The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform

Lloyd B. Minor - One of the best experts on this subject based on the ideXlab platform.

David M Lasker - One of the best experts on this subject based on the ideXlab platform.

D. Straumann - One of the best experts on this subject based on the ideXlab platform.

  • Vestibular neuritis: Vertigo and the High-Acceleration vestibulo-ocular reflex
    Journal of Neurology, 2008
    Co-Authors: A. Palla, D. Straumann, A. M. Bronstein
    Abstract:

    Patients after vestibular neuritis (VN) often report persistent dizziness and disequilibrium. We correlated persistent symptoms with sustained impairment of the High-Acceleration horizontal vestibulo-ocular reflex as determined by quantitative searchcoil head-impulse testing (qHIT). In 47 patients, qHIT was recorded 0–60 months and symptoms assessed with the Yardley Vertigo Symptom Scale short form ≥ 18 months after VN onset. No correlation between the magnitude of High-Acceleration vestibular impairment and the severity of vertigo symptoms was observed. The lack of a symptom-qHIT correlation suggests that defective compensation at a more rostral level in the central nervous system may be responsible for protracted symptoms in VN patients.

  • Recovery of the High-Acceleration Vestibulo-ocular Reflex After Vestibular Neuritis
    Journal of the Association for Research in Otolaryngology, 2004
    Co-Authors: A. Palla, D. Straumann
    Abstract:

    Vestibular neuritis (VN) usually leads to a sudden gain asymmetry of the High-Acceleration horizontal vestibulo-ocular reflex (VOR). We asked whether this asymmetry decreases over time indicating peripheral recovery and/or central compensation. The horizontal VOR during rapid rotational head impulses to both sides was recorded with search coils in 37 patients at different time periods (1–240 weeks) after the onset of VN. In ten patients, sequential measurements were performed. Gains of the VOR during head impulses toward the ipsilesional side significantly increased after the initial drop (average gains: < 1 week: 0.35; 1–4 weeks: 0.33; 4–40 weeks: 0.55; 40–240 weeks: 0.50). Gains on the contralesional side, however, were only slightly reduced and showed no significant change. We conclude that, in contrast to patients after hemilabyrinthectomy or unilateral vestibular neurectomy, the ocular response to ipsilesional rotations in patients after VN improves over time. This finding suggests that ipsilesional recovery is peripheral or, if central, depends on spared peripheral function. The physiology of linear and nonlinear VOR pathways predicts a considerable gain reduction for contralesional head impulses if central compensation mechanisms are not engaged. Thus, the relatively preserved gain on the contralesional side can be explained only by central “upregulation”. Apparently, for High Accelerations of the head, effective central compensation after VN does not aim to balance the gains of the VOR but tries to boost the contralesional gain close to normal.

Elena A. Lomonova - One of the best experts on this subject based on the ideXlab platform.

A. Palla - One of the best experts on this subject based on the ideXlab platform.

  • Vestibular neuritis: Vertigo and the High-Acceleration vestibulo-ocular reflex
    Journal of Neurology, 2008
    Co-Authors: A. Palla, D. Straumann, A. M. Bronstein
    Abstract:

    Patients after vestibular neuritis (VN) often report persistent dizziness and disequilibrium. We correlated persistent symptoms with sustained impairment of the High-Acceleration horizontal vestibulo-ocular reflex as determined by quantitative searchcoil head-impulse testing (qHIT). In 47 patients, qHIT was recorded 0–60 months and symptoms assessed with the Yardley Vertigo Symptom Scale short form ≥ 18 months after VN onset. No correlation between the magnitude of High-Acceleration vestibular impairment and the severity of vertigo symptoms was observed. The lack of a symptom-qHIT correlation suggests that defective compensation at a more rostral level in the central nervous system may be responsible for protracted symptoms in VN patients.

  • Recovery of the High-Acceleration Vestibulo-ocular Reflex After Vestibular Neuritis
    Journal of the Association for Research in Otolaryngology, 2004
    Co-Authors: A. Palla, D. Straumann
    Abstract:

    Vestibular neuritis (VN) usually leads to a sudden gain asymmetry of the High-Acceleration horizontal vestibulo-ocular reflex (VOR). We asked whether this asymmetry decreases over time indicating peripheral recovery and/or central compensation. The horizontal VOR during rapid rotational head impulses to both sides was recorded with search coils in 37 patients at different time periods (1–240 weeks) after the onset of VN. In ten patients, sequential measurements were performed. Gains of the VOR during head impulses toward the ipsilesional side significantly increased after the initial drop (average gains: < 1 week: 0.35; 1–4 weeks: 0.33; 4–40 weeks: 0.55; 40–240 weeks: 0.50). Gains on the contralesional side, however, were only slightly reduced and showed no significant change. We conclude that, in contrast to patients after hemilabyrinthectomy or unilateral vestibular neurectomy, the ocular response to ipsilesional rotations in patients after VN improves over time. This finding suggests that ipsilesional recovery is peripheral or, if central, depends on spared peripheral function. The physiology of linear and nonlinear VOR pathways predicts a considerable gain reduction for contralesional head impulses if central compensation mechanisms are not engaged. Thus, the relatively preserved gain on the contralesional side can be explained only by central “upregulation”. Apparently, for High Accelerations of the head, effective central compensation after VN does not aim to balance the gains of the VOR but tries to boost the contralesional gain close to normal.