The Experts below are selected from a list of 141318 Experts worldwide ranked by ideXlab platform
R T Zavala - One of the best experts on this subject based on the ideXlab platform.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
The Astrophysical Journal, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z = 0.055, shows two compact radio nuclei, imaged by very long baseline interferometry at 7 mas separation, making it the closest known resolved supermassive black hole binary (SMBHB). An important question is whether this unique object is young and was caught on the way to a gravitational in-spiral and merger, or has "stalled" at 7 pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
arXiv: Astrophysics of Galaxies, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z=0.055 shows two compact radio nuclei, imaged by VLBI at 7mas separation, making it the closest known resolved super-massive black hole binary (SMBHB). An important question is whether this unique object is young, caught on the way to a gravitational in-spiral and merger, or has `stalled' at 7pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
Steven R Blanke - One of the best experts on this subject based on the ideXlab platform.
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Remodeling the Host Environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA)
Frontiers in cellular and infection microbiology, 2012Co-Authors: Ik Jung Kim, Steven R BlankeAbstract:Virulence mechanisms underlying Helicobacter pylori persistence and disease remain poorly understood, in part, because the factors underlying disease risk are multifactorial and complex. Among the bacterial factors that contribute to the cumulative pathophysiology associated with H. pylori infections, the vacuolating cytotoxin (VacA) is one of the most important. Analogous to a number of H. pylori genes, the vacA gene exhibits allelic mosaicism, and human epidemiological studies have revealed that several families of toxin alleles are predictive of more severe disease. Animal model studies suggest that VacA may contribute to pathogenesis in several ways. VacA functions as an intracellular-acting protein exotoxin. However, VacA does not fit the current prototype of AB intracellular-acting bacterial toxins, which elaborate modulatory effects through the action of an enzymatic domain translocated inside Host cells. Rather, VacA may represent an alternative prototype for AB intracellular acting toxins that modulate cellular homeostasis by forming ion-conducting intracellular membrane channels. Although VacA seems to form channels in several different membranes, one of the most important target sites is the mitochondrial inner membrane. VacA apparently take advantage of an unusual intracellular trafficking pathway to mitochondria, where the toxin is imported and depolarizes the inner membrane to disrupt mitochondrial dynamics and cellular energy homeostasis as a mechanism for engaging the apoptotic machinery within Host cells. VacA remodeling of the gastric Environment appears to be fine-tuned through the action of the Type IV effector protein CagA which, in part, limits the cytotoxic effects of VacA in cells colonized by H. pylori.
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Remodeling the Host Environment: Modulation of the Gastric Epithelium by the Helicobacter pylori vacuolating toxin (VacA)
Frontiers Media S.A., 2012Co-Authors: Ik-jung Ekim, Steven R BlankeAbstract:Virulence mechanisms underlying Helicobacter pylori persistence and disease remain poorly understood, in part, because disease risk is multifactorial and complex. Among the bacterial factors that contribute to the cumulative pathophysiology associated with H. pylori infections, the vacuolating cytotoxin (VacA) is one of the most important. Analogous to a number of H. pylori genes, the vacA gene exhibits allelic mosaicism, with several alleles clearly associated with more severe disease. VacA is secreted by Helicobacter pylori as an intracellular-acting exotoxin. However, VacA does not fit the current prototype of AB intracellular-acting bacterial toxins, which elaborate modulatory effects through the action of an enzymatic domain translocated inside Host cells. Rather, VacA may represent an alternative prototype of AB intracellular acting toxins that modulate membrane-regulated homeostasis by forming ion-conducting intracellular membrane channels. Although VacA seems to form channels in several different membranes, one of the most important target sites is the mitochondrial inner membrane. VacA subverts intracellular trafficking to mitochondria, where the toxin depolarizes the inner membrane to disrupt mitochondrial dynamics and cellular energy homeostasis as a mechanism for engaging the apoptotic machinery within Host cells
Roger W Romani - One of the best experts on this subject based on the ideXlab platform.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
The Astrophysical Journal, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z = 0.055, shows two compact radio nuclei, imaged by very long baseline interferometry at 7 mas separation, making it the closest known resolved supermassive black hole binary (SMBHB). An important question is whether this unique object is young and was caught on the way to a gravitational in-spiral and merger, or has "stalled" at 7 pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
arXiv: Astrophysics of Galaxies, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z=0.055 shows two compact radio nuclei, imaged by VLBI at 7mas separation, making it the closest known resolved super-massive black hole binary (SMBHB). An important question is whether this unique object is young, caught on the way to a gravitational in-spiral and merger, or has `stalled' at 7pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
Christine Jones - One of the best experts on this subject based on the ideXlab platform.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
The Astrophysical Journal, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z = 0.055, shows two compact radio nuclei, imaged by very long baseline interferometry at 7 mas separation, making it the closest known resolved supermassive black hole binary (SMBHB). An important question is whether this unique object is young and was caught on the way to a gravitational in-spiral and merger, or has "stalled" at 7 pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
arXiv: Astrophysics of Galaxies, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z=0.055 shows two compact radio nuclei, imaged by VLBI at 7mas separation, making it the closest known resolved super-massive black hole binary (SMBHB). An important question is whether this unique object is young, caught on the way to a gravitational in-spiral and merger, or has `stalled' at 7pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
S S Murray - One of the best experts on this subject based on the ideXlab platform.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
The Astrophysical Journal, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z = 0.055, shows two compact radio nuclei, imaged by very long baseline interferometry at 7 mas separation, making it the closest known resolved supermassive black hole binary (SMBHB). An important question is whether this unique object is young and was caught on the way to a gravitational in-spiral and merger, or has "stalled" at 7 pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.
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a multi wavelength study of the Host Environment of smbhb 4c 37 11
arXiv: Astrophysics of Galaxies, 2013Co-Authors: Roger W Romani, W Forman, Christine Jones, S S Murray, A C S Readhead, Greg Taylor, R T ZavalaAbstract:4C+37.11, at z=0.055 shows two compact radio nuclei, imaged by VLBI at 7mas separation, making it the closest known resolved super-massive black hole binary (SMBHB). An important question is whether this unique object is young, caught on the way to a gravitational in-spiral and merger, or has `stalled' at 7pc. We describe new radio/optical/X-ray observations of the massive Host and its surrounding X-ray halo. These data reveal X-ray/optical channels following the radio outflow and large scale edges in the X-ray halo. These structures are promising targets for further study which should elucidate their relationship to the unique SMBHB core.