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Zamudio Mendocilla, Andrea Selene - One of the best experts on this subject based on the ideXlab platform.

  • Hallazgos clínicos de hiperandrogenismo en lesbianas de la ciudad de trujillo
    Universidad Privada Antenor Orrego - UPAO, 2018
    Co-Authors: Zamudio Mendocilla, Andrea Selene
    Abstract:

    Objective: To determine that the clinical findings of hyperandrogenism Acne, Alopecia and Hirsutism, are associated with lesbianism in women of the City of Trujillo. Material and Method: A qualitative, analytical and observational study of a comparative cohort was carried out. The statistical test of proportions of normal distribution was applied, with level of significance of 5%. The study population consisted of 200 women: 100 lesbian women and 100 non-lesbian women aged 18 to 65 years of age in the city of Trujillo, who voluntarily agreed to be part of the study in accordance with the inclusion criteria. Results: The frequency of acne is 21% in lesbian women and 14% in non-lesbian women; the frequency of Alopecia is 10% in lesbian women and 6% in non-lesbian women; the frequency of Hirsutism is 5% in lesbian women and 2% in non-lesbian women, being considered of low statistical significance p> 0.05. Central obesity as an anthropometric indicator is more frequent in lesbian women 49% than in non-lesbian women 19%, with a high statistical significance of p 0.05. La obesidad central como indicador antropométrico es más frecuente en mujeres lesbianas 49% que en mujeres no lesbianas 19%, manifestándose alta significancia estadística p< 0.001. Conclusión: El Acné, la Alopecia y el Hirsutismo no se asocian de forma significativa al lesbianismo en mujeres de la Ciudad de Trujillo; estos hallazgos son más frecuentes en mujeres lesbianas que en mujeres no lesbianas. La “Obesidad Central es un factor asociado al hiperandrogenismo del lesbianismo en mujeres de la ciudad de Trujillo; su frecuencia es mayor y significativa en mujeres lesbianas

  • Hallazgos clínicos de hiperandrogenismo en lesbianas de la ciudad de Trujillo
    Universidad Privada Antenor Orrego - UPAO, 2018
    Co-Authors: Zamudio Mendocilla, Andrea Selene
    Abstract:

    Objetivo: Determinar que los hallazgos clínicos de hiperandrogenismo Acné, Alopecia e Hirsutismo, se asocian al lesbianismo en mujeres de la Ciudad de Trujillo. Material y Método: Se llevó a cabo un estudio de tipo cualitativo, analítico y observacional de cohorte comparativo. Se aplicó la prueba estadística de proporciones de distribución normal, con nivel de significancia del 5%. La población de estudio estuvo constituida por 200 mujeres: 100 mujeres lesbianas y 100 mujeres no lesbianas de 18 a 65 años de edad de la ciudad de Trujillo, que voluntariamente aceptaron ser parte del estudio de conformidad a los criterios de inclusión. Resultados: La frecuencia del Acné es 21% en mujeres lesbianas y 14% en no lesbianas; la frecuencia de la Alopecia es 10% en mujeres lesbianas y 6% en no lesbianas; la frecuencia de Hirsutismo es 5% en mujeres lesbianas y 2% en no lesbianas, considerándose de baja significancia estadística p>0.05. La obesidad central como indicador antropométrico es más frecuente en mujeres lesbianas 49% que en mujeres no lesbianas 19%, manifestándose alta significancia estadística p< 0.001. Conclusión: El Acné, la Alopecia y el Hirsutismo no se asocian de forma significativa al lesbianismo en mujeres de la Ciudad de Trujillo; estos hallazgos son más frecuentes en mujeres lesbianas que en mujeres no lesbianas. La “Obesidad Central es un factor asociado al hiperandrogenismo del lesbianismo en mujeres de la ciudad de Trujillo; su frecuencia es mayor y significativa en mujeres lesbianas.Objective: To determine that the clinical findings of hyperandrogenism Acne, Alopecia and Hirsutism, are associated with lesbianism in women of the City of Trujillo. Material and Method: A qualitative, analytical and observational study of a comparative cohort was carried out. The statistical test of proportions of normal distribution was applied, with level of significance of 5%. The study population consisted of 200 women: 100 lesbian women and 100 non-lesbian women aged 18 to 65 years of age in the city of Trujillo, who voluntarily agreed to be part of the study in accordance with the inclusion criteria. Results: The frequency of acne is 21% in lesbian women and 14% in non-lesbian women; the frequency of Alopecia is 10% in lesbian women and 6% in non-lesbian women; the frequency of Hirsutism is 5% in lesbian women and 2% in non-lesbian women, being considered of low statistical significance p> 0.05. Central obesity as an anthropometric indicator is more frequent in lesbian women 49% than in non-lesbian women 19%, with a high statistical significance of p

Ricardo Azziz - One of the best experts on this subject based on the ideXlab platform.

  • long term response of Hirsutism and other hyperandrogenic symptoms to combination therapy in polycystic ovary syndrome
    Journal of Womens Health, 2018
    Co-Authors: Uche Ezeh, Andy Huang, Melanie Landay, Ricardo Azziz
    Abstract:

    Abstract Background: Polycystic ovary syndrome (PCOS) affects 5%–15% of women and is the most common cause of Hirsutism. Data on the time-course of improvement to suppressive therapy and predictors of that response in PCOS are lacking. The objectives of our study are to determine the long-term response and identify predictors of response in PCOS women treated with suppressive therapy, including spironolactone (SPL) + oral contraceptives (OCs). Materials and Methods: Retrospective cross-sectional analysis of 200 women with PCOS (1990 NIH criteria) treated with suppressive therapy in general, and a subgroup of 138 subjects treated with OCP+SPL who had been prospectively included in a biorepository. Main outcome measure included improvement rate per 100 person-month of follow-up for Hirsutism, menstrual irregularity and acne measured qualitatively as “feeling better”, and changes in the severity of Hirsutism quantified by modified Ferriman-Gallwey [mF-G] score. Results: During a mean follow-up of 34.2 months...

  • visually scoring Hirsutism
    Human Reproduction Update, 2010
    Co-Authors: Bulent O. Yildiz, Ricardo Azziz, Sheila Bolour, Keslie S Woods, April Moore
    Abstract:

    † Summary † Supplementary data background: Hirsutism is the presence of excess body or facial terminal (coarse) hair growth in females in a male-like pattern, affects 5-15% of women, and is an important sign of underlying androgen excess. Different methods are available for the assessment of hair growth in women. methods: We conducted a literature search and analyzed the published studies that reported methods for the assessment of hair growth. We review the basic physiology of hair growth, the development of methods for visually quantifying hair growth, the comparison of these methods with objective measurements of hair growth, how Hirsutism may be defined using a visual scoring method, the influence of race and ethnicity on hirsut- ism, and the impact of Hirsutism in diagnosing androgen excess and polycystic ovary syndrome. results: Objective methods for the assessment of hair growth including photographic evaluations and microscopic measurements are available but these techniques have limitations for clinical use, including a significant degree of complexity and a high cost. Alternatively, methods for visually scoring or quantifying the amount of terminal body and facial hair growth have been in use since the early 1920s; these methods are semi-quantitative at best and subject to significant inter-observer variability. The most common visual method of scoring the extent of body and facial terminal hair growth in use today is based on a modification of the method originally described by Ferriman and Gallwey in 1961 (i.e. the mFG method). conclusion: Overall, the mFG scoring method is a useful visual instrument for assessing excess terminal hair growth, and the presence of Hirsutism, in women.

  • reanalyzing the modified ferriman gallwey score is there a simpler method for assessing the extent of Hirsutism
    Fertility and Sterility, 2009
    Co-Authors: Heather Cook, Kathleen Brennan, Ricardo Azziz
    Abstract:

    Objective To determine whether assessing the extent of terminal hair growth in a subset of the traditional nine areas included in the modified Ferriman-Gallwey (mFG) score can serve as a simpler predictor of total body Hirsutism when compared with the full scoring system, and to determine if this new model can accurately distinguish hirsute from nonhirsute women. Design Cross-sectional analysis. Setting Two tertiary care academic referral centers. Patient(s) 1,951 patients presenting for symptoms of androgen excess. Intervention(s) History and physical examination, including mFG score. Main Outcome Measure(s) Total body Hirsutism. Result(s) A regression model using all nine body areas indicated that the combination of upper abdomen, lower abdomen, and chin was the best predictor of the total full mFG score. Using this subset of three body areas is accurate in distinguishing true hirsute from nonhirsute women when defining true Hirsutism as mFG >7. Conclusion(s) Scoring terminal hair growth only on the chin and abdomen can serve as a simple yet reliable predictor of total body Hirsutism when compared with full-body scoring using the traditional mFG system.

  • the evaluation and management of Hirsutism
    Obstetrics & Gynecology, 2003
    Co-Authors: Ricardo Azziz
    Abstract:

    Abstract Hirsutism is the presence of terminal (coarse) hairs in females in a male-like pattern, affecting between 5% and 15% of women, depending on definition. Hirsutism has a significant negative impact on psychosocial development and is usually a sign of an underlying endocrine abnormality—namely, androgen excess. The most common cause of androgen excess is the polycystic ovary syndrome (PCOS), with 21-hydroxylase–deficient nonclassic adrenal hyperplasia, the hyperandrogenic insulin-resistant acanthosis nigricans syndrome, androgen-secreting tumors, and androgenic drug intake occurring less frequently. However, although 70–80% of patients with androgen excess demonstrate Hirsutism, this sign may be less prevalent among women of Asian extraction. Conversely, not all hirsute patients have evidence of detectable androgen excess, as 5–15% of these women have “idiopathic Hirsutism,” with normal ovulatory function and androgen levels. There is a strong familial predilection for Hirsutism, primarily because the underlying endocrine disorders (eg, PCOS) and the factors regulating the development of hair growth (eg, androgen receptor activity, 5α-reductase activity) have a strong genetic component. The diagnostic evaluation of the potentially hirsute patient first involves confirming the presence of Hirsutism and then excluding associated or etiological abnormalities and disorders (eg, ovulatory dysfunction, adrenal hyperplasia, diabetes, thyroid hormone abnormalities). Treatment should be undertaken using combination therapy, to possibly include 1) hormonal suppression (oral contraceptives, long-acting gonadotropin-releasing hormone analogues, and insulin sensitizers), 2) peripheral androgen blockade (spironolactone, flutamide, cyproterone acetate, or finasteride), and 3) mechanical/cosmetic amelioration and destruction of the unwanted hairs (electrology and, potentially, laser hair removal). The application of eflornithine hydrochloride 13.9% topical cream may also be useful to ameliorate unwanted facial hair growth. Overall, although Hirsutism is a frequent and distressing abnormality often signaling an underlying endocrine disorder, a systematic approach to evaluation will uncover the etiology, and combination therapy will provide satisfactory treatment for most patients.

  • idiopathic Hirsutism an uncommon cause of Hirsutism in alabama
    Fertility and Sterility, 1998
    Co-Authors: Ricardo Azziz, Wende T Waggoner, Tatiana Ochoa, Eric S Knochenhauer, Larry R Boots
    Abstract:

    Abstract Objective: To determine the prevalence of idiopathic Hirsutism among a population of consecutive hirsute patients. Design: Prospective cohort study. Setting: University-based clinic. Patient(s): Premenopausal women with a complaint of Hirsutism who were not receiving hormonal therapy. Intervention(s): Evaluations for total and free testosterone, (T), 17-hydroxyprogesterone (17-HP), and DHEAS serum levels. Main Outcome Measure(s): Ovulatory function in women with cycles of ≤35 days in length was assessed with a basal body temperature (BBT) calendar and day 22–24 progesterone levels. Result(s): Of 132 consecutive hirsute women studied, 68 had cycles of >35 days in length. Of the remaining 64 patients, 25 also had oligo/anovulation by BBT and day 22–24 progesterone level. Of the 39 patients with Hirsutism and regular ovulatory function, 22 had total and free T and DHEAS levels within normal limits. Conclusion(s): If idiopathic Hirsutism is defined by the presence of Hirsutism, regular ovulation, and normal androgen levels, only 17% of consecutive hirsute patients can be diagnosed with the disorder. Alternatively, if idiopathic Hirsutism is based solely on the presence of Hirsutism and regular ovulation, regardless of androgen levels, then 29% of the total hirsute population can be considered as having idiopathic Hirsutism. Importantly, 40% of hirsute patients with a history of "regular cycles" were actually oligo/anovulatory, indicating the need to objectively assess ovulatory function in such patients.

Marjoriitta Jarvelin - One of the best experts on this subject based on the ideXlab platform.

  • metabolic and reproductive characteristics of first degree relatives of women with self reported oligo amenorrhoea and Hirsutism
    Gynecological Endocrinology, 2011
    Co-Authors: Assi Torvinen, Stephen Franks, Riitta Koivunen, Anneli Pouta, Hannu Martikainen, Aini Bloigu, Annaliisa Hartikainen, Mark I Mccarthy, Aimo Ruokonen, Marjoriitta Jarvelin
    Abstract:

    Objective. To investigate the occurrence of oligo-amenorrhoea and Hirsutism, infertility and metabolic morbidity among first-degree relatives of women with and without self-reported oligo-amenorrhoea and Hirsutism.Design. Nested case-control study.Setting, population and methods. A postal questionnaire about symptoms of oligo-amenorrhoea and Hirsutism was sent to all women of the Northern Finland Birth Cohort 1966 (n = 5889). From this population were randomly selected 98 women with both symptoms and 163 without symptoms. A further questionnaire on the occurrence of oligo-amenorrhoea, Hirsutism, infertility, early balding and metabolic morbidity in their relatives was sent to this subpopulation.Main findings. We obtained data on 183 relatives of 43 women with symptoms and 412 relatives of 86 symptomless women. Compared with relatives of symptomless women, mothers of women with symptoms suffered significantly more often from Hirsutism and menstrual disorders, and sisters more often from Hirsutism and infer...

  • fecundability and spontaneous abortions in women with self reported oligo amenorrhea and or Hirsutism northern finland birth cohort 1966 study
    Human Reproduction, 2008
    Co-Authors: R Koivunen, Anneli Pouta, Aini Bloigu, S Franks, H Martikainen, Ulla Sovio, A L Hartikainen, M I Mccarthy, A Ruokonen, Marjoriitta Jarvelin
    Abstract:

    BACKGROUND: Women with polycystic ovary syndrome (PCOS) suffer from anovulatory infertility and hospital-based studies suggest that they have an increased risk of spontaneous abortion. Our aim was to investigate the proportion of women, with self-reported oligo-amenorrhea and/or Hirsutism in a general population, who had suffered from infertility, the percentage of them managing to conceive and their rate of spontaneous abortion. METHODS: At age 31, a postal questionnaire including questions about Hirsutism and oligo-amenorrhea was sent to all women from the population-based Northern Finland Birth Cohort 1966 (total n = 5889). Of these, 4535 (79.5%) answered the questionnaire, 1103 reported Hirsutism and/or oligo/amenorrhea (symptomatic women) and 3420 were non-symptomatic. The fecundability ratio (FR) was defined as the probability of conception of a clinically detectable pregnancy within 12 months. RESULTS: The overall pregnancy (77.7% versus 75.6%) and spontaneous abortion (19.3% versus 18.6%) rates did not differ between the two groups and the risk of spontaneous abortion was not associated with body mass index (BMI), waist-to-hip ratio (WHR) or waist circumference. Symptomatic women had suffered more often from infertility than non-symptomatic women (19.4% versus 11.1%, P < 0.01). Oligo-amenorrhea and/or Hirsutism (FR = 0.74, P < 0.001) and obesity (FR = 0.68, P = 0.002) were both independently associated with decreased fecundability, but symptomatic women had become pregnant and had one or two successful deliveries as often as non-symptomatic women. CONCLUSIONS: Women with self-reported oligo-amenorrhea and/or Hirsutism had lower fecundability and suffered more often from infertility, but had at least one delivery as often as non-symptomatic women, and did not exhibit an increased risk of spontaneous abortion.

  • metabolic cardiovascular disease risk factors in women with self reported symptoms of oligomenorrhea and or Hirsutism northern finland birth cohort 1966 study
    Obstetrical & Gynecological Survey, 2005
    Co-Authors: Saara Taponen, Stephen Franks, Anneli Pouta, Hannu Martikainen, Annaliisa Hartikainen, Mark I Mccarthy, Marjoriitta Jarvelin, Ulla Sovio, Jaana Laitinen, Mika Paldanius
    Abstract:

    Many of the metabolic disturbances in women with polycystic ovary syndrome (PCOS) are also unfavorable risk factors for cardiovascular disease (CVD), but an association between PCOS and increased CVD risk has not been definitively demonstrated. The investigators attempted to determine whether women having symptoms typical of PCOS (Hirsutism and/or oligomenorrhea) at age 31 years differ from asymptomatic control subjects with respect to CVD risk factors. The 518 women enrolled in the study were compared with 1036 randomly selected controls. The least favorable risk factor profile was found in symptomatic women who, compared with control subjects, had significantly higher C-reactive protein and triglyceride levels, higher body mass indices and waist-hip ratios, and higher systolic and diastolic blood pressures. At the same time, the symptomatic women had lower levels of high-density lipoprotein cholesterol (HDL-C). Total cholesterol and low-density lipoprotein cholesterol levels did not differ significantly between the 2 groups. Women with Hirsutism alone had risk factors comparable to those of asymptomatic controls. Risk factors in women whose testosterone levels exceeded 3 nmol/L were similar to those in women having both symptoms, whether or not Hirsutism was present. Those with lower testosterone levels resembled the control women, even if Hirsutism was present. No significant association was found between CVD risk factors and body mass index. Among obese women, cases had significantly lower levels of HDL-C and higher triglyceride levels than controls. Oligomenorrhea and Hirsutism may be signs of an underlying metabolic disorder that increases CVD risk in women, especially when both symptoms are present and associated with obesity. Young women with clinical features of PCOS should have their CVD risk status monitored on a regular basis, continuing into middle age.

Hector F Escobarmorreale - One of the best experts on this subject based on the ideXlab platform.

  • diagnosis and management of Hirsutism
    Society for Endocrinology BES 2013, 2013
    Co-Authors: Hector F Escobarmorreale
    Abstract:

    Hirsutism is a frequent medical complaint that usually results from relatively benign functional disorders including the polycystic ovary syndrome, which is the most frequent etiology. The essential tool for the diagnosis of Hirsutism is a complete clinical history and physical examination, because functional causes begin peripubertally and progress slowly, whereas the very rare androgen-secreting neoplasms have a sudden onset and a rapid progression of Hirsutism, and usually associate clinical signs of virilization and defeminization. In all cases, diagnosis requires quantification of Hirsutism using the modified Ferriman-Gallwey score, measurement of circulating androgen concentrations, a detailed study of ovaulatory function, and possibly an ovarian ultrasound. Treatment must consider not only amelioration of Hirsutism but also treatment of the underlying etiology and of any metabolic associations. When caused by a functional disorder, treatment of Hirsutism should be chronic and should include cosmetic as well as pharmacological interventions such as oral contraceptives and antiandrogens. For nonfunctional disorders, treatment should focus on solving the underlying etiology as Hirsutism is usually responsive to the elimination of the source of androgen excess.

  • epidemiology diagnosis and management of Hirsutism a consensus statement by the androgen excess and polycystic ovary syndrome society
    Human Reproduction Update, 2012
    Co-Authors: Hector F Escobarmorreale, Enrico Carmina, Alessandra Gambineri, Fahrettin Kelestimur, Didier Dewailly, Paolo Moghetti, M Pugeat, Jie Qiao, C N Wijeyaratne, Selma F Witchel
    Abstract:

    Background Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age. Methods We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of Hirsutism. Results The prevalence of Hirsutism is ~10% in most populations, with the important exception of Far-East Asian women who present Hirsutism less frequently. Although usually caused by relatively benign functional conditions, with the polycystic ovary syndrome leading the list of the most frequent etiologies, Hirsutism may be the presenting symptom of a life-threatening tumor requiring immediate intervention. Conclusions Following evidence-based diagnostic and treatment strategies that address not only the amelioration of Hirsutism but also the treatment of the underlying etiology is essential for the proper management of affected women, especially considering that Hirsutism is, in most cases, a chronic disorder needing long-term follow-up. Accordingly, we provide evidence-based guidelines for the etiological diagnosis and for the management of this frequent medical complaint.

  • a prospective study of the prevalence of the polycystic ovary syndrome in unselected caucasian women from spain
    The Journal of Clinical Endocrinology and Metabolism, 2000
    Co-Authors: Miryam Asuncion, Rosa Calvo, Jose San L Millan, Jose Sancho, Sergio Avila, Hector F Escobarmorreale
    Abstract:

    We prospectively estimated the prevalence of the polycystic ovary syndrome (PCOS), as defined by the NIH/NICHHD 1990 endocrine criteria, in a population of 154 Caucasian women of reproductive age reporting spontaneously for blood donation. Anthropometric data; the presence of Hirsutism, acne, and androgenic alopecia; and the menstrual history were recorded by a single investigator. In 145 women, blood samples were also obtained for measurement of serum androgen levels. PCOS was defined by the presence of 1) oligomenorrhea, 2) clinical and/or biochemical hyperandrogenism, and 3) exclusion of hyperprolactinemia, thyroid disorders, and nonclassic 21-hydroxylase deficiency. Hirsutism was defined by a modified Ferriman-Gallwey score of 8 or more, acne was considered as a sign of hyperandrogenism when persistent after the second decade of life, and hyperandrogenemia was defined by an increase in circulating testosterone or dehydroepiandrosterone sulfate or an increase in the free androgen index above the 95th percentile of the control values derived from the nonhirsute, nonacneic women having regular menses who were not receiving hormonal therapy. PCOS was present in 10(6.5%), Hirsutism was present in 11 (7.1%), and acne was present in 19 (12.3%) of the 154 women. Our results demonstrate a 6.5% prevalence of PCOS, as defined, in a minimally biased population of Caucasian women from Spain. The polycystic ovary syndrome, Hirsutism, and acne are common endocrine disorders in women.

Enrico Carmina - One of the best experts on this subject based on the ideXlab platform.

  • epidemiology diagnosis and management of Hirsutism a consensus statement by the androgen excess and polycystic ovary syndrome society
    Human Reproduction Update, 2012
    Co-Authors: Hector F Escobarmorreale, Enrico Carmina, Alessandra Gambineri, Fahrettin Kelestimur, Didier Dewailly, Paolo Moghetti, M Pugeat, Jie Qiao, C N Wijeyaratne, Selma F Witchel
    Abstract:

    Background Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age. Methods We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of Hirsutism. Results The prevalence of Hirsutism is ~10% in most populations, with the important exception of Far-East Asian women who present Hirsutism less frequently. Although usually caused by relatively benign functional conditions, with the polycystic ovary syndrome leading the list of the most frequent etiologies, Hirsutism may be the presenting symptom of a life-threatening tumor requiring immediate intervention. Conclusions Following evidence-based diagnostic and treatment strategies that address not only the amelioration of Hirsutism but also the treatment of the underlying etiology is essential for the proper management of affected women, especially considering that Hirsutism is, in most cases, a chronic disorder needing long-term follow-up. Accordingly, we provide evidence-based guidelines for the etiological diagnosis and for the management of this frequent medical complaint.

  • prevalence of idiopathic Hirsutism
    European Journal of Endocrinology, 1998
    Co-Authors: Enrico Carmina
    Abstract:

    Objective: To evaluate the prevalence of idiopathic Hirsutism in a large population of hirsute women. Design: 588 hirsute women (mean age 24 6 1, range 15‐36 years) were evaluated as outpatients at the Department of Endocrinology of the University of Palermo, Italy. The diagnosis of idiopathic Hirsutism was established in hirsute patients presenting regular ovulatory menstrual cycles and normal serum androgen levels (total testosterone, unbound testosterone and dehydroepiandrosterone sulfate). Methods: Hirsutism was calculated by the Ferriman-Gallwey-Lorenzo index. Serum androgens were evaluated in the follicular phase (days 5 or 6) and normal androgen ranges were calculated as the mean 6 2 S.D. of serum levels of 30 ovulatory non-hirsute women. The presence of ovulation was determined by serum progesterone levels during the presumed luteal phase (days 21 or 22). All steroids were determined by specific RIAs. Results: 36 hirsute women (6%) had regular ovulatory cycles and normal androgen levels and were diagnosed as being affected by idiopathic Hirsutism. Conclusions: Idiopathic Hirsutism is a relatively uncommon cause of Hirsutism, affecting approximately 6% of our population.

  • serum androsterone conjugates differentiate between acne and Hirsutism in hyperandrogenic women
    Fertility and Sterility, 1991
    Co-Authors: Frank Z Stanczyk, Rogerio A Lobo, Enrico Carmina, Robert K Matteri
    Abstract:

    Objective To determine if among hyperandrogenic women acne may be differentiated from Hirsutism by markers of peripheral androgen metabolism. Design Prospective outpatient study of 36 hyperandrogenic women and controls divided into groups based on the presence or absence of significant Hirsutism and the presence or absence of moderate to severe acne. Serum levels of adrenal and ovarian derived androgens were elevated but similar in all patient groups. Interventions Measurement of serum androgens including metabolites of 5 α -reductase activity: 3 α -androstanediol glucuronide and sulfate and androsterone (A) glucuronide and sulfate. Results 3 α -androstanediol glucuronide and sulfate were elevated in all groups ( P P P Conclusions Altered peripheral metabolism in acne may favor the formation of A conjugates, which may help differentiate acne from Hirsutism among hyperandrogenic women.