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C Darke - One of the best experts on this subject based on the ideXlab platform.

  • a f ab 2 fragment blocking study of the HLA B14 Antigen
    Tissue Antigens, 2008
    Co-Authors: C Darke
    Abstract:

    The HLA-B14 Antigen exists in two serologically distinct forms termed Bw64 and Bw65. These two B14 subgroups were studied using the ability of F(ab')2 fragments from HLA-B14 and Bw6 antisera to block the binding of cytotoxic HLA antibodies directed towards the same or an adjacent Antigenic site. The findings suggest that the B14 Antigen consists of several Antigenic determinants some of which are spatially distinct and others which are closely associated. A "common" determinant possessed by both B14 subtypes is proposed which is separate from a Bw64 (or Bw65) site. Additional determinants that B14 shares with B8, B18 and B38/B39 appear to be distinct from the Bw64/Bw65 site, variably associated with the B14 "common" determinant but closely adjoining the Bw6 Antigen.

Postencephalitic Parkinsonism - One of the best experts on this subject based on the ideXlab platform.

  • Journal of Neurology, Neurosurgery, and Psychiatry 1983;46:688-693 Matters arising
    2016
    Co-Authors: Histocompatibility Antigens, Postencephalitic Parkinsonism
    Abstract:

    Sir: We have read with interest the article on histocompatibility Antigens and post-encephalitic Parkinsonism by Lees et all recently published in your joumal. The authors compared the phenotypic frequen-cies of selected histocompatibility Antigens in 21. patients with postencephalitic Parkin-sonism and controls, and did not find any differences between the groups. Missing, however, were the ethnic composition of both the patient and control populations, and the Antigenic frequency data with resultant p values corrected statistically for total number of Antigens tested in each HLA locus. We had previously reported a highly significantly increased frequency of HLA-B14 Antigen (corrected p = 0.001) in 18 unrelated American-Jewish patients of Eastem European extraction who had clas-sical postencephalitic (von Economo's) Parkinson's disease, compared with 147 ethnically-matched controls;2 the 17 patients with idiopathic Parkinson's disease concurrently studied did not show any evi-dent differences in HLA frequencies com-pared to the same matched controls. In our paper, we emphasised that we were dealing with a specific, relatively homogeneous, ethnically-defined and matched study population, and that we were well aware of the known wide variations in prevalence of specific HLA Antigens in various ethnic groups. The disease association we reported, while not necessarily reflecting genetic susceptibility to the disease, cer-tainly suggests the possibility that a genetic factor may play a role in the pathogenesis of this particular variant of Parkinsonism in certain ethnic groups. The negative study of Lees et al, while of interest, is not com-parable to ours, nor does it negate our con-tentions

Histocompatibility Antigens - One of the best experts on this subject based on the ideXlab platform.

  • Journal of Neurology, Neurosurgery, and Psychiatry 1983;46:688-693 Matters arising
    2016
    Co-Authors: Histocompatibility Antigens, Postencephalitic Parkinsonism
    Abstract:

    Sir: We have read with interest the article on histocompatibility Antigens and post-encephalitic Parkinsonism by Lees et all recently published in your joumal. The authors compared the phenotypic frequen-cies of selected histocompatibility Antigens in 21. patients with postencephalitic Parkin-sonism and controls, and did not find any differences between the groups. Missing, however, were the ethnic composition of both the patient and control populations, and the Antigenic frequency data with resultant p values corrected statistically for total number of Antigens tested in each HLA locus. We had previously reported a highly significantly increased frequency of HLA-B14 Antigen (corrected p = 0.001) in 18 unrelated American-Jewish patients of Eastem European extraction who had clas-sical postencephalitic (von Economo's) Parkinson's disease, compared with 147 ethnically-matched controls;2 the 17 patients with idiopathic Parkinson's disease concurrently studied did not show any evi-dent differences in HLA frequencies com-pared to the same matched controls. In our paper, we emphasised that we were dealing with a specific, relatively homogeneous, ethnically-defined and matched study population, and that we were well aware of the known wide variations in prevalence of specific HLA Antigens in various ethnic groups. The disease association we reported, while not necessarily reflecting genetic susceptibility to the disease, cer-tainly suggests the possibility that a genetic factor may play a role in the pathogenesis of this particular variant of Parkinsonism in certain ethnic groups. The negative study of Lees et al, while of interest, is not com-parable to ours, nor does it negate our con-tentions