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  • the influence of placental malaria infection and maternal Hypergammaglobulinemia on transplacental transfer of antibodies and igg subclasses in a rural west african population
    The Journal of Infectious Diseases, 2001
    Co-Authors: Brown J Okoko, Lalanga H Wesumperuma, Martin O C Ota, Margaret Pinder, Winston A S Banya, Silver F Gomez, Keith P W J Mcadam, Anthony C Hart
    Abstract:

    Two hundred thirteen mother-baby pairs in The Gambia were studied to determine the influence of placental malaria infection and maternal Hypergammaglobulinemia on transplacental antibody transfer. Antibody transfer for herpes simplex virus 1 (HSV-1), respiratory syncytial virus (RSV), and varicella-zoster virus (VZV) was significantly reduced by placental malaria infection by 69%, 58%, and 55%, respectively. Maternal Hypergammaglobulinemia was associated with a significant reduction in antibody transfer for HSV-1, RSV, VZV, and pneumococcus by 89%, 90%, 91%, and 88%, respectively. In addition, placental malaria infection was associated with a significant reduction in transfer of IgG1, IgG2, and IgG4 (P<.01, P=.01, and P=.03, respectively) but not of IgG3 (P=.59). Maternal Hypergammaglobulinemia significantly impaired the transfer of IgG1 and IgG2 (P=.01) but not of IgG3 or IgG4 (P=.62 and P=.59, respectively). Placental malaria infection and maternal Hypergammaglobulinemia were associated with reduction in the transplacental transfer of these specific antibodies, IgG1, and IgG2 in this Gambian population.

  • The Influence of Placental Malaria Infection and Maternal Hypergammaglobulinemia on Transplacental Transfer of Antibodies and IgG Subclasses in a Rural West African Population
    The Journal of Infectious Diseases, 2001
    Co-Authors: Brown J Okoko, Lalanga H Wesumperuma, Martin O C Ota, Margaret Pinder, Winston A S Banya, Silver F Gomez, Keith P W J Mcadam, Anthony C Hart
    Abstract:

    Two hundred thirteen mother-baby pairs in The Gambia were studied to determine the influence of placental malaria infection and maternal Hypergammaglobulinemia on transplacental antibody transfer. Antibody transfer for herpes simplex virus 1 (HSV-1), respiratory syncytial virus (RSV), and varicella-zoster virus (VZV) was significantly reduced by placental malaria infection by 69%, 58%, and 55%, respectively. Maternal Hypergammaglobulinemia was associated with a significant reduction in antibody transfer for HSV-1, RSV, VZV, and pneumococcus by 89%, 90%, 91%, and 88%, respectively. In addition, placental malaria infection was associated with a significant reduction in transfer of IgG1, IgG2, and IgG4 (P

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