The Experts below are selected from a list of 19071 Experts worldwide ranked by ideXlab platform
Z Shi - One of the best experts on this subject based on the ideXlab platform.
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The Cochrane Library - Hyaluronate for temporomandibular joint disorders
The Cochrane database of systematic reviews, 2013Co-Authors: Z Shi, C Guo, Manal A. AwadAbstract:Background Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of Hyaluronate for TMD has been used for nearly 2 decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. Objectives To assess the effectiveness of intra-articular injection of Hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. Search methods Intensive electronic and handsearches were carried out. The Cochrane Oral Health Group's Trials Register (September 2001), CENTRAL (The Cochrane Library 2001, Issue 3), MEDLINE (1966 to May 2001), PubMed (up to March 2002), EMBASE (1980 to August 2001), SIGLE (1980 to December 2001), CBMdisc (1983 to July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. Selection criteria Randomized or quasi-randomized controlled trials (RCTs), with single or double blind design, testing the effectiveness of Hyaluronate for patients with temporomandibular joint disorders. Data collection and analysis Two review authors independently extracted data, and three review authors independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. Main results Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared Hyaluronate with placebo. Long term effects (3 months or longer) are in favour of Hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR = 1.71, 95% CI: 1.05, 2.77) from two of the studies (n = 71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of Hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without Hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the Hyaluronate groups. No quality of life data were reported Authors' conclusions There is insufficient, consistent evidence to either support or refute the use of Hyaluronate for treating patients with TMD. Further high quality RCTs of Hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
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Hyaluronate for temporomandibular joint disorders.
The Cochrane database of systematic reviews, 2003Co-Authors: Z Shi, C Guo, M AwadAbstract:Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of Hyaluronate for TMD has been used for nearly two decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. To assess the effectiveness of intra-articular injection of Hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. Intensive electronic and handsearches were carried out. The Oral Health Group's Trials Register (September 2001), The Cochrane Library CENTRAL database (Issue 3, 2001), MEDLINE (1966- May 2001), PubMed ( up to March 2002), EMBASE (1974 - August 2001), SIGLE (1980 - December 2001), CBMdisc (1983 - July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. Randomized or quasi-randomized controlled trials (RCTs), with single or double blind, design testing the effectiveness of Hyaluronate for patients with temporomandibular joint disorders. Two reviewers independently extracted data, and three reviewers independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared Hyaluronate with placebo. Long term effects (three months or longer) are in favour of Hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR=1.71, 95%CI: 1.05, 2.77) from two of the studies (n=71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of Hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without Hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the Hyaluronate groups. No quality of life data were reported There is insufficient, consistent evidence to either support or refute the use of Hyaluronate for treating patients with TMD. Further high quality RCTs of Hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
M Awad - One of the best experts on this subject based on the ideXlab platform.
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Hyaluronate for temporomandibular joint disorders.
The Cochrane database of systematic reviews, 2003Co-Authors: Z Shi, C Guo, M AwadAbstract:Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of Hyaluronate for TMD has been used for nearly two decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. To assess the effectiveness of intra-articular injection of Hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. Intensive electronic and handsearches were carried out. The Oral Health Group's Trials Register (September 2001), The Cochrane Library CENTRAL database (Issue 3, 2001), MEDLINE (1966- May 2001), PubMed ( up to March 2002), EMBASE (1974 - August 2001), SIGLE (1980 - December 2001), CBMdisc (1983 - July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. Randomized or quasi-randomized controlled trials (RCTs), with single or double blind, design testing the effectiveness of Hyaluronate for patients with temporomandibular joint disorders. Two reviewers independently extracted data, and three reviewers independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared Hyaluronate with placebo. Long term effects (three months or longer) are in favour of Hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR=1.71, 95%CI: 1.05, 2.77) from two of the studies (n=71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of Hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without Hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the Hyaluronate groups. No quality of life data were reported There is insufficient, consistent evidence to either support or refute the use of Hyaluronate for treating patients with TMD. Further high quality RCTs of Hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
C Guo - One of the best experts on this subject based on the ideXlab platform.
