The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Mohsen Janghorbani - One of the best experts on this subject based on the ideXlab platform.
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Hip Circumference height and risk of type 2 diabetes systematic review and meta analysis
Obesity Reviews, 2012Co-Authors: Mohsen Janghorbani, F Momeni, Mohsen DehghaniAbstract:Although several epidemiological studies have investigated the relationsHip between type 2 diabetes mellitus (T2DM) and Hip Circumference or height, the results are inconsistent. The present systematic review and meta-analysis of published observational studies was conducted to assess the effects of Hip Circumference and height on diabetes risk. Online databases were searched through January 2012, and the reference lists of pertinent articles reporting observational studies in humans were examined. Pooled relative risks (RR) and 95% confidence intervals (CI) were calculated with a random-effects model. Eighteen studies (nine cross-sectional and nine cohort) were included, with 250,497 participants and 7,765 cases of T2DM. Hip Circumference was inversely associated with an increased risk of T2DM in men (summary RR [95% CI] 0.60 [0.45, 0.80]) and women (0.54 [0.42, 0.70]). These results were consistent between cross-sectional and cohort studies. An inverse association between height and T2DM was observed in women only (summary RR [95% CI] 0.83 [0.73, 0.95]). Our meta-analysis strongly supports an inverse relationsHip between Hip Circumference and risk of T2DM in men and women. The inverse association between height and risk was significant only in women.
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associations of Hip Circumference and height with incidence of type 2 diabetes the isfahan diabetes prevention study
Acta Diabetologica, 2012Co-Authors: Mohsen Janghorbani, Masoud AminiAbstract:The aim of this study was to determine the effects of Hip Circumference (HC) and height on diabetes incidence in non-diabetic first-degree relatives (FDRs) of patients with type 2 diabetes. A total of 1,092 (254 men and 838 women) non-diabetics FDRs ≥ 30 years old in 2003–2005 were followed through 2010 for the occurrence of type 2 diabetes. At baseline and through follow-ups, participants were underwent a standard 75 g 2-h oral glucose tolerance test. The incidence of type 2 diabetes was 17.0 (95% CI: 13.7, 20.2) (13.0 men and 18.1 women) per 1,000 person-year based on 6,015 person-years of follow-up. Height was inversely associated with diabetes incidence. The age-, gender-, and waist-adjusted relative risk (95% CI) of diabetes was 0.54 (0.31, 0.93) for highest quartile of height and 0.59 (0.25, 1.37) for highest quartile of HC compared with lowest quartile. These data indicate that height was inversely associated with diabetes incidence, independently of gender among FDRs of patients with type 2 diabetes.
Xiao-ou Shu - One of the best experts on this subject based on the ideXlab platform.
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prediagnosis body mass index and waist Hip Circumference ratio in association with colorectal cancer survival
International Journal of Cancer, 2017Co-Authors: Yong-bing Xiang, Gong Yang, Yu-tang Gao, Xiao-ou Shu, Nan Wang, Nikhil K Khankari, Hui Cai, Wei ZhengAbstract:The association of obesity on survival among patients with colorectal cancer (CRC) has not been well characterized. We investigated the association of pre-diagnostic body mass index (BMI)/waist-Hip ratio (WHR) and total/cause-specific mortality in CRC patients. This study included 1,452 patients who participated in two large cohort studies and were diagnosed with CRC during follow-up period. Participants were measured for anthropometrics and interviewed to collect relevant information at baseline, prior to any cancer diagnosis. Data on site-specific cancer incidence and cause-specific mortality were obtained via in-person surveys and annual record linkage with cancer and vital statistics registries. Cox proportional hazard models were used to evaluate the associations of BMI and WHR with survival. A total of 547 participants died during the follow-up period, including 499 who died of CRC. Relative to normal BMI (18.5 to < 25.0 kg/m2), obesity (BMI ≥ 30 kg/m2) was associated with increased mortality resulting from all causes (Hazard Ratio (HR) = 1.5, 95% Confidence Interval (CI): 1.1-2.1) and CRC (HR = 1.5, 95% CI: 1.1-2.1). Elevated risk of death was also found among underweight patients (BMI <18.5 kg/m2), although not all risk estimates were statistically significant. Overweight BMI (25.0 to < 30.0 kg/m2) was not associated with risk of death among CRC patients, nor was WHR. In conclusion, pre-diagnostic BMI was associated with survival among CRC patients following a U-shape pattern; obesity was associated with high mortality after CRC diagnosis. These findings provide support for maintaining healthy weight to improve the survival of CRC patients. This article is protected by copyright. All rights reserved.
