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Wayne R Thomas - One of the best experts on this subject based on the ideXlab platform.

  • House Dust Allergy and immunotherapy
    Human Vaccines & Immunotherapeutics, 2012
    Co-Authors: Wayne R Thomas
    Abstract:

    HDM Allergy is associated with asthma, allergic rhinitis and atopic dermatitis. In many countries childhood asthma is predominantly found in HDM-allergic children with their probability of developing disease being proportional to their IgE antibody titers and the early development of Th2 responses. While the pathogenesis is complex and increasingly linked to infection the immunologically-based allergen immunotherapy and anti-IgE antibody therapy are highly beneficial. Immunotherapy could be a short-term treatment providing lifelong relief but the current regimens depend on repeated administration of allergen over years. Immunological investigations point to a contribution of responses outside the Th2 pathway and multiple potential but unproven control mechanisms. Over half of the IgE antibodies are directed to the group 1 and 2 allergens with most of remainder to the group 4, 5, 7 and 21 allergens. This hierarchy found in high and low responders provides a platform for introducing defined allergens into immunotherapy and defined reagents for investigation.

Goro Mogi - One of the best experts on this subject based on the ideXlab platform.

  • effect of terfenadine on substance p and vasoactive intestinal polypeptide concentrations in nasal secretions from patients with nasal Allergy
    Journal of Pharmacy and Pharmacology, 2011
    Co-Authors: Masaharu Takeyama, Kazuo Mori, Norifumi Morikawa, Shunji Asakura, Tokuo Chaen, Noritake Watanabe, Goro Mogi
    Abstract:

    — Before terfenadine treatment, the mean substance P and vasoactive intestinal polypeptide (VIP) concentrations in nasal secretions from nasal Allergy patients tended to be higher than the values of healthy subjects. During terfenadine treatment, the mean substance P concentrations in nasal secretions from patients allergic to House Dust or pollen were significantly decreased to 62 and 39% of the initial values, respectively. The mean VIP concentrations in nasal secretions from the House Dust Allergy patients and the pollen Allergy patients were significantly decreased to 52 and 18% of the initial values, respectively. Plasma substance P and VIP concentrations were not affected by nasal allergic symptom and terfenadine treatment.

  • substance p and vasoactive intestinal peptide in nasal secretions and plasma from patients with nasal Allergy
    Annals of Otology Rhinology and Laryngology, 1993
    Co-Authors: Tokuo Chaen, Kazuo Mori, Noritake Watanabe, Goro Mogi, Masaharu Takeyama
    Abstract:

    To clarify the role of substance P (SP) and vasoactive intestinal peptide (VIP) in nasal Allergy, we measured their concentrations in the nasal secretions and plasma of normal subjects and patients with nasal Allergy to House Dust and Japanese cedar pollen by competitive enzyme-linked immunoassay. The mean levels of SP (224 pmol/L) and VIP (41.6 pmol/L) in the nasal secretions of normal subjects were significantly higher than those in plasma (SP 3.04 pmol/L and VIP 1.04 pmol/L; p < .01). The mean levels of SP and VIP in the nasal secretions of the pollinosis group were significantly higher than those of the control group (p < .05 and p < .01), while the levels of the House Dust Allergy group were not higher than those of the control group. Intranasal allergen challenge significantly reduced SP levels in the nasal secretions of the Allergy groups, while it did not influence VIP levels in the nasal secretions. These findings suggest that SP and VIP are actively secreted into the nose and may play an importa...

Masaharu Takeyama - One of the best experts on this subject based on the ideXlab platform.

  • effect of terfenadine on substance p and vasoactive intestinal polypeptide concentrations in nasal secretions from patients with nasal Allergy
    Journal of Pharmacy and Pharmacology, 2011
    Co-Authors: Masaharu Takeyama, Kazuo Mori, Norifumi Morikawa, Shunji Asakura, Tokuo Chaen, Noritake Watanabe, Goro Mogi
    Abstract:

    — Before terfenadine treatment, the mean substance P and vasoactive intestinal polypeptide (VIP) concentrations in nasal secretions from nasal Allergy patients tended to be higher than the values of healthy subjects. During terfenadine treatment, the mean substance P concentrations in nasal secretions from patients allergic to House Dust or pollen were significantly decreased to 62 and 39% of the initial values, respectively. The mean VIP concentrations in nasal secretions from the House Dust Allergy patients and the pollen Allergy patients were significantly decreased to 52 and 18% of the initial values, respectively. Plasma substance P and VIP concentrations were not affected by nasal allergic symptom and terfenadine treatment.

  • substance p and vasoactive intestinal peptide in nasal secretions and plasma from patients with nasal Allergy
    Annals of Otology Rhinology and Laryngology, 1993
    Co-Authors: Tokuo Chaen, Kazuo Mori, Noritake Watanabe, Goro Mogi, Masaharu Takeyama
    Abstract:

    To clarify the role of substance P (SP) and vasoactive intestinal peptide (VIP) in nasal Allergy, we measured their concentrations in the nasal secretions and plasma of normal subjects and patients with nasal Allergy to House Dust and Japanese cedar pollen by competitive enzyme-linked immunoassay. The mean levels of SP (224 pmol/L) and VIP (41.6 pmol/L) in the nasal secretions of normal subjects were significantly higher than those in plasma (SP 3.04 pmol/L and VIP 1.04 pmol/L; p < .01). The mean levels of SP and VIP in the nasal secretions of the pollinosis group were significantly higher than those of the control group (p < .05 and p < .01), while the levels of the House Dust Allergy group were not higher than those of the control group. Intranasal allergen challenge significantly reduced SP levels in the nasal secretions of the Allergy groups, while it did not influence VIP levels in the nasal secretions. These findings suggest that SP and VIP are actively secreted into the nose and may play an importa...

Jan G R De Monchy - One of the best experts on this subject based on the ideXlab platform.

  • interpretation of skin tests to House Dust mite and relationship to other Allergy parameters in patients with asthma and chronic obstructive pulmonary disease
    The Journal of Allergy and Clinical Immunology, 1993
    Co-Authors: Paul L P Brand, Huib A M Kerstjens, Henk M Jansen, Henk F Kauffman, Jan G R De Monchy
    Abstract:

    Abstract Background: The relationships between allergic symptoms after exposure to House Dust, Allergy parameters (skin test to House Dust mite [HDM], total IgE, HDM-specific IgE, and blood eosinophil counts), and several confounding variables (age, sex, smoking habits, and airway hyperresponsiveness) were evaluated in 235 patients with asthma and chronic obstructive pulmonary disease (COPD). Results: Skin tests had higher diagnostic value (sensitivity plus specificity) for symptomatic Allergy than specific IgE (1.45 versus 1.36) or total IgE (1.16). The other Allergy parameters gave no additional information on symptoms once the skin test was known. Expressing the skin test relative to the histamine control proved slightly better than uncorrected wheal size, but this probably has limited clinical value. The best cutoff level for a positive skin test was 0.7 when the histamine wheal size was accounted for by division, −6 mm when subtraction was used, and 7 mm for absolute wheal size. These cutoff levels proved equally applicable in various subgroups of patients with asthma and COPD. Only the skin test and female sex were independent predictors of allergic symptoms. Conclusion: We conclude that skin tests to HDM are better predictors for clinical Allergy than total or specific IgE levels and eosinophil count, and that they are applicable in most patients with asthma and with COPD.

Tokuo Chaen - One of the best experts on this subject based on the ideXlab platform.

  • effect of terfenadine on substance p and vasoactive intestinal polypeptide concentrations in nasal secretions from patients with nasal Allergy
    Journal of Pharmacy and Pharmacology, 2011
    Co-Authors: Masaharu Takeyama, Kazuo Mori, Norifumi Morikawa, Shunji Asakura, Tokuo Chaen, Noritake Watanabe, Goro Mogi
    Abstract:

    — Before terfenadine treatment, the mean substance P and vasoactive intestinal polypeptide (VIP) concentrations in nasal secretions from nasal Allergy patients tended to be higher than the values of healthy subjects. During terfenadine treatment, the mean substance P concentrations in nasal secretions from patients allergic to House Dust or pollen were significantly decreased to 62 and 39% of the initial values, respectively. The mean VIP concentrations in nasal secretions from the House Dust Allergy patients and the pollen Allergy patients were significantly decreased to 52 and 18% of the initial values, respectively. Plasma substance P and VIP concentrations were not affected by nasal allergic symptom and terfenadine treatment.

  • substance p and vasoactive intestinal peptide in nasal secretions and plasma from patients with nasal Allergy
    Annals of Otology Rhinology and Laryngology, 1993
    Co-Authors: Tokuo Chaen, Kazuo Mori, Noritake Watanabe, Goro Mogi, Masaharu Takeyama
    Abstract:

    To clarify the role of substance P (SP) and vasoactive intestinal peptide (VIP) in nasal Allergy, we measured their concentrations in the nasal secretions and plasma of normal subjects and patients with nasal Allergy to House Dust and Japanese cedar pollen by competitive enzyme-linked immunoassay. The mean levels of SP (224 pmol/L) and VIP (41.6 pmol/L) in the nasal secretions of normal subjects were significantly higher than those in plasma (SP 3.04 pmol/L and VIP 1.04 pmol/L; p < .01). The mean levels of SP and VIP in the nasal secretions of the pollinosis group were significantly higher than those of the control group (p < .05 and p < .01), while the levels of the House Dust Allergy group were not higher than those of the control group. Intranasal allergen challenge significantly reduced SP levels in the nasal secretions of the Allergy groups, while it did not influence VIP levels in the nasal secretions. These findings suggest that SP and VIP are actively secreted into the nose and may play an importa...