The Experts below are selected from a list of 120 Experts worldwide ranked by ideXlab platform
Liu Guang-hui - One of the best experts on this subject based on the ideXlab platform.
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Clinical Analysis of Curosurf Replacment Therapy in Newborn Infants with Hyaline Membrane Disease
Chinese Journal of General Practice, 2011Co-Authors: Liu Guang-huiAbstract:Objective To investigate the effect of pulmonary surfactant(PS) in the treatment of neonatal Hyaline Membrane Disease(NHMD).Methods 34 patients with Hyaline Membrane Disease were divided into treatment group and control group(17 cases each).The control group was set to heat incubators,tube feeding support,and treatment of complications,maintain homeostasis,breathing machine oxygen therapy.On the basis of the control group,the treatment group was treated with PS 100 mg/kg intratracheally.6 h and 24 h blood gas analysis,ventilator parameters and computer time,hospital stay,mortality were analyzed.Results The blood gas analysis,ventilator parameters,the average duration of mechanical ventilation,length of stay and mortality were statistically significant between the two groups.Conclusion PS in the treatment of Hyaline Membrane Disease can significantly improve the outcome and shorten the duration of mechanical ventilation and hospital stay and reduce mortality.
M. Kirschfink - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of complement activation in premature newborn infants with Hyaline Membrane Disease
European journal of pediatrics, 1993Co-Authors: R. Cat, N. A. Rosario, I. Taborda De Messias, T. D. Resener, M. KirschfinkAbstract:Fifteen premature newborns with Hyaline Membrane Disease causing acute respiratory distress were evaluated for complement activation. A high intrapulmonary right-to-left shunt and marked arterial-alveolar oxygen difference indicated the severity of the respiratory failure. Twenty preterm healthy infants served as controls. Total haemolytic activity, plasma concentrations of complement components and regulatory proteins (C3, C4, C1-inhibitor, factors H and I) as well as activation products (C3a, C3dg, C1rsC1-inhibitor, C3b(Bb)P) gave no evidence of significant complement activation. Functional activity of the ubiquitous regulatory protein C1-inhibitor was significantly reduced without impact on classical pathway activation. These data suggest that, in contrast to the adult form of respiratory distress syndrome, the low-pressure pulmonary oedema characterising Hyaline Membrane Disease is not mediated by activation of the complement system.
L. N. J. Archer - One of the best experts on this subject based on the ideXlab platform.
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Doppler assessment of pulmonary artery pressure and extrapulmonary shunting in the acute phase of Hyaline Membrane Disease.
Archives of Disease in Childhood, 1991Co-Authors: N. J. Evans, L. N. J. ArcherAbstract:The natural history of pulmonary artery pressure and extrapulmonary shunting in acute Hyaline Membrane Disease was studied by serial Doppler echocardiography in 57 preterm infants, 38 with, and 19 without, Hyaline Membrane Disease. Pulmonary artery pressure was assessed non-invasively by its inverse relationship with the ratio of pulmonary artery Doppler time to peak velocity: right ventricular ejection time. The mean ratio was significantly lower in the infants with Hyaline Membrane Disease. The mean ratio for each infant with Hyaline Membrane Disease varied widely and did not correlate with criteria of maturity or severity of Disease. Individual ratios correlated with arterial pH. Between 60-80 hours after birth, 14 of 18 infants with Hyaline Membrane Disease (78%) and one of 19 without (5%) had patent ductus arteriosus. Left to right and bidirectional shunting at ductal and atrial level were common; pure right to left shunting was uncommon. The mean ratio seen with bidirectional shunting was significantly lower than that seen with left to right shunting. Ratios and patterns of extra pulmonary shunting were similar when the fractional inspired oxygen (FIO2) was greater than 0.9 compared with when it was less than 0.9. Pulmonary artery pressure is high during the acute phase of Hyaline Membrane Disease but varies widely among infants. A few infants have extrapulmonary right to left shunting, and these infants are difficult to detect clinically.
E N Hey - One of the best experts on this subject based on the ideXlab platform.
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Pulmonary and systemic arterial pressure in Hyaline Membrane Disease.
Archives of disease in childhood, 1992Co-Authors: J R Skinner, R J Boys, S Hunter, E N HeyAbstract:Systolic pulmonary arterial pressure was determined serially over the first 10 days of life in 33 babies with Hyaline Membrane Disease by measuring the peak velocity of pansystolic tricuspid valve regurgitation, using Doppler ultrasound, and applying the Bernoulli equation. Results are presented in age groups 0-12, 13-36, 37-72, and 73-96 hours respectively. The incidence of tricuspid valve regurgitation was 92, 97, 80, and 64% (falling to 35% by day 10) compared with 53, 50, 31, and 0% in 17 healthy premature infants. In comparing healthy babies with those with Hyaline Membrane Disease, no allowance was made for right atrial pressure. The derived 'right ventricle to right atrial (RV-RA) pressure difference', was expressed as a ratio of systemic arterial (systolic) pressure. Over the first three days, this ratio fell much faster in the healthy babies. Values were 0.78:1, 0.77:1, and 0.72:1 in babies with Hyaline Membrane Disease and 0.87:1, 0.53:1, and 0.44:1 in healthy babies. Ductal patency was prolonged in babies with Hyaline Membrane Disease (75% on day 4 compared with 6% in healthy babies). The incidence of bidirectional ductal flow, indicating balanced pulmonary and systemic arterial pressures, was 79, 53, 30, and 20%, and in healthy babies was 41% at 0-12 hours and zero thereafter. Pulmonary arterial pressure was then calculated by adding a right atrial pressure estimate of 5 mm Hg to the RV-RA difference when the babies were ventilated. Babies of lower gestation had lower values. The pulmonary: systemic arterial pressure ratio showed considerable temporal variability, but fell with age and was raised by high mean airway pressure and pneumothorax (through a reduction in systemic pressure), and less noticeably by carbon dioxide tension. It did not correlate significantly with other indices of Disease severity. Hyaline Membrane Disease is associated with delayed postnatal circulatory adaptation characterized by pulmonary hypertension, systemic hypotension, and prolonged ductal patency.
R. Cat - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of complement activation in premature newborn infants with Hyaline Membrane Disease
European journal of pediatrics, 1993Co-Authors: R. Cat, N. A. Rosario, I. Taborda De Messias, T. D. Resener, M. KirschfinkAbstract:Fifteen premature newborns with Hyaline Membrane Disease causing acute respiratory distress were evaluated for complement activation. A high intrapulmonary right-to-left shunt and marked arterial-alveolar oxygen difference indicated the severity of the respiratory failure. Twenty preterm healthy infants served as controls. Total haemolytic activity, plasma concentrations of complement components and regulatory proteins (C3, C4, C1-inhibitor, factors H and I) as well as activation products (C3a, C3dg, C1rsC1-inhibitor, C3b(Bb)P) gave no evidence of significant complement activation. Functional activity of the ubiquitous regulatory protein C1-inhibitor was significantly reduced without impact on classical pathway activation. These data suggest that, in contrast to the adult form of respiratory distress syndrome, the low-pressure pulmonary oedema characterising Hyaline Membrane Disease is not mediated by activation of the complement system.