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Hip Circumference and the Risk of Type 2 Diabetes in Middle-Aged and Elderly Men and Women: The Shanghai Women and Shanghai Men’s Health Studies
Annals of epidemiology, 2011Co-Authors: Baqiyyah Conway, Yong-bing Xiang, Raquel Villegas, Xianglan Zhang, Gong Yang, Yu-tang Gao, Wei Zhang, Xiao-ou ShuAbstract:Type 2 diabetes is becoming an increasing problem worldwide. The rise in Asian populations is particularly alarming, with China accounting for 12% of the global annual increase in diabetes and arguably the highest prevalence worldwide (1). The increased risk of diabetes associated with body mass index (BMI) and abdominal adiposity is well established and is thought to be primarily mediated through increased circulating levels of non-esterified fatty acids, or free fatty acids (FFA), released from the more lipolytically active visceral and abdominal subcutaneous adiposity depots (2–5). FFA interfere with intracellular insulin signaling and increase hepatic gluconeogenesis (6); overexposure of the liver and muscle tissue to FFA leads to hepatic (3, 7) and muscle insulin resistance (3, 8). In addition to the insulin resistance resulting from long term exposure to high FFA levels, high FFA levels are also thought to be toxic to the pancreatic islets (2, 9). In contrast to abdominal fat, gluteofemoral subcutaneous fat is less lipolytically active and appears to serve as a metabolic sink, trapping excess FFA and thus protecting other body tissues and organs from chronic exposure to high levels of FFA. Increased thigh fat is associated with increased insulin sensitivity (10). A few reports indicate that an increased Hip Circumference for a given waist Circumference is associated with a decreased risk of type 2 diabetes (11–14). However, these reports have been based on European populations. To our knowledge, there has only been one report on the relationsHip of Hip Circumference with the risk of type 2 diabetes in a Chinese population; however neither waist Circumference or BMI were accounted for (15). Furthermore, it remains unknown whether the association between Hip Circumference and type 2 diabetes risk may vary by BMI. We report here a comprehensive evaluation of the relationsHip of Hip Circumference with the incidence of type 2 diabetes in two large cohort studies of over 130,000 Chinese men and women. Because of the sexual dimorphism in fat distribution (16) and FFA metabolism (16–17), analyses were conducted sex-specifically.
Aaron R. Folsom - One of the best experts on this subject based on the ideXlab platform.
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Association of Hip Circumference With Incident Diabetes and Coronary Heart Disease The Atherosclerosis Risk in Communities Study
American journal of epidemiology, 2009Co-Authors: Emily D. Parker, Mark A. Pereira, June Stevens, Aaron R. FolsomAbstract:When waist Circumference is taken into account, larger Hip Circumference is associated with reduced risk factors for diabetes and cardiovascular disease. The authors investigated the prospective association of Hip Circumference with type 2 diabetes and coronary heart disease (CHD) incidence in a biracial cohort of men and women in 4 US communities. A total of 10,767 participants from the Atherosclerosis Risk in Communities (ARIC) study were followed from 1987 to 1998. Hip and waist Circumferences and body mass index (BMI) were modeled separately and mutually in association with incident diabetes and CHD by using proportional hazards regression. After adjustment for age, race, sex, and clinical center, Hip Circumference was positively associated with incident diabetes. However, after further controlling for waist Circumference, BMI, and confounding variables, successive quintiles of Hip Circumference were associated with a statistically significant reduced hazard of incident diabetes (hazard ratios = 1.00, 0.79, 0.60, 0.44, 0.41). Similarly, successive quintiles of Hip Circumference were associated with a statistically significant reduced hazard of CHD after controlling for waist Circumference, BMI, and confounding variables (hazard ratios = 1.00, 0.92, 0.75, 0.63, 0.50). Although excess adiposity is a general risk factor for diabetes and CHD, for a given BMI and waist Circumference, greater Hip Circumference appears to lessen the risk of diabetes and CHD.
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The association of Hip Circumference with incident Hip fracture in a cohort of postmenopausal women: the Iowa Women's Health Study.
Annals of epidemiology, 2008Co-Authors: Emily D. Parker, Mark A. Pereira, Beth A Virnig, Aaron R. FolsomAbstract:Purpose As the mean age of the U.S. population increases, the public health burden of osteoporotic fractures is expected to increase. This study prospectively examined the independent association of Hip Circumference with Hip fracture. Methods The prospective association of Hip Circumference and Hip fracture was examined in a cohort of 30,652 postmenopausal women. Results Compared with the lowest quintile, successive quintiles of Hip Circumference were associated with a reduced hazard (i.e., hazard ratio [HR]) of Hip fracture over 18 years of follow-up (HRs = 1.00, 0.78, 0.74, 0.76, 0.69, p for trend = 0.0015) after adjusting for age. Controlling for waist, this association persisted (HRs = 1.00, 0.78, 0.73, 0.72, 0.54, p for trend = 0.0006). When additionally controlling for body mass index (BMI), we found that the association of Hip fracture with Hip Circumference was attenuated to the null whereas the association with successive quintiles of BMI remained significant and inverse (HRs = 1.00, 0.55, 0.45, 0.40, 0.35, p for trend Conclusions Although Hip Circumference has a strong inverse association with risk of Hip fracture, this association was not independent of BMI. These results suggest that, in the prediction of Hip fracture risk, overall body size may be more important than body composition of the femoral-gluteal region.
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body fat distribution and 5 year risk of death in older women
JAMA, 1993Co-Authors: Aaron R. Folsom, Susan A Kaye, Thomas A Sellers, Ching Ping Hong, James R Cerhan, John D Potter, Ronald J PrineasAbstract:Objective. —To test the hypothesis that both body mass index (expressed as the ratio of weight in kilograms per height in meters squared) and the ratio of waist Circumference to Hip Circumference are positively associated with mortality risk in older women. Design. —Prospective cohort study with a 5-year follow-up period. Setting. —General community. Participants. —Random sample of 41 837 Iowa women aged 55 to 69 years. Main Outcome Measure. —Total mortality (1504 deaths). Main Results. —Body mass index, an index of relative weight, was associated with mortality in a J-shaped fashion: rates were elevated in the leanest as well as in the most obese women. In contrast, waist/Hip Circumference ratio was strongly and positively associated with mortality in a dose-response manner. Adjusted for age, body mass index, smoking, education level, marital status, estrogen use, and alcohol use, a 0.15-unit increase in waist/Hip Circumference ratio (eg, a 15-cm [6-in] increase in waist measurement in a woman with 100-cm [40-in] Hips) was associated with a 60% greater relative risk of death. The observed associations were not explained to any great degree by bias from weight loss prior to baseline or higher early deaths among lean participants. Conclusions. —Waist/Hip Circumference ratio is a better marker than body mass index of risk of death in older women. Waist/Hip Circumference ratio should be measured as part of routine surveillance and risk monitoring in medical practice. JAMA . 1993;269:483-487)
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associations of body mass and fat distribution with sex hormone concentrations in postmenopausal women
International Journal of Epidemiology, 1991Co-Authors: Susan A Kaye, Aaron R. Folsom, Ronald J Prineas, John T Soler, John D PotterAbstract:The associations of body mass and body fat distribution, as measured by waist-to-Hip Circumference ratio, with serum concentrations of sex hormones and sex hormone binding globulin were examined in 88 postmenopausal women. Body mass index (BMI) was significantly and negatively associated with sex hormone binding globulin (SHBG) (r = -0.41), luteinizing hormone (LH) (r = -0.40) and follicle stimulating hormone (FSH) (r = -0.38) and was also significantly positively associated with both total and free oestradiol (r = 0.40 and 0.45, respectively). Waist-to-Hip Circumference ratio was significantly negatively correlated with SHBG (r = -0.53), LH (r = -0.35), and FSH (r = -0.35). After adjustment for BMI and other related factors, waist-to-Hip Circumference ratio was significantly and negatively associated with SHBG, LH, and FSH, and demonstrated a significant curvilinear relationsHip with free testosterone. These results suggest that in postmenopausal women, abdominal adiposity is associated with a relatively more androgenic sex hormone profile.
Masoud Amini - One of the best experts on this subject based on the ideXlab platform.
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associations of Hip Circumference and height with incidence of type 2 diabetes the isfahan diabetes prevention study
Acta Diabetologica, 2012Co-Authors: Mohsen Janghorbani, Masoud AminiAbstract:The aim of this study was to determine the effects of Hip Circumference (HC) and height on diabetes incidence in non-diabetic first-degree relatives (FDRs) of patients with type 2 diabetes. A total of 1,092 (254 men and 838 women) non-diabetics FDRs ≥ 30 years old in 2003–2005 were followed through 2010 for the occurrence of type 2 diabetes. At baseline and through follow-ups, participants were underwent a standard 75 g 2-h oral glucose tolerance test. The incidence of type 2 diabetes was 17.0 (95% CI: 13.7, 20.2) (13.0 men and 18.1 women) per 1,000 person-year based on 6,015 person-years of follow-up. Height was inversely associated with diabetes incidence. The age-, gender-, and waist-adjusted relative risk (95% CI) of diabetes was 0.54 (0.31, 0.93) for highest quartile of height and 0.59 (0.25, 1.37) for highest quartile of HC compared with lowest quartile. These data indicate that height was inversely associated with diabetes incidence, independently of gender among FDRs of patients with type 2 diabetes.
Gong Yang - One of the best experts on this subject based on the ideXlab platform.
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prediagnosis body mass index and waist Hip Circumference ratio in association with colorectal cancer survival
International Journal of Cancer, 2017Co-Authors: Yong-bing Xiang, Gong Yang, Yu-tang Gao, Xiao-ou Shu, Nan Wang, Nikhil K Khankari, Hui Cai, Wei ZhengAbstract:The association of obesity on survival among patients with colorectal cancer (CRC) has not been well characterized. We investigated the association of pre-diagnostic body mass index (BMI)/waist-Hip ratio (WHR) and total/cause-specific mortality in CRC patients. This study included 1,452 patients who participated in two large cohort studies and were diagnosed with CRC during follow-up period. Participants were measured for anthropometrics and interviewed to collect relevant information at baseline, prior to any cancer diagnosis. Data on site-specific cancer incidence and cause-specific mortality were obtained via in-person surveys and annual record linkage with cancer and vital statistics registries. Cox proportional hazard models were used to evaluate the associations of BMI and WHR with survival. A total of 547 participants died during the follow-up period, including 499 who died of CRC. Relative to normal BMI (18.5 to < 25.0 kg/m2), obesity (BMI ≥ 30 kg/m2) was associated with increased mortality resulting from all causes (Hazard Ratio (HR) = 1.5, 95% Confidence Interval (CI): 1.1-2.1) and CRC (HR = 1.5, 95% CI: 1.1-2.1). Elevated risk of death was also found among underweight patients (BMI <18.5 kg/m2), although not all risk estimates were statistically significant. Overweight BMI (25.0 to < 30.0 kg/m2) was not associated with risk of death among CRC patients, nor was WHR. In conclusion, pre-diagnostic BMI was associated with survival among CRC patients following a U-shape pattern; obesity was associated with high mortality after CRC diagnosis. These findings provide support for maintaining healthy weight to improve the survival of CRC patients. This article is protected by copyright. All rights reserved.
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Hip Circumference and the Risk of Type 2 Diabetes in Middle-Aged and Elderly Men and Women: The Shanghai Women and Shanghai Men’s Health Studies
Annals of epidemiology, 2011Co-Authors: Baqiyyah Conway, Yong-bing Xiang, Raquel Villegas, Xianglan Zhang, Gong Yang, Yu-tang Gao, Wei Zhang, Xiao-ou ShuAbstract:Type 2 diabetes is becoming an increasing problem worldwide. The rise in Asian populations is particularly alarming, with China accounting for 12% of the global annual increase in diabetes and arguably the highest prevalence worldwide (1). The increased risk of diabetes associated with body mass index (BMI) and abdominal adiposity is well established and is thought to be primarily mediated through increased circulating levels of non-esterified fatty acids, or free fatty acids (FFA), released from the more lipolytically active visceral and abdominal subcutaneous adiposity depots (2–5). FFA interfere with intracellular insulin signaling and increase hepatic gluconeogenesis (6); overexposure of the liver and muscle tissue to FFA leads to hepatic (3, 7) and muscle insulin resistance (3, 8). In addition to the insulin resistance resulting from long term exposure to high FFA levels, high FFA levels are also thought to be toxic to the pancreatic islets (2, 9). In contrast to abdominal fat, gluteofemoral subcutaneous fat is less lipolytically active and appears to serve as a metabolic sink, trapping excess FFA and thus protecting other body tissues and organs from chronic exposure to high levels of FFA. Increased thigh fat is associated with increased insulin sensitivity (10). A few reports indicate that an increased Hip Circumference for a given waist Circumference is associated with a decreased risk of type 2 diabetes (11–14). However, these reports have been based on European populations. To our knowledge, there has only been one report on the relationsHip of Hip Circumference with the risk of type 2 diabetes in a Chinese population; however neither waist Circumference or BMI were accounted for (15). Furthermore, it remains unknown whether the association between Hip Circumference and type 2 diabetes risk may vary by BMI. We report here a comprehensive evaluation of the relationsHip of Hip Circumference with the incidence of type 2 diabetes in two large cohort studies of over 130,000 Chinese men and women. Because of the sexual dimorphism in fat distribution (16) and FFA metabolism (16–17), analyses were conducted sex-specifically.