The Experts below are selected from a list of 59241 Experts worldwide ranked by ideXlab platform
Laetitia Zona - One of the best experts on this subject based on the ideXlab platform.
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hras Signal transduction promotes hepatitis c virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host & Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, Nazha Sidahmedadrar, C Thumann, Helen J Harris, Amy BarnesAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin β1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
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HRas Signal transduction promotes hepatitis C virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host and Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, C Thumann, Amy Barnes, N Sidahmed-adrar, H Harris, J Florentin, Rajiv G Tawar, Fei Xiao, Marine TurekAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin beta1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
Amy Barnes - One of the best experts on this subject based on the ideXlab platform.
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hras Signal transduction promotes hepatitis c virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host & Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, Nazha Sidahmedadrar, C Thumann, Helen J Harris, Amy BarnesAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin β1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
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HRas Signal transduction promotes hepatitis C virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host and Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, C Thumann, Amy Barnes, N Sidahmed-adrar, H Harris, J Florentin, Rajiv G Tawar, Fei Xiao, Marine TurekAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin beta1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
C Thumann - One of the best experts on this subject based on the ideXlab platform.
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hras Signal transduction promotes hepatitis c virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host & Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, Nazha Sidahmedadrar, C Thumann, Helen J Harris, Amy BarnesAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin β1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
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HRas Signal transduction promotes hepatitis C virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host and Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, C Thumann, Amy Barnes, N Sidahmed-adrar, H Harris, J Florentin, Rajiv G Tawar, Fei Xiao, Marine TurekAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin beta1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
Joachim Lupberger - One of the best experts on this subject based on the ideXlab platform.
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hras Signal transduction promotes hepatitis c virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host & Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, Nazha Sidahmedadrar, C Thumann, Helen J Harris, Amy BarnesAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin β1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
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HRas Signal transduction promotes hepatitis C virus cell entry by triggering assembly of the Host tetraspanin receptor complex
Cell Host and Microbe, 2013Co-Authors: Laetitia Zona, Joachim Lupberger, C Thumann, Amy Barnes, N Sidahmed-adrar, H Harris, J Florentin, Rajiv G Tawar, Fei Xiao, Marine TurekAbstract:Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the Host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR Signaling, as a key Host Signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin beta1 and Ras-related protein Rap2B in hepatocyte membranes. HRas Signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas Signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.
Shubhangi B. Patil - One of the best experts on this subject based on the ideXlab platform.
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A robust encryption method for speech data hiding in digital images for optimized security
2015 International Conference on Pervasive Computing (ICPC), 2015Co-Authors: Sheetal A. Kulkarni, Shubhangi B. PatilAbstract:Steganography is a art of hiding information in a Host Signal. It is very important to hide the secret data efficiently, as many attacks made on the data communication. The Host Signal can be a still image, speech or video and the message Signal that is hidden in the Host Signal can be a text, image or an audio Signal. The cryptography concept is used for locking the secret message in the cover file. The cryptography makes the secret message not understood unless the decryption key is available. It is related with constructing and analyzing various methods that overcome the influence of third parties. Modern cryptography works on the disciplines like mathematics, computer science and electrical engineering. In this paper a symmetric key is developed which consists of reshuffling and secret arrangement of secret Signal data bits in cover Signal data bits. In this paper the authors have performed the encryption process on secret speech Signal data bits-level to achieve greater strength of encryption which is hidden inside the cover image. The encryption algorithm applied with embedding method is the robust secure method for data hiding.
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High capacity and robust speech data hiding in colour images
2014 IEEE Global Conference on Wireless Computing & Networking (GCWCN), 2014Co-Authors: Sheetal A. Kulkarni, Shubhangi B. PatilAbstract:Steganography is a method for hiding information in a Host Signal. The Host Signal can be a still image, speech or video and the message Signal that is hidden in the Host Signal can be a text, image or an audio Signal. In this method Host Signal is image and secret message is audio Signal. In this paper, a data hiding scheme by Discrete Wavelet Transform with LSB substitution is proposed. By applying Discrete Wavelet Transform on secret message, message data is hidden in the LSB's of the colour image pixels. The worst case mean-squareerror and PSNR between the stego-image and the cover-image is derived. Experimental results show that the stego-image is visually indistinguishable from the original cover-image. In this paper male/female speeches are hiding inside digital images. Discrete Wavelet Transform (DWT) is applied on secret speech Signal followed by LSB method to obtain the stego-image at transmitter side. At receiver end Inverse Discrete Wavelet transform applied on stego image and secret Signal can retrieve by LSB method.