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Francisca Clea Florenco De Sousa - One of the best experts on this subject based on the ideXlab platform.
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anxiolytic like effects of o methyl n 2 6 dihydroxybenzoyl tyramine riparin iii from aniba riparia nees mez lauraceae in mice
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Carla Thiciane Vasconcelos De Melo, Andreisa Paiva Monteiro, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros Viana, Vera Targino Moreira Lima, Caroline Porto Leite, Fernando Luiz Oliveira De Araujo, Francisca Clea Florenco De SousaAbstract:This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (Nees) Mez (Lauraceae) in animal models of open field, rota rod, elevated plus maze and Hole Board Tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod Test nor in the number of squares crossed in the open field Test. However, riparin III decreased the number of grooming and rearing. In the plus maze Test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the Holes of the Hole Board Test. These results show that riparin III presents anxiolytic effects in the plus maze and Hole Board Tests which are not influenced by the locomotor activity in the open field Test.
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antianxiety effects of riparin i from aniba riparia nees mez lauraceae in mice
Phytotherapy Research, 2005Co-Authors: Francisca Clea Florenco De Sousa, Stanley Juan Chavez Gutierrez, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Glicio Reboucas Oliveira, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros VianaAbstract:This work presents the behavioral effects of riparin I (methyl ether of N-benzoyl tyramine) from unripe fruit of Aniba riparia (Lauraceae) on the elevated plus maze, open field, rota rod and Hole Board Tests in mice. Riparin I was administered acutely by intraperitoneal (i.p.) and oral routes to male mice at doses of 25 and 50 mg/kg. The results showed that riparin I (25 and 50 mg/kg, i.p. and per os) increased the number of entries and the time of permanence in the open arms in the plus maze Test. Similarly, in the Hole Board Test, riparin I in both routes increased the number of head dips. Riparin I with both doses and routes had no effects on spontaneous motor activity in mice or in the rota rod Test, but decreased the number of groomings. These results showed that riparin I by both administration routes has effects on the central nervous system with antianxiety effects on the plus maze and Hole Board Tests. The substance is devoid of myorelaxant effects. Copyright © 2005 John Wiley & Sons, Ltd.
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antianxiety and antidepressant effects of riparin iii from aniba riparia nees mez lauraceae in mice
Pharmacology Biochemistry and Behavior, 2004Co-Authors: Francisca Clea Florenco De Sousa, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Silvânia Maria Mendes Vasconcelos, Jose Maria Barbosafilho, Vera Targino Moreira Lima, Stanley Juan Chaves Gutierrez, B A Pereira, M F Fonteles, G S B VianaAbstract:This work presents behavioral effects of methyl ethers of N-(2,6-dihydroxybenzoyl) tyramine (riparin III) isolated from the unripe fruit of Aniba riparia on the open field, elevated plus maze (EPM), rotarod, Hole Board, barbiturate-induced sleeping time, tail suspension and forced swimming Tests in mice. Riparin III was administered intraperitoneally to male mice at single doses of 25 and 50 mg/kg. The results showed that riparin III with both doses had no effects on spontaneous motor activity in mice or in the rotarod Test, but decreased the number of grooming and rearing. At the dose of 50 mg/kg, riparin III increased the number of entries in the open arms of the EPM Test as compared with control. Similarly, in the Hole-Board Test, both doses increased the number of head dips. There was a reduction on the sleeping latency with both doses and a prolongation of the pentobarbital-induced sleeping time with the dose of 25 mg/kg. In the tail suspension Test, similar to imipramine (30 mg/kg), riparin III at the dose of 50 mg/kg presented a reduction in the immobility time. In the forced swimming Test, both doses of riparin III decreased the immobility time. These results showed that riparin III potentiated the barbiturate-induced sleeping time and presented antidepressant- and anxiolytic-like effects.
Silvânia Maria Mendes Vasconcelos - One of the best experts on this subject based on the ideXlab platform.
