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Bob Siegerink - One of the best experts on this subject based on the ideXlab platform.
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Hypercoagulability and the risk of recurrence in young women with myocardial infarction or ischaemic stroke a cohort study
BMC Cardiovascular Disorders, 2019Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:We aimed to investigate the role of Hypercoagulability on the risk of lifetime cardiovascular recurrences after myocardial infarction or ischaemic stroke. Young women (< 50 years) with either myocardial infarction (n = 197) or ischaemic stroke (n = 107) were followed between 1995 and 2012 in the RATIO follow-up study. To determine whether Hypercoagulability affects the risk or recurrence, a coagulation score based on acquired and inherited markers was compiled and used in a quartile analysis. Hazard ratios (HRs) obtained from Cox proportional models and adjusted for several cardiovascular risk factors were used to compare quartiles of the coagulation score for the risk of recurrence. During a median follow-up of 19 years, 59 cardiovascular recurrences occurred. In patients with myocardial infarction no association was found between a high prothrombotic score and recurrences (highest quartile vs lowest quartile HR 0.7, 95% CI, 0.3–1.8). Conversely, ischaemic stroke patients with a high prothrombotic score showed a doubling in risk of long-term cardiovascular recurrences (HR 1.9, 95% CI 0.6–6.3) compared with ischaemic stroke patients and low levels of the score, with a dose response relationship. An increased coagulation tendency might be associated with long-term cardiovascular risk in women with ischaemic stroke, but not in women with myocardial infarction.
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Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women
Journal of Thrombosis and Haemostasis, 2015Co-Authors: Alberto Maino, Ale Algra, Bob Siegerink, F R RosendaalAbstract:Summary Background Myocardial infarction (MI) and ischemic stroke (IS) are acute forms of arterial thrombosis and share some, but not all, risk factors, indicating different pathophysiological mechanisms. Objective This study aims to determine if Hypercoagulability has a differential effect on the risk of MI and IS. Patients and methods We reviewed the results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives study, a population-based case–control study involving young women (< 50 years) with MI, non-cardioembolic IS and healthy controls. From these data, relative odds ratios (ORIS/ORMI) and their corresponding confidence intervals for all prothrombotic factors that were studied in both subgroups were calculated. Results Twenty-nine prothrombotic risk factors were identified as measures of Hypercoagulability. Twenty-two of these risk factors (21/29, 72%) had a relative odds ratios > 1; for 12 (41%), it was > 2; and for 5 (17%), it was > 2.75. The five risk factors with the largest differences in associations were high levels of activated factor XI (FXI) and FXII, kallikrein, the presence of lupus anticoagulans, and a genetic variation in the FXIII gene. Conclusion In young women, prothrombotic factors are associated more with the risk of IS than with MI risk, suggesting a different role of Hypercoagulability in the mechanism leading to these two diseases.
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Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction a systematic review
PLOS ONE, 2015Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of Hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RR IS ) was compared with the effect on MI (RR MI ) by calculating their ratio (RRR = RR IS /RR MI ). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers. Conclusions: These results suggest that Hypercoagulability has a more pronounced effect on the risk of IS than that of MI.
Alberto Maino - One of the best experts on this subject based on the ideXlab platform.
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Hypercoagulability and the risk of recurrence in young women with myocardial infarction or ischaemic stroke a cohort study
BMC Cardiovascular Disorders, 2019Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:We aimed to investigate the role of Hypercoagulability on the risk of lifetime cardiovascular recurrences after myocardial infarction or ischaemic stroke. Young women (< 50 years) with either myocardial infarction (n = 197) or ischaemic stroke (n = 107) were followed between 1995 and 2012 in the RATIO follow-up study. To determine whether Hypercoagulability affects the risk or recurrence, a coagulation score based on acquired and inherited markers was compiled and used in a quartile analysis. Hazard ratios (HRs) obtained from Cox proportional models and adjusted for several cardiovascular risk factors were used to compare quartiles of the coagulation score for the risk of recurrence. During a median follow-up of 19 years, 59 cardiovascular recurrences occurred. In patients with myocardial infarction no association was found between a high prothrombotic score and recurrences (highest quartile vs lowest quartile HR 0.7, 95% CI, 0.3–1.8). Conversely, ischaemic stroke patients with a high prothrombotic score showed a doubling in risk of long-term cardiovascular recurrences (HR 1.9, 95% CI 0.6–6.3) compared with ischaemic stroke patients and low levels of the score, with a dose response relationship. An increased coagulation tendency might be associated with long-term cardiovascular risk in women with ischaemic stroke, but not in women with myocardial infarction.
