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Guillaume Monneret - One of the best experts on this subject based on the ideXlab platform.

  • Decreased Human Leukocyte Antigen DR on Circulating Monocytes Expression After Severe Pediatric Trauma: An Exploratory Report.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Car, 2020
    Co-Authors: Fleur Cour-andlauer, Brenda M. Morrow, Mignon Mcculloch, Etienne Javouhey, Sandrine Lecour, Sebastian Van As, Solenn Remy, Guillaume Monneret, Andrew C. Argent
    Abstract:

    Objectives Major trauma in adults induces immune dysfunction, with diminished expression of Human Leukocyte Antigen-DR on circulating monocytes. No pediatric data are available. This study described the kinetics of Human Leukocyte Antigen-DR on circulating monocytes following major pediatric trauma and relationships between Human Leukocyte Antigen-DR on circulating monocytes and outcomes. Design Prospective observational study. Setting PICU and trauma unit at a tertiary-care university hospital in South Africa. Patients Children between 1 month and 13 years hospitalized for severe brain trauma or trauma with an Injury Severity Score greater than or equal to 16, from November 2016 to March 2017. Interventions None. Measurements and main results We included 36 children. Median (interquartile range) age and Injury Severity Score were 7 years (4.9-10.5 yr) and 25 years (22.7-30 yr), respectively. Blood samples (n = 83) for standardized Human Leukocyte Antigen-DR on circulating monocytes measurement were collected at days 1-2, 3-4, and 8-9 after injury (D1, D3, and D8, respectively). On D1, median (interquartile range) Human Leukocyte Antigen-DR on circulating monocytes was markedly reduced relative to normal values (7,031 [5,204-11,201] antibodies per cell). There was a significant increase in Human Leukocyte Antigen-DR on circulating monocytes from D1 to D8. Although all patients with secondary infections (n = 8; 22%) had Human Leukocyte Antigen-DR on circulating monocytes less than 15,000 antibodies per cell at D3, Human Leukocyte Antigen-DR on circulating monocytes levels were not associated with the occurrence of secondary infections (p = 0.22). At D3, Human Leukocyte Antigen-DR on circulating monocytes was significantly higher in patients discharged home (n = 21) by Day 30 after trauma compared with those who died or were still hospitalized (n = 14) (p = 0.02). Conclusions Pediatric severe trauma induced an early and dramatic decrease in Human Leukocyte Antigen-DR on circulating monocytes expression. This alteration of innate immunity was not associated with the occurrence of secondary infection, possibly due to a lack of statistical power. However, Human Leukocyte Antigen-DR on circulating monocytes at Day 3 is a potential indicator of those at high risk of secondary infection and worse outcomes.

  • low monocyte Human Leukocyte Antigen dr is independently associated with nosocomial infections after septic shock
    Intensive Care Medicine, 2010
    Co-Authors: Caroline Landelle, Nicolas Voirin, Julien Bohé, Alain Lepape, Eve Tognet, Fabienne Venet, Philippe Vanhems, Guillaume Monneret
    Abstract:

    Purpose Sepsis-induced immunosuppression is postulated to contribute to a heightened risk of nosocomial infection (NI). This prospective, single-center, observational study was conducted to assess whether low monocyte Human Leukocyte Antigen-DR expression (mHLA-DR), proposed as a global biomarker of sepsis immunosuppression, was associated with an increased incidence of NI after septic shock.

  • Soluble Human Leukocyte Antigen-G5 in septic shock : Marked and persisting elevation as a predictor of survival
    Critical care medicine, 2007
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Irène Krawice-radanne, Julien Bohé, Alain Lepape, Nathalie Rouas-freiss, Edgardo D. Carosella
    Abstract:

    Objective: Although it is established that septic shock induces immunosuppression, the mechanisms for this phenomenon remain poorly understood. Human Leukocyte Antigen-G exerts strong inhibitory effects that are directed at different arms of the immune system. The main objective of the current study was to measure Human Leukocyte Antigen-G (soluble and membrane proteins) in septic shock. Design: Observational study. Setting: Adult intensive care units in a university hospital. Patients: Sixty-four consecutive patients with septic shock (7 days of follow-up). Interventions: None. Measurements and Main Results: We measured plasma Human Leukocyte Antigen-G5 (with enzyme linked immunosorbent assay) and Human Leukocyte Antigen-G1 (with flow cytometry) expression on circulating Leukocytes. As early as days 1-2 after the onset of shock, we observed a marked elevation of soluble Human Leukocyte Antigen-G5 in patients: 60 ng/mL (34-146) as median (Q1-Q3) (reference values

