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Bruce J German - One of the best experts on this subject based on the ideXlab platform.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate a protective gut colonization in breast-fed newborns.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HM...
Ayoub Mitha - One of the best experts on this subject based on the ideXlab platform.
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the impact of neonatal unit policies on breast milk feeding at discharge of moderate preterm infants the epipage 2 cohort study
Maternal and Child Nutrition, 2019Co-Authors: Ayoub Mitha, Aurelie Piedvache, Babak Khoshnood, Jeanne Fresson, Isabelle Glorieux, Jeanmichel Roue, B Blondel, Melanie Durox, Antoine Burguet, Pierreyves AncelAbstract:Facilitating factors and barriers to breast milk feeding (BMF) for preterm infants have been mainly studied in very preterm populations, but little is known about moderate preterm infants. We aimed to analyze hospital unit characteristics and BMF policies associated with BMF at discharge for infants born at 32 to 34 weeks' gestation. EPIPAGE-2, a French national cohort of preterm births, included 883 infants born at 32 to 34 weeks' gestation. We investigated kangaroo care in the first 24 hr, early involvement of parents in feeding support, volume of the unit, BMF information given to mothers hospitalized for threatened preterm delivery, protocols for BMF, presence of a professional trained in Human Lactation, unit training in neurodevelopmental care, and regional BMF initiation rates in the general population. Multilevel logistic regression analysis was used to investigate associations between unit policies and BMF at discharge, adjusted for individual characteristics and estimating odds ratios (ORs) and 95% confidence intervals (CIs). Overall, 59% (490/828) of infants received BMF at discharge (27% to 87% between units). Rates of BMF at discharge were higher with kangaroo care (adjusted OR 2.03 [95% CI 1.01, 4.10]), early involvement of parents in feeding support (1.94 [1.23, 3.04]), unit training in a neurodevelopmental care programme (2.57 [1.18, 5.60]), and in regions with a high level of BMF initiation in the general population (1.85 [1.05, 3.28]). Creating synergies by interventions at the unit and population level may reduce the variability in BMF rates at discharge for moderate preterm infants.
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unit policies and breast milk feeding at discharge of very preterm infants the epipage 2 cohort study
Paediatric and Perinatal Epidemiology, 2019Co-Authors: Ayoub Mitha, Aurelie Piedvache, Isabelle Glorieux, Jeanmichel Roue, B Blondel, Melanie Durox, Antoine Burguet, Jennifer Zeitlin, Monique KaminskiAbstract:Background Facilitating factors and barriers to breast milk feeding (BMF) very preterm (VP) infants have been widely studied at the individual level. We aimed to describe and analyse factors associated with BMF at discharge for VP infants, with a special focus on unit policies aiming to support BMF. Methods We described BMF at discharge in 3108 VP infants enrolled in EPIPAGE-2, a French national cohort. Variables of interest were kangaroo care during the 1st week of life (KC); unit's policies supporting BMF initiation (BMF information systematically given to mothers hospitalised for threatened preterm delivery and breast milk expression proposed within 6 hours after birth) and BMF maintenance (availability of protocols for BMF and a special room for mothers to pump milk); the presence in units of a professional trained in Human Lactation and regional BMF initiation rates in the general population. Associations were investigated by multilevel logistic regression analysis, with adjustment on individual factors. Results In total, 47.2% of VP infants received BMF at discharge (range among units 21.1%-84.0%). Unit policies partly explained this variation, regardless of individual factors. BMF at discharge was associated with KC (adjusted odds ratio (aOR) 2.26 (95% confidence interval (CI) 1.40, 3.65)), with policies supporting BMF initiation (aOR 2.19 (95% CI 1.27, 3.77)) and maintenance (aOR 2.03 (95% CI 1.17, 3.55)), but not with BMF initiation rates in the general population. Conclusion Adopting policies of higher performing units could be an effective strategy for increasing BMF rates at discharge among VP infants.
Riccardo G Locascio - One of the best experts on this subject based on the ideXlab platform.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate a protective gut colonization in breast-fed newborns.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HM...
Samara L Freeman - One of the best experts on this subject based on the ideXlab platform.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate a protective gut colonization in breast-fed newborns.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HM...
Milady R Ninonuevo - One of the best experts on this subject based on the ideXlab platform.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate a protective gut colonization in breast-fed newborns.
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glycoprofiling of bifidobacterial consumption of Human milk oligosaccharides demonstrates strain specific preferential consumption of small chain glycans secreted in early Human Lactation
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Riccardo G Locascio, Milady R Ninonuevo, Samara L Freeman, David A Sela, Rudolf Grimm, Carlito B Lebrilla, David A Mills, Bruce J GermanAbstract:The molecular basis by which Human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, Human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in Human breast milk at the onset and constantly through the first month of Lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HM...