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Arne Viestenz - One of the best experts on this subject based on the ideXlab platform.
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Periokuläre Metastase als Differenzialdiagnose eines „pyogenen Granuloms“ und Therapiemarker einer Systemerkrankung
Der Ophthalmologe, 2019Co-Authors: Jens Heichel, U. Siebolts, Claudia Wickenhauser, Arne ViestenzAbstract:Background A pyogenic granuloma is a frequent palpebral pseudotumor. Showing a typical clinical picture after an inflammation (Hordeolum, chalazion) it can be easily diagnosed and sometimes a histopathological analysis is thought to be unnecessary. Methods A case report of a patient suffering from a palpebral metastasis of a clear cell renal cell carcinoma (cRCC) as an atypical differential diagnosis of an inflammatory pseudotumor of the eyelid is presented. Results A 72-year-old man presented for surgical treatment of a pyogenic granuloma. The medial portion of the inferior eyelid showed a nodular and pediculate lesion of the tarsal conjunctiva. At the time of presentation the patient was receiving adjuvant systemic treatment with cabozantinib because of lymphonodal and pulmonal metastases of the cRCC. The tumor was resected and the histopathological examination revealed a sarcomatoid dedifferentiated metastasis of the cRCC. After 4 weeks the tumor showed a local recurrence and histologically a local relapse was found. Therefore, a change in the systemic therapy was initiated (nivolumab). In the follow-up of 18 months no recurrence of the palpebral tumor occurred. A stable disease condition of the cRCC was achieved. Conclusion Even if the clinical aspect of an inflammatory tumor of the lids seems to be clear, a histopathological examination is still necessary. An interdisciplinary approach with reevaluation of the systemic therapy led to an improvement of the patient treatment. Einleitung Das „pyogene Granulom“ gehört zu den geläufigen palpebralen Pseudotumoren. Das zumeist typische klinische Bild, verbunden mit einer entsprechenden Anamnese mit stattgehabter Entzündung (Hordeolum/Chalazion), kann die Notwendigkeit einer histopathologischen Abklärung als überflüssig erscheinen lassen. Methoden Anhand einer Kasuistik wird ein metastasiertes Nierenzellkarzinom als überraschende Differenzialdiagnose zu einem entzündlichen Pseudotumor des Augenlides dargestellt. Ergebnisse Ein 72 Jahre alter Mann wurde zur chirurgischen Entfernung eines „pyogenen Granuloms“ vorgestellt. Es zeigte sich eine nodulär-gestielte Raumforderung, ausgehend vom inneren Lidblatt im Bereich des medialen Unterlides des linken Auges. Zum Zeitpunkt der Vorstellung erhielt der Mann eine adjuvante Systemtherapie (Cabozantinib) bei lymphonodal und pulmonal metastasiertem klarzelligem Nierenzellkarzinom. Die Veränderung des Augenlides wurde reseziert und zur histopathologischen Aufarbeitung eingesandt. Hier zeigte sich das Zellbild einer sarkomatoid entdifferenzierten Metastase im Rahmen der genannten Grunderkrankung. Nach 4 Wochen kam es an gleicher Stelle zu einem größenprogredienten Lokalrezidiv. Der Lidtumor wurde erneut reseziert und histopathologisch untersucht. Die Metastase war nochmals gewachsen. Daraufhin wurde die onkologische Klinik kontaktiert, um eine Umstellung der Systemtherapie einzuleiten. Nach Neueinstellung der Therapie mit Nivolumab kam es zu keinem erneuten Lokalrezidiv. Das Follow-up beträgt nunmehr 18 Monate. Die Grundkrankheit ist seither kontrolliert. Schlussfolgerung Auch klinisch vermeintlich eindeutig einzustufende tumoröse periokuläre Veränderungen bedürfen einer histopathologischen Abklärung. Eine interdisziplinäre Re-Evaluierung mit Umstellung der Systemtherapie ermöglichte eine bessere Patientenversorgung.
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Periokuläre Metastase als Differenzialdiagnose eines „pyogenen Granuloms“ und Therapiemarker einer Systemerkrankung
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2019Co-Authors: Jens Heichel, U. Siebolts, Claudia Wickenhauser, Arne ViestenzAbstract:Einleitung Das „pyogene Granulom“ gehort zu den gelaufigen palpebralen Pseudotumoren. Das zumeist typische klinische Bild, verbunden mit einer entsprechenden Anamnese mit stattgehabter Entzundung (Hordeolum/Chalazion), kann die Notwendigkeit einer histopathologischen Abklarung als uberflussig erscheinen lassen.
Kay Dickersin - One of the best experts on this subject based on the ideXlab platform.
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The Cochrane Library - Non-surgical interventions for acute internal Hordeolum.
The Cochrane database of systematic reviews, 2017Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background A Hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and resolves without treatment; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. If unresolved, an acute internal Hordeolum can become chronic, or can develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness, and when possible, the safety, of non-surgical treatments for acute internal hordeola compared with observation or placebo. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register (2016; Issue 12)), MEDLINE Ovid, MEDLINE Ovid Epub Ahead of Print, MEDLINE Ovid In-Process & Other Non-Indexed Citations, MEDLINE(R) Ovid Daily (January 1946 to December 2016), Embase (January 1947 to December 2016), PubMed (1948 to December 2016), Latin American and Caribbean Literature on Health Sciences (LILACS (January 1982 to December 2016)), the metaRegister of Controlled Trials (mRCT; www.controlled-trials.com (last searched 26 July 2012)), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We used no date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 2 December 2016. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of participants diagnosed with an acute internal Hordeolum. Studies of participants with external hordeola (styes), chronic hordeola, or chalazia were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared with observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results No trials were identified for this review. Most of the references identified through our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal hordeola reported recommendations for treatment, were reports of interventional case series, case studies, or other types of observational study designs, and were published more than 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of an internal Hordeolum. Controlled clinical trials would be useful to determine which interventions are effective for the treatment of acute internal hordeola.
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non surgical interventions for acute internal Hordeolum
Cochrane Database of Systematic Reviews, 2017Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background A Hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and resolves without treatment; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. If unresolved, an acute internal Hordeolum can become chronic, or can develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness, and when possible, the safety, of non-surgical treatments for acute internal hordeola compared with observation or placebo. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register (2016; Issue 12)), MEDLINE Ovid, MEDLINE Ovid Epub Ahead of Print, MEDLINE Ovid In-Process & Other Non-Indexed Citations, MEDLINE(R) Ovid Daily (January 1946 to December 2016), Embase (January 1947 to December 2016), PubMed (1948 to December 2016), Latin American and Caribbean Literature on Health Sciences (LILACS (January 1982 to December 2016)), the metaRegister of Controlled Trials (mRCT; www.controlled-trials.com (last searched 26 July 2012)), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We used no date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 2 December 2016. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of participants diagnosed with an acute internal Hordeolum. Studies of participants with external hordeola (styes), chronic hordeola, or chalazia were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared with observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results No trials were identified for this review. Most of the references identified through our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal hordeola reported recommendations for treatment, were reports of interventional case series, case studies, or other types of observational study designs, and were published more than 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of an internal Hordeolum. Controlled clinical trials would be useful to determine which interventions are effective for the treatment of acute internal hordeola.
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The Cochrane Library - Interventions for acute internal Hordeolum
The Cochrane database of systematic reviews, 2013Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. If unresolved, acute internal Hordeolum can become chronic or develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness and safety of non-surgical treatments for acute internal Hordeolum compared to observation or placebo. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of patients diagnosed with acute internal Hordeolum. Studies of patients with external Hordeolum (stye), chronic Hordeolum or chalazion were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared to observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by the electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results There were no trials identified for inclusion in this review. The majority of the references identified from our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal Hordeolum reported mostly recommendations for treatment or were reports of interventional case series, case studies, or other types of observational study designs and were published over 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of Hordeolum. Controlled clinical trials would be useful in determining which interventions are effective for the treatment of acute internal Hordeolum.
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interventions for acute internal Hordeolum
Cochrane Database of Systematic Reviews, 2013Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. If unresolved, acute internal Hordeolum can become chronic or develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness and safety of non-surgical treatments for acute internal Hordeolum compared to observation or placebo. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of patients diagnosed with acute internal Hordeolum. Studies of patients with external Hordeolum (stye), chronic Hordeolum or chalazion were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared to observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by the electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results There were no trials identified for inclusion in this review. The majority of the references identified from our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal Hordeolum reported mostly recommendations for treatment or were reports of interventional case series, case studies, or other types of observational study designs and were published over 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of Hordeolum. Controlled clinical trials would be useful in determining which interventions are effective for the treatment of acute internal Hordeolum.
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Interventions for acute internal Hordeolum.
The Cochrane database of systematic reviews, 2010Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. If unresolved, acute internal Hordeolum can become chronic or develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. The objective of this review was to investigate the effectiveness and safety of non-surgical treatments for acute internal Hordeolum compared to observation or placebo. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. The selection criteria for this review included randomized or quasi-randomized clinical trials of patients diagnosed with acute internal Hordeolum. Studies of patients with external Hordeolum (stye), chronic Hordeolum or chalazion were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared to observation, placebo, or other active interventions. Two review authors independently assessed the references identified by the electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. There were no trials identified for inclusion in this review. The majority of the references identified from our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal Hordeolum reported mostly recommendations for treatment or were reports of interventional case series, case studies, or other types of observational study designs and were published over 20 years ago. We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of Hordeolum. Controlled clinical trials would be useful in determining which interventions are effective for the treatment of acute internal Hordeolum.
Jens Heichel - One of the best experts on this subject based on the ideXlab platform.
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Periokuläre Metastase als Differenzialdiagnose eines „pyogenen Granuloms“ und Therapiemarker einer Systemerkrankung
Der Ophthalmologe, 2019Co-Authors: Jens Heichel, U. Siebolts, Claudia Wickenhauser, Arne ViestenzAbstract:Background A pyogenic granuloma is a frequent palpebral pseudotumor. Showing a typical clinical picture after an inflammation (Hordeolum, chalazion) it can be easily diagnosed and sometimes a histopathological analysis is thought to be unnecessary. Methods A case report of a patient suffering from a palpebral metastasis of a clear cell renal cell carcinoma (cRCC) as an atypical differential diagnosis of an inflammatory pseudotumor of the eyelid is presented. Results A 72-year-old man presented for surgical treatment of a pyogenic granuloma. The medial portion of the inferior eyelid showed a nodular and pediculate lesion of the tarsal conjunctiva. At the time of presentation the patient was receiving adjuvant systemic treatment with cabozantinib because of lymphonodal and pulmonal metastases of the cRCC. The tumor was resected and the histopathological examination revealed a sarcomatoid dedifferentiated metastasis of the cRCC. After 4 weeks the tumor showed a local recurrence and histologically a local relapse was found. Therefore, a change in the systemic therapy was initiated (nivolumab). In the follow-up of 18 months no recurrence of the palpebral tumor occurred. A stable disease condition of the cRCC was achieved. Conclusion Even if the clinical aspect of an inflammatory tumor of the lids seems to be clear, a histopathological examination is still necessary. An interdisciplinary approach with reevaluation of the systemic therapy led to an improvement of the patient treatment. Einleitung Das „pyogene Granulom“ gehört zu den geläufigen palpebralen Pseudotumoren. Das zumeist typische klinische Bild, verbunden mit einer entsprechenden Anamnese mit stattgehabter Entzündung (Hordeolum/Chalazion), kann die Notwendigkeit einer histopathologischen Abklärung als überflüssig erscheinen lassen. Methoden Anhand einer Kasuistik wird ein metastasiertes Nierenzellkarzinom als überraschende Differenzialdiagnose zu einem entzündlichen Pseudotumor des Augenlides dargestellt. Ergebnisse Ein 72 Jahre alter Mann wurde zur chirurgischen Entfernung eines „pyogenen Granuloms“ vorgestellt. Es zeigte sich eine nodulär-gestielte Raumforderung, ausgehend vom inneren Lidblatt im Bereich des medialen Unterlides des linken Auges. Zum Zeitpunkt der Vorstellung erhielt der Mann eine adjuvante Systemtherapie (Cabozantinib) bei lymphonodal und pulmonal metastasiertem klarzelligem Nierenzellkarzinom. Die Veränderung des Augenlides wurde reseziert und zur histopathologischen Aufarbeitung eingesandt. Hier zeigte sich das Zellbild einer sarkomatoid entdifferenzierten Metastase im Rahmen der genannten Grunderkrankung. Nach 4 Wochen kam es an gleicher Stelle zu einem größenprogredienten Lokalrezidiv. Der Lidtumor wurde erneut reseziert und histopathologisch untersucht. Die Metastase war nochmals gewachsen. Daraufhin wurde die onkologische Klinik kontaktiert, um eine Umstellung der Systemtherapie einzuleiten. Nach Neueinstellung der Therapie mit Nivolumab kam es zu keinem erneuten Lokalrezidiv. Das Follow-up beträgt nunmehr 18 Monate. Die Grundkrankheit ist seither kontrolliert. Schlussfolgerung Auch klinisch vermeintlich eindeutig einzustufende tumoröse periokuläre Veränderungen bedürfen einer histopathologischen Abklärung. Eine interdisziplinäre Re-Evaluierung mit Umstellung der Systemtherapie ermöglichte eine bessere Patientenversorgung.
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Periokuläre Metastase als Differenzialdiagnose eines „pyogenen Granuloms“ und Therapiemarker einer Systemerkrankung
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2019Co-Authors: Jens Heichel, U. Siebolts, Claudia Wickenhauser, Arne ViestenzAbstract:Einleitung Das „pyogene Granulom“ gehort zu den gelaufigen palpebralen Pseudotumoren. Das zumeist typische klinische Bild, verbunden mit einer entsprechenden Anamnese mit stattgehabter Entzundung (Hordeolum/Chalazion), kann die Notwendigkeit einer histopathologischen Abklarung als uberflussig erscheinen lassen.
Kristina Lindsley - One of the best experts on this subject based on the ideXlab platform.
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The Cochrane Library - Non-surgical interventions for acute internal Hordeolum.
The Cochrane database of systematic reviews, 2017Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background A Hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and resolves without treatment; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. If unresolved, an acute internal Hordeolum can become chronic, or can develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness, and when possible, the safety, of non-surgical treatments for acute internal hordeola compared with observation or placebo. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register (2016; Issue 12)), MEDLINE Ovid, MEDLINE Ovid Epub Ahead of Print, MEDLINE Ovid In-Process & Other Non-Indexed Citations, MEDLINE(R) Ovid Daily (January 1946 to December 2016), Embase (January 1947 to December 2016), PubMed (1948 to December 2016), Latin American and Caribbean Literature on Health Sciences (LILACS (January 1982 to December 2016)), the metaRegister of Controlled Trials (mRCT; www.controlled-trials.com (last searched 26 July 2012)), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We used no date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 2 December 2016. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of participants diagnosed with an acute internal Hordeolum. Studies of participants with external hordeola (styes), chronic hordeola, or chalazia were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared with observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results No trials were identified for this review. Most of the references identified through our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal hordeola reported recommendations for treatment, were reports of interventional case series, case studies, or other types of observational study designs, and were published more than 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of an internal Hordeolum. Controlled clinical trials would be useful to determine which interventions are effective for the treatment of acute internal hordeola.
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non surgical interventions for acute internal Hordeolum
Cochrane Database of Systematic Reviews, 2017Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background A Hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and resolves without treatment; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. If unresolved, an acute internal Hordeolum can become chronic, or can develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness, and when possible, the safety, of non-surgical treatments for acute internal hordeola compared with observation or placebo. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register (2016; Issue 12)), MEDLINE Ovid, MEDLINE Ovid Epub Ahead of Print, MEDLINE Ovid In-Process & Other Non-Indexed Citations, MEDLINE(R) Ovid Daily (January 1946 to December 2016), Embase (January 1947 to December 2016), PubMed (1948 to December 2016), Latin American and Caribbean Literature on Health Sciences (LILACS (January 1982 to December 2016)), the metaRegister of Controlled Trials (mRCT; www.controlled-trials.com (last searched 26 July 2012)), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We used no date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 2 December 2016. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of participants diagnosed with an acute internal Hordeolum. Studies of participants with external hordeola (styes), chronic hordeola, or chalazia were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared with observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results No trials were identified for this review. Most of the references identified through our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal hordeola reported recommendations for treatment, were reports of interventional case series, case studies, or other types of observational study designs, and were published more than 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of an internal Hordeolum. Controlled clinical trials would be useful to determine which interventions are effective for the treatment of acute internal hordeola.
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The Cochrane Library - Interventions for acute internal Hordeolum
The Cochrane database of systematic reviews, 2013Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. If unresolved, acute internal Hordeolum can become chronic or develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness and safety of non-surgical treatments for acute internal Hordeolum compared to observation or placebo. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of patients diagnosed with acute internal Hordeolum. Studies of patients with external Hordeolum (stye), chronic Hordeolum or chalazion were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared to observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by the electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results There were no trials identified for inclusion in this review. The majority of the references identified from our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal Hordeolum reported mostly recommendations for treatment or were reports of interventional case series, case studies, or other types of observational study designs and were published over 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of Hordeolum. Controlled clinical trials would be useful in determining which interventions are effective for the treatment of acute internal Hordeolum.
