The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Lennart Hammarstrom - One of the best experts on this subject based on the ideXlab platform.
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identification of igf a Hinge region containing ig class and igd in xenopus tropicalis
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Yaofeng Zhao, Qiang Panhammarstrom, Nancy Wertz, Xiaofeng Zhang, J E Butler, Lennart HammarstromAbstract:Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by Cφ), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a Hinge Exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic Hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3′ of Cμ, that shares features with the Cδ gene in fish and mammals. The latter gene contains eight constant-region-encoding Exons and, unlike the chimeric splicing of μCH1 onto the IgD heavy chain in teleost fish, it is expressed as a unique IgD heavy chain. The IgH locus of X. tropicalis shows a 5′ VH-DH-JH-Cμ-Cδ-Cχ-Cυ-Cφ 3′ organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor.
Hammarstrom Lennart - One of the best experts on this subject based on the ideXlab platform.
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Identification of IgF, a Hinge-region-containing Ig class, and IgD in Xenopus tropicalis
proceedings of the national academy of sciences of the united states of america, 2006Co-Authors: Zhao Yaofeng, Pan-hammarstrom Qiang, Yu Shuyang, Wertz Nancy, Zhang Xiaofeng, Li Ning, Butler, John E., Hammarstrom LennartAbstract:Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by C-phi), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a Hinge Exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic Hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3' of C-mu, that shares features with the C-delta gene in fish and mammals. The latter gene contains eight constant-region-encoding Exons and, unlike the chimeric splicing of mu C(H)1 onto the IgD heavy chain in teleost fish, it is expressed as a unique IgD heavy chain. The IgH locus of X. tropicalis shows a 5' V-H-D-H-J(H)-C-mu-C-delta-C-chi- C-upsilon-C-phi 3' organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor.Multidisciplinary SciencesSCI(E)0ARTICLE3212087-1209210
Yaofeng Zhao - One of the best experts on this subject based on the ideXlab platform.
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identification of igf a Hinge region containing ig class and igd in xenopus tropicalis
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Yaofeng Zhao, Qiang Panhammarstrom, Nancy Wertz, Xiaofeng Zhang, J E Butler, Lennart HammarstromAbstract:Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by Cφ), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a Hinge Exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic Hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3′ of Cμ, that shares features with the Cδ gene in fish and mammals. The latter gene contains eight constant-region-encoding Exons and, unlike the chimeric splicing of μCH1 onto the IgD heavy chain in teleost fish, it is expressed as a unique IgD heavy chain. The IgH locus of X. tropicalis shows a 5′ VH-DH-JH-Cμ-Cδ-Cχ-Cυ-Cφ 3′ organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor.
Zhao Yaofeng - One of the best experts on this subject based on the ideXlab platform.
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Identification of IgF, a Hinge-region-containing Ig class, and IgD in Xenopus tropicalis
proceedings of the national academy of sciences of the united states of america, 2006Co-Authors: Zhao Yaofeng, Pan-hammarstrom Qiang, Yu Shuyang, Wertz Nancy, Zhang Xiaofeng, Li Ning, Butler, John E., Hammarstrom LennartAbstract:Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by C-phi), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a Hinge Exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic Hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3' of C-mu, that shares features with the C-delta gene in fish and mammals. The latter gene contains eight constant-region-encoding Exons and, unlike the chimeric splicing of mu C(H)1 onto the IgD heavy chain in teleost fish, it is expressed as a unique IgD heavy chain. The IgH locus of X. tropicalis shows a 5' V-H-D-H-J(H)-C-mu-C-delta-C-chi- C-upsilon-C-phi 3' organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor.Multidisciplinary SciencesSCI(E)0ARTICLE3212087-1209210
J E Butler - One of the best experts on this subject based on the ideXlab platform.
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identification of igf a Hinge region containing ig class and igd in xenopus tropicalis
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Yaofeng Zhao, Qiang Panhammarstrom, Nancy Wertz, Xiaofeng Zhang, J E Butler, Lennart HammarstromAbstract:Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by Cφ), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a Hinge Exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic Hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3′ of Cμ, that shares features with the Cδ gene in fish and mammals. The latter gene contains eight constant-region-encoding Exons and, unlike the chimeric splicing of μCH1 onto the IgD heavy chain in teleost fish, it is expressed as a unique IgD heavy chain. The IgH locus of X. tropicalis shows a 5′ VH-DH-JH-Cμ-Cδ-Cχ-Cυ-Cφ 3′ organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor.