C. ZouboulisAbstract:Comorbidities of Hidradenitis suppurativa (acne inversa) were reviewed by extracting original and review publications included in MEDLINE, EMBASE and COCHRANE libraries using the terms "Hidradenitis," "Verneuil" and "acne inversa." Follicular occlusion disorders, inflammatory bowel diseases, especially Crohn's disease, spondylarthropathy, other hyperergic diseases, genetic keratin disorders associated with follicular occlusion and squamous cell carcinoma were the most common Hidradenitis suppurativa comorbid diseases. A first classification of these major comorbidities and their possible genetic background reveals a list of chromosome loci and genes, which could be Hidradenitis suppurativa candidates. Most of these diseases belong to the group of autoinflammatory disorders, where Th17 cell cytokines seem to play a central role.