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Eugenio Aguglia - One of the best experts on this subject based on the ideXlab platform.
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efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs.
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Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs. © 2010 Elsevier B.V. and ECNP.
Siegfried Kasper - One