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Thomas C. Wascher - One of the best experts on this subject based on the ideXlab platform.
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insulin resistance as a risk factor for carotid atherosclerosis a comparison of the Homeostasis Model Assessment and the short insulin tolerance test
Stroke, 2008Co-Authors: Harald Sourij, I. Schmoelzer, Peter Dittrich, Bernhard Paulweber, Bernhard Iglseder, Thomas C. WascherAbstract:Background and Purpose— The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. Methods— A total of 1771 middle-aged white patients were investigated. Intima media thickness (IMT) and extent of carotid atherosclerosis were quantified by ultrasound. HOMA was calculated and an insulin tolerance test was performed. Results— HOMA and kITT were significant predictors for average carotid IMT (P<0.001). After adjustment for age and the components of the metabolic syndrome, HOMA still remained an independent predictor for IMTavg (P=0.02), whereas kITT failed to do so. HOMA and kITT were also predictive (P=0.004 and P=0.024) for carotid plaques and extent of carotid atherosclerosis (P<0.001). After adjustment for age and the components of the metabolic syndrome, neither HOMA nor kITT were ...
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Insulin resistance as a risk factor for carotid atherosclerosis: a comparison of the Homeostasis Model Assessment and the short insulin tolerance test.
Stroke, 2008Co-Authors: Harald Sourij, I. Schmoelzer, Peter Dittrich, Bernhard Paulweber, Bernhard Iglseder, Thomas C. WascherAbstract:Background and Purpose— The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. Methods— A total of 1771 middle-aged white patients were investigated. Intima media thickness (IMT) and extent of carotid atherosclerosis were quantified by ultrasound. HOMA was calculated and an insulin tolerance test was performed. Results— HOMA and kITT were significant predictors for average carotid IMT (P
Mervat E Behiry - One of the best experts on this subject based on the ideXlab platform.
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Abdominal subcutaneous fat thickness and Homeostasis Model Assessment of insulin resistance as simple predictors of nonalcoholic steatohepatitis.
Diabetes Metabolic Syndrome and Obesity: Targets and Therapy, 2019Co-Authors: Mona A. Hegazy, Maysa A Samy, Afaf Tawfik, Mervat Naguib, Ahmed Ezzat, Mervat E BehiryAbstract:Background: Obesity, insulin resistance, and diabetes are major risk factors for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the association between different grades of NAFLD and abdominal subcutaneous fat thickness with the Homeostasis Model Assessment of insulin resistance (HOMA-IR). Methods: In this pilot study, 59 obese nondiabetic participants with NAFLD were enrolled. Total cholesterol, HbA1c, and HOMA-IR were measured. Abdominal subcutaneous fat thickness in the midline just below the xiphoid process in front of the left lobe of the liver (LSFT) and in the umbilical region (USFT), and the degree of hepatic steatosis, were evaluated by ultrasound scans, and their correlation with the degree of steatosis and the NAFLD Activity Score in liver biopsy was assessed. Results: Of the 59 studied participants, 15 had mild, 17 had moderate, and 27 had severe hepatic steatosis by abdominal ultrasound. The mean ± SD HOMA-IR level in NAFLD patients was 5.41±2.70. The severity of hepatic steatosis positively correlated with body mass index (P
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abdominal subcutaneous fat thickness and Homeostasis Model Assessment of insulin resistance as simple predictors of nonalcoholic steatohepatitis
Diabetes Metabolic Syndrome and Obesity: Targets and Therapy, 2019Co-Authors: Mona A. Hegazy, Maysa A Samy, Afaf Tawfik, Mervat Naguib, Ahmed Ezzat, Mervat E BehiryAbstract:Background: Obesity, insulin resistance, and diabetes are major risk factors for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the association between different grades of NAFLD and abdominal subcutaneous fat thickness with the Homeostasis Model Assessment of insulin resistance (HOMA-IR). Methods: In this pilot study, 59 obese nondiabetic participants with NAFLD were enrolled. Total cholesterol, HbA1c, and HOMA-IR were measured. Abdominal subcutaneous fat thickness in the midline just below the xiphoid process in front of the left lobe of the liver (LSFT) and in the umbilical region (USFT), and the degree of hepatic steatosis, were evaluated by ultrasound scans, and their correlation with the degree of steatosis and the NAFLD Activity Score in liver biopsy was assessed. Results: Of the 59 studied participants, 15 had mild, 17 had moderate, and 27 had severe hepatic steatosis by abdominal ultrasound. The mean ± SD HOMA-IR level in NAFLD patients was 5.41±2.70. The severity of hepatic steatosis positively correlated with body mass index (P<0.001), HOMA-IR (P<0.001), serum triglycerides (P=0.001), LSFT (P<0.001), and USFT (P<0.001). Receiver operating characteristics analysis showed that LSFT at a cut-off of 3.45 cm is the most accurate predictor of severe hepatic steatosis, with 74.1% sensitivity and 84.4% specificity. The best cut-off of USFT for identifying severe hepatic steatosis is 4.55 cm, with 63% sensitivity and 81.3% specificity. Conclusion: Abdominal subcutaneous fat thicknesses in front of the left lobe of the liver and in the umbilical region, together with HOMA-IR, are reliable indicators of the severity of NAFLD in obese nondiabetic individuals.