  • persisting low monocyte Human Leukocyte Antigen dr expression predicts mortality in septic shock
    Intensive Care Medicine, 2006
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Julien Bohé, Alain Lepape, Fabienne Venet, Annelise Debard, Helene Thizy, Jacques Bienvenu, Francois Gueyffier, Philippe Vanhems
    Abstract:

    Objective The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from immunosuppression. We assessed whether a low monocyte Human Leukocyte Antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in patients who survived the initial 48 h of septic shock.

Nicolas Voirin - One of the best experts on this subject based on the ideXlab platform.

  • low monocyte Human Leukocyte Antigen dr is independently associated with nosocomial infections after septic shock
    Intensive Care Medicine, 2010
    Co-Authors: Caroline Landelle, Nicolas Voirin, Julien Bohé, Alain Lepape, Eve Tognet, Fabienne Venet, Philippe Vanhems, Guillaume Monneret
    Abstract:

    Purpose Sepsis-induced immunosuppression is postulated to contribute to a heightened risk of nosocomial infection (NI). This prospective, single-center, observational study was conducted to assess whether low monocyte Human Leukocyte Antigen-DR expression (mHLA-DR), proposed as a global biomarker of sepsis immunosuppression, was associated with an increased incidence of NI after septic shock.

  • Soluble Human Leukocyte Antigen-G5 in septic shock : Marked and persisting elevation as a predictor of survival
    Critical care medicine, 2007
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Irène Krawice-radanne, Julien Bohé, Alain Lepape, Nathalie Rouas-freiss, Edgardo D. Carosella
    Abstract:

    Objective: Although it is established that septic shock induces immunosuppression, the mechanisms for this phenomenon remain poorly understood. Human Leukocyte Antigen-G exerts strong inhibitory effects that are directed at different arms of the immune system. The main objective of the current study was to measure Human Leukocyte Antigen-G (soluble and membrane proteins) in septic shock. Design: Observational study. Setting: Adult intensive care units in a university hospital. Patients: Sixty-four consecutive patients with septic shock (7 days of follow-up). Interventions: None. Measurements and Main Results: We measured plasma Human Leukocyte Antigen-G5 (with enzyme linked immunosorbent assay) and Human Leukocyte Antigen-G1 (with flow cytometry) expression on circulating Leukocytes. As early as days 1-2 after the onset of shock, we observed a marked elevation of soluble Human Leukocyte Antigen-G5 in patients: 60 ng/mL (34-146) as median (Q1-Q3) (reference values

  • persisting low monocyte Human Leukocyte Antigen dr expression predicts mortality in septic shock
    Intensive Care Medicine, 2006
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Julien Bohé, Alain Lepape, Fabienne Venet, Annelise Debard, Helene Thizy, Jacques Bienvenu, Francois Gueyffier, Philippe Vanhems
    Abstract:

    Objective The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from immunosuppression. We assessed whether a low monocyte Human Leukocyte Antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in patients who survived the initial 48 h of septic shock.

Julien Bohé - One of the best experts on this subject based on the ideXlab platform.

  • low monocyte Human Leukocyte Antigen dr is independently associated with nosocomial infections after septic shock
    Intensive Care Medicine, 2010
    Co-Authors: Caroline Landelle, Nicolas Voirin, Julien Bohé, Alain Lepape, Eve Tognet, Fabienne Venet, Philippe Vanhems, Guillaume Monneret
    Abstract:

    Purpose Sepsis-induced immunosuppression is postulated to contribute to a heightened risk of nosocomial infection (NI). This prospective, single-center, observational study was conducted to assess whether low monocyte Human Leukocyte Antigen-DR expression (mHLA-DR), proposed as a global biomarker of sepsis immunosuppression, was associated with an increased incidence of NI after septic shock.

