The Experts below are selected from a list of 14829 Experts worldwide ranked by ideXlab platform

S Sekiguchi - One of the best experts on this subject based on the ideXlab platform.

  • HLA dr dq and t cell Antigen receptor constant beta genes in japanese patients with ulcerative colitis
    Clinical and Experimental Immunology, 2008
    Co-Authors: Ken Kobayashi, M Atoh, Y Konoeda, A Yagita, H Inoko, S Sekiguchi
    Abstract:

    : We studied the T cell Antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 Antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 Antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 Antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 Antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 Antigen may be important in the pathogenesis of Japanese UC.

Ken Kobayashi - One of the best experts on this subject based on the ideXlab platform.

  • HLA dr dq and t cell Antigen receptor constant beta genes in japanese patients with ulcerative colitis
    Clinical and Experimental Immunology, 2008
    Co-Authors: Ken Kobayashi, M Atoh, Y Konoeda, A Yagita, H Inoko, S Sekiguchi
    Abstract:

    : We studied the T cell Antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 Antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 Antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 Antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 Antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 Antigen may be important in the pathogenesis of Japanese UC.

M Atoh - One of the best experts on this subject based on the ideXlab platform.

  • HLA dr dq and t cell Antigen receptor constant beta genes in japanese patients with ulcerative colitis
    Clinical and Experimental Immunology, 2008
    Co-Authors: Ken Kobayashi, M Atoh, Y Konoeda, A Yagita, H Inoko, S Sekiguchi
    Abstract:

    : We studied the T cell Antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 Antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 Antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 Antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 Antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 Antigen may be important in the pathogenesis of Japanese UC.

Y Konoeda - One of the best experts on this subject based on the ideXlab platform.

  • HLA dr dq and t cell Antigen receptor constant beta genes in japanese patients with ulcerative colitis
    Clinical and Experimental Immunology, 2008
    Co-Authors: Ken Kobayashi, M Atoh, Y Konoeda, A Yagita, H Inoko, S Sekiguchi
    Abstract:

    : We studied the T cell Antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 Antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 Antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 Antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 Antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 Antigen may be important in the pathogenesis of Japanese UC.

A Yagita - One of the best experts on this subject based on the ideXlab platform.

  • HLA dr dq and t cell Antigen receptor constant beta genes in japanese patients with ulcerative colitis
    Clinical and Experimental Immunology, 2008
    Co-Authors: Ken Kobayashi, M Atoh, Y Konoeda, A Yagita, H Inoko, S Sekiguchi
    Abstract:

    : We studied the T cell Antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 Antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 Antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 Antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 Antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 Antigen may be important in the pathogenesis of Japanese UC.