The Experts below are selected from a list of 747 Experts worldwide ranked by ideXlab platform
Timothy Clark - One of the best experts on this subject based on the ideXlab platform.
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facile formation of β hydroxyboronate esters by a cu catalyzed diboration matteson Homologation sequence
2014Co-Authors: Cameron M. Moore, Casey R. Medina, Peter C. Cannamela, Melissa L. Mcintosh, Carl J. Ferber, Andrew J. Roering, Timothy ClarkAbstract:The copper-catalyzed diboration of aldehydes was used in conjunction with the Matteson Homologation, providing the efficient synthesis of β-hydroxyboronate esters. The oxygen-bound boronate ester was found to play a key role in mediating the Homologation Reaction, which was compared to the α-hydroxyboronate ester (isolated hydrolysis product). The synthetic utility of the diboration/Homologation sequence was demonstrated through the oxidation of one product to provide a 1,2-diol.
Joana Gordo - One of the best experts on this subject based on the ideXlab platform.
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catalyst free aziridination and unexpected Homologation of aziridines from imines
2010Co-Authors: Paula S Branco, Vivek P Raje, Jorge Dourado, Joana GordoAbstract:Aziridination and Homologation Reaction of N-sulfonylimines are easily achieved by the present new, very simple, rapid and mild procedure using diazomethane as carbene source without any catalyst.
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catalyst free aziridination and unexpected Homologation of aziridines from imines
2010Co-Authors: Paula S Branco, Vivek P Raje, Jorge Dourado, Joana GordoAbstract:Aziridination and unpredicted Homologation Reaction of N-sulfonylimines were achieved easily with a very simple, rapid and mild procedure through the use of diazomethane without the presence of any catalyst. The method represents an attractive alternative to metal-catalyzed processes.
Andrew J. Roering - One of the best experts on this subject based on the ideXlab platform.
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Facile Formation of β‑Hydroxyboronate Esters by a Cu-Catalyzed Diboration/Matteson Homologation Sequence
2016Co-Authors: Andrew J. Roering, Timothy B. ClarkAbstract:ABSTRACT: The copper-catalyzed diboration of aldehydes was used in conjunction with the Matteson Homologation, providing the efficient synthesis of β-hydroxyboronate esters. The oxygen-bound boronate ester was found to play a key role in mediating the Homologation Reaction, which was compared to the α-hydroxyboronate ester (isolated hydrolysis product). The synthetic utility of the diboration/Homologation sequence was demonstrated through the oxidation of one product to provide a 1,2-diol. Advances in methods that incorporate boron into organiccompounds1−11 and those which utilize the carbon−boron bond1,6,7,10−15 for a variety of transformations have resulted in its extensive use as a synthetic handle in target-directed synthesis. Boron has also seen numerous direct applications to health issues, including the first boron-containing pharmaceutical drug Velcade.16,17 While the traditional methods to incorporate boron into an organic substrate, such as hydroboration of alkenes an
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Facile Formation of β‑Hydroxyboronate Esters by a Cu-Catalyzed Diboration/Matteson Homologation Sequence
2015Co-Authors: Cameron M. Moore, Casey R. Medina, Peter C. Cannamela, Melissa L. Mcintosh, Carl J. Ferber, Andrew J. Roering, Timothy B. ClarkAbstract:The copper-catalyzed diboration of aldehydes was used in conjunction with the Matteson Homologation, providing the efficient synthesis of β-hydroxyboronate esters. The oxygen-bound boronate ester was found to play a key role in mediating the Homologation Reaction, which was compared to the α-hydroxyboronate ester (isolated hydrolysis product). The synthetic utility of the diboration/Homologation sequence was demonstrated through the oxidation of one product to provide a 1,2-diol
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facile formation of β hydroxyboronate esters by a cu catalyzed diboration matteson Homologation sequence
2014Co-Authors: Cameron M. Moore, Casey R. Medina, Peter C. Cannamela, Melissa L. Mcintosh, Carl J. Ferber, Andrew J. Roering, Timothy ClarkAbstract:The copper-catalyzed diboration of aldehydes was used in conjunction with the Matteson Homologation, providing the efficient synthesis of β-hydroxyboronate esters. The oxygen-bound boronate ester was found to play a key role in mediating the Homologation Reaction, which was compared to the α-hydroxyboronate ester (isolated hydrolysis product). The synthetic utility of the diboration/Homologation sequence was demonstrated through the oxidation of one product to provide a 1,2-diol.
Cameron M. Moore - One of the best experts on this subject based on the ideXlab platform.
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facile formation of β hydroxyboronate esters by a cu catalyzed diboration matteson Homologation sequence
2014Co-Authors: Cameron M. Moore, Casey R. Medina, Peter C. Cannamela, Melissa L. Mcintosh, Carl J. Ferber, Andrew J. Roering, Timothy ClarkAbstract:The copper-catalyzed diboration of aldehydes was used in conjunction with the Matteson Homologation, providing the efficient synthesis of β-hydroxyboronate esters. The oxygen-bound boronate ester was found to play a key role in mediating the Homologation Reaction, which was compared to the α-hydroxyboronate ester (isolated hydrolysis product). The synthetic utility of the diboration/Homologation sequence was demonstrated through the oxidation of one product to provide a 1,2-diol.
Haiying Zhao - One of the best experts on this subject based on the ideXlab platform.
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synthesis of allene ferrocenes through cui mediated crabbe Homologation Reaction
2013Co-Authors: Shufeng Chen, Binglong Wang, Qing Yan, Jinxiang Shi, Haiying ZhaoAbstract:A concise and efficient method for the synthesis of bifunctional allene ferrocenes based on the modified Crabbe Homologation Reaction of ferrocenylacetylenes with paraformaldehyde promoted by CuI was developed. The presented synthesis proceeded readily with high compatibility of sensitive functional groups on the cyclopentadiene ring providing good to excellent yields of the desired products.
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synthesis of alleneferrocenes through cui mediated crabbe Homologation Reaction
2013Co-Authors: Shufeng Chen, Binglong Wang, Qing Yan, Jinxiang Shi, Haiying ZhaoAbstract:A concise and efficient method for the synthesis of bifunctional allene ferrocenes based on the modified Crabbe Homologation Reaction of ferrocenylacetylenes with paraformaldehyde promoted by CuI was developed. The presented synthesis proceeded readily with high compatibility of sensitive functional groups on the cyclopentadiene ring providing good to excellent yields of the desired products.