  • Soluble Human Leukocyte Antigen-G5 in septic shock : Marked and persisting elevation as a predictor of survival
    Critical care medicine, 2007
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Irène Krawice-radanne, Julien Bohé, Alain Lepape, Nathalie Rouas-freiss, Edgardo D. Carosella
    Abstract:

    Objective: Although it is established that septic shock induces immunosuppression, the mechanisms for this phenomenon remain poorly understood. Human Leukocyte Antigen-G exerts strong inhibitory effects that are directed at different arms of the immune system. The main objective of the current study was to measure Human Leukocyte Antigen-G (soluble and membrane proteins) in septic shock. Design: Observational study. Setting: Adult intensive care units in a university hospital. Patients: Sixty-four consecutive patients with septic shock (7 days of follow-up). Interventions: None. Measurements and Main Results: We measured plasma Human Leukocyte Antigen-G5 (with enzyme linked immunosorbent assay) and Human Leukocyte Antigen-G1 (with flow cytometry) expression on circulating Leukocytes. As early as days 1-2 after the onset of shock, we observed a marked elevation of soluble Human Leukocyte Antigen-G5 in patients: 60 ng/mL (34-146) as median (Q1-Q3) (reference values

  • persisting low monocyte Human Leukocyte Antigen dr expression predicts mortality in septic shock
    Intensive Care Medicine, 2006
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Julien Bohé, Alain Lepape, Fabienne Venet, Annelise Debard, Helene Thizy, Jacques Bienvenu, Francois Gueyffier, Philippe Vanhems
    Abstract:

    Objective The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from immunosuppression. We assessed whether a low monocyte Human Leukocyte Antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in patients who survived the initial 48 h of septic shock.

Alain Lepape - One of the best experts on this subject based on the ideXlab platform.

  • low monocyte Human Leukocyte Antigen dr is independently associated with nosocomial infections after septic shock
    Intensive Care Medicine, 2010
    Co-Authors: Caroline Landelle, Nicolas Voirin, Julien Bohé, Alain Lepape, Eve Tognet, Fabienne Venet, Philippe Vanhems, Guillaume Monneret
    Abstract:

    Purpose Sepsis-induced immunosuppression is postulated to contribute to a heightened risk of nosocomial infection (NI). This prospective, single-center, observational study was conducted to assess whether low monocyte Human Leukocyte Antigen-DR expression (mHLA-DR), proposed as a global biomarker of sepsis immunosuppression, was associated with an increased incidence of NI after septic shock.

  • Soluble Human Leukocyte Antigen-G5 in septic shock : Marked and persisting elevation as a predictor of survival
    Critical care medicine, 2007
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Irène Krawice-radanne, Julien Bohé, Alain Lepape, Nathalie Rouas-freiss, Edgardo D. Carosella
    Abstract:

    Objective: Although it is established that septic shock induces immunosuppression, the mechanisms for this phenomenon remain poorly understood. Human Leukocyte Antigen-G exerts strong inhibitory effects that are directed at different arms of the immune system. The main objective of the current study was to measure Human Leukocyte Antigen-G (soluble and membrane proteins) in septic shock. Design: Observational study. Setting: Adult intensive care units in a university hospital. Patients: Sixty-four consecutive patients with septic shock (7 days of follow-up). Interventions: None. Measurements and Main Results: We measured plasma Human Leukocyte Antigen-G5 (with enzyme linked immunosorbent assay) and Human Leukocyte Antigen-G1 (with flow cytometry) expression on circulating Leukocytes. As early as days 1-2 after the onset of shock, we observed a marked elevation of soluble Human Leukocyte Antigen-G5 in patients: 60 ng/mL (34-146) as median (Q1-Q3) (reference values

  • persisting low monocyte Human Leukocyte Antigen dr expression predicts mortality in septic shock
    Intensive Care Medicine, 2006
    Co-Authors: Guillaume Monneret, Nicolas Voirin, Julien Bohé, Alain Lepape, Fabienne Venet, Annelise Debard, Helene Thizy, Jacques Bienvenu, Francois Gueyffier, Philippe Vanhems
    Abstract:

    Objective The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from immunosuppression. We assessed whether a low monocyte Human Leukocyte Antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in patients who survived the initial 48 h of septic shock.

Lars Alfredsson - One of the best experts on this subject based on the ideXlab platform.