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anxiolytic like effects of o methyl n 2 6 dihydroxybenzoyl tyramine riparin iii from aniba riparia nees mez lauraceae in mice
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Carla Thiciane Vasconcelos De Melo, Andreisa Paiva Monteiro, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros Viana, Vera Targino Moreira Lima, Caroline Porto Leite, Fernando Luiz Oliveira De Araujo, Francisca Clea Florenco De SousaAbstract:This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (Nees) Mez (Lauraceae) in animal models of open field, rota rod, elevated plus maze and Hole Board Tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod Test nor in the number of squares crossed in the open field Test. However, riparin III decreased the number of grooming and rearing. In the plus maze Test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the Holes of the Hole Board Test. These results show that riparin III presents anxiolytic effects in the plus maze and Hole Board Tests which are not influenced by the locomotor activity in the open field Test.
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antianxiety effects of riparin i from aniba riparia nees mez lauraceae in mice
Phytotherapy Research, 2005Co-Authors: Francisca Clea Florenco De Sousa, Stanley Juan Chavez Gutierrez, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Glicio Reboucas Oliveira, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros VianaAbstract:This work presents the behavioral effects of riparin I (methyl ether of N-benzoyl tyramine) from unripe fruit of Aniba riparia (Lauraceae) on the elevated plus maze, open field, rota rod and Hole Board Tests in mice. Riparin I was administered acutely by intraperitoneal (i.p.) and oral routes to male mice at doses of 25 and 50 mg/kg. The results showed that riparin I (25 and 50 mg/kg, i.p. and per os) increased the number of entries and the time of permanence in the open arms in the plus maze Test. Similarly, in the Hole Board Test, riparin I in both routes increased the number of head dips. Riparin I with both doses and routes had no effects on spontaneous motor activity in mice or in the rota rod Test, but decreased the number of groomings. These results showed that riparin I by both administration routes has effects on the central nervous system with antianxiety effects on the plus maze and Hole Board Tests. The substance is devoid of myorelaxant effects. Copyright © 2005 John Wiley & Sons, Ltd.
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antianxiety and antidepressant effects of riparin iii from aniba riparia nees mez lauraceae in mice
Pharmacology Biochemistry and Behavior, 2004Co-Authors: Francisca Clea Florenco De Sousa, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Silvânia Maria Mendes Vasconcelos, Jose Maria Barbosafilho, Vera Targino Moreira Lima, Stanley Juan Chaves Gutierrez, B A Pereira, M F Fonteles, G S B VianaAbstract:This work presents behavioral effects of methyl ethers of N-(2,6-dihydroxybenzoyl) tyramine (riparin III) isolated from the unripe fruit of Aniba riparia on the open field, elevated plus maze (EPM), rotarod, Hole Board, barbiturate-induced sleeping time, tail suspension and forced swimming Tests in mice. Riparin III was administered intraperitoneally to male mice at single doses of 25 and 50 mg/kg. The results showed that riparin III with both doses had no effects on spontaneous motor activity in mice or in the rotarod Test, but decreased the number of grooming and rearing. At the dose of 50 mg/kg, riparin III increased the number of entries in the open arms of the EPM Test as compared with control. Similarly, in the Hole-Board Test, both doses increased the number of head dips. There was a reduction on the sleeping latency with both doses and a prolongation of the pentobarbital-induced sleeping time with the dose of 25 mg/kg. In the tail suspension Test, similar to imipramine (30 mg/kg), riparin III at the dose of 50 mg/kg presented a reduction in the immobility time. In the forced swimming Test, both doses of riparin III decreased the immobility time. These results showed that riparin III potentiated the barbiturate-induced sleeping time and presented antidepressant- and anxiolytic-like effects.
Florian Holsboer - One of the best experts on this subject based on the ideXlab platform.