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Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women
Journal of Thrombosis and Haemostasis, 2015Co-Authors: Alberto Maino, Ale Algra, Bob Siegerink, F R RosendaalAbstract:Summary Background Myocardial infarction (MI) and ischemic stroke (IS) are acute forms of arterial thrombosis and share some, but not all, risk factors, indicating different pathophysiological mechanisms. Objective This study aims to determine if Hypercoagulability has a differential effect on the risk of MI and IS. Patients and methods We reviewed the results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives study, a population-based case–control study involving young women (< 50 years) with MI, non-cardioembolic IS and healthy controls. From these data, relative odds ratios (ORIS/ORMI) and their corresponding confidence intervals for all prothrombotic factors that were studied in both subgroups were calculated. Results Twenty-nine prothrombotic risk factors were identified as measures of Hypercoagulability. Twenty-two of these risk factors (21/29, 72%) had a relative odds ratios > 1; for 12 (41%), it was > 2; and for 5 (17%), it was > 2.75. The five risk factors with the largest differences in associations were high levels of activated factor XI (FXI) and FXII, kallikrein, the presence of lupus anticoagulans, and a genetic variation in the FXIII gene. Conclusion In young women, prothrombotic factors are associated more with the risk of IS than with MI risk, suggesting a different role of Hypercoagulability in the mechanism leading to these two diseases.
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Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction a systematic review
PLOS ONE, 2015Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of Hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RR IS ) was compared with the effect on MI (RR MI ) by calculating their ratio (RRR = RR IS /RR MI ). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers. Conclusions: These results suggest that Hypercoagulability has a more pronounced effect on the risk of IS than that of MI.
Ale Algra - One of the best experts on this subject based on the ideXlab platform.
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Hypercoagulability and the risk of recurrence in young women with myocardial infarction or ischaemic stroke a cohort study
BMC Cardiovascular Disorders, 2019Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:We aimed to investigate the role of Hypercoagulability on the risk of lifetime cardiovascular recurrences after myocardial infarction or ischaemic stroke. Young women (< 50 years) with either myocardial infarction (n = 197) or ischaemic stroke (n = 107) were followed between 1995 and 2012 in the RATIO follow-up study. To determine whether Hypercoagulability affects the risk or recurrence, a coagulation score based on acquired and inherited markers was compiled and used in a quartile analysis. Hazard ratios (HRs) obtained from Cox proportional models and adjusted for several cardiovascular risk factors were used to compare quartiles of the coagulation score for the risk of recurrence. During a median follow-up of 19 years, 59 cardiovascular recurrences occurred. In patients with myocardial infarction no association was found between a high prothrombotic score and recurrences (highest quartile vs lowest quartile HR 0.7, 95% CI, 0.3–1.8). Conversely, ischaemic stroke patients with a high prothrombotic score showed a doubling in risk of long-term cardiovascular recurrences (HR 1.9, 95% CI 0.6–6.3) compared with ischaemic stroke patients and low levels of the score, with a dose response relationship. An increased coagulation tendency might be associated with long-term cardiovascular risk in women with ischaemic stroke, but not in women with myocardial infarction.
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Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women
Journal of Thrombosis and Haemostasis, 2015Co-Authors: Alberto Maino, Ale Algra, Bob Siegerink, F R RosendaalAbstract:Summary Background Myocardial infarction (MI) and ischemic stroke (IS) are acute forms of arterial thrombosis and share some, but not all, risk factors, indicating different pathophysiological mechanisms. Objective This study aims to determine if Hypercoagulability has a differential effect on the risk of MI and IS. Patients and methods We reviewed the results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives study, a population-based case–control study involving young women (< 50 years) with MI, non-cardioembolic IS and healthy controls. From these data, relative odds ratios (ORIS/ORMI) and their corresponding confidence intervals for all prothrombotic factors that were studied in both subgroups were calculated. Results Twenty-nine prothrombotic risk factors were identified as measures of Hypercoagulability. Twenty-two of these risk factors (21/29, 72%) had a relative odds ratios > 1; for 12 (41%), it was > 2; and for 5 (17%), it was > 2.75. The five risk factors with the largest differences in associations were high levels of activated factor XI (FXI) and FXII, kallikrein, the presence of lupus anticoagulans, and a genetic variation in the FXIII gene. Conclusion In young women, prothrombotic factors are associated more with the risk of IS than with MI risk, suggesting a different role of Hypercoagulability in the mechanism leading to these two diseases.
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Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction a systematic review
PLOS ONE, 2015Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of Hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RR IS ) was compared with the effect on MI (RR MI ) by calculating their ratio (RRR = RR IS /RR MI ). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers. Conclusions: These results suggest that Hypercoagulability has a more pronounced effect on the risk of IS than that of MI.
F R Rosendaal - One of the best experts on this subject based on the ideXlab platform.
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Hypercoagulability and the risk of recurrence in young women with myocardial infarction or ischaemic stroke a cohort study
BMC Cardiovascular Disorders, 2019Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:We aimed to investigate the role of Hypercoagulability on the risk of lifetime cardiovascular recurrences after myocardial infarction or ischaemic stroke. Young women (< 50 years) with either myocardial infarction (n = 197) or ischaemic stroke (n = 107) were followed between 1995 and 2012 in the RATIO follow-up study. To determine whether Hypercoagulability affects the risk or recurrence, a coagulation score based on acquired and inherited markers was compiled and used in a quartile analysis. Hazard ratios (HRs) obtained from Cox proportional models and adjusted for several cardiovascular risk factors were used to compare quartiles of the coagulation score for the risk of recurrence. During a median follow-up of 19 years, 59 cardiovascular recurrences occurred. In patients with myocardial infarction no association was found between a high prothrombotic score and recurrences (highest quartile vs lowest quartile HR 0.7, 95% CI, 0.3–1.8). Conversely, ischaemic stroke patients with a high prothrombotic score showed a doubling in risk of long-term cardiovascular recurrences (HR 1.9, 95% CI 0.6–6.3) compared with ischaemic stroke patients and low levels of the score, with a dose response relationship. An increased coagulation tendency might be associated with long-term cardiovascular risk in women with ischaemic stroke, but not in women with myocardial infarction.
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Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women
Journal of Thrombosis and Haemostasis, 2015Co-Authors: Alberto Maino, Ale Algra, Bob Siegerink, F R RosendaalAbstract:Summary Background Myocardial infarction (MI) and ischemic stroke (IS) are acute forms of arterial thrombosis and share some, but not all, risk factors, indicating different pathophysiological mechanisms. Objective This study aims to determine if Hypercoagulability has a differential effect on the risk of MI and IS. Patients and methods We reviewed the results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives study, a population-based case–control study involving young women (< 50 years) with MI, non-cardioembolic IS and healthy controls. From these data, relative odds ratios (ORIS/ORMI) and their corresponding confidence intervals for all prothrombotic factors that were studied in both subgroups were calculated. Results Twenty-nine prothrombotic risk factors were identified as measures of Hypercoagulability. Twenty-two of these risk factors (21/29, 72%) had a relative odds ratios > 1; for 12 (41%), it was > 2; and for 5 (17%), it was > 2.75. The five risk factors with the largest differences in associations were high levels of activated factor XI (FXI) and FXII, kallikrein, the presence of lupus anticoagulans, and a genetic variation in the FXIII gene. Conclusion In young women, prothrombotic factors are associated more with the risk of IS than with MI risk, suggesting a different role of Hypercoagulability in the mechanism leading to these two diseases.
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Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction a systematic review
PLOS ONE, 2015Co-Authors: Alberto Maino, F R Rosendaal, Ale Algra, Flora Peyvandi, Bob SiegerinkAbstract:Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of Hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RR IS ) was compared with the effect on MI (RR MI ) by calculating their ratio (RRR = RR IS /RR MI ). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers. Conclusions: These results suggest that Hypercoagulability has a more pronounced effect on the risk of IS than that of MI.
Ralph L Sacco - One of the best experts on this subject based on the ideXlab platform.
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aortic atherosclerosis Hypercoagulability and stroke the apris aortic plaque and risk of ischemic stroke study
Journal of the American College of Cardiology, 2008Co-Authors: Marco R Di Tullio, Shunichi Homma, Ralph L SaccoAbstract:Objectives Our goal was to assess the effect of Hypercoagulability on the risk of stroke in patients with aortic plaques. Background Atherosclerotic plaques in the aortic arch are a risk factor for ischemic stroke. Their relationship with blood Hypercoagulability, which might enhance their embolic potential and affect treatment and prevention, is not known. Methods We performed transesophageal echocardiography in 255 patients with first acute ischemic stroke and in 209 control subjects matched by age, gender, and race/ethnicity. The association between arch plaques and Hypercoagulability, and its effect on the stroke risk, was assessed with a case-control design. Stroke patients were then followed prospectively to assess recurrent stroke and death. Results Large (≥4 mm) arch plaques were associated with increased stroke risk (adjusted odds ratio [OR]: 2.4, 95% confidence interval [CI]: 1.3 to 4.6), especially when ulcerations or superimposed thrombus were present (adjusted OR: 3.3, 95% CI: 1.4 to 8.2). Prothrombin fragment F 1.2, an indicator of thrombin generation, was associated with large plaques in stroke patients (p = 0.02), but not in control subjects. Over a mean follow-up of 55.1 ± 37.2 months, stroke patients with large plaques and F 1.2 over the median value had a significantly higher risk of recurrent stroke and death than those with large plaques but lower F 1.2 levels (230 events per 1,000 person-years vs. 85 events per 1,000 person-years; p = 0.05). Conclusions In patients presenting with acute ischemic stroke, large aortic plaques are associated with blood Hypercoagulability, suggesting a role for coagulation activation in the stroke mechanism. Coexistence of large aortic plaques and blood Hypercoagulability is associated with an increased risk of recurrent stroke and death.
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aortic atherosclerosis Hypercoagulability and stroke the aortic plaque and risk of ischemic stroke apris study
Journal of the American College of Cardiology, 2008Co-Authors: Marco R Di Tullio, Shunichi Homma, Ralph L SaccoAbstract:Objective To assess the effect of Hypercoagulability on the risk of stroke in patients with aortic plaques.