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The Cochrane Library - Hyaluronate for temporomandibular joint disorders
The Cochrane database of systematic reviews, 2013Co-Authors: Z Shi, C Guo, Manal A. AwadAbstract:Background Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of Hyaluronate for TMD has been used for nearly 2 decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. Objectives To assess the effectiveness of intra-articular injection of Hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. Search methods Intensive electronic and handsearches were carried out. The Cochrane Oral Health Group's Trials Register (September 2001), CENTRAL (The Cochrane Library 2001, Issue 3), MEDLINE (1966 to May 2001), PubMed (up to March 2002), EMBASE (1980 to August 2001), SIGLE (1980 to December 2001), CBMdisc (1983 to July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. Selection criteria Randomized or quasi-randomized controlled trials (RCTs), with single or double blind design, testing the effectiveness of Hyaluronate for patients with temporomandibular joint disorders. Data collection and analysis Two review authors independently extracted data, and three review authors independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. Main results Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared Hyaluronate with placebo. Long term effects (3 months or longer) are in favour of Hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR = 1.71, 95% CI: 1.05, 2.77) from two of the studies (n = 71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of Hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without Hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the Hyaluronate groups. No quality of life data were reported Authors' conclusions There is insufficient, consistent evidence to either support or refute the use of Hyaluronate for treating patients with TMD. Further high quality RCTs of Hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
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Hyaluronate for temporomandibular joint disorders.
The Cochrane database of systematic reviews, 2003Co-Authors: Z Shi, C Guo, M AwadAbstract:Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of Hyaluronate for TMD has been used for nearly two decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. To assess the effectiveness of intra-articular injection of Hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. Intensive electronic and handsearches were carried out. The Oral Health Group's Trials Register (September 2001), The Cochrane Library CENTRAL database (Issue 3, 2001), MEDLINE (1966- May 2001), PubMed ( up to March 2002), EMBASE (1974 - August 2001), SIGLE (1980 - December 2001), CBMdisc (1983 - July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. Randomized or quasi-randomized controlled trials (RCTs), with single or double blind, design testing the effectiveness of Hyaluronate for patients with temporomandibular joint disorders. Two reviewers independently extracted data, and three reviewers independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared Hyaluronate with placebo. Long term effects (three months or longer) are in favour of Hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR=1.71, 95%CI: 1.05, 2.77) from two of the studies (n=71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of Hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without Hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the Hyaluronate groups. No quality of life data were reported There is insufficient, consistent evidence to either support or refute the use of Hyaluronate for treating patients with TMD. Further high quality RCTs of Hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
Manal A. Awad - One of the best experts on this subject based on the ideXlab platform.
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The Cochrane Library - Hyaluronate for temporomandibular joint disorders
The Cochrane database of systematic reviews, 2013Co-Authors: Z Shi, C Guo, Manal A. AwadAbstract:Background Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of Hyaluronate for TMD has been used for nearly 2 decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. Objectives To assess the effectiveness of intra-articular injection of Hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. Search methods Intensive electronic and handsearches were carried out. The Cochrane Oral Health Group's Trials Register (September 2001), CENTRAL (The Cochrane Library 2001, Issue 3), MEDLINE (1966 to May 2001), PubMed (up to March 2002), EMBASE (1980 to August 2001), SIGLE (1980 to December 2001), CBMdisc (1983 to July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. Selection criteria Randomized or quasi-randomized controlled trials (RCTs), with single or double blind design, testing the effectiveness of Hyaluronate for patients with temporomandibular joint disorders. Data collection and analysis Two review authors independently extracted data, and three review authors independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. Main results Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared Hyaluronate with placebo. Long term effects (3 months or longer) are in favour of Hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR = 1.71, 95% CI: 1.05, 2.77) from two of the studies (n = 71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of Hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without Hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the Hyaluronate groups. No quality of life data were reported Authors' conclusions There is insufficient, consistent evidence to either support or refute the use of Hyaluronate for treating patients with TMD. Further high quality RCTs of Hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
