The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Pierre Grandclaudon - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of cyclic enehydrazides by ring-closing metathesis
Synthesis, 2006Co-Authors: Stephane Lebrun, Eric Deniau, Axel Couture, Pierre GrandclaudonAbstract:A series of five- and six-membered unsaturated hydrazides were efficiently prepared from precursor dienehydrazides through a ring-closing metathesis (RCM) reaction. The parent compounds were easily obtained by sequential acylation and alkylation of appropriate Hydrazines.
Stephane Lebrun - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of cyclic enehydrazides by ring-closing metathesis
Synthesis, 2006Co-Authors: Stephane Lebrun, Eric Deniau, Axel Couture, Pierre GrandclaudonAbstract:A series of five- and six-membered unsaturated hydrazides were efficiently prepared from precursor dienehydrazides through a ring-closing metathesis (RCM) reaction. The parent compounds were easily obtained by sequential acylation and alkylation of appropriate Hydrazines.
Eric Deniau - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of cyclic enehydrazides by ring-closing metathesis
Synthesis, 2006Co-Authors: Stephane Lebrun, Eric Deniau, Axel Couture, Pierre GrandclaudonAbstract:A series of five- and six-membered unsaturated hydrazides were efficiently prepared from precursor dienehydrazides through a ring-closing metathesis (RCM) reaction. The parent compounds were easily obtained by sequential acylation and alkylation of appropriate Hydrazines.
Axel Couture - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of cyclic enehydrazides by ring-closing metathesis
Synthesis, 2006Co-Authors: Stephane Lebrun, Eric Deniau, Axel Couture, Pierre GrandclaudonAbstract:A series of five- and six-membered unsaturated hydrazides were efficiently prepared from precursor dienehydrazides through a ring-closing metathesis (RCM) reaction. The parent compounds were easily obtained by sequential acylation and alkylation of appropriate Hydrazines.
Konstantin Majorov - One of the best experts on this subject based on the ideXlab platform.
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synthesis and antituberculosis activity of indole pyridine derived hydrazides hydrazide hydrazones and thiosemicarbazones
Bioorganic & Medicinal Chemistry Letters, 2016Co-Authors: V S Velezheva, Albert G Kornienko, Konstantin Kazarian, B V Nikonenko, Patrick J. Brennan, Sergey E. Lyubimov, P. A. Ivanov, Konstantin MajorovAbstract:Abstract We describe the design, synthesis, and in vitro antimycobacterial activity of a series of novel simple hybrid hydrazides and hydrazide–hydrazones combining indole and pyridine nuclei. The compounds are derivatives of 1-acetylindoxyl or substituted indole-3-carboxaldehydes tethered via a hydrazine group by simple C N or double C N bonds with 3- and 4-pyridines, 1-oxide 3- and 4-pyridine carbohydrazides. The most active of 15 compounds showed MICs values against an INH-sensitive strain of Mycobacterium tuberculosis H37Rv equal to that of INH (0.05–2 μg/mL). Five compounds demonstrated appreciable activity against the INH-resistant M. tuberculosis CN-40 clinical isolate (MICs: 2–5 μg/mL), providing justification for further in vivo studies.
