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David N. Glass - One of the best experts on this subject based on the ideXlab platform.
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juvenile idiopathic arthritis and hla class i and class ii interactions and age at onset effects
Arthritis & Rheumatism, 2010Co-Authors: Jill A Hollenbach, Henry A. Erlich, Susan D Thompson, Teodorica L Bugawan, Mary Ryan, Marc Sudman, Miranda C Marion, Carl D Langefeld, Glenys Thomson, David N. GlassAbstract:Objective The aim of this study was to quantitate risk and to examine heterogeneity for HLA at high resolution in patients with the most common subtypes of juvenile idiopathic arthritis (JIA), IgM rheumatoid factor–negative polyarticular JIA and oligoarticular JIA. Use of 4-digit comprehensive HLA typing enabled great precision, and a large cohort allowed for consideration of both age at disease onset and disease subtype. Methods Polymerase chain reaction–based high-resolution HLA typing for class I and class II loci was accomplished for 820 patients with JIA and 273 control subjects. Specific HLA epitopes, potential interactions of alleles at specific loci and between loci (accounting for linkage disequilibrium and haplotypic associations), and an assessment of the current International League of Associations for Rheumatology classification criteria were considered. Results An HLA–DRB1/DQB1 effect was shown to be exclusively attributable to DRB1 and was similar between patients with oligoarticular JIA and a younger subgroup of patients with polyarticular JIA. Furthermore, patients with polyarticular JIA showed age-specific related effects, with disease susceptibility in the group older than age 6 years limited to an effect of the HLA–DRB1*08 haplotype, which is markedly different from the additional susceptibility haplotypes, HLA–DRB1*1103/1104, found in the group with oligoarticular JIA and the group of younger patients with polyarticular JIA. Also in contrast to findings for oligoarticular JIA, patients with polyarticular arthritis had no evidence of an HLA class I effect. Markers associated with a reduced risk of disease included DRB1*1501, DRB1*0401, and DRB1*0701. DRB1*1501 was shown to reduce risk across the whole cohort, whereas DRB1*0401 and DRB1*0701 were protective for selected JIA subtypes. Surprisingly, the disease predisposition mediated by DPB1*0201 in individuals without any disease-predisposing DRB1 alleles was great enough to overcome even the very strong protective effect observed for DRB1*1501. Conclusion Inherited HLA factors in JIA show similarities overall as well as differences between JIA subtypes.
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Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Hector Melin-aldana, Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Murray H. Passo, Joseph Ginsberg, Miles J. Burke, David N. GlassAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis
Immunogenetics, 1990Co-Authors: Catherine Kerckhove, Hector Melin-aldana, Janalee Taylor, Daniel J. Lovell, Maruja S. Elma, Lorie Luyrink, Patricia Donnelly, Walter P. Maksymowych, Edmund Choi, David N. GlassAbstract:We studied the first domain of the HLA-DRB1 , HLA-DQA1 , and HLA-DQB1 loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis). Serology, restriction fragment length polymorphism (RFLP), and polymerase chain reaction (PCR) oligotyping revealed that 62, including all the EOPA-JRA patients, carried the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype. Approximately onefifth of the controls carried atypical HLA-DRB1, HLA-DQA1 , and/or HLA-DQB1 loci on their HLA-DRw8 haplotype confirmed by family studies. DNA sequences of HLA-DRB1, DQA1, and DQB1 alleles in patients and controls were identical to those previously reported. Disease association studies in 113 EOPA-JRA patients and 207 controls unselected for HLA-DRw8 revealed that the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype was associated with a higher relative risk (RR) for disease (RR = 12.8, χ^2 = 48.8, P < 10^−4) than was the serologically defined presence of HLA-DRw8 (RR = 8, χ^2 = 39, P < 10^−4). Further analysis suggested that the DQ genes on HLA-DRw8 haplotypes are as likely as the DR genes to contribute to the pathogenesis of EOPA-JRA. This study increases to five the number of HLA-DR/DQ haplotypes identified in HLA-DRw8 Caucasians.
Joseph E. Levinson - One of the best experts on this subject based on the ideXlab platform.
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Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Hector Melin-aldana, Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Murray H. Passo, Joseph Ginsberg, Miles J. Burke, David N. GlassAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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human leukocyte antigen drb1 1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Hector MelinaldanaAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
Janalee Taylor - One of the best experts on this subject based on the ideXlab platform.