Philip T Lavin - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of intraarticular sodium Hyaluronate in knee osteoarthritis
Clinical Orthopaedics and Related Research, 2001Co-Authors: Kenneth D. Brandt, Joel A Block, Joseph P Michalski, Larry W Moreland, Jacques R Caldwell, Philip T LavinAbstract:A prospective, multicenter, randomized, double-blind, controlled trial was conducted in 226 patients with knee osteoarthritis to evaluate the safety and efficacy of intraarticular injections of sodium Hyaluronate. Patients were randomized to three weekly injections of 30 mg sodium Hyaluronate or physiologic saline (control) and were observed for an additional 25 weeks. In comparison with the control group, among patients who completed at least 15 weeks of the study and whose Western Ontario and McMaster Universities Osteoarthritis Index pain score for the contralateral knee was less than 12 at baseline, sodium Hyaluronate injection resulted in improvement in Western Ontario and McMaster Universities Osteoarthritis Index pain score, patient and investigator global assessments, and pain on standing from Weeks 7 to 27. Fifty-eight percent of patients treated with sodium Hyaluronate achieved a 5-unit or greater improvement in mean pain score from Weeks 7 through 27, compared with 40% of control patients. In addition, nearly twice as many patients treated with sodium Hyaluronate as with saline (30% versus 17%, respectively) achieved a net improvement of at least 7 units. In contrast to treatment with saline, Western Ontario and McMaster Universities Osteoarthritis Index pain score for the contralateral knee was inversely related to the magnitude of improvement after treatment with sodium Hyaluronate. Few side effects were attributed to treatment, and no differences between treatment groups were seen in this respect (sodium Hyaluronate, nine [8%]; saline, 11 [10%]). The incidence of injection site reactions was low (sodium Hyaluronate, 1.2 %; saline, 1.5%). The results indicate that sodium Hyaluronate treatment is well tolerated and produces statistically and clinically significant improvement of symptoms in patients with mild to moderate knee osteoarthritis in whom pain in the contralateral knee is relatively modest.
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efficacy and safety of intraarticular sodium Hyaluronate in knee osteoarthritis orthovisc study group
Clinical Orthopaedics and Related Research, 2001Co-Authors: Kenneth D. Brandt, Joel A Block, Joseph P Michalski, Larry W Moreland, Jacques R Caldwell, Philip T LavinAbstract:A prospective, multicenter, randomized, double-blind, controlled trial was conducted in 226 patients with knee osteoarthritis to evaluate the safety and efficacy of intraarticular injections of sodium Hyaluronate. Patients were randomized to three weekly injections of 30 mg sodium Hyaluronate or physiologic saline (control) and were observed for an additional 25 weeks. In comparison with the control group, among patients who completed at least 15 weeks of the study and whose Western Ontario and McMaster Universities Osteoarthritis Index pain score for the contralateral knee was less than 12 at baseline, sodium Hyaluronate injection resulted in improvement in Western Ontario and McMaster Universities Osteoarthritis Index pain score, patient and investigator global assessments, and pain on standing from Weeks 7 to 27. Fifty-eight percent of patients treated with sodium Hyaluronate achieved a 5-unit or greater improvement in mean pain score from Weeks 7 through 27, compared with 40% of control patients. In addition, nearly twice as many patients treated with sodium Hyaluronate as with saline (30% versus 17%, respectively) achieved a net improvement of at least 7 units. In contrast to treatment with saline, Western Ontario and McMaster Universities Osteoarthritis Index pain score for the contralateral knee was inversely related to the magnitude of improvement after treatment with sodium Hyaluronate. Few side effects were attributed to treatment, and no differences between treatment groups were seen in this respect (sodium Hyaluronate, nine [8%]; saline, 11 [10%]). The incidence of injection site reactions was low (sodium Hyaluronate, 1.2 %; saline, 1.5%). The results indicate that sodium Hyaluronate treatment is well tolerated and produces statistically and clinically significant improvement of symptoms in patients with mild to moderate knee osteoarthritis in whom pain in the contralateral knee is relatively modest.