Harald Sourij - One of the best experts on this subject based on the ideXlab platform.
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insulin resistance as a risk factor for carotid atherosclerosis a comparison of the Homeostasis Model Assessment and the short insulin tolerance test
Stroke, 2008Co-Authors: Harald Sourij, I. Schmoelzer, Peter Dittrich, Bernhard Paulweber, Bernhard Iglseder, Thomas C. WascherAbstract:Background and Purpose— The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. Methods— A total of 1771 middle-aged white patients were investigated. Intima media thickness (IMT) and extent of carotid atherosclerosis were quantified by ultrasound. HOMA was calculated and an insulin tolerance test was performed. Results— HOMA and kITT were significant predictors for average carotid IMT (P<0.001). After adjustment for age and the components of the metabolic syndrome, HOMA still remained an independent predictor for IMTavg (P=0.02), whereas kITT failed to do so. HOMA and kITT were also predictive (P=0.004 and P=0.024) for carotid plaques and extent of carotid atherosclerosis (P<0.001). After adjustment for age and the components of the metabolic syndrome, neither HOMA nor kITT were ...
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Insulin resistance as a risk factor for carotid atherosclerosis: a comparison of the Homeostasis Model Assessment and the short insulin tolerance test.
Stroke, 2008Co-Authors: Harald Sourij, I. Schmoelzer, Peter Dittrich, Bernhard Paulweber, Bernhard Iglseder, Thomas C. WascherAbstract:Background and Purpose— The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. Methods— A total of 1771 middle-aged white patients were investigated. Intima media thickness (IMT) and extent of carotid atherosclerosis were quantified by ultrasound. HOMA was calculated and an insulin tolerance test was performed. Results— HOMA and kITT were significant predictors for average carotid IMT (P
C E Tan - One of the best experts on this subject based on the ideXlab platform.
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Homeostasis Model Assessment in a population with mixed ethnicity: the 1992 Singapore National Health Survey
Diabetes Research and Clinical Practice, 2000Co-Authors: E S Tai, S C Lim, S K Chew, B Y Tan, C E TanAbstract:Abstract We studied insulin resistance and β-cell function with reference to ethnic group, glucose tolerance and other coronary artery disease risk factors in a cross section of the Singapore population which comprises Chinese, Malays and Asian Indians. 3568 individuals aged 18–69 were examined. Blood pressure, anthropometric data, blood lipids, glucose and insulin were assayed in the fasting state. Glucose and serum insulin were measured 2 h after an oral glucose challenge. Insulin resistance and β-cell function were calculated using Homeostasis Model Assessment. Asian Indians had higher insulin resistance than Chinese or Malays. Impaired glucose tolerance (IGT) and diabetes mellitus (DM) were associated with greater insulin resistance and impaired β-cell function compared to normal glucose tolerance (NGT). Insulin resistance was positively correlated with blood pressure in women and total cholesterol, LDL cholesterol and triglyceride in both men and women. It was negatively correlated with HDL cholesterol and LDL/apolipoprotein B ratio. β-cell function showed no significant correlations with the cardiovascular risk factors studied. It appears that both impaired β-cell function and insulin resistance are important for the development of hyperglycemia whereas insulin resistance alone seems more important in the development of coronary artery disease as it correlates with several known coronary artery disease risk factors.
