The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
María D. Díaz-de-villegas - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective Construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α-Hydroxyaldehyde Derivatives by the Aza-Prins Reaction.
The Journal of organic chemistry, 2017Co-Authors: Alejandro Mahía, Ramón Badorrey, J. A. Galvez, María D. Díaz-de-villegasAbstract:(R)-2,3-Di-O-benzylglyceraldehyde and N-tosyl homoallylamine undergo aza-Prins cyclization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2-tosyl-6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected intramolecular nucleophilic attack. Our work has opened a new route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabicyclo[3.2.1]octane derivatives from chiral α-Hydroxyaldehyde derivatives in one step.
Bradley S. Davidson - One of the best experts on this subject based on the ideXlab platform.
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synthetic studies toward the microtubule stabilizing agent laulimalide synthesis of the c15 c28 fragment
Tetrahedron Letters, 2001Co-Authors: Travis B Messenger, Bradley S. DavidsonAbstract:Abstract The C 15 –C 28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps with an overall yield of 14%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry and the 19,20- syn -diol was generated through the addition of a mixed vinyl zincate to a protected α-Hydroxyaldehyde.
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Synthetic studies toward the microtubule-stabilizing agent laulimalide: synthesis of the C15–C28 fragment
Tetrahedron Letters, 2001Co-Authors: B. Travis Messenger, Bradley S. DavidsonAbstract:Abstract The C 15 –C 28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps with an overall yield of 14%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry and the 19,20- syn -diol was generated through the addition of a mixed vinyl zincate to a protected α-Hydroxyaldehyde.
A. C. Kunwar - One of the best experts on this subject based on the ideXlab platform.
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Ugi‐Type Four‐Component Reaction for a Novel Synthesis of 5‐Oxo‐perhydrofuro[3,2‐b]pyran Carboxylate Derivatives.
ChemInform, 2011Co-Authors: B. V. Subba Reddy, Nilanjan Majumder, A. V. Hara Gopal, Deepak Chatterjee, A. C. KunwarAbstract:The reaction involving a sugar Hydroxyaldehyde and Meldrum′s acid produces a mixture of polycyclic lactones (V) and the corresponding diesters (VI).
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Ugi-type four-component reaction for a novel synthesis of 5-oxo-perhydrofuro[3,2-b]pyran carboxylate derivatives
Tetrahedron Letters, 2010Co-Authors: B. V. Subba Reddy, Nilanjan Majumder, A. V. Hara Gopal, Deepak Chatterjee, A. C. KunwarAbstract:The four-component coupling (4CC) of sugar Hydroxyaldehyde, Meldrum’s acid, isocyanide, and a secondary alcohol in dichloromethane has been accomplished at room temperature in a highly stereoselective manner to produce a novel class of carbohydrate derivatives, 5-oxo-perhydrofuro[3,2-b]pyrans in good yields with trans-selectivity. The stereochemistry of the products was assigned by various NMR experiments.
Alejandro Mahía - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective Construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α-Hydroxyaldehyde Derivatives by the Aza-Prins Reaction.
The Journal of organic chemistry, 2017Co-Authors: Alejandro Mahía, Ramón Badorrey, J. A. Galvez, María D. Díaz-de-villegasAbstract:(R)-2,3-Di-O-benzylglyceraldehyde and N-tosyl homoallylamine undergo aza-Prins cyclization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2-tosyl-6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected intramolecular nucleophilic attack. Our work has opened a new route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabicyclo[3.2.1]octane derivatives from chiral α-Hydroxyaldehyde derivatives in one step.
Ramón Badorrey - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective Construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α-Hydroxyaldehyde Derivatives by the Aza-Prins Reaction.
The Journal of organic chemistry, 2017Co-Authors: Alejandro Mahía, Ramón Badorrey, J. A. Galvez, María D. Díaz-de-villegasAbstract:(R)-2,3-Di-O-benzylglyceraldehyde and N-tosyl homoallylamine undergo aza-Prins cyclization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2-tosyl-6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected intramolecular nucleophilic attack. Our work has opened a new route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabicyclo[3.2.1]octane derivatives from chiral α-Hydroxyaldehyde derivatives in one step.
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Diastereoselective Construction of the 6‑Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α‑Hydroxyaldehyde Derivatives by the Aza-Prins Reaction
2017Co-Authors: Alejandro Mahía, Ramón Badorrey, José A. Gálvez, María D. Díaz-de-villegasAbstract:(R)-2,3-Di-O-benzylglyceraldehyde and N-tosyl homoallylamine undergo aza-Prins cyclization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2-tosyl-6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected intramolecular nucleophilic attack. Our work has opened a new route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabicyclo[3.2.1]octane derivatives from chiral α-Hydroxyaldehyde derivatives in one step
