The Experts below are selected from a list of 1437 Experts worldwide ranked by ideXlab platform
Richard F Hurrell - One of the best experts on this subject based on the ideXlab platform.
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dual fortification of salt with iodine and microencapsulated iron a randomized double blind controlled trial in moroccan schoolchildren
The American Journal of Clinical Nutrition, 2003Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Background: In many developing countries children are at high risk of both goiter and iron deficiency anemia. Objective: In a series of studies in northern Morocco we developed and tested a dual-fortified salt (DFS) containing iodine and microencapsulated iron. Design: To establish the DFS fortification concentration we measured salt intake by 3-d weighed food records and estimated iron bioavailability from the local diet by using published algorithms. We then formulated a DFS containing 25 aeg iodine/g salt (as potassium iodide) and 1 mg iron/g salt (as ferrous sulfate hydrate encapsulated with partially Hydrogenated Vegetable Oil). After storage and acceptability trials we compared the efficacy of the DFS to that of iodized salt in a 9-mo randomized double-blind trial in iodine-deficient 6-15-y-old children (n=377). Results: Mean salt intake in school-age children was 7-12 g/d and estimated iron bioavailability from the local diet was 0.4-4.3%. After storage for 20 wk the DFS and iodized salt were not significantly different in iodine content and color stability was acceptable when the compounds were added to local meals. During the efficacy trial urinary iodine concentrations and thyroid volumes improved significantly (P < 0.001 an < 0.05 respectively) from baseline in both groups. At 40 wk mean hemoglobin concentrations in the DFS group had increased by 14 g/L (P<0.01) and serum ferritin transferrin receptor and zinc protoporphyrin concentrations were significantly better (P<0.05) in the DFS group than in the iodized salt group. The prevalence of iron deficiency anemia in the DFS group decreased from 35% at baseline to 8% at 40 wk (P<0.001). Conclusion: A DFS containing iodine and encapsulated iron can be an effective fortification strategy. (authors)
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addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous iron deficient children a randomized double blind controlled trial
European Journal of Endocrinology, 2002Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Objective: In many developing countries, children are at high risk for both goiter and anemia. Iron (Fe) deficiency adversely effects thyroid metabolism and reduces efficacy of iodine prophylaxis in areas of endemic goiter. The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia. Design and methods: In a 9-month, randomized, double-blind trial, 6 ‐ 15 year-old children ðn ¼ 377Þ were given iodized salt (25mg iodine/g salt) or dual-fortified salt with iodine (25mg iodine/g salt) and Fe (1 mg Fe/g salt, as ferrous sulfate microencapsulated with partially Hydrogenated Vegetable Oil). Results: In the dual-fortified salt group, hemoglobin and Fe status improved significantly compared with the iodized salt group ðP , 0:05Þ: At 40 weeks, the mean decrease in thyroid volume measured by ultrasound in the dual-fortified salt group (2 38%) was twice that of the iodized salt group (2 18%) ðP , 0:01Þ: Compared with the iodized salt group, serum thyroxine was significantly increased ðP , 0:05Þ and the prevalence of hypothyroidism and goiter decreased ðP , 0:01Þ in the dual-fortified salt group. Conclusion: Addition of encapsulated Fe to iodized salt improves the efficacy of iodine in goitrous children with a high prevalence of anemia.
Michael B Zimmermann - One of the best experts on this subject based on the ideXlab platform.
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dual fortification of salt with iodine and microencapsulated iron a randomized double blind controlled trial in moroccan schoolchildren
The American Journal of Clinical Nutrition, 2003Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Background: In many developing countries children are at high risk of both goiter and iron deficiency anemia. Objective: In a series of studies in northern Morocco we developed and tested a dual-fortified salt (DFS) containing iodine and microencapsulated iron. Design: To establish the DFS fortification concentration we measured salt intake by 3-d weighed food records and estimated iron bioavailability from the local diet by using published algorithms. We then formulated a DFS containing 25 aeg iodine/g salt (as potassium iodide) and 1 mg iron/g salt (as ferrous sulfate hydrate encapsulated with partially Hydrogenated Vegetable Oil). After storage and acceptability trials we compared the efficacy of the DFS to that of iodized salt in a 9-mo randomized double-blind trial in iodine-deficient 6-15-y-old children (n=377). Results: Mean salt intake in school-age children was 7-12 g/d and estimated iron bioavailability from the local diet was 0.4-4.3%. After storage for 20 wk the DFS and iodized salt were not significantly different in iodine content and color stability was acceptable when the compounds were added to local meals. During the efficacy trial urinary iodine concentrations and thyroid volumes improved significantly (P < 0.001 an < 0.05 respectively) from baseline in both groups. At 40 wk mean hemoglobin concentrations in the DFS group had increased by 14 g/L (P<0.01) and serum ferritin transferrin receptor and zinc protoporphyrin concentrations were significantly better (P<0.05) in the DFS group than in the iodized salt group. The prevalence of iron deficiency anemia in the DFS group decreased from 35% at baseline to 8% at 40 wk (P<0.001). Conclusion: A DFS containing iodine and encapsulated iron can be an effective fortification strategy. (authors)
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addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous iron deficient children a randomized double blind controlled trial
European Journal of Endocrinology, 2002Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Objective: In many developing countries, children are at high risk for both goiter and anemia. Iron (Fe) deficiency adversely effects thyroid metabolism and reduces efficacy of iodine prophylaxis in areas of endemic goiter. The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia. Design and methods: In a 9-month, randomized, double-blind trial, 6 ‐ 15 year-old children ðn ¼ 377Þ were given iodized salt (25mg iodine/g salt) or dual-fortified salt with iodine (25mg iodine/g salt) and Fe (1 mg Fe/g salt, as ferrous sulfate microencapsulated with partially Hydrogenated Vegetable Oil). Results: In the dual-fortified salt group, hemoglobin and Fe status improved significantly compared with the iodized salt group ðP , 0:05Þ: At 40 weeks, the mean decrease in thyroid volume measured by ultrasound in the dual-fortified salt group (2 38%) was twice that of the iodized salt group (2 18%) ðP , 0:01Þ: Compared with the iodized salt group, serum thyroxine was significantly increased ðP , 0:05Þ and the prevalence of hypothyroidism and goiter decreased ðP , 0:01Þ in the dual-fortified salt group. Conclusion: Addition of encapsulated Fe to iodized salt improves the efficacy of iodine in goitrous children with a high prevalence of anemia.
Christophe Zeder - One of the best experts on this subject based on the ideXlab platform.
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dual fortification of salt with iodine and microencapsulated iron a randomized double blind controlled trial in moroccan schoolchildren
The American Journal of Clinical Nutrition, 2003Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Background: In many developing countries children are at high risk of both goiter and iron deficiency anemia. Objective: In a series of studies in northern Morocco we developed and tested a dual-fortified salt (DFS) containing iodine and microencapsulated iron. Design: To establish the DFS fortification concentration we measured salt intake by 3-d weighed food records and estimated iron bioavailability from the local diet by using published algorithms. We then formulated a DFS containing 25 aeg iodine/g salt (as potassium iodide) and 1 mg iron/g salt (as ferrous sulfate hydrate encapsulated with partially Hydrogenated Vegetable Oil). After storage and acceptability trials we compared the efficacy of the DFS to that of iodized salt in a 9-mo randomized double-blind trial in iodine-deficient 6-15-y-old children (n=377). Results: Mean salt intake in school-age children was 7-12 g/d and estimated iron bioavailability from the local diet was 0.4-4.3%. After storage for 20 wk the DFS and iodized salt were not significantly different in iodine content and color stability was acceptable when the compounds were added to local meals. During the efficacy trial urinary iodine concentrations and thyroid volumes improved significantly (P < 0.001 an < 0.05 respectively) from baseline in both groups. At 40 wk mean hemoglobin concentrations in the DFS group had increased by 14 g/L (P<0.01) and serum ferritin transferrin receptor and zinc protoporphyrin concentrations were significantly better (P<0.05) in the DFS group than in the iodized salt group. The prevalence of iron deficiency anemia in the DFS group decreased from 35% at baseline to 8% at 40 wk (P<0.001). Conclusion: A DFS containing iodine and encapsulated iron can be an effective fortification strategy. (authors)
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addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous iron deficient children a randomized double blind controlled trial
European Journal of Endocrinology, 2002Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Objective: In many developing countries, children are at high risk for both goiter and anemia. Iron (Fe) deficiency adversely effects thyroid metabolism and reduces efficacy of iodine prophylaxis in areas of endemic goiter. The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia. Design and methods: In a 9-month, randomized, double-blind trial, 6 ‐ 15 year-old children ðn ¼ 377Þ were given iodized salt (25mg iodine/g salt) or dual-fortified salt with iodine (25mg iodine/g salt) and Fe (1 mg Fe/g salt, as ferrous sulfate microencapsulated with partially Hydrogenated Vegetable Oil). Results: In the dual-fortified salt group, hemoglobin and Fe status improved significantly compared with the iodized salt group ðP , 0:05Þ: At 40 weeks, the mean decrease in thyroid volume measured by ultrasound in the dual-fortified salt group (2 38%) was twice that of the iodized salt group (2 18%) ðP , 0:01Þ: Compared with the iodized salt group, serum thyroxine was significantly increased ðP , 0:05Þ and the prevalence of hypothyroidism and goiter decreased ðP , 0:01Þ in the dual-fortified salt group. Conclusion: Addition of encapsulated Fe to iodized salt improves the efficacy of iodine in goitrous children with a high prevalence of anemia.
T Torresani - One of the best experts on this subject based on the ideXlab platform.
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dual fortification of salt with iodine and microencapsulated iron a randomized double blind controlled trial in moroccan schoolchildren
The American Journal of Clinical Nutrition, 2003Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Background: In many developing countries children are at high risk of both goiter and iron deficiency anemia. Objective: In a series of studies in northern Morocco we developed and tested a dual-fortified salt (DFS) containing iodine and microencapsulated iron. Design: To establish the DFS fortification concentration we measured salt intake by 3-d weighed food records and estimated iron bioavailability from the local diet by using published algorithms. We then formulated a DFS containing 25 aeg iodine/g salt (as potassium iodide) and 1 mg iron/g salt (as ferrous sulfate hydrate encapsulated with partially Hydrogenated Vegetable Oil). After storage and acceptability trials we compared the efficacy of the DFS to that of iodized salt in a 9-mo randomized double-blind trial in iodine-deficient 6-15-y-old children (n=377). Results: Mean salt intake in school-age children was 7-12 g/d and estimated iron bioavailability from the local diet was 0.4-4.3%. After storage for 20 wk the DFS and iodized salt were not significantly different in iodine content and color stability was acceptable when the compounds were added to local meals. During the efficacy trial urinary iodine concentrations and thyroid volumes improved significantly (P < 0.001 an < 0.05 respectively) from baseline in both groups. At 40 wk mean hemoglobin concentrations in the DFS group had increased by 14 g/L (P<0.01) and serum ferritin transferrin receptor and zinc protoporphyrin concentrations were significantly better (P<0.05) in the DFS group than in the iodized salt group. The prevalence of iron deficiency anemia in the DFS group decreased from 35% at baseline to 8% at 40 wk (P<0.001). Conclusion: A DFS containing iodine and encapsulated iron can be an effective fortification strategy. (authors)
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addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous iron deficient children a randomized double blind controlled trial
European Journal of Endocrinology, 2002Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Objective: In many developing countries, children are at high risk for both goiter and anemia. Iron (Fe) deficiency adversely effects thyroid metabolism and reduces efficacy of iodine prophylaxis in areas of endemic goiter. The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia. Design and methods: In a 9-month, randomized, double-blind trial, 6 ‐ 15 year-old children ðn ¼ 377Þ were given iodized salt (25mg iodine/g salt) or dual-fortified salt with iodine (25mg iodine/g salt) and Fe (1 mg Fe/g salt, as ferrous sulfate microencapsulated with partially Hydrogenated Vegetable Oil). Results: In the dual-fortified salt group, hemoglobin and Fe status improved significantly compared with the iodized salt group ðP , 0:05Þ: At 40 weeks, the mean decrease in thyroid volume measured by ultrasound in the dual-fortified salt group (2 38%) was twice that of the iodized salt group (2 18%) ðP , 0:01Þ: Compared with the iodized salt group, serum thyroxine was significantly increased ðP , 0:05Þ and the prevalence of hypothyroidism and goiter decreased ðP , 0:01Þ in the dual-fortified salt group. Conclusion: Addition of encapsulated Fe to iodized salt improves the efficacy of iodine in goitrous children with a high prevalence of anemia.
Noureddine Chaouki - One of the best experts on this subject based on the ideXlab platform.
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dual fortification of salt with iodine and microencapsulated iron a randomized double blind controlled trial in moroccan schoolchildren
The American Journal of Clinical Nutrition, 2003Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Background: In many developing countries children are at high risk of both goiter and iron deficiency anemia. Objective: In a series of studies in northern Morocco we developed and tested a dual-fortified salt (DFS) containing iodine and microencapsulated iron. Design: To establish the DFS fortification concentration we measured salt intake by 3-d weighed food records and estimated iron bioavailability from the local diet by using published algorithms. We then formulated a DFS containing 25 aeg iodine/g salt (as potassium iodide) and 1 mg iron/g salt (as ferrous sulfate hydrate encapsulated with partially Hydrogenated Vegetable Oil). After storage and acceptability trials we compared the efficacy of the DFS to that of iodized salt in a 9-mo randomized double-blind trial in iodine-deficient 6-15-y-old children (n=377). Results: Mean salt intake in school-age children was 7-12 g/d and estimated iron bioavailability from the local diet was 0.4-4.3%. After storage for 20 wk the DFS and iodized salt were not significantly different in iodine content and color stability was acceptable when the compounds were added to local meals. During the efficacy trial urinary iodine concentrations and thyroid volumes improved significantly (P < 0.001 an < 0.05 respectively) from baseline in both groups. At 40 wk mean hemoglobin concentrations in the DFS group had increased by 14 g/L (P<0.01) and serum ferritin transferrin receptor and zinc protoporphyrin concentrations were significantly better (P<0.05) in the DFS group than in the iodized salt group. The prevalence of iron deficiency anemia in the DFS group decreased from 35% at baseline to 8% at 40 wk (P<0.001). Conclusion: A DFS containing iodine and encapsulated iron can be an effective fortification strategy. (authors)
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addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous iron deficient children a randomized double blind controlled trial
European Journal of Endocrinology, 2002Co-Authors: Michael B Zimmermann, Noureddine Chaouki, T Torresani, Christophe Zeder, Amina Saad, Richard F HurrellAbstract:Objective: In many developing countries, children are at high risk for both goiter and anemia. Iron (Fe) deficiency adversely effects thyroid metabolism and reduces efficacy of iodine prophylaxis in areas of endemic goiter. The study aim was to determine if co-fortification of iodized salt with Fe would improve efficacy of the iodine in goitrous children with a high prevalence of anemia. Design and methods: In a 9-month, randomized, double-blind trial, 6 ‐ 15 year-old children ðn ¼ 377Þ were given iodized salt (25mg iodine/g salt) or dual-fortified salt with iodine (25mg iodine/g salt) and Fe (1 mg Fe/g salt, as ferrous sulfate microencapsulated with partially Hydrogenated Vegetable Oil). Results: In the dual-fortified salt group, hemoglobin and Fe status improved significantly compared with the iodized salt group ðP , 0:05Þ: At 40 weeks, the mean decrease in thyroid volume measured by ultrasound in the dual-fortified salt group (2 38%) was twice that of the iodized salt group (2 18%) ðP , 0:01Þ: Compared with the iodized salt group, serum thyroxine was significantly increased ðP , 0:05Þ and the prevalence of hypothyroidism and goiter decreased ðP , 0:01Þ in the dual-fortified salt group. Conclusion: Addition of encapsulated Fe to iodized salt improves the efficacy of iodine in goitrous children with a high prevalence of anemia.