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Homeostasis Model Assessment in a population with mixed ethnicity: the 1992 Singapore National Health Survey.
Diabetes research and clinical practice, 2000Co-Authors: E S Tai, S C Lim, S K Chew, B Y Tan, C E TanAbstract:We studied insulin resistance and beta-cell function with reference to ethnic group, glucose tolerance and other coronary artery disease risk factors in a cross section of the Singapore population which comprises Chinese, Malays and Asian Indians. 3568 individuals aged 18-69 were examined. Blood pressure, anthropometric data, blood lipids, glucose and insulin were assayed in the fasting state. Glucose and serum insulin were measured 2 h after an oral glucose challenge. Insulin resistance and beta-cell function were calculated using Homeostasis Model Assessment. Asian Indians had higher insulin resistance than Chinese or Malays. Impaired glucose tolerance (IGT) and diabetes mellitus (DM) were associated with greater insulin resistance and impaired beta-cell function compared to normal glucose tolerance (NGT). Insulin resistance was positively correlated with blood pressure in women and total cholesterol, LDL cholesterol and triglyceride in both men and women. It was negatively correlated with HDL cholesterol and LDL/apolipoprotein B ratio. beta-cell function showed no significant correlations with the cardiovascular risk factors studied. It appears that both impaired beta-cell function and insulin resistance are important for the development of hyperglycemia whereas insulin resistance alone seems more important in the development of coronary artery disease as it correlates with several known coronary artery disease risk factors.
Farzad Hadaegh - One of the best experts on this subject based on the ideXlab platform.
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fasting plasma glucose is a stronger predictor of diabetes than triglyceride glucose index triglycerides high density lipoprotein cholesterol and Homeostasis Model Assessment of insulin resistance tehran lipid and glucose study
Acta Diabetologica, 2018Co-Authors: Maryam Tohidi, Fereidoun Azizi, Noushin Sadat Ahanchi, Aidin Baghbanioskouei, Farzad HadaeghAbstract:Aims To compare the impact of triglyceride–glucose index (TyG-index), the product of fasting plasma glucose (FPG) and triglycerides (TG) with FPG, 2 h post-challenge plasma glucose (2 h-PCPG), TG/high-density lipoprotein cholesterol (TG/HDL-C), and Homeostasis Model Assessment of insulin resistance (HOMA-IR) indices for prediction of type 2 diabetes (T2D) in Iranian adults during a median follow-up of 12 years.
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Fasting plasma glucose is a stronger predictor of diabetes than triglyceride-glucose index, triglycerides/high-density lipoprotein cholesterol, and Homeostasis Model Assessment of insulin resistance: Tehran Lipid and Glucose Study.
Acta diabetologica, 2018Co-Authors: Maryam Tohidi, Fereidoun Azizi, Aidin Baghbani-oskouei, Noushin Sadat Ahanchi, Farzad HadaeghAbstract:Aims To compare the impact of triglyceride–glucose index (TyG-index), the product of fasting plasma glucose (FPG) and triglycerides (TG) with FPG, 2 h post-challenge plasma glucose (2 h-PCPG), TG/high-density lipoprotein cholesterol (TG/HDL-C), and Homeostasis Model Assessment of insulin resistance (HOMA-IR) indices for prediction of type 2 diabetes (T2D) in Iranian adults during a median follow-up of 12 years.
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Cut-off points of Homeostasis Model Assessment of insulin resistance, beta-cell function, and fasting serum insulin to identify future type 2 diabetes: Tehran Lipid and Glucose Study
Acta diabetologica, 2015Co-Authors: Asghar Ghasemi, Maryam Tohidi, Arash Derakhshan, Mitra Hasheminia, Fereidoun Azizi, Farzad HadaeghAbstract:Aims To determine cut-off points of Homeostasis Model Assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-B), insulin sensitivity (HOMA-S), and fasting insulin for identifying the subjects with type 2 diabetes mellitus (T2DM) in Iranian adults using data from a prospective population-based study.