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interventions for acute internal Hordeolum
Cochrane Database of Systematic Reviews, 2013Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Background Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. If unresolved, acute internal Hordeolum can become chronic or develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. Objectives The objective of this review was to investigate the effectiveness and safety of non-surgical treatments for acute internal Hordeolum compared to observation or placebo. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. Selection criteria The selection criteria for this review included randomized or quasi-randomized clinical trials of patients diagnosed with acute internal Hordeolum. Studies of patients with external Hordeolum (stye), chronic Hordeolum or chalazion were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared to observation, placebo, or other active interventions. Data collection and analysis Two review authors independently assessed the references identified by the electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. Main results There were no trials identified for inclusion in this review. The majority of the references identified from our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal Hordeolum reported mostly recommendations for treatment or were reports of interventional case series, case studies, or other types of observational study designs and were published over 20 years ago. Authors' conclusions We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of Hordeolum. Controlled clinical trials would be useful in determining which interventions are effective for the treatment of acute internal Hordeolum.
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Interventions for acute internal Hordeolum.
The Cochrane database of systematic reviews, 2010Co-Authors: Kristina Lindsley, Jason J. Nichols, Kay DickersinAbstract:Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. If unresolved, acute internal Hordeolum can become chronic or develop into a chalazion. External hordeola, also known as styes, were not included in the scope of this review. The objective of this review was to investigate the effectiveness and safety of non-surgical treatments for acute internal Hordeolum compared to observation or placebo. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. The selection criteria for this review included randomized or quasi-randomized clinical trials of patients diagnosed with acute internal Hordeolum. Studies of patients with external Hordeolum (stye), chronic Hordeolum or chalazion were excluded. Non-surgical interventions of interest included the use of hot or warm compresses, lid scrubs, antibiotics, or steroids compared to observation, placebo, or other active interventions. Two review authors independently assessed the references identified by the electronic searches for inclusion in this review. No relevant studies were found. The reasons for exclusion were documented. There were no trials identified for inclusion in this review. The majority of the references identified from our search reported on external hordeola or chronic internal hordeola. The few references specific to acute internal Hordeolum reported mostly recommendations for treatment or were reports of interventional case series, case studies, or other types of observational study designs and were published over 20 years ago. We did not find any evidence for or against the effectiveness of non-surgical interventions for the treatment of Hordeolum. Controlled clinical trials would be useful in determining which interventions are effective for the treatment of acute internal Hordeolum.
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IMPLEMENTASI DAN PERANCANGAN SISTEM PAKAR UNTUK DIAGNOSA PENYAKIT MATA PADA MANUSIA BERBASIS PEMROGRAMAN CLIPS
2011Co-Authors: Nazrul Effendy, Febry Wikatmono, M, Haekal Hasan, Nandan SuteresnaAbstract:Seperti kita ketahui penyakit mata pada manusia ada bermacam-macam seperti Glaukoma, Hordeolum, Kalazion, Katarak, Konjungtivitis, Entropion. Penyakit mata adalah penyakit yang berbahaya, bila tidak segera didiagnosa dan diobati maka dapat menimbulkan kebutaan pada mata ataupun timbul penyakit lainnya. Penyakit mata tersebut dapat didiagnosa melalui gejala-gejala yang timbul yang diderita oleh manusia tersebut ataupun melalui gambaran klinisnya. Dengan menggunakan sistem pakar maka penyakit mata tersebut dapat didiagnosa dan diobati secara tepat dengan prinsip pembentukan basis aturan dan pembangunan komponen dilakukan pada lingkungan pengembangan, sedangkan lingkungan konsultasi digunakan sebagai sistem konsultasi oleh orang yang bukan ahli ataupun yang sudah ahli. Sistem pakar sebagai sistem yang mengadopsi kepakaran manusia ke dalam komputer dan memiliki kedudukan strategis sebagai sistem yang dapat membantu menyelesaikan permasalahan di bidang kedokteran. Sulitnya menentukan jenis penyakit karena rumitnya berbagai gejala yang mengiringinya, dapat dibantu dengan merepresentasikan gejala suatu penyakit ke dalam suatu bahasa pemrograman komputer (Wardana, 2008). Pada penelitian ini, dikembangkan suatu metode untuk mediagnosa 26 jenis penyakit mata berdasarkan 53 jenis gejala , gambaran klinis yang mengiringi serata pengobatan yang sesuai. Lingkungan pengembangan sistem pakar pada penelitian ini menggunakan bahasa pemrograman CLIPS