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long term anxiolytic and antidepressant like behavioural effects of tiagabine a selective gaba transporter 1 gat 1 inhibitor coincide with a decrease in hpa system activity in c57bl 6 mice
Journal of Psychopharmacology, 2010Co-Authors: Christoph K Thoeringer, Florian Holsboer, Angelika Erhardt, Inge Sillaber, M. Mueller, Martin E KeckAbstract:Gamma-aminobutyric acid (GABA) system plays a pivotal role in the pathophysiology of anxiety and mood disorders. This study was aimed to assess the anxiolytic and antidepressant-like properties of tiagabine, an inhibitor of the GABA transporter-1 (GAT-1), after acute and chronic administration in C57BL/6JOlaHsD mice with paroxetine as a positive control. In first experiments, the acute administration of tiagabine (7.5 mg/kg, orally [PO]) and paroxetine (10 mg/kg PO) induced anxiolytic effects in the elevated plus maze Test and the modified Hole Board Test and an antidepressant-like effect in the forced swim Test. Chronic application of tiagabine (7.5 mg/kg PO) and paroxetine (10 mg/kg PO) for 22 days revealed an anxiolytic and antidepressant-like efficacy of tiagabine only. In a further experiment, we analysed the impact of chronic tiagabine versus paroxetine treatment on the hypothalamic-pituitary-adrenocortical (HPA) system regulation. GAT-1 blockade induced a setpoint-shift of the stress hormone system...
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consequences of chronic social stress on behaviour and vasopressin gene expression in the pvn of dba 2olahsd mice influence of treatment with the crhr1 antagonist r121919 nbi 30775
Journal of Psychopharmacology, 2009Co-Authors: Angelika Erhardt, Florian Holsboer, Frauke Ohl, Marianne B Muller, A Rodel, Tobias Welt, Martin E KeckAbstract:Accumulating evidence suggests that corticotropin-releasing hormone (CRH) neurocircuitry modulate the neuroendocrine and behavioural phenotypes in depression and anxiety. Thus, the administration of the selective CRH-receptor 1 (CRHR1)—antagonist R121919/NBI 30775 has proven its ability to act as an anxiolytic in rats. It is still unclear whether vasopressinergic neuronal circuits, which are known to be involved in the regulation of emotionality, are affected by R121919/NBI 30775. Using DBA/2OlaHsd mice, we investigated the effects of chronic social defeat and concomitant treatment with R121919/NBI 30775 on 1) the behavioural profile in the modified Hole Board Test and 2) in-situ hybridization analysis—based expression of arginine vasopressin (AVP) and CRH mRNA in both the hypothalamic paraventricular nucleus and supraoptic nucleus. The results suggest that chronic social defeat leads to increased avoidance behaviour and reduction in directed exploration, general exploration, and locomotion. Chronic treat...
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impact of high and low anxiety on cognitive performance in a modified Hole Board Test in c57bl 6 and dba 2 mice
European Journal of Neuroscience, 2003Co-Authors: Angelika Roedel, E B Binder, Florian HolsboerAbstract:: We investigated the interaction between behavioural dimensions and cognitive performance in the inbred mouse strains C57BL/6 and DBA/2, which have previously been found to differ in cognitive performance and emotionality. Because it has never been evaluated whether cognitive performance and emotional behaviour are interrelated in these strains, we analysed various behavioural dimensions and cognitive functions in parallel using the modified Hole Board Test. We could show that naive BL6 and DBA mice distinctly differed in terms of anxiety-related behaviour. Principal component analysis on the phenotyping data showed that anxiety-related behaviour was described by identical parameters and was not correlated to locomotion in the two strains. During cognitive Testing, DBA mice habituated faster and performed better than BL6 mice. Principal component analysis indicated a close correlation between anxiety-related behaviour and cognitive performance in DBA mice, being associated with a highly successful cognitive performance. In BL6 mice, cognition was correlated to general exploration. This correlation turned out to be less successful in performing the modified Hole Board Test. Our findings support the idea that high anxiety may interact with specific cognitive processing, thus offering a promising animal model for future preclinical research on the interaction of anxiety and cognition.
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differential analysis of behavior and diazepam induced alterations in c57bl 6n and balb c mice using the modified Hole Board Test
Journal of Psychiatric Research, 2001Co-Authors: Frauke Ohl, Inge Sillaber, Martin E Keck, E Binder, Florian HolsboerAbstract:A variety of Test procedures are used in preclinical research on behavioral pharmacology and to dissociate behavioral differences or pharmacologically induced behavioral alterations several independent Tests are usually performed. In the present study we introduce a modified Hole Board procedure for mice which allows us to investigate a variety of behavioral parameters such as anxiety, risk assessment, exploration, locomotion, food-intake inhibition, novelty seeking, and arousal by using only one Test. The modified Hole Board was established by investigating the behavior of two inbred mouse strains, C57BL/6 and BALB. Significant differences in terms of locomotor activity, general exploration, and other parameters were found. Moreover, strain-specific exploration strategies could be detected in the modified Hole Board. Further, the Test was validated by investigating the effects of diazepam as standard anxiolytic on the behavior in both mouse strains. Acute administration of diazepam (1 and 3 mg/kg) induced strong sedative effects in a dose-dependent manner in C57BL/6 mice. In BALB mice, the lower dosage of diazepam showed an activating and anxiolytic action while the 3 mg dosage revealed a slight sedative but still anxiolytic effect in these animals. Taken together, the results demonstrate that the modified Hole Board enables to differentially investigate behavioral phenotypes and also pharmacologically-induced behavioral alterations in mice. Therefore, this new strategy allows to reduce the number of experimental animals and the time needed, thus, representing an effective screening-tool for behavioral investigations.
Carla Thiciane Vasconcelos De Melo - One of the best experts on this subject based on the ideXlab platform.
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anxiolytic like effects of o methyl n 2 6 dihydroxybenzoyl tyramine riparin iii from aniba riparia nees mez lauraceae in mice
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Carla Thiciane Vasconcelos De Melo, Andreisa Paiva Monteiro, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros Viana, Vera Targino Moreira Lima, Caroline Porto Leite, Fernando Luiz Oliveira De Araujo, Francisca Clea Florenco De SousaAbstract:This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (Nees) Mez (Lauraceae) in animal models of open field, rota rod, elevated plus maze and Hole Board Tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod Test nor in the number of squares crossed in the open field Test. However, riparin III decreased the number of grooming and rearing. In the plus maze Test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the Holes of the Hole Board Test. These results show that riparin III presents anxiolytic effects in the plus maze and Hole Board Tests which are not influenced by the locomotor activity in the open field Test.
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antianxiety effects of riparin i from aniba riparia nees mez lauraceae in mice
Phytotherapy Research, 2005Co-Authors: Francisca Clea Florenco De Sousa, Stanley Juan Chavez Gutierrez, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Glicio Reboucas Oliveira, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros VianaAbstract:This work presents the behavioral effects of riparin I (methyl ether of N-benzoyl tyramine) from unripe fruit of Aniba riparia (Lauraceae) on the elevated plus maze, open field, rota rod and Hole Board Tests in mice. Riparin I was administered acutely by intraperitoneal (i.p.) and oral routes to male mice at doses of 25 and 50 mg/kg. The results showed that riparin I (25 and 50 mg/kg, i.p. and per os) increased the number of entries and the time of permanence in the open arms in the plus maze Test. Similarly, in the Hole Board Test, riparin I in both routes increased the number of head dips. Riparin I with both doses and routes had no effects on spontaneous motor activity in mice or in the rota rod Test, but decreased the number of groomings. These results showed that riparin I by both administration routes has effects on the central nervous system with antianxiety effects on the plus maze and Hole Board Tests. The substance is devoid of myorelaxant effects. Copyright © 2005 John Wiley & Sons, Ltd.
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antianxiety and antidepressant effects of riparin iii from aniba riparia nees mez lauraceae in mice
Pharmacology Biochemistry and Behavior, 2004Co-Authors: Francisca Clea Florenco De Sousa, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Silvânia Maria Mendes Vasconcelos, Jose Maria Barbosafilho, Vera Targino Moreira Lima, Stanley Juan Chaves Gutierrez, B A Pereira, M F Fonteles, G S B VianaAbstract:This work presents behavioral effects of methyl ethers of N-(2,6-dihydroxybenzoyl) tyramine (riparin III) isolated from the unripe fruit of Aniba riparia on the open field, elevated plus maze (EPM), rotarod, Hole Board, barbiturate-induced sleeping time, tail suspension and forced swimming Tests in mice. Riparin III was administered intraperitoneally to male mice at single doses of 25 and 50 mg/kg. The results showed that riparin III with both doses had no effects on spontaneous motor activity in mice or in the rotarod Test, but decreased the number of grooming and rearing. At the dose of 50 mg/kg, riparin III increased the number of entries in the open arms of the EPM Test as compared with control. Similarly, in the Hole-Board Test, both doses increased the number of head dips. There was a reduction on the sleeping latency with both doses and a prolongation of the pentobarbital-induced sleeping time with the dose of 25 mg/kg. In the tail suspension Test, similar to imipramine (30 mg/kg), riparin III at the dose of 50 mg/kg presented a reduction in the immobility time. In the forced swimming Test, both doses of riparin III decreased the immobility time. These results showed that riparin III potentiated the barbiturate-induced sleeping time and presented antidepressant- and anxiolytic-like effects.
Glauce Socorro De Barros Viana - One of the best experts on this subject based on the ideXlab platform.
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anxiolytic like effects of o methyl n 2 6 dihydroxybenzoyl tyramine riparin iii from aniba riparia nees mez lauraceae in mice
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Carla Thiciane Vasconcelos De Melo, Andreisa Paiva Monteiro, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros Viana, Vera Targino Moreira Lima, Caroline Porto Leite, Fernando Luiz Oliveira De Araujo, Francisca Clea Florenco De SousaAbstract:This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (Nees) Mez (Lauraceae) in animal models of open field, rota rod, elevated plus maze and Hole Board Tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod Test nor in the number of squares crossed in the open field Test. However, riparin III decreased the number of grooming and rearing. In the plus maze Test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the Holes of the Hole Board Test. These results show that riparin III presents anxiolytic effects in the plus maze and Hole Board Tests which are not influenced by the locomotor activity in the open field Test.
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antianxiety effects of riparin i from aniba riparia nees mez lauraceae in mice
Phytotherapy Research, 2005Co-Authors: Francisca Clea Florenco De Sousa, Stanley Juan Chavez Gutierrez, Andreisa Paiva Monteiro, Carla Thiciane Vasconcelos De Melo, Glicio Reboucas Oliveira, Silvânia Maria Mendes Vasconcelos, Marta Maria De Franca Fonteles, Jose Maria Barbosafilho, Glauce Socorro De Barros VianaAbstract:This work presents the behavioral effects of riparin I (methyl ether of N-benzoyl tyramine) from unripe fruit of Aniba riparia (Lauraceae) on the elevated plus maze, open field, rota rod and Hole Board Tests in mice. Riparin I was administered acutely by intraperitoneal (i.p.) and oral routes to male mice at doses of 25 and 50 mg/kg. The results showed that riparin I (25 and 50 mg/kg, i.p. and per os) increased the number of entries and the time of permanence in the open arms in the plus maze Test. Similarly, in the Hole Board Test, riparin I in both routes increased the number of head dips. Riparin I with both doses and routes had no effects on spontaneous motor activity in mice or in the rota rod Test, but decreased the number of groomings. These results showed that riparin I by both administration routes has effects on the central nervous system with antianxiety effects on the plus maze and Hole Board Tests. The substance is devoid of myorelaxant effects. Copyright © 2005 John Wiley & Sons, Ltd.