The Experts below are selected from a list of 351 Experts worldwide ranked by ideXlab platform
Ronald Grigg - One of the best experts on this subject based on the ideXlab platform.
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palladium catalysed tandem cyclisation anion capture part 8 cascade Hydrostannylation cyclisation anion capture and cascade hydroboration cyclisation anion capture on solid phase
Tetrahedron, 2001Co-Authors: Ronald Grigg, William S. Maclachlan, Visuvanathar Sridharan, David Macpherson, Selvaratnam SuganthanAbstract:Abstract Up to four bonds and five stereocentres are created, in five component processes (five point diversity), utilising resin bound aryl iodides by hydroboration or Hydrostannylation of alkynes, followed by cyclisation–anion capture involving Suzuki or Stille reactions. Three small libraries were prepared to validate the chemistry.
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sequential decarboxylative azomethine ylide cycloaddition palladium catalysed Hydrostannylation cyclisation anion capture processes
Tetrahedron, 2001Co-Authors: Ronald Grigg, Martin Jones, Michelle Mctiernan, Visuvanathar SridharanAbstract:Abstract A novel tactical combination of the iminium ion induced decarboxylative generation of azomethine ylides, from secondary acyclic and cyclic α-amino acids, and their 1,3-dipolar cycloaddition, with regioselective palladium catalysed Hydrostannylation of terminal alkynes, and subsequent cyclisation-anion capture of the organostannane is described. A major increase in molecular complexity results with the formation of 5 bonds, 5 stereocentres, 2 rings and 1 tetra-substituted carbon centre.
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palladium catalysed tandem cyclisation anion capture part 7 synthesis of derivatives of α amino esters nitrogen heterocycles and β aryl heteroaryl ethylamines via in situ generated vinylstannanes
Tetrahedron, 2001Co-Authors: Adele Casaschi, Ronald Grigg, J M SansanoAbstract:Abstract Palladium catalysed in situ Hydrostannylation of terminal alkynes containing a β-N atom affords mainly α-vinylstannanes which serve as anion capture agents in palladium catalysed cyclisation–anion capture processes leading to derivatives of α-amino esters, nitrogen heterocycles and β-aryl/heteroaryl ethylamines in good yield.
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palladium catalysed tandem cyclisation anion capture part 5 cascade Hydrostannylation bis cyclisation intramolecular anion capture synthesis of bridged and spiro cyclic small and macrocyclic heterocycles
Tetrahedron, 2000Co-Authors: Adele Casaschi, Ronald Grigg, J M Sansano, D.a. Wilson, James RedpathAbstract:A series of O- and N-α,ω-enyne derivatives of 2-iodoarylethers and 2-iodoarylamides undergo palladium catalysed cascade Hydrostannylation of the ω-alkyne moiety at 0–25°C followed by bis-cyclisation at 100–110°C terminating in intramolecular sp3–sp2 Stille coupling. These cascades provide a wide range of 5/6 and 5/12–17 membered bicyclic spiro- and bridged-ring heterocycles.
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Palladium catalysed cascade Hydrostannylation-bis-cyclisation-intramolecular anion capture. Routes to bridged- and spiro-cyclic small and macrocyclic heterocycles
Tetrahedron Letters, 1996Co-Authors: Adele Casaschi, Ronald Grigg, J M Sansano, D.a. Wilson, James RedpathAbstract:Palladium catalysed cascade Hydrostannylation of terminal alkynes in α,ω-enynes at 0–25°C followed by bis-cyclisation initiated by insertion of Pd(0) into an aryl iodide at 100–110°C and terminating in an intramolecular Stille coupling provides a wide range of exo-methylene 56 and 512-17 membered spiro- and bridged-ring heterocycles.
Xiaoniu Fang - One of the best experts on this subject based on the ideXlab platform.
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a one pot stereoselective synthesis of 2 ethoxycarbonyl substituted 1 3 dienes and 1 3 enynes by Hydrostannylation stille tandem reaction of tributyltin hydride with alkynyl esters and alkenyl or alkynyl halides
Applied Organometallic Chemistry, 2009Co-Authors: Xiaoniu FangAbstract:2-Ethoxycarbonyl-substituted 1,3-dienes and 1,3-enynes can be stereoselectively synthesized in one pot under mild conditions, in good yields, by the palladium-catalyzed Hydrostannylation of alkynyl esters, followed by Stille coupling with alkenyl or alkynyl halides, respectively. Copyright © 2009 John Wiley & Sons, Ltd.
Hong Zhao - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective Synthesis of Difunctionalized 1,3-Dienes Containing Tin and Sulfonyl Groups by Palladium-Catalyzed Regio- and Stereocontrolled Addition Reactions
European Journal of Organic Chemistry, 2011Co-Authors: Hong Zhao, Weisen YangAbstract:Using palladium-catalyzed addition reactions, a terminal alkyne, an acetylenic sulfone, and a tin hydride comprise the building blocks for the construction of difunctionalized 1,3-dienes containing tin and sulfonyl groups in an atom-economical fashion. Terminal alkynes 1 undergo clean cis addition to acetylenic sulfones 2 in the presence of catalytic amounts of palladium acetate and tri(2,6-dimethoxyphenyl)phosphane to give (E)-1-sulfonyl-substituted 1,3-enynes 3 in excellent yields. Hydrostannylation of 1,3-enynes 3 with tributyltin hydride in the presence of Pd(PPh3)4 affords regio- and stereoselectively (1E,3E)-1-sulfonyl-3-tributylstannyl-substituted 1,3-dienes 4 in excellent yields.
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stereoselective synthesis of 1z 3e 2 ethoxycarbonyl substituted 1 3 dienes via stille coupling of e α stannyl α β unsaturated esters with alkenyl halides
Synthetic Communications, 2009Co-Authors: Hong ZhaoAbstract:Abstract Palladium-catalyzed Hydrostannylation of alkynyl esters in benzene at room temperature gives stereoselectively (E)-α-stannyl-α,β-unsaturated esters 1 in good yields. (E)-α-Stannyl-α,β-unsaturated esters 1 are difunctional group reagents that undergo Stille coupling reactions with alkenyl halides 2 in the presence of Pd(PPh3)4 and CuI co-catalyst to afford stereoselectively (1Z,3E)-2-ethoxycarbonyl-substituted 1,3-dienes 3 in good yields.
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a one pot stereoselective synthesis of z 2 sulfonyl substituted 1 3 enynes by Hydrostannylation stille tandem reaction of acetylenic sulfones
Chinese Journal of Chemistry, 2008Co-Authors: Hong Zhao, Haiyun ZhangAbstract:(Z)-2-Sulfonyl-substituted 1,3-enynes can be stereoselectively synthesized in one pot by the palladium-catalyzed Hydrostannylation of acetylenic sulfones, followed by Stille coupling with alkynyl bromides. The present method has the advantages of readily available starting materials, straightforward and simple procedures, mild reaction conditions and good yields.
J M Sansano - One of the best experts on this subject based on the ideXlab platform.
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palladium catalysed tandem cyclisation anion capture part 7 synthesis of derivatives of α amino esters nitrogen heterocycles and β aryl heteroaryl ethylamines via in situ generated vinylstannanes
Tetrahedron, 2001Co-Authors: Adele Casaschi, Ronald Grigg, J M SansanoAbstract:Abstract Palladium catalysed in situ Hydrostannylation of terminal alkynes containing a β-N atom affords mainly α-vinylstannanes which serve as anion capture agents in palladium catalysed cyclisation–anion capture processes leading to derivatives of α-amino esters, nitrogen heterocycles and β-aryl/heteroaryl ethylamines in good yield.
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palladium catalysed tandem cyclisation anion capture part 5 cascade Hydrostannylation bis cyclisation intramolecular anion capture synthesis of bridged and spiro cyclic small and macrocyclic heterocycles
Tetrahedron, 2000Co-Authors: Adele Casaschi, Ronald Grigg, J M Sansano, D.a. Wilson, James RedpathAbstract:A series of O- and N-α,ω-enyne derivatives of 2-iodoarylethers and 2-iodoarylamides undergo palladium catalysed cascade Hydrostannylation of the ω-alkyne moiety at 0–25°C followed by bis-cyclisation at 100–110°C terminating in intramolecular sp3–sp2 Stille coupling. These cascades provide a wide range of 5/6 and 5/12–17 membered bicyclic spiro- and bridged-ring heterocycles.
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Palladium catalysed cascade Hydrostannylation-bis-cyclisation-intramolecular anion capture. Routes to bridged- and spiro-cyclic small and macrocyclic heterocycles
Tetrahedron Letters, 1996Co-Authors: Adele Casaschi, Ronald Grigg, J M Sansano, D.a. Wilson, James RedpathAbstract:Palladium catalysed cascade Hydrostannylation of terminal alkynes in α,ω-enynes at 0–25°C followed by bis-cyclisation initiated by insertion of Pd(0) into an aryl iodide at 100–110°C and terminating in an intramolecular Stille coupling provides a wide range of exo-methylene 56 and 512-17 membered spiro- and bridged-ring heterocycles.
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Sequential Hydrostannylation-cyclisation of δ- and ω-allenyl aryl halides. Cyclisation at the proximal carbon
Tetrahedron, 1996Co-Authors: Ronald Grigg, J M SansanoAbstract:Abstract Palladium catalysed Hydrostannylation of (Bu 3 SnH, THF, 0°C) of δ- and ω-allenyl aryl halides followed by mono- or bis-cyclisation (MeCN, 80°C) affords small (5–7), large (11–17) and spirocyclic rings in which cyclisation occurs at the proximal carbon of the orginal allene. The reaction proceeds via stereoselective allylstannane formation. The cyclisation products are α-vinyl oxygen- and nitrogen-heterocycles.
James Redpath - One of the best experts on this subject based on the ideXlab platform.
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palladium catalysed tandem cyclisation anion capture part 5 cascade Hydrostannylation bis cyclisation intramolecular anion capture synthesis of bridged and spiro cyclic small and macrocyclic heterocycles
Tetrahedron, 2000Co-Authors: Adele Casaschi, Ronald Grigg, J M Sansano, D.a. Wilson, James RedpathAbstract:A series of O- and N-α,ω-enyne derivatives of 2-iodoarylethers and 2-iodoarylamides undergo palladium catalysed cascade Hydrostannylation of the ω-alkyne moiety at 0–25°C followed by bis-cyclisation at 100–110°C terminating in intramolecular sp3–sp2 Stille coupling. These cascades provide a wide range of 5/6 and 5/12–17 membered bicyclic spiro- and bridged-ring heterocycles.
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Palladium catalysed cascade Hydrostannylation-bis-cyclisation-intramolecular anion capture. Routes to bridged- and spiro-cyclic small and macrocyclic heterocycles
Tetrahedron Letters, 1996Co-Authors: Adele Casaschi, Ronald Grigg, J M Sansano, D.a. Wilson, James RedpathAbstract:Palladium catalysed cascade Hydrostannylation of terminal alkynes in α,ω-enynes at 0–25°C followed by bis-cyclisation initiated by insertion of Pd(0) into an aryl iodide at 100–110°C and terminating in an intramolecular Stille coupling provides a wide range of exo-methylene 56 and 512-17 membered spiro- and bridged-ring heterocycles.
