The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform

Zhengkui Zhou - One of the best experts on this subject based on the ideXlab platform.

  • Differential genetic regulation of canine Hip dysplasia and osteoarthritis. PLoS ONE 5(10):e13219. doi: 10.1371/journal.pone.0013219 PMID
    2010
    Co-Authors: Zhengkui Zhou, Xihui Sheng, Zhiwu Zhang, Keyan Zhao, Lan Zhu, Gang Guo, Steve G, Friedenberg Linda S. Hunter, Elizabeth Corey, Nancy S. Moise
    Abstract:

    Background: Canine Hip dysplasia (HD) is a common polygenic trait characterized by Hip Malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human Hip which also leads to OA. Methodology/Principal Findings: A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at,22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with,3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNP

  • Differential genetic regulation of canine Hip dysplasia and osteoarthritis.
    Public Library of Science (PLoS), 2010
    Co-Authors: Zhengkui Zhou, Xihui Sheng, Zhiwu Zhang, Keyan Zhao, Lan Zhu, Gang Guo, Steve G Friedenberg, Linda S Hunter, Wendy S Vandenberg-foels, William E Hornbuckle
    Abstract:

    Canine Hip dysplasia (HD) is a common polygenic trait characterized by Hip Malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human Hip which also leads to OA.A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with Hip OA.The identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and Hip OA, which are common and debilitating conditions in both dogs and humans

Jakob Klit - One of the best experts on this subject based on the ideXlab platform.

  • Hip Malformation is a very common finding in young patients scheduled for total Hip arthroplasty
    Archives of Orthopaedic and Trauma Surgery, 2018
    Co-Authors: Dennis Karimi, Thomas Kallemose, Anders Troelsen, Jakob Klit
    Abstract:

    In Denmark, 20% of all registered total Hip arthroplasties (THA) from 1995 to 2014 has been patients younger than 60 years with primary idiopathic osteoarthritis (OA). It is speculated that Hip Malformations may be a major contributor to early OA development. It has been shown that Hip Malformation may compromise implant position and, therefore, identifying and knowing the incidence of Malformations is important. Our aim was to assess the prevalence and type of Hip Malformations in a cohort of younger patients undergoing THA. In this prospective two center cohort study, 95 consecutive patients (106 Hips) met the inclusion criteria. One observer performed radiographic measurements for Malformations and radiographic OA. Inter- and intraobserver variability was assessed. From 95 patients (male n = 52 and female n = 43) age ranged from 35 to 59 years and prevalences of Hip Malformations were; CAM-deformity 50.9 and 25.5%, coxa profunda 33 and 27.4%, acetabular retroversion 33 and 29.2%, and acetabular dysplasia 10.4 and 3.8%. All patients showed minimum of one Malformation. Prevalences of Tonnis grade 0–1 were 22.6% and 2–3 were 77.4%. All patients showed Malformations, especially high prevalences were found for CAM-deformity, coxa profunda and acetabular retroversion. Identifying these Malformations is fairly simple and recognizing the high prevalence may help surgeons avoid pitfalls during implant positioning in THA surgery. Further, focus on Hip Malformations may facilitate correct referral to joint-preserving surgery before OA develops.

Hornbuckle William E. - One of the best experts on this subject based on the ideXlab platform.

  • Differential Genetic Regulation of Canine Hip Dysplasia and Osteoarthritis
    Public Library of Science, 2010
    Co-Authors: Zhou Zhengkui, Sheng Xihui, Zhang Zhiwu, Zhao Keyan, Zhu Lan, Guo Gang, Friedenberg Steve G., Hunter Linda S., Vandenberg-foels Wendy S., Hornbuckle William E.
    Abstract:

    Canine Hip dysplasia (HD) is a common polygenic trait characterized by Hip Malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human Hip which also leads to OA.A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with Hip OA.) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and Hip OA, which are common and debilitating conditions in both dogs and humans

William E Hornbuckle - One of the best experts on this subject based on the ideXlab platform.

  • Differential genetic regulation of canine Hip dysplasia and osteoarthritis.
    Public Library of Science (PLoS), 2010
    Co-Authors: Zhengkui Zhou, Xihui Sheng, Zhiwu Zhang, Keyan Zhao, Lan Zhu, Gang Guo, Steve G Friedenberg, Linda S Hunter, Wendy S Vandenberg-foels, William E Hornbuckle
    Abstract:

    Canine Hip dysplasia (HD) is a common polygenic trait characterized by Hip Malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human Hip which also leads to OA.A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with Hip OA.The identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and Hip OA, which are common and debilitating conditions in both dogs and humans

Nancy S. Moise - One of the best experts on this subject based on the ideXlab platform.

  • Differential genetic regulation of canine Hip dysplasia and osteoarthritis. PLoS ONE 5(10):e13219. doi: 10.1371/journal.pone.0013219 PMID
    2010
    Co-Authors: Zhengkui Zhou, Xihui Sheng, Zhiwu Zhang, Keyan Zhao, Lan Zhu, Gang Guo, Steve G, Friedenberg Linda S. Hunter, Elizabeth Corey, Nancy S. Moise
    Abstract:

    Background: Canine Hip dysplasia (HD) is a common polygenic trait characterized by Hip Malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human Hip which also leads to OA. Methodology/Principal Findings: A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at,22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with,3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNP