The Experts below are selected from a list of 231 Experts worldwide ranked by ideXlab platform
Lutz Walter - One of the best experts on this subject based on the ideXlab platform.
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The major Histocompatibility Complex of the rat (Rattus norvegicus)
Immunogenetics, 2001Co-Authors: Eberhard Günther, Lutz WalterAbstract:This review of the RT1 Complex, the major Histocompatibility Complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 Complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 Complex provides important information for using the rat as a model of experimental transplantation and Complex diseases.
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The major Histocompatibility Complex of the rat (Rattus norvegicus)
Immunogenetics, 2001Co-Authors: Eberhard Günther, Lutz WalterAbstract:This review of the RT1 Complex, the major Histocompatibility Complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 Complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 Complex provides important information for using the rat as a model of experimental transplantation and Complex diseases.
Eberhard Günther - One of the best experts on this subject based on the ideXlab platform.
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The major Histocompatibility Complex of the rat (Rattus norvegicus)
Immunogenetics, 2001Co-Authors: Eberhard Günther, Lutz WalterAbstract:This review of the RT1 Complex, the major Histocompatibility Complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 Complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 Complex provides important information for using the rat as a model of experimental transplantation and Complex diseases.
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The major Histocompatibility Complex of the rat (Rattus norvegicus)
Immunogenetics, 2001Co-Authors: Eberhard Günther, Lutz WalterAbstract:This review of the RT1 Complex, the major Histocompatibility Complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 Complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 Complex provides important information for using the rat as a model of experimental transplantation and Complex diseases.
Masanori Kasahara - One of the best experts on this subject based on the ideXlab platform.
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Evolution of the major Histocompatibility Complex: Molecular cloning of major Histocompatibility Complex class I from the amphibian Xenopus (major Histocompatibility Complex class II/immunoglobulin superfamily/CDl/expression library)
2016Co-Authors: Martin F. Flajnik, Camilo Canel, Jack Kramer, Masanori KasaharaAbstract:Class I major Histocompatibility Complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher verte- brates. The immunoglobulin-like a-3 domain is more similar to the immunoglobulin-like domains of mammalian class II 13 chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.
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The chromosomal duplication model of the major Histocompatibility Complex
Immunological reviews, 1999Co-Authors: Masanori KasaharaAbstract:The major Histocompatibility Complex (MHC) is a genetic region that has been extensively studied by immunologists, molecular biologists, and evolutionary biologists. Nevertheless, our knowledge of how the MHC acquired its present-day organization is quite limited. The recent discovery that the mammalian genome contains regions paralogous to the MHC has led us to the proposal that the MHC region of jawed vertebrates arose as a result of ancient chromosomal duplications. Here, I review the current status of this proposal.
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Evolution of the major Histocompatibility Complex: molecular cloning of major Histocompatibility Complex class I from the amphibian Xenopus
Proceedings of the National Academy of Sciences of the United States of America, 1991Co-Authors: Martin F. Flajnik, Camilo Canel, Jack Kramer, Masanori KasaharaAbstract:Abstract Class I major Histocompatibility Complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.
Don C. Wiley - One of the best experts on this subject based on the ideXlab platform.
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Peptide binding to the major Histocompatibility Complex molecules: Current Opinion in Structural Biology 1992, 2:300–304
Current Opinion in Structural Biology, 1992Co-Authors: D R Madden, Don C. WileyAbstract:Abstract Each major Histocompatibility Complex molecule must bind any one of a large spectrum of peptides for presentation to the T cells of the immune system. Results on the sequences, biochemistry and three-dimensional structure of peptides bound to major Histocompatibility Complex molecules offer new insights into this interaction.
Paul Harris - One of the best experts on this subject based on the ideXlab platform.
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Peptides Bound to Major Histocompatibility Complex Molecules
Peptides, 1998Co-Authors: Antonella Maffei, Paul HarrisAbstract:Abstract Maffei, A. and P. E. Harris. Peptides bound to major Histocompatibility Complex molecules. Peptides 19 (1) 179–198, 1998.—Peptides are the means by which immune effector T cells recognize and defend against the foreign proteins of pathogens. T cell recognition of these molecules, however, is strictly dependent on peptide binding to the receptor-like molecules of the major Histocompatibility Complex (MHC) locus. The basic unit of recognition is a trimolecular Complex consisting of the T cell antigen receptor, the MHC molecule, and the MHC-bound peptide ligand. The multistep process that culminates in MHC presentation of peptides to T cells begins in the last phases of protein catabolism. While the individual roles of many key molecules involved in peptide presentation have recently been defined, there still remain many questions regarding processing of proteins into MHC-bound peptides. This review summarizes the recent developments in peptide antigen processing for MHC molecules, with focus on how proteins are believed to be sampled and selected for degradation into peptides.