The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform
Susanne Ruge - One of the best experts on this subject based on the ideXlab platform.
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Human Placental Lactogen and pregnancy associated plasma protein a in first trimester and subsequent fetal growth
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Steen Sorensen, Susanne RugeAbstract:Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of Human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p<0.01 andp<0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p<0.02).Conclusions. Higher levels of Human Placental Lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe b...
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Human Placental Lactogen and pregnancy‐associated plasma protein A in first trimester and subsequent fetal growth
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Steen Sorensen, Susanne RugeAbstract:Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of Human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p
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Depressed serum levels of Human Placental Lactogen in first trimester vaginal bleeding.
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Susanne Ruge, Steen SorensenAbstract:BACKGROUND: It has previously been shown that serum levels of pregnancy-associated plasma protein A (PAPP-A) are depressed in patients with early pregnancy bleeding and a live gestation. We examined whether Human Placental Lactogen (hPL) levels show a similar pattern. METHOD: Prospective study in the 8th-14th gestational week comparing serum levels in 69 women with early pregnancy bleeding with those in 93 control pregnancies. RESULTS: Serum levels of hPL were significantly depressed in women with early pregnancy bleeding (p < 0.0001). CONCLUSIONS: The findings suggest a primary affection of the placenta in early pregnancy bleeding.
Jan Fog Pedersen - One of the best experts on this subject based on the ideXlab platform.
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Human Placental Lactogen and pregnancy associated plasma protein a in first trimester and subsequent fetal growth
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Steen Sorensen, Susanne RugeAbstract:Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of Human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p<0.01 andp<0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p<0.02).Conclusions. Higher levels of Human Placental Lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe b...
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Human Placental Lactogen and pregnancy‐associated plasma protein A in first trimester and subsequent fetal growth
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Steen Sorensen, Susanne RugeAbstract:Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of Human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p
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Depressed serum levels of Human Placental Lactogen in first trimester vaginal bleeding.
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Susanne Ruge, Steen SorensenAbstract:BACKGROUND: It has previously been shown that serum levels of pregnancy-associated plasma protein A (PAPP-A) are depressed in patients with early pregnancy bleeding and a live gestation. We examined whether Human Placental Lactogen (hPL) levels show a similar pattern. METHOD: Prospective study in the 8th-14th gestational week comparing serum levels in 69 women with early pregnancy bleeding with those in 93 control pregnancies. RESULTS: Serum levels of hPL were significantly depressed in women with early pregnancy bleeding (p < 0.0001). CONCLUSIONS: The findings suggest a primary affection of the placenta in early pregnancy bleeding.
Steen Sorensen - One of the best experts on this subject based on the ideXlab platform.
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Human Placental Lactogen and pregnancy associated plasma protein a in first trimester and subsequent fetal growth
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Steen Sorensen, Susanne RugeAbstract:Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of Human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p<0.01 andp<0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p<0.02).Conclusions. Higher levels of Human Placental Lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe b...
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Human Placental Lactogen and pregnancy‐associated plasma protein A in first trimester and subsequent fetal growth
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Steen Sorensen, Susanne RugeAbstract:Objective. To study in an optimized design the possible relation between serum levels in weeks 8-14 of Human Placental Lactogen and pregnancy-associated plasma protein A and fetal size at delivery.Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.Results. Serum levels of Human Placental Lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p
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Depressed serum levels of Human Placental Lactogen in first trimester vaginal bleeding.
Acta Obstetricia et Gynecologica Scandinavica, 1995Co-Authors: Jan Fog Pedersen, Susanne Ruge, Steen SorensenAbstract:BACKGROUND: It has previously been shown that serum levels of pregnancy-associated plasma protein A (PAPP-A) are depressed in patients with early pregnancy bleeding and a live gestation. We examined whether Human Placental Lactogen (hPL) levels show a similar pattern. METHOD: Prospective study in the 8th-14th gestational week comparing serum levels in 69 women with early pregnancy bleeding with those in 93 control pregnancies. RESULTS: Serum levels of hPL were significantly depressed in women with early pregnancy bleeding (p < 0.0001). CONCLUSIONS: The findings suggest a primary affection of the placenta in early pregnancy bleeding.
Charles S Nicoll - One of the best experts on this subject based on the ideXlab platform.
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Human Placental Lactogen directly inhibits rat cartilage growth processes in vivo and in vitro
European Journal of Endocrinology, 1993Co-Authors: Mimi H Chiang, Kevin M Kelley, Charles S NicollAbstract:: We have recently reported that Human Placental Lactogen inhibits the growth of young female rats without changing the serum levels of insulin like growth factor-I. Accordingly, experiments were conducted to determine whether Human Placental Lactogen could directly inhibit cartilage growth processes in vivo and in vitro. Osmotic minipumps with attached polyethylene catheters were used to infuse the hormone for seven days into the left hindlimb of three-month-old female rats via the common iliac artery. The right hindlimb of each animal served as an internal control. Infusion of the Placental Lactogen at 10 micrograms/rat/day caused a slight (10%) but significant decrease in the width of the tibial epiphysial cartilage plate and a higher dose (100 micrograms/rat/day) caused a greater degree of inhibition (25%). However, the higher dose also inhibited the tibial cartilage plate of the contralateral (non-infused) limb. The possibility that Human Placental Lactogen could directly inhibit cartilage anabolic activity in vitro was evaluated by measuring the incorporation of 35SO4 into costal cartilage explants from three to four-month-old female rats. The Placental hormone inhibited the incorporation of 35SO4 in a dose-related manner at concentrations ranging from 1.0 to 100 micrograms/l. As a test of the specificity of this inhibition the effect of the hormone on the incorporation of 35SO4 into cartilage explants from Coho salmon was determined. The Placental Lactogen did not affect incorporation of the sulfate into the fish cartilage over a range of doses from 1.0 to 1000 micrograms/l.(ABSTRACT TRUNCATED AT 250 WORDS)
Mimi H Chiang - One of the best experts on this subject based on the ideXlab platform.
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Human Placental Lactogen directly inhibits rat cartilage growth processes in vivo and in vitro
European Journal of Endocrinology, 1993Co-Authors: Mimi H Chiang, Kevin M Kelley, Charles S NicollAbstract:: We have recently reported that Human Placental Lactogen inhibits the growth of young female rats without changing the serum levels of insulin like growth factor-I. Accordingly, experiments were conducted to determine whether Human Placental Lactogen could directly inhibit cartilage growth processes in vivo and in vitro. Osmotic minipumps with attached polyethylene catheters were used to infuse the hormone for seven days into the left hindlimb of three-month-old female rats via the common iliac artery. The right hindlimb of each animal served as an internal control. Infusion of the Placental Lactogen at 10 micrograms/rat/day caused a slight (10%) but significant decrease in the width of the tibial epiphysial cartilage plate and a higher dose (100 micrograms/rat/day) caused a greater degree of inhibition (25%). However, the higher dose also inhibited the tibial cartilage plate of the contralateral (non-infused) limb. The possibility that Human Placental Lactogen could directly inhibit cartilage anabolic activity in vitro was evaluated by measuring the incorporation of 35SO4 into costal cartilage explants from three to four-month-old female rats. The Placental hormone inhibited the incorporation of 35SO4 in a dose-related manner at concentrations ranging from 1.0 to 100 micrograms/l. As a test of the specificity of this inhibition the effect of the hormone on the incorporation of 35SO4 into cartilage explants from Coho salmon was determined. The Placental Lactogen did not affect incorporation of the sulfate into the fish cartilage over a range of doses from 1.0 to 1000 micrograms/l.(ABSTRACT TRUNCATED AT 250 WORDS)