  • A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis
    Arthritis & Rheumatism, 2013
    Co-Authors: Xia Jiang, Henrik Källberg, Lisbeth Ärlestig, Solbritt Rantapää-dahlqvist, Lars Klareskog, Leonid Padyukov, Lars Alfredsson
    Abstract:

    A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis

  • smoking and two Human Leukocyte Antigen genes interact to increase the risk for multiple sclerosis
    Brain, 2011
    Co-Authors: Anna Karin Hedstrom, E Sundqvist, Maria Baarnhielm, Nina Nordin, Jan Hillert, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
    Abstract:

    Both genetic and environmental factors display low or modest associations with multiple sclerosis. Hypothetically, gene–environment interactions may exert much stronger effects. In this study, we investigated potential interactions between genetic risk factors and smoking in relation to risk of developing multiple sclerosis. A population-based case–control study involving incident cases of multiple sclerosis (843 cases, 1209 controls) was performed in Sweden. Cases and controls were classified according to their smoking status and Human Leukocyte Antigen DRB1 as well as Human Leukocyte Antigen A genotypes. Subjects with different genotypes and smoking habits were compared with regard to incidence of multiple sclerosis, by calculating odds ratios with 95% confidence intervals employing logistic regression. The potential interaction between different genotypes, as well as between genotype and smoking, was evaluated by calculating attributable proportion due to interaction. A significant interaction between two genetic risk factors, carriage of Human Leukocyte Antigen DRB1*15 and absence of Human Leukocyte Antigen A*02, was observed among smokers whereas such an interaction was absent among non-smokers. There were considerable differences in odds ratios between the various groups. Compared with non-smokers with neither of the genetic risk factors, the odds ratio was 13.5 (8.1–22.6) for smokers with both genetic risk factors. The odds ratio for smokers without genetic risk was 1.4 (0.9–2.1) and the odds ratio for non-smokers with both genetic risk factors was 4.9 (3.6–6.6). Among those with both genetic risk factors, smoking increased the risk by a factor of 2.8 in comparison with a factor of 1.4 among those without the genetic risk factors. The risk of developing multiple sclerosis associated with Human Leukocyte Antigen genotypes may be strongly influenced by smoking status. The findings are consistent with our hypothesis that priming of the immune response in the lungs may subsequently lead to multiple sclerosis in genetically susceptible people. * Abbreviation : HLA : Human Leukocyte Antigen

  • Smoking and two Human Leukocyte Antigen genes interact to increase the risk for multiple sclerosis.
    Brain : a journal of neurology, 2011
    Co-Authors: Anna Karin Hedstrom, E Sundqvist, Maria Baarnhielm, Nina Nordin, Jan Hillert, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
    Abstract:

    Both genetic and environmental factors display low or modest associations with multiple sclerosis. Hypothetically, gene-environment interactions may exert much stronger effects. In this study, we investigated potential interactions between genetic risk factors and smoking in relation to risk of developing multiple sclerosis. A population-based case-control study involving incident cases of multiple sclerosis (843 cases, 1209 controls) was performed in Sweden. Cases and controls were classified according to their smoking status and Human Leukocyte Antigen DRB1 as well as Human Leukocyte Antigen A genotypes. Subjects with different genotypes and smoking habits were compared with regard to incidence of multiple sclerosis, by calculating odds ratios with 95% confidence intervals employing logistic regression. The potential interaction between different genotypes, as well as between genotype and smoking, was evaluated by calculating attributable proportion due to interaction. A significant interaction between two genetic risk factors, carriage of Human Leukocyte Antigen DRB1*15 and absence of Human Leukocyte Antigen A*02, was observed among smokers whereas such an interaction was absent among non-smokers. There were considerable differences in odds ratios between the various groups. Compared with non-smokers with neither of the genetic risk factors, the odds ratio was 13.5 (8.1-22.6) for smokers with both genetic risk factors. The odds ratio for smokers without genetic risk was 1.4 (0.9-2.1) and the odds ratio for non-smokers with both genetic risk factors was 4.9 (3.6-6.6). Among those with both genetic risk factors, smoking increased the risk by a factor of 2.8 in comparison with a factor of 1.4 among those without the genetic risk factors. The risk of developing multiple sclerosis associated with Human Leukocyte Antigen genotypes may be strongly influenced by smoking status. The findings are consistent with our hypothesis that priming of the immune response in the lungs may subsequently lead to multiple sclerosis in genetically susceptible people.