The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Alessandro Prete - One of the best experts on this subject based on the ideXlab platform.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Angela E Taylor, David J Smith, Mark A Foster, Sibylle KohlerAbstract:Context Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid a life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency who are exposed to major stress. Design and participants Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N = 83], sepsis [N = 100], and combat stress [N = 105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200 mg Hydrocortisone over 24 hours in 4 different delivery modes (continuous intravenous infusion; 6-hourly oral, intramuscular or intravenous bolus administration). Main outcome measure We measured total serum cortisol and cortisone, free serum cortisol, and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modeling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modeling identified continuous intravenous infusion of 200 mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100 mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, Sibylle KohlerAbstract:CONTEXT: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. OBJECTIVE: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. DESIGN AND PARTICIPANTS: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). MAIN OUTCOME MEASURE: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. RESULTS: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. CONCLUSIONS: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery in adrenal insufficiency
medRxiv, 2020Co-Authors: Alessandro Prete, Sibylle Kohler, Violet Fazelsanderson, John Komninos, Donna M Oneil, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, D. VassiliadiAbstract:Context: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. Design and Participants: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). Main Outcome Measure: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
Sibylle Kohler - One of the best experts on this subject based on the ideXlab platform.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Angela E Taylor, David J Smith, Mark A Foster, Sibylle KohlerAbstract:Context Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid a life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency who are exposed to major stress. Design and participants Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N = 83], sepsis [N = 100], and combat stress [N = 105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200 mg Hydrocortisone over 24 hours in 4 different delivery modes (continuous intravenous infusion; 6-hourly oral, intramuscular or intravenous bolus administration). Main outcome measure We measured total serum cortisol and cortisone, free serum cortisol, and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modeling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modeling identified continuous intravenous infusion of 200 mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100 mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, Sibylle KohlerAbstract:CONTEXT: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. OBJECTIVE: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. DESIGN AND PARTICIPANTS: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). MAIN OUTCOME MEASURE: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. RESULTS: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. CONCLUSIONS: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery in adrenal insufficiency
medRxiv, 2020Co-Authors: Alessandro Prete, Sibylle Kohler, Violet Fazelsanderson, John Komninos, Donna M Oneil, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, D. VassiliadiAbstract:Context: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. Design and Participants: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). Main Outcome Measure: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
Angela E Taylor - One of the best experts on this subject based on the ideXlab platform.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Angela E Taylor, David J Smith, Mark A Foster, Sibylle KohlerAbstract:Context Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid a life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency who are exposed to major stress. Design and participants Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N = 83], sepsis [N = 100], and combat stress [N = 105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200 mg Hydrocortisone over 24 hours in 4 different delivery modes (continuous intravenous infusion; 6-hourly oral, intramuscular or intravenous bolus administration). Main outcome measure We measured total serum cortisol and cortisone, free serum cortisol, and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modeling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modeling identified continuous intravenous infusion of 200 mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100 mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, Sibylle KohlerAbstract:CONTEXT: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. OBJECTIVE: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. DESIGN AND PARTICIPANTS: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). MAIN OUTCOME MEASURE: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. RESULTS: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. CONCLUSIONS: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery in adrenal insufficiency
medRxiv, 2020Co-Authors: Alessandro Prete, Sibylle Kohler, Violet Fazelsanderson, John Komninos, Donna M Oneil, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, D. VassiliadiAbstract:Context: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. Design and Participants: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). Main Outcome Measure: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
Irina Bancos - One of the best experts on this subject based on the ideXlab platform.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Angela E Taylor, David J Smith, Mark A Foster, Sibylle KohlerAbstract:Context Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid a life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency who are exposed to major stress. Design and participants Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N = 83], sepsis [N = 100], and combat stress [N = 105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200 mg Hydrocortisone over 24 hours in 4 different delivery modes (continuous intravenous infusion; 6-hourly oral, intramuscular or intravenous bolus administration). Main outcome measure We measured total serum cortisol and cortisone, free serum cortisol, and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modeling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modeling identified continuous intravenous infusion of 200 mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100 mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery
The Journal of Clinical Endocrinology and Metabolism, 2020Co-Authors: Alessandro Prete, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, Sibylle KohlerAbstract:CONTEXT: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. OBJECTIVE: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. DESIGN AND PARTICIPANTS: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). MAIN OUTCOME MEASURE: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. RESULTS: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. CONCLUSIONS: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
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prevention of adrenal crisis cortisol responses to major stress compared to stress dose Hydrocortisone delivery in adrenal insufficiency
medRxiv, 2020Co-Authors: Alessandro Prete, Sibylle Kohler, Violet Fazelsanderson, John Komninos, Donna M Oneil, Irina Bancos, Mark Foster, Angela E Taylor, David J Smith, D. VassiliadiAbstract:Context: Patients with adrenal insufficiency require increased Hydrocortisone cover during major stress to avoid life-threatening adrenal crisis. However, current treatment recommendations are not evidence-based. Objective: To identify the most appropriate mode of Hydrocortisone delivery in patients with adrenal insufficiency exposed to major stress. Design and Participants: Cross-sectional study: 122 unstressed healthy subjects and 288 subjects exposed to different stressors (major trauma [N=83], sepsis [N=100], and combat stress [N=105]). Longitudinal study: 22 patients with preserved adrenal function undergoing elective surgery. Pharmacokinetic study: 10 patients with primary adrenal insufficiency undergoing administration of 200mg Hydrocortisone over 24 hours in four different delivery modes (continuous intravenous infusion; six-hourly oral, intramuscular or intravenous bolus administration). Main Outcome Measure: We measured total serum cortisol and cortisone, free serum cortisol and urinary glucocorticoid metabolite excretion by mass spectrometry. Linear pharmacokinetic modelling was used to determine the most appropriate mode and dose of Hydrocortisone administration in patients with adrenal insufficiency exposed to major stress. Results: Serum cortisol was increased in all stress conditions, with the highest values observed in surgery and sepsis. Continuous intravenous Hydrocortisone was the only administration mode persistently achieving median cortisol concentrations in the range observed during major stress. Linear pharmacokinetic modelling identified continuous intravenous infusion of 200mg Hydrocortisone over 24 hours, preceded by an initial bolus of 50-100mg Hydrocortisone, as best suited for maintaining cortisol concentrations in the required range. Conclusions: Continuous intravenous Hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress.
Marko Turpeinen - One of the best experts on this subject based on the ideXlab platform.
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transepidermal water loss and absorption of Hydrocortisone in widespread dermatitis
British Journal of Dermatology, 1993Co-Authors: Kristiina Aaltokorte, Marko TurpeinenAbstract:Summary Percutaneous absorption of Hydrocortisone was measured in tbree children and six adults with widespread dermatitis, after the application of 1% bydrocortisone cream. Before appiication of the cream, the transepidermal water loss (TEWL) was measured on six skin areas. A highly significant correlation was found between the post-application rise in plasma cortisol level and the mean transepidermal water loss. Thus, measurement of TEWL affords a simple, non-invasive method for assessing the systemic effect of Hydrocortisone applied to widespread dermatitis.
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transepidermal water loss and absorption of Hydrocortisone in widespread dermatitis
British Journal of Dermatology, 1993Co-Authors: Kristiina Aaltokorte, Marko TurpeinenAbstract:Summary Percutaneous absorption of Hydrocortisone was measured in tbree children and six adults with widespread dermatitis, after the application of 1% bydrocortisone cream. Before appiication of the cream, the transepidermal water loss (TEWL) was measured on six skin areas. A highly significant correlation was found between the post-application rise in plasma cortisol level and the mean transepidermal water loss. Thus, measurement of TEWL affords a simple, non-invasive method for assessing the systemic effect of Hydrocortisone applied to widespread dermatitis.