The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Petra Nio Filgueiras De Athaydefilho - One of the best experts on this subject based on the ideXlab platform.
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involvement of pro inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5 4 isopropylphenyl 3 phenyl imidazolidine 2 4 dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Faba Ola La Lis De Carvalho, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Diogo Vilar Da Fonsaaca, Severino Araaojo De Sousa, Petra Nio Filgueiras De AthaydefilhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p<0.01 or p<0.001) in the latency to the first writhing and reduction in the number of abdominal writhing (p<0.001). Furthermore, all doses reduced the nociceptive response in the first (p<0.05 or p<0.001) and second (p<0.001) phases of the formalin test. This effect was inhibited by pretreatment with the antagonists naloxone, sulpiride and caffeine. Additionally, IM-7 (75, 150 and 300 mg/kg, i.p.) reduced (p<0.05 or p<0.001) the glutamate-induced nociceptive response. Carrageenan-induced paw edema was strongly reduced following treatment with all doses of IM-7 (p<0.05, p<0.01 or p<0.001), and so were leukocyte migration and levels of interleukin-1β (300 mg/kg: p<0.001) and tumor necrosis factor-α (300 mg/kg: p<0.01) in carrageenan-induced peritonitis. Therefore, IM-7 decreased the nociceptive response via a mechanism involving the opioid, dopaminergic, and adenosinergic receptors. Its anti-inflammatory action also contributed by decreasing the release of pro-inflammatory cytokines. Key words: Pain, inflammation, IM-7, nociception.
Petrônio Filgueiras De Athayde-filho - One of the best experts on this subject based on the ideXlab platform.
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Involvement of pro-inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Fab Iola L Elis De Carvalho, Diogo Vilar Da Fonsêca, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Severino Ara Ujo De Sousa, Petrônio Filgueiras De Athayde-filhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p
M Arcia Regina Piuvezam - One of the best experts on this subject based on the ideXlab platform.
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Involvement of pro-inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Fab Iola L Elis De Carvalho, Diogo Vilar Da Fonsêca, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Severino Ara Ujo De Sousa, Petrônio Filgueiras De Athayde-filhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p
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involvement of pro inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5 4 isopropylphenyl 3 phenyl imidazolidine 2 4 dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Faba Ola La Lis De Carvalho, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Diogo Vilar Da Fonsaaca, Severino Araaojo De Sousa, Petra Nio Filgueiras De AthaydefilhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p<0.01 or p<0.001) in the latency to the first writhing and reduction in the number of abdominal writhing (p<0.001). Furthermore, all doses reduced the nociceptive response in the first (p<0.05 or p<0.001) and second (p<0.001) phases of the formalin test. This effect was inhibited by pretreatment with the antagonists naloxone, sulpiride and caffeine. Additionally, IM-7 (75, 150 and 300 mg/kg, i.p.) reduced (p<0.05 or p<0.001) the glutamate-induced nociceptive response. Carrageenan-induced paw edema was strongly reduced following treatment with all doses of IM-7 (p<0.05, p<0.01 or p<0.001), and so were leukocyte migration and levels of interleukin-1β (300 mg/kg: p<0.001) and tumor necrosis factor-α (300 mg/kg: p<0.01) in carrageenan-induced peritonitis. Therefore, IM-7 decreased the nociceptive response via a mechanism involving the opioid, dopaminergic, and adenosinergic receptors. Its anti-inflammatory action also contributed by decreasing the release of pro-inflammatory cytokines. Key words: Pain, inflammation, IM-7, nociception.
Antônia Rosangela Soares Penha - One of the best experts on this subject based on the ideXlab platform.
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Involvement of pro-inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Fab Iola L Elis De Carvalho, Diogo Vilar Da Fonsêca, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Severino Ara Ujo De Sousa, Petrônio Filgueiras De Athayde-filhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p
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involvement of pro inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5 4 isopropylphenyl 3 phenyl imidazolidine 2 4 dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Faba Ola La Lis De Carvalho, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Diogo Vilar Da Fonsaaca, Severino Araaojo De Sousa, Petra Nio Filgueiras De AthaydefilhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p<0.01 or p<0.001) in the latency to the first writhing and reduction in the number of abdominal writhing (p<0.001). Furthermore, all doses reduced the nociceptive response in the first (p<0.05 or p<0.001) and second (p<0.001) phases of the formalin test. This effect was inhibited by pretreatment with the antagonists naloxone, sulpiride and caffeine. Additionally, IM-7 (75, 150 and 300 mg/kg, i.p.) reduced (p<0.05 or p<0.001) the glutamate-induced nociceptive response. Carrageenan-induced paw edema was strongly reduced following treatment with all doses of IM-7 (p<0.05, p<0.01 or p<0.001), and so were leukocyte migration and levels of interleukin-1β (300 mg/kg: p<0.001) and tumor necrosis factor-α (300 mg/kg: p<0.01) in carrageenan-induced peritonitis. Therefore, IM-7 decreased the nociceptive response via a mechanism involving the opioid, dopaminergic, and adenosinergic receptors. Its anti-inflammatory action also contributed by decreasing the release of pro-inflammatory cytokines. Key words: Pain, inflammation, IM-7, nociception.
Mirian Graciela Da Silva Stiebbe Salvadori - One of the best experts on this subject based on the ideXlab platform.
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Involvement of pro-inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Fab Iola L Elis De Carvalho, Diogo Vilar Da Fonsêca, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Severino Ara Ujo De Sousa, Petrônio Filgueiras De Athayde-filhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p
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involvement of pro inflammatory cytokines and nociceptive pathways on the pharmacological activity of Hydantoin Derivative 5 4 isopropylphenyl 3 phenyl imidazolidine 2 4 dione
African Journal of Pharmacy and Pharmacology, 2016Co-Authors: Faba Ola La Lis De Carvalho, Antônia Rosangela Soares Penha, Mirian Graciela Da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, M Arcia Regina Piuvezam, Diogo Vilar Da Fonsaaca, Severino Araaojo De Sousa, Petra Nio Filgueiras De AthaydefilhoAbstract:Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the Hydantoin Derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed increase (p<0.01 or p<0.001) in the latency to the first writhing and reduction in the number of abdominal writhing (p<0.001). Furthermore, all doses reduced the nociceptive response in the first (p<0.05 or p<0.001) and second (p<0.001) phases of the formalin test. This effect was inhibited by pretreatment with the antagonists naloxone, sulpiride and caffeine. Additionally, IM-7 (75, 150 and 300 mg/kg, i.p.) reduced (p<0.05 or p<0.001) the glutamate-induced nociceptive response. Carrageenan-induced paw edema was strongly reduced following treatment with all doses of IM-7 (p<0.05, p<0.01 or p<0.001), and so were leukocyte migration and levels of interleukin-1β (300 mg/kg: p<0.001) and tumor necrosis factor-α (300 mg/kg: p<0.01) in carrageenan-induced peritonitis. Therefore, IM-7 decreased the nociceptive response via a mechanism involving the opioid, dopaminergic, and adenosinergic receptors. Its anti-inflammatory action also contributed by decreasing the release of pro-inflammatory cytokines. Key words: Pain, inflammation, IM-7, nociception.
