Histopathology

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Sigit Kirana Lintang Bhima - One of the best experts on this subject based on the ideXlab platform.

  • perbandingan pemberian brodifakum ld50 dan ld100 terhadap perubahan gambaran histopatologi usus halus tikus wistar
    DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ), 2016
    Co-Authors: Alfian Salahudin Al Ayoubi, Tuntas Dhanardhono, Sigit Kirana Lintang Bhima
    Abstract:

    Background : Brodifacoum is an anticoagulant substance which usually used as pest control, but this substance has a poisoning effect the body. Brodifacoum is absorbed through gastrointestinal tract which can cause the disorder of blod clotting by slowing down the process of epoxide reductase of vitamin-K. Aim : To know the comparison of Histopathology Rattus norvegicus Intestine against brodifacoum administration LD50 and LD100. Methods : This study was an experimental study with post test only group design. The sample of this study are 27 Rattus norvegicus which given per oral administration of brodifacoum. Barthel Manja scores were used to assess changes in intestine Histopatology. Normal and desquamation are a minor damage, while erosion and ulcers are major damage. Non-parametric test of Mann-Whitney to the results are revealed significant if p <0.05. Results : On LD50, 2 rats died on days 3, 5 on day 5, and 2 rats terminated on day 7. In LD100 2 rats died on day 3, 2 on day 5, and 5 rats terminated on day 7. On LD50 groups there are 66,67% minor damage and 33,33% major damage, while in LD100 groups there are 55,56% minor damage and 44,44% major damage. Test non parametric Mann-Whitney in the control group with LD50 was found p = 0.269, in control group with LD100 was found p = 0106, then group with the LD50 and LD100 found p = 0.159. Conclusion : There are not significant differentiation of histopatology picture between LD50 and LD100 dose ( p = 0.159 )

  • PERBANDINGAN PEMBERIAN BRODIFAKUM LD50 DAN LD100 TERHADAP PERUBAHAN GAMBARAN HISTOPATOLOGI USUS HALUS TIKUS WISTAR
    2016
    Co-Authors: Alfian Salahudin Al Ayoubi, Tuntas Dhanardhono, Sigit Kirana Lintang Bhima
    Abstract:

    Background : Brodifacoum is an anticoagulant substance which usually used as pest control, but this substance has a poisoning effect the body. Brodifacoum is absorbed through gastrointestinal tract which can cause the disorder of blod clotting by slowing down the process of epoxide reductase of vitamin-K. Aim : To know the comparison of Histopathology Rattus norvegicus Intestine against brodifacoum administration LD50 and LD100. Methods : This study was an experimental study with post test only group design. The sample of this study are 27 Rattus norvegicus which given per oral administration of brodifacoum. Barthel Manja scores were used to assess changes in intestine Histopatology. Normal and desquamation are a minor damage, while erosion and ulcers are major damage. Non-parametric test of Mann-Whitney to the results are revealed significant if p

Alfian Salahudin Al Ayoubi - One of the best experts on this subject based on the ideXlab platform.

  • perbandingan pemberian brodifakum ld50 dan ld100 terhadap perubahan gambaran histopatologi usus halus tikus wistar
    DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ), 2016
    Co-Authors: Alfian Salahudin Al Ayoubi, Tuntas Dhanardhono, Sigit Kirana Lintang Bhima
    Abstract:

    Background : Brodifacoum is an anticoagulant substance which usually used as pest control, but this substance has a poisoning effect the body. Brodifacoum is absorbed through gastrointestinal tract which can cause the disorder of blod clotting by slowing down the process of epoxide reductase of vitamin-K. Aim : To know the comparison of Histopathology Rattus norvegicus Intestine against brodifacoum administration LD50 and LD100. Methods : This study was an experimental study with post test only group design. The sample of this study are 27 Rattus norvegicus which given per oral administration of brodifacoum. Barthel Manja scores were used to assess changes in intestine Histopatology. Normal and desquamation are a minor damage, while erosion and ulcers are major damage. Non-parametric test of Mann-Whitney to the results are revealed significant if p <0.05. Results : On LD50, 2 rats died on days 3, 5 on day 5, and 2 rats terminated on day 7. In LD100 2 rats died on day 3, 2 on day 5, and 5 rats terminated on day 7. On LD50 groups there are 66,67% minor damage and 33,33% major damage, while in LD100 groups there are 55,56% minor damage and 44,44% major damage. Test non parametric Mann-Whitney in the control group with LD50 was found p = 0.269, in control group with LD100 was found p = 0106, then group with the LD50 and LD100 found p = 0.159. Conclusion : There are not significant differentiation of histopatology picture between LD50 and LD100 dose ( p = 0.159 )

  • PERBANDINGAN PEMBERIAN BRODIFAKUM LD50 DAN LD100 TERHADAP PERUBAHAN GAMBARAN HISTOPATOLOGI USUS HALUS TIKUS WISTAR
    2016
    Co-Authors: Alfian Salahudin Al Ayoubi, Tuntas Dhanardhono, Sigit Kirana Lintang Bhima
    Abstract:

    Background : Brodifacoum is an anticoagulant substance which usually used as pest control, but this substance has a poisoning effect the body. Brodifacoum is absorbed through gastrointestinal tract which can cause the disorder of blod clotting by slowing down the process of epoxide reductase of vitamin-K. Aim : To know the comparison of Histopathology Rattus norvegicus Intestine against brodifacoum administration LD50 and LD100. Methods : This study was an experimental study with post test only group design. The sample of this study are 27 Rattus norvegicus which given per oral administration of brodifacoum. Barthel Manja scores were used to assess changes in intestine Histopatology. Normal and desquamation are a minor damage, while erosion and ulcers are major damage. Non-parametric test of Mann-Whitney to the results are revealed significant if p

Muhartono Muhartono - One of the best experts on this subject based on the ideXlab platform.

  • The Influence of Green Tea Infusion (Camellia sinensis) on Renal Histopathological Overview of Male White Rats (Rattus Norvegicus) Sprague Dawley Strain Induced by Ethanol
    'Society of Pharmaceutical Tecnocrats', 2020
    Co-Authors: Muhartono Muhartono, Fitriana, Katya Rizqita
    Abstract:

    Aims: This sudy aims to determine the effect infusion  of green tea (Camellia sinensis) to the renal Histopathology picture of male white rats (Rattus norvegicus) Sprague dawley strain ethanol-induced. Methods: This study used 30 rats divided into 5 groups. The negative control (K-) was given distilled water 2 mL/day, the positive control (K +) was given ethanol 2 mL/day, the treatment group (P1, P2, P3) was given ethanol 2 mL and green tea infusion with respective doses of 0.375, 0.75 and 1.5 grams orally for 14 days. Then the renal retrieval is done to be examined microscopically. Results: The mean kidney damage score obtained was K- = 0.36; K + = 3.24; P1 = 2.52; P2 = 2,4; and P3 = 2.2. Data analysis with One Way Anova Test and continued with Pos Hoc and found significant differences in K- to K+, P1, P2, P3; K+ is significant to K-, P1, P2, P3; and P1, P2, P3 are significant to K- & K+. Conclusion: There is an effect of infusion of green tea (Camellia sinensis) on the renal histopathological picture of male white rats (Rattus norvegicus) ethanol-induced Sprague dawley strain. Keywords: alcohol, antioxidant, ethanol, green tea, renal histopatholog

  • THE The Effect of Green Tea Infusion (Camellia sinensis) on Histopathology of White Rat (Rattus norvegicus) Liver Sprague dawley Strain Induced by Ethanol
    'Society of Pharmaceutical Tecnocrats', 2020
    Co-Authors: Muhartono Muhartono, Salsabila, Nabilah Amirah, Ayu, Putu Ristyaning
    Abstract:

    Aims: This research aims to determine the effect of green tea infusion (Camellia sinensis) on the hitopathology of white rat liver induced by ethanol. Method: This study used 30 rats divided into 5 groups as follow negative control group (K1) given aquades, positive control group (K2) given 20% 2 mL/day peroral, treatment group 1, 2, 3 (P1, P2, P3) given 20% ethanol 2 mL/day peroral followed by green tea infusion with doses 0,375 g/day, 0,75 g/day, and 1,5 g/day single dose per oral for 14 days. The the liver of the rat is taken for microscopic examination. The mean Manja Roenigk scores obtained were K1=1,16, K2=3,36, P1=2,8, P2=2,68, and P3=2,56. Data were tested with the Kruskal-wallis test followed by Mann whitney’s post hoc test. Results:  The results showed a significant mean difference between positive group (K2) and the treatment group P1, P2, and P3. There is no significant mean difference between P1-P2, P1-P3, and P2-P3 which means giving green tea infusion (Cameliia sinensis) in P2 and P3 gave almost the same effect as P1. Conclusion: There is an effect of giving green tea infusion (Camellia sinensis) to the Histopathology of white rat liver induced by ethanol. Keywords: antioxidants, ethanol, green tea infusion, liver Histopathology

Tuntas Dhanardhono - One of the best experts on this subject based on the ideXlab platform.

  • perbandingan pemberian brodifakum ld50 dan ld100 terhadap perubahan gambaran histopatologi usus halus tikus wistar
    DIPONEGORO MEDICAL JOURNAL ( JURNAL KEDOKTERAN DIPONEGORO ), 2016
    Co-Authors: Alfian Salahudin Al Ayoubi, Tuntas Dhanardhono, Sigit Kirana Lintang Bhima
    Abstract:

    Background : Brodifacoum is an anticoagulant substance which usually used as pest control, but this substance has a poisoning effect the body. Brodifacoum is absorbed through gastrointestinal tract which can cause the disorder of blod clotting by slowing down the process of epoxide reductase of vitamin-K. Aim : To know the comparison of Histopathology Rattus norvegicus Intestine against brodifacoum administration LD50 and LD100. Methods : This study was an experimental study with post test only group design. The sample of this study are 27 Rattus norvegicus which given per oral administration of brodifacoum. Barthel Manja scores were used to assess changes in intestine Histopatology. Normal and desquamation are a minor damage, while erosion and ulcers are major damage. Non-parametric test of Mann-Whitney to the results are revealed significant if p <0.05. Results : On LD50, 2 rats died on days 3, 5 on day 5, and 2 rats terminated on day 7. In LD100 2 rats died on day 3, 2 on day 5, and 5 rats terminated on day 7. On LD50 groups there are 66,67% minor damage and 33,33% major damage, while in LD100 groups there are 55,56% minor damage and 44,44% major damage. Test non parametric Mann-Whitney in the control group with LD50 was found p = 0.269, in control group with LD100 was found p = 0106, then group with the LD50 and LD100 found p = 0.159. Conclusion : There are not significant differentiation of histopatology picture between LD50 and LD100 dose ( p = 0.159 )

  • PERBANDINGAN PEMBERIAN BRODIFAKUM LD50 DAN LD100 TERHADAP PERUBAHAN GAMBARAN HISTOPATOLOGI USUS HALUS TIKUS WISTAR
    2016
    Co-Authors: Alfian Salahudin Al Ayoubi, Tuntas Dhanardhono, Sigit Kirana Lintang Bhima
    Abstract:

    Background : Brodifacoum is an anticoagulant substance which usually used as pest control, but this substance has a poisoning effect the body. Brodifacoum is absorbed through gastrointestinal tract which can cause the disorder of blod clotting by slowing down the process of epoxide reductase of vitamin-K. Aim : To know the comparison of Histopathology Rattus norvegicus Intestine against brodifacoum administration LD50 and LD100. Methods : This study was an experimental study with post test only group design. The sample of this study are 27 Rattus norvegicus which given per oral administration of brodifacoum. Barthel Manja scores were used to assess changes in intestine Histopatology. Normal and desquamation are a minor damage, while erosion and ulcers are major damage. Non-parametric test of Mann-Whitney to the results are revealed significant if p

Ayu, Putu Ristyaning - One of the best experts on this subject based on the ideXlab platform.

  • THE The Effect of Green Tea Infusion (Camellia sinensis) on Histopathology of White Rat (Rattus norvegicus) Liver Sprague dawley Strain Induced by Ethanol
    'Society of Pharmaceutical Tecnocrats', 2020
    Co-Authors: Muhartono Muhartono, Salsabila, Nabilah Amirah, Ayu, Putu Ristyaning
    Abstract:

    Aims: This research aims to determine the effect of green tea infusion (Camellia sinensis) on the hitopathology of white rat liver induced by ethanol. Method: This study used 30 rats divided into 5 groups as follow negative control group (K1) given aquades, positive control group (K2) given 20% 2 mL/day peroral, treatment group 1, 2, 3 (P1, P2, P3) given 20% ethanol 2 mL/day peroral followed by green tea infusion with doses 0,375 g/day, 0,75 g/day, and 1,5 g/day single dose per oral for 14 days. The the liver of the rat is taken for microscopic examination. The mean Manja Roenigk scores obtained were K1=1,16, K2=3,36, P1=2,8, P2=2,68, and P3=2,56. Data were tested with the Kruskal-wallis test followed by Mann whitney’s post hoc test. Results:  The results showed a significant mean difference between positive group (K2) and the treatment group P1, P2, and P3. There is no significant mean difference between P1-P2, P1-P3, and P2-P3 which means giving green tea infusion (Cameliia sinensis) in P2 and P3 gave almost the same effect as P1. Conclusion: There is an effect of giving green tea infusion (Camellia sinensis) to the Histopathology of white rat liver induced by ethanol. Keywords: antioxidants, ethanol, green tea infusion, liver Histopathology

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