The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform

Okada S - One of the best experts on this subject based on the ideXlab platform.

  • Hydrocortisone Sodium Phosphate Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Iwata M, Koide T, Maekawa K, Saito H, Tanimoto T, Okada S
    Abstract:

    The raw material of Hydrocortisone Sodium Phosphate was examined for the preparation of the "Hydrocortisone Sodium Phosphate Reference Standard (Control 001)". The analytical data obtained were: pH, 8.3: optical rotation, [alpha]D20 = +126.2 degrees; UV spectrum, lambda max of 248 nm and specific absorbance in water at 248 nm = 338.6; IR spectrum, same as that of the Hydrocortisone Sodium Phosphate Reference Standard (Control 891); free phosphoric acid, 0.2%; free Hydrocortisone, 0.01%; thin-layer chromatography, no impurity was detected until 200 micrograms; high-performance liquid chromatography, total amount of impurities estimated to be less than 0.2%; residual solvent, 0.0% (acetone) and 0.02% (ethanol); loss on drying, 1.5%. Based on the above results, the raw material was authorized as the Hydrocortisone Sodium Phosphate Reference Standard (Control 001) of the National Institute of Health Sciences.

Masahiro Tani - One of the best experts on this subject based on the ideXlab platform.

  • Systemic contact dermatitis caused by systemic corticosteroid use.
    Archives of dermatology, 1997
    Co-Authors: Yozo Murata, Kimiko Kumano, Takahiro Ueda, Toko Nakamura, Masahiro Tani
    Abstract:

    Adelayed-type generalized skin eruption after systemic corticosteroid administration is rare. We describe a patient with systemic contact dermatitis caused by corticosteroid use. Report of a Case. A 62-year-old woman had a history of a burn treated with ointment containing Hydrocortisone in 1990. No adverse effects were noted. In 1992, she was given an intra-articular injection of methylprednisolone acetate in the knee because of arthrosis. On that evening she developed erythema around the neck. In January 1994, because of sudden deafness, she was given an intravenous injection of Hydrocortisone Sodium Phosphate, 500 mg, for 2 days, and then developed erythema on the neck, trunk, and thighs in the evening on the first day of injection. Methylprednisolone Sodium succinate was substituted for the Hydrocortisone. The eruption developed into a generalized rash. The methylprednisolone treatment was discontinued and the eruption resolved. She was referred to us for an evaluation of the eruption. The

Gregory L. Eastwood - One of the best experts on this subject based on the ideXlab platform.

  • Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by Hydrocortisone Sodium Phosphate of chronic gastric ulcers in the rat.
    The American Journal of Medicine, 1991
    Co-Authors: Hajime Kuwayama, Yutaka Matsuo, Gregory L. Eastwood
    Abstract:

    We have previously shown that chronic sucralfate ingestion stimulates gastric epithelial proliferation in rats, which may explain one of the beneficial effects of sucralfate in healing of peptic ulcers. In a separate study, we have found that chronic steroid administration delays the healing of experimental gastric ulcers in rats. This study was designed to test the beneficial effects of sucralfate, cimetidine, and lansoprazole (AG-1749, a new proton pump inhibitor), on the delayed healing by steroids in rat chronic gastric ulcers. Chronic gastric ulcers were produced in male Wistar rats, weighing 180 g, by the application of 100% acetic acid. The rats were randomly divided into five groups; (1) control, (2) vehicle alone, (3) 10 mg/kg lansoprazole, (4) 500 mg/kg sucralfate, and (5) 100 mg/kg cimetidine. Except for controls, all rats received daily intraperitoneal injections of 2.5 mg/kg Hydrocortisone Sodium Phosphate. Tested drugs were administered intragastrically (lansoprazole and sucralfate) or intraperitoneally (cimetidine) twice a day for 2 weeks. Rats were sacrificed 14 days later and ulcer size was measured. Chronic administration of Hydrocortisone Sodium Phosphate resulted in a significant delay of ulcer healing induced by acetic acid. Treatment with either lansoprazole or sucralfate abolished the deleterious effect of steroids, whereas cimetidine had no effect. These results indicate that lansoprazole and sucralfate overcome the delayed healing by steroids of chronic gastric ulcers in the rat.

Iwata M - One of the best experts on this subject based on the ideXlab platform.

  • Hydrocortisone Sodium Phosphate Reference Standard (Control 001) of National Institute of Health Sciences
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2001
    Co-Authors: Iwata M, Koide T, Maekawa K, Saito H, Tanimoto T, Okada S
    Abstract:

    The raw material of Hydrocortisone Sodium Phosphate was examined for the preparation of the "Hydrocortisone Sodium Phosphate Reference Standard (Control 001)". The analytical data obtained were: pH, 8.3: optical rotation, [alpha]D20 = +126.2 degrees; UV spectrum, lambda max of 248 nm and specific absorbance in water at 248 nm = 338.6; IR spectrum, same as that of the Hydrocortisone Sodium Phosphate Reference Standard (Control 891); free phosphoric acid, 0.2%; free Hydrocortisone, 0.01%; thin-layer chromatography, no impurity was detected until 200 micrograms; high-performance liquid chromatography, total amount of impurities estimated to be less than 0.2%; residual solvent, 0.0% (acetone) and 0.02% (ethanol); loss on drying, 1.5%. Based on the above results, the raw material was authorized as the Hydrocortisone Sodium Phosphate Reference Standard (Control 001) of the National Institute of Health Sciences.

Yozo Murata - One of the best experts on this subject based on the ideXlab platform.

  • Systemic contact dermatitis caused by systemic corticosteroid use.
    Archives of dermatology, 1997
    Co-Authors: Yozo Murata, Kimiko Kumano, Takahiro Ueda, Toko Nakamura, Masahiro Tani
    Abstract:

    Adelayed-type generalized skin eruption after systemic corticosteroid administration is rare. We describe a patient with systemic contact dermatitis caused by corticosteroid use. Report of a Case. A 62-year-old woman had a history of a burn treated with ointment containing Hydrocortisone in 1990. No adverse effects were noted. In 1992, she was given an intra-articular injection of methylprednisolone acetate in the knee because of arthrosis. On that evening she developed erythema around the neck. In January 1994, because of sudden deafness, she was given an intravenous injection of Hydrocortisone Sodium Phosphate, 500 mg, for 2 days, and then developed erythema on the neck, trunk, and thighs in the evening on the first day of injection. Methylprednisolone Sodium succinate was substituted for the Hydrocortisone. The eruption developed into a generalized rash. The methylprednisolone treatment was discontinued and the eruption resolved. She was referred to us for an evaluation of the eruption. The