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Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Hector Melin-aldana, Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Murray H. Passo, Joseph Ginsberg, Miles J. Burke, David N. GlassAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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human leukocyte antigen drb1 1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Hector MelinaldanaAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis
Immunogenetics, 1990Co-Authors: Catherine Kerckhove, Hector Melin-aldana, Janalee Taylor, Daniel J. Lovell, Maruja S. Elma, Lorie Luyrink, Patricia Donnelly, Walter P. Maksymowych, Edmund Choi, David N. GlassAbstract:We studied the first domain of the HLA-DRB1 , HLA-DQA1 , and HLA-DQB1 loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis). Serology, restriction fragment length polymorphism (RFLP), and polymerase chain reaction (PCR) oligotyping revealed that 62, including all the EOPA-JRA patients, carried the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype. Approximately onefifth of the controls carried atypical HLA-DRB1, HLA-DQA1 , and/or HLA-DQB1 loci on their HLA-DRw8 haplotype confirmed by family studies. DNA sequences of HLA-DRB1, DQA1, and DQB1 alleles in patients and controls were identical to those previously reported. Disease association studies in 113 EOPA-JRA patients and 207 controls unselected for HLA-DRw8 revealed that the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype was associated with a higher relative risk (RR) for disease (RR = 12.8, χ^2 = 48.8, P < 10^−4) than was the serologically defined presence of HLA-DRw8 (RR = 8, χ^2 = 39, P < 10^−4). Further analysis suggested that the DQ genes on HLA-DRw8 haplotypes are as likely as the DR genes to contribute to the pathogenesis of EOPA-JRA. This study increases to five the number of HLA-DR/DQ haplotypes identified in HLA-DRw8 Caucasians.
Daniel J. Lovell - One of the best experts on this subject based on the ideXlab platform.
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Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Hector Melin-aldana, Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Murray H. Passo, Joseph Ginsberg, Miles J. Burke, David N. GlassAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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human leukocyte antigen drb1 1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Hector MelinaldanaAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis
Immunogenetics, 1990Co-Authors: Catherine Kerckhove, Hector Melin-aldana, Janalee Taylor, Daniel J. Lovell, Maruja S. Elma, Lorie Luyrink, Patricia Donnelly, Walter P. Maksymowych, Edmund Choi, David N. GlassAbstract:We studied the first domain of the HLA-DRB1 , HLA-DQA1 , and HLA-DQB1 loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis). Serology, restriction fragment length polymorphism (RFLP), and polymerase chain reaction (PCR) oligotyping revealed that 62, including all the EOPA-JRA patients, carried the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype. Approximately onefifth of the controls carried atypical HLA-DRB1, HLA-DQA1 , and/or HLA-DQB1 loci on their HLA-DRw8 haplotype confirmed by family studies. DNA sequences of HLA-DRB1, DQA1, and DQB1 alleles in patients and controls were identical to those previously reported. Disease association studies in 113 EOPA-JRA patients and 207 controls unselected for HLA-DRw8 revealed that the HLA-DRB1*0801, DQA1*0401, DQB1*0402 genotype was associated with a higher relative risk (RR) for disease (RR = 12.8, χ^2 = 48.8, P < 10^−4) than was the serologically defined presence of HLA-DRw8 (RR = 8, χ^2 = 39, P < 10^−4). Further analysis suggested that the DQ genes on HLA-DRw8 haplotypes are as likely as the DR genes to contribute to the pathogenesis of EOPA-JRA. This study increases to five the number of HLA-DR/DQ haplotypes identified in HLA-DRw8 Caucasians.
Edward H. Giannini - One of the best experts on this subject based on the ideXlab platform.
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Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Hector Melin-aldana, Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Murray H. Passo, Joseph Ginsberg, Miles J. Burke, David N. GlassAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.
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human leukocyte antigen drb1 1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis
The Journal of Pediatrics, 1992Co-Authors: Edward H. Giannini, Janalee Taylor, Daniel J. Lovell, Joseph E. Levinson, Hector MelinaldanaAbstract:To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauclarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye disease during a mean follow-up period after the onset of arthritis of 15.8 years (minimum of 5.5 years). Control subjects were 218 healthy, unrelated individuals. The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis. Only one split of human leukocyte antigen (HLA)-DR5, HLA-DRB1 * 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value=7.52; p =0.036 adjusted; odds ratio 3.45); HLA-DQA1 * 0501 and HLA-DQB1 * 0301, both in linkage disequilibrium with HLA-DRB1 * 1104, also were significantly associated with eye disease. Patients with both the DRB1 * 1104 and DPB1 * 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. The presence of HLA-DRB1 * 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. Although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the HLA class II gene DRB1 * 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution.