The Experts below are selected from a list of 513 Experts worldwide ranked by ideXlab platform
James W. Young - One of the best experts on this subject based on the ideXlab platform.
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breakthrough scedosporium apiospermum pseudallescheria boydii brain abscess during therapy for invasive pulmonary aspergillosis following high risk allogeneic hematopoietic stem cell transplantation scedosporiasis and recent advances in antifungal th
Transplant Infectious Disease, 2002Co-Authors: Aqsa Safdar, Esperanza B Papadopoulos, James W. YoungAbstract:: Systemic scedosporiasis due to the anamorph or asexual form Scedosporium apiospermum (Pseudallescheria boydii) has become an important cause of opportunistic mycosis, especially in patients undergoing high-risk hematopoietic stem cell transplantation. We report a case of rapidly progressive cerebellar Hyalohyphomycosis due to Scedosporium apiospermum in an allogeneic marrow graft recipient receiving treatment for severe graft-versus-host disease. This fatal breakthrough intracranial abscess, due to amphotericin B-resistant (minimum inhibitory concentration > 16 micro g/ml) mold, developed during the course of systemic antifungal therapy given for multicentric pulmonary aspergillosis. Despite treatment with high-dose Abelcet (10 mg/kg daily), free amphotericin B was not detected in postmortem cerebellar tissue. A broad-spectrum triazole-based agent (voriconazole/UK-109, 496--Vfend), and a novel fungal cell wall inhibitor, an echinocandin/pneumocandin analog (caspofungin/MK-0991--Cancidas), which exhibit excellent in vitro activity against most clinical Pseudallescheria boydii-Scedosporium apiospermum isolates, have recently become available in the United States and may provide much needed treatment options for patients at risk.
Aqsa Safdar - One of the best experts on this subject based on the ideXlab platform.
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breakthrough scedosporium apiospermum pseudallescheria boydii brain abscess during therapy for invasive pulmonary aspergillosis following high risk allogeneic hematopoietic stem cell transplantation scedosporiasis and recent advances in antifungal th
Transplant Infectious Disease, 2002Co-Authors: Aqsa Safdar, Esperanza B Papadopoulos, James W. YoungAbstract:: Systemic scedosporiasis due to the anamorph or asexual form Scedosporium apiospermum (Pseudallescheria boydii) has become an important cause of opportunistic mycosis, especially in patients undergoing high-risk hematopoietic stem cell transplantation. We report a case of rapidly progressive cerebellar Hyalohyphomycosis due to Scedosporium apiospermum in an allogeneic marrow graft recipient receiving treatment for severe graft-versus-host disease. This fatal breakthrough intracranial abscess, due to amphotericin B-resistant (minimum inhibitory concentration > 16 micro g/ml) mold, developed during the course of systemic antifungal therapy given for multicentric pulmonary aspergillosis. Despite treatment with high-dose Abelcet (10 mg/kg daily), free amphotericin B was not detected in postmortem cerebellar tissue. A broad-spectrum triazole-based agent (voriconazole/UK-109, 496--Vfend), and a novel fungal cell wall inhibitor, an echinocandin/pneumocandin analog (caspofungin/MK-0991--Cancidas), which exhibit excellent in vitro activity against most clinical Pseudallescheria boydii-Scedosporium apiospermum isolates, have recently become available in the United States and may provide much needed treatment options for patients at risk.
David A Schwartz - One of the best experts on this subject based on the ideXlab platform.
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pathology of Hyalohyphomycosis caused by scedosporium apiospermum pseudallescheria boydii an emerging mycosis
Human Pathology, 1998Co-Authors: Talaat Tadros, Kimberly A Workowski, Robert J Siegel, Steven Hunter, David A SchwartzAbstract:The genus Scedosporium contains two medically significant species of emerging mycotic agents, S apiospermum and S prolificans, which have received scant attention. Scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus Pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and histopathologic features. Scedosporium prolificans is a recently recognized agent of bone, soft tissue, and joint infections that occurs with highest frequency in children and young adults. S prolificans may also cause potentially fatal disseminated infections in immunocompromised persons. The drug sensitivities of both Scedosporium species are significantly different from those of most other fungi, and thus identification of these organisms is important. Unfortunately, the pathological features of Scedosporium infections may be easily confused with other mycotic agents, resulting in delayed or inappropriate medical therapy. Because many pathologists and clinicians are unfamiliar with the significance of Scedosporium spp. infection, this communication describes three persons with differing clinical and pathological presentations of S apiospermum infection. In one patient with sickle cell disease and chronic mycotic sinusitis, fungal colonies of S apiospermum removed from the sinuses showed a pattern of alternating zones of mycelial hypercellularity and hypocellularity associated with conidiation, similar to a previous report of P boydii infection. The clinicopathologic features of an immunocompetent person with S apiospermum osteomyelitis, and a patient with S apiospermum infection of the brain after bone marrow transplantation, are also described.
Talaat Tadros - One of the best experts on this subject based on the ideXlab platform.
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pathology of Hyalohyphomycosis caused by scedosporium apiospermum pseudallescheria boydii an emerging mycosis
Human Pathology, 1998Co-Authors: Talaat Tadros, Kimberly A Workowski, Robert J Siegel, Steven Hunter, David A SchwartzAbstract:The genus Scedosporium contains two medically significant species of emerging mycotic agents, S apiospermum and S prolificans, which have received scant attention. Scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus Pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and histopathologic features. Scedosporium prolificans is a recently recognized agent of bone, soft tissue, and joint infections that occurs with highest frequency in children and young adults. S prolificans may also cause potentially fatal disseminated infections in immunocompromised persons. The drug sensitivities of both Scedosporium species are significantly different from those of most other fungi, and thus identification of these organisms is important. Unfortunately, the pathological features of Scedosporium infections may be easily confused with other mycotic agents, resulting in delayed or inappropriate medical therapy. Because many pathologists and clinicians are unfamiliar with the significance of Scedosporium spp. infection, this communication describes three persons with differing clinical and pathological presentations of S apiospermum infection. In one patient with sickle cell disease and chronic mycotic sinusitis, fungal colonies of S apiospermum removed from the sinuses showed a pattern of alternating zones of mycelial hypercellularity and hypocellularity associated with conidiation, similar to a previous report of P boydii infection. The clinicopathologic features of an immunocompetent person with S apiospermum osteomyelitis, and a patient with S apiospermum infection of the brain after bone marrow transplantation, are also described.
Steven Hunter - One of the best experts on this subject based on the ideXlab platform.
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pathology of Hyalohyphomycosis caused by scedosporium apiospermum pseudallescheria boydii an emerging mycosis
Human Pathology, 1998Co-Authors: Talaat Tadros, Kimberly A Workowski, Robert J Siegel, Steven Hunter, David A SchwartzAbstract:The genus Scedosporium contains two medically significant species of emerging mycotic agents, S apiospermum and S prolificans, which have received scant attention. Scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus Pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and histopathologic features. Scedosporium prolificans is a recently recognized agent of bone, soft tissue, and joint infections that occurs with highest frequency in children and young adults. S prolificans may also cause potentially fatal disseminated infections in immunocompromised persons. The drug sensitivities of both Scedosporium species are significantly different from those of most other fungi, and thus identification of these organisms is important. Unfortunately, the pathological features of Scedosporium infections may be easily confused with other mycotic agents, resulting in delayed or inappropriate medical therapy. Because many pathologists and clinicians are unfamiliar with the significance of Scedosporium spp. infection, this communication describes three persons with differing clinical and pathological presentations of S apiospermum infection. In one patient with sickle cell disease and chronic mycotic sinusitis, fungal colonies of S apiospermum removed from the sinuses showed a pattern of alternating zones of mycelial hypercellularity and hypocellularity associated with conidiation, similar to a previous report of P boydii infection. The clinicopathologic features of an immunocompetent person with S apiospermum osteomyelitis, and a patient with S apiospermum infection of the brain after bone marrow transplantation, are also described.