The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform
T. Alex Perkins - One of the best experts on this subject based on the ideXlab platform.
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Model-based analysis of experimental data from interconnected, row-configured huts elucidates multifaceted effects of a volatile chemical on Aedes aegypti mosquitoes
Parasites & Vectors, 2018Co-Authors: Quirine A. Ten Bosch, Fanny Castro-llanos, Hortance Manda, Nicole L. Achee, Amy C Morrison, John P. Grieco, T. Alex PerkinsAbstract:BackgroundInsecticides used against Aedes aegypti and other disease vectors can elicit a multitude of dose-dependent effects on behavioral and bionomic traits. Estimating the potential epidemiological impact of a product requires thorough understanding of these effects and their interplay at different dosages. Volatile spatial repellent (SR) products come with an additional layer of complexity due to the potential for altered movement of affected mosquitoes and diffusion of volatile particles of the product beyond the treated house. Here, we propose a paired experimental design and statistical inference framework for estimating these nuanced effects of volatile SRs.MethodWe fitted a continuous-time Markov chain model in a Bayesian framework to data on marked mosquitoes released in interconnected experimental huts conducted in Iquitos, Peru. We estimated the effects of two dosages of transfluthrin on Ae. aegypti behaviors associated with human-vector contact: repellency, exiting and knockdown in the treated space and in connected, adjacent huts. We validated the framework using simulated data.ResultsThe odds of a female Ae. aegypti being repelled, and thus prevented from entering a treated hut ( H _T), increased at both dosages (low dosage: odds = 1.64, 95% Highest Density Interval (HDI) = 1.30–2.09; high dosage: odds = 1.35, HDI = 1.04–1.67). The relative risk of exiting from the treated hut was reduced (low: RR = 0.70, HDI = 0.62–1.09; high: RR = 0.70, HDI = 0.40–1.06), with this effect carrying over to untreated spaces two huts away from the treated hut ( H _2) (low: RR = 0.79, HDI = 0.59–1.01; high: RR = 0.66, HDI = 0.50–0.87). Knockdown rates were increased in both treated and downstream huts, particularly under high dosage ( H _T: RR = 8.37, HDI = 2.11–17.35; H _1: RR = 1.39, HDI = 0.52–2.69; H _2: RR = 2.22, HDI = 0.96–3.86).ConclusionsOur framework is effective at elucidating multiple effects of volatile chemicals used in SR products, as well as their downstream effects. For the examined formulations of transfluthrin, we found notable dose-dependent effects on repellency, movement and knockdown that carry over to adjacent, untreated spaces.
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Model-based analysis of experimental data from interconnected, row-configured huts elucidates multifaceted effects of a volatile chemical on Aedes aegypti mosquitoes
Parasites & vectors, 2018Co-Authors: Quirine A. Ten Bosch, Fanny Castro-llanos, Hortance Manda, Nicole L. Achee, Amy C Morrison, John P. Grieco, T. Alex PerkinsAbstract:Insecticides used against Aedes aegypti and other disease vectors can elicit a multitude of dose-dependent effects on behavioral and bionomic traits. Estimating the potential epidemiological impact of a product requires thorough understanding of these effects and their interplay at different dosages. Volatile spatial repellent (SR) products come with an additional layer of complexity due to the potential for altered movement of affected mosquitoes and diffusion of volatile particles of the product beyond the treated house. Here, we propose a paired experimental design and statistical inference framework for estimating these nuanced effects of volatile SRs. We fitted a continuous-time Markov chain model in a Bayesian framework to data on marked mosquitoes released in interconnected experimental huts conducted in Iquitos, Peru. We estimated the effects of two dosages of transfluthrin on Ae. aegypti behaviors associated with human-vector contact: repellency, exiting and knockdown in the treated space and in connected, adjacent huts. We validated the framework using simulated data. The odds of a female Ae. aegypti being repelled, and thus prevented from entering a treated hut (HT), increased at both dosages (low dosage: odds = 1.64, 95% Highest Density Interval (HDI) = 1.30–2.09; high dosage: odds = 1.35, HDI = 1.04–1.67). The relative risk of exiting from the treated hut was reduced (low: RR = 0.70, HDI = 0.62–1.09; high: RR = 0.70, HDI = 0.40–1.06), with this effect carrying over to untreated spaces two huts away from the treated hut (H2) (low: RR = 0.79, HDI = 0.59–1.01; high: RR = 0.66, HDI = 0.50–0.87). Knockdown rates were increased in both treated and downstream huts, particularly under high dosage (HT: RR = 8.37, HDI = 2.11–17.35; H1: RR = 1.39, HDI = 0.52–2.69; H2: RR = 2.22, HDI = 0.96–3.86). Our framework is effective at elucidating multiple effects of volatile chemicals used in SR products, as well as their downstream effects. For the examined formulations of transfluthrin, we found notable dose-dependent effects on repellency, movement and knockdown that carry over to adjacent, untreated spaces.
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Model-based analysis of experimental hut data elucidates multifaceted effects of a volatile chemical on Aedes aegypti mosquitoes
2017Co-Authors: Quirine A. Ten Bosch, Fanny Castro-llanos, Hortance Manda, Nicole L. Achee, Amy C Morrison, John P. Grieco, T. Alex PerkinsAbstract:Background. Insecticides used against Aedes aegypti and other disease vectors can elicit a multitude of dose-dependent effects on behavioral and bionomic traits. Estimating the potential epidemiological impact of a product requires thorough understanding of these effects and their interplay at different dosages. Volatile spatial repellent (SR) products come with an additional layer of complexity due to the potential for movement of affected mosquitoes or volatile particles of the product beyond the treated house. Here, we propose a statistical inference framework for estimating these nuanced effects of volatile SRs. Methods. We fitted a continuous-time Markov chain model in a Bayesian framework to mark-release-recapture (MRR) data from an experimental hut study conducted in Iquitos, Peru. We estimated the effects of two dosages of transfluthrin on Ae. aegypti behaviors associated with human-vector contact: repellency, exiting, and knockdown in the treated space and in downstream adjacent huts. We validated the framework using simulated data. Results. The odds of a female Ae. aegypti being repelled from a treated hut (HT) increased at both dosages (low dosage: odds = 1.64, 95% Highest Density Interval (HDI) = 1.30-2.09; high dosage: odds = 1.35, HDI = 1.04-1.67). The relative risk of exiting from the treated hut was reduced (low: RR = 0.70, HDI = 0.62-1.09; high: RR = 0.70, HDI = 0.40-1.06), with this effect carrying over to untreated spaces as far as two huts away from the treated hut (H2) (low: RR = 0.79, HDI = 0.59-1.01; high: RR = 0.66, HDI = 0.50-0.87). Knockdown rates were increased in both treated and downstream huts, particularly under high dosage (HT: RR = 8.37, HDI = 2.11-17.35; H1: RR = 1.39, HDI = 0.52-2.69; H2: RR = 2.22, HDI = 0.96-3.86). Conclusions. Our statistical inference framework is effective at elucidating multiple effects of volatile chemicals used in SR products, as well as their downstream effects. This framework provides a powerful tool for early selection of candidate SR product formulations worth advancing to costlier epidemiological trials, which are ultimately necessary for proof of concept of public health value and subsequent formal endorsement by health authorities.
Antonella Palmese - One of the best experts on this subject based on the ideXlab platform.
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A statistical standard siren measurement of the Hubble constant from the LIGO/Virgo gravitational wave compact object merger GW190814 and Dark Energy Survey galaxies
The Astrophysical Journal, 2020Co-Authors: Antonella Palmese, J. Devicente, Maria E. S. Pereira, J. Annis, W. G. Hartley, K. Herner, Marcelle Soares-santos, Martin Crocce, Dragan Huterer, I. Magaña HernandezAbstract:We present a measurement of the Hubble constant $H_0$ using the gravitational wave (GW) event GW190814, which resulted from the coalescence of a 23 $M_\odot$ black hole with a 2.6 $M_\odot$ compact object, as a standard siren. No compelling electromagnetic counterpart has been identified for this event, thus our analysis accounts for thousands of potential host galaxies within a statistical framework. The redshift information is obtained from the photometric redshift (photo-$z$) catalog from the Dark Energy Survey. The luminosity distance is provided by the LIGO/Virgo gravitational wave sky map. Since this GW event has the second-smallest localization volume after GW170817, GW190814 is likely to provide the best constraint on cosmology from a single standard siren without identifying an electromagnetic counterpart. Our analysis uses photo-$z$ probability distribution functions and corrects for photo-$z$ biases. We also reanalyze the binary-black hole GW170814 within this updated framework. We explore how our findings impact the $H_0$ constraints from GW170817, the only GW merger associated with a unique host galaxy. From a combination of GW190814, GW170814 and GW170817, our analysis yields $H_0 = 72.0^{+ 12}_{- 8.2 }~{\rm km~s^{-1}~Mpc^{-1}}$ (68\% Highest Density Interval, HDI) for a prior in $H_0$ uniform between $[20,140]~{\rm km~s^{-1}~Mpc^{-1}}$. The addition of GW190814 and GW170814 to GW170817 improves the 68\% HDI from GW170817 alone by $\sim 18\%$, showing how well-localized mergers without counterparts can provide a significant contribution to standard siren measurements, provided that a complete galaxy catalog is available at the location of the event.
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a statistical standard siren measurement of the hubble constant from the ligo virgo gravitational wave compact object merger gw190814 and dark energy survey galaxies
The Astrophysical Journal, 2020Co-Authors: Antonella Palmese, J. Devicente, Maria E. S. Pereira, J. Annis, W. G. Hartley, K. Herner, Martin Crocce, Dragan Huterer, M Soaressantos, Magana I HernandezAbstract:We present a measurement of the Hubble constant $H_0$ using the gravitational wave (GW) event GW190814, which resulted from the coalescence of a 23 $M_\odot$ black hole with a 2.6 $M_\odot$ compact object, as a standard siren. No compelling electromagnetic counterpart with associated host galaxy has been identified for this event, thus our analysis accounts for $\sim$ 2,700 potential host galaxies within a statistical framework. The redshift information is obtained from the photometric redshift (photo-$z$) catalog from the Dark Energy Survey. The luminosity distance is provided by the gravitational wave sky map published by the LIGO/Virgo Collaboration. Since this GW event has the second-smallest sky localization area after GW170817, GW190814 is likely to provide the best constraint on cosmology from a single standard siren without identifying an electromagnetic counterpart. Our analysis uses photo-$z$ probability distribution functions and corrects for photo-$z$ biases. We also reanalyze the binary-black hole GW170814 within this updated framework. We explore how our findings impact the $H_0$ constraints from GW170817, the only GW merger associated with a unique host galaxy, and therefore the most powerful standard siren to date. From a combination of GW190814, GW170814 and GW170817, our analysis yields $H_0 = 69.0^{+ 14}_{- 7.5 }~{\rm km~s^{-1}~Mpc^{-1}}$ (68% Highest Density Interval, HDI) for a prior in $H_0$ uniform between $[20,140]~{\rm km~s^{-1}~Mpc^{-1}}$. The addition of GW190814 and GW170814 to GW170817 improves the 68% HDI from GW170817 alone by $\sim 12\%$, showing how well-localized mergers without counterparts can provide a marginal contribution to standard siren measurements, provided that a complete galaxy catalog is available at the location of the event.
I. Magaña Hernandez - One of the best experts on this subject based on the ideXlab platform.
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A statistical standard siren measurement of the Hubble constant from the LIGO/Virgo gravitational wave compact object merger GW190814 and Dark Energy Survey galaxies
The Astrophysical Journal, 2020Co-Authors: Antonella Palmese, J. Devicente, Maria E. S. Pereira, J. Annis, W. G. Hartley, K. Herner, Marcelle Soares-santos, Martin Crocce, Dragan Huterer, I. Magaña HernandezAbstract:We present a measurement of the Hubble constant $H_0$ using the gravitational wave (GW) event GW190814, which resulted from the coalescence of a 23 $M_\odot$ black hole with a 2.6 $M_\odot$ compact object, as a standard siren. No compelling electromagnetic counterpart has been identified for this event, thus our analysis accounts for thousands of potential host galaxies within a statistical framework. The redshift information is obtained from the photometric redshift (photo-$z$) catalog from the Dark Energy Survey. The luminosity distance is provided by the LIGO/Virgo gravitational wave sky map. Since this GW event has the second-smallest localization volume after GW170817, GW190814 is likely to provide the best constraint on cosmology from a single standard siren without identifying an electromagnetic counterpart. Our analysis uses photo-$z$ probability distribution functions and corrects for photo-$z$ biases. We also reanalyze the binary-black hole GW170814 within this updated framework. We explore how our findings impact the $H_0$ constraints from GW170817, the only GW merger associated with a unique host galaxy. From a combination of GW190814, GW170814 and GW170817, our analysis yields $H_0 = 72.0^{+ 12}_{- 8.2 }~{\rm km~s^{-1}~Mpc^{-1}}$ (68\% Highest Density Interval, HDI) for a prior in $H_0$ uniform between $[20,140]~{\rm km~s^{-1}~Mpc^{-1}}$. The addition of GW190814 and GW170814 to GW170817 improves the 68\% HDI from GW170817 alone by $\sim 18\%$, showing how well-localized mergers without counterparts can provide a significant contribution to standard siren measurements, provided that a complete galaxy catalog is available at the location of the event.
Magana I Hernandez - One of the best experts on this subject based on the ideXlab platform.
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a statistical standard siren measurement of the hubble constant from the ligo virgo gravitational wave compact object merger gw190814 and dark energy survey galaxies
The Astrophysical Journal, 2020Co-Authors: Antonella Palmese, J. Devicente, Maria E. S. Pereira, J. Annis, W. G. Hartley, K. Herner, Martin Crocce, Dragan Huterer, M Soaressantos, Magana I HernandezAbstract:We present a measurement of the Hubble constant $H_0$ using the gravitational wave (GW) event GW190814, which resulted from the coalescence of a 23 $M_\odot$ black hole with a 2.6 $M_\odot$ compact object, as a standard siren. No compelling electromagnetic counterpart with associated host galaxy has been identified for this event, thus our analysis accounts for $\sim$ 2,700 potential host galaxies within a statistical framework. The redshift information is obtained from the photometric redshift (photo-$z$) catalog from the Dark Energy Survey. The luminosity distance is provided by the gravitational wave sky map published by the LIGO/Virgo Collaboration. Since this GW event has the second-smallest sky localization area after GW170817, GW190814 is likely to provide the best constraint on cosmology from a single standard siren without identifying an electromagnetic counterpart. Our analysis uses photo-$z$ probability distribution functions and corrects for photo-$z$ biases. We also reanalyze the binary-black hole GW170814 within this updated framework. We explore how our findings impact the $H_0$ constraints from GW170817, the only GW merger associated with a unique host galaxy, and therefore the most powerful standard siren to date. From a combination of GW190814, GW170814 and GW170817, our analysis yields $H_0 = 69.0^{+ 14}_{- 7.5 }~{\rm km~s^{-1}~Mpc^{-1}}$ (68% Highest Density Interval, HDI) for a prior in $H_0$ uniform between $[20,140]~{\rm km~s^{-1}~Mpc^{-1}}$. The addition of GW190814 and GW170814 to GW170817 improves the 68% HDI from GW170817 alone by $\sim 12\%$, showing how well-localized mergers without counterparts can provide a marginal contribution to standard siren measurements, provided that a complete galaxy catalog is available at the location of the event.
K. Herner - One of the best experts on this subject based on the ideXlab platform.
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A statistical standard siren measurement of the Hubble constant from the LIGO/Virgo gravitational wave compact object merger GW190814 and Dark Energy Survey galaxies
The Astrophysical Journal, 2020Co-Authors: Antonella Palmese, J. Devicente, Maria E. S. Pereira, J. Annis, W. G. Hartley, K. Herner, Marcelle Soares-santos, Martin Crocce, Dragan Huterer, I. Magaña HernandezAbstract:We present a measurement of the Hubble constant $H_0$ using the gravitational wave (GW) event GW190814, which resulted from the coalescence of a 23 $M_\odot$ black hole with a 2.6 $M_\odot$ compact object, as a standard siren. No compelling electromagnetic counterpart has been identified for this event, thus our analysis accounts for thousands of potential host galaxies within a statistical framework. The redshift information is obtained from the photometric redshift (photo-$z$) catalog from the Dark Energy Survey. The luminosity distance is provided by the LIGO/Virgo gravitational wave sky map. Since this GW event has the second-smallest localization volume after GW170817, GW190814 is likely to provide the best constraint on cosmology from a single standard siren without identifying an electromagnetic counterpart. Our analysis uses photo-$z$ probability distribution functions and corrects for photo-$z$ biases. We also reanalyze the binary-black hole GW170814 within this updated framework. We explore how our findings impact the $H_0$ constraints from GW170817, the only GW merger associated with a unique host galaxy. From a combination of GW190814, GW170814 and GW170817, our analysis yields $H_0 = 72.0^{+ 12}_{- 8.2 }~{\rm km~s^{-1}~Mpc^{-1}}$ (68\% Highest Density Interval, HDI) for a prior in $H_0$ uniform between $[20,140]~{\rm km~s^{-1}~Mpc^{-1}}$. The addition of GW190814 and GW170814 to GW170817 improves the 68\% HDI from GW170817 alone by $\sim 18\%$, showing how well-localized mergers without counterparts can provide a significant contribution to standard siren measurements, provided that a complete galaxy catalog is available at the location of the event.
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a statistical standard siren measurement of the hubble constant from the ligo virgo gravitational wave compact object merger gw190814 and dark energy survey galaxies
The Astrophysical Journal, 2020Co-Authors: Antonella Palmese, J. Devicente, Maria E. S. Pereira, J. Annis, W. G. Hartley, K. Herner, Martin Crocce, Dragan Huterer, M Soaressantos, Magana I HernandezAbstract:We present a measurement of the Hubble constant $H_0$ using the gravitational wave (GW) event GW190814, which resulted from the coalescence of a 23 $M_\odot$ black hole with a 2.6 $M_\odot$ compact object, as a standard siren. No compelling electromagnetic counterpart with associated host galaxy has been identified for this event, thus our analysis accounts for $\sim$ 2,700 potential host galaxies within a statistical framework. The redshift information is obtained from the photometric redshift (photo-$z$) catalog from the Dark Energy Survey. The luminosity distance is provided by the gravitational wave sky map published by the LIGO/Virgo Collaboration. Since this GW event has the second-smallest sky localization area after GW170817, GW190814 is likely to provide the best constraint on cosmology from a single standard siren without identifying an electromagnetic counterpart. Our analysis uses photo-$z$ probability distribution functions and corrects for photo-$z$ biases. We also reanalyze the binary-black hole GW170814 within this updated framework. We explore how our findings impact the $H_0$ constraints from GW170817, the only GW merger associated with a unique host galaxy, and therefore the most powerful standard siren to date. From a combination of GW190814, GW170814 and GW170817, our analysis yields $H_0 = 69.0^{+ 14}_{- 7.5 }~{\rm km~s^{-1}~Mpc^{-1}}$ (68% Highest Density Interval, HDI) for a prior in $H_0$ uniform between $[20,140]~{\rm km~s^{-1}~Mpc^{-1}}$. The addition of GW190814 and GW170814 to GW170817 improves the 68% HDI from GW170817 alone by $\sim 12\%$, showing how well-localized mergers without counterparts can provide a marginal contribution to standard siren measurements, provided that a complete galaxy catalog is available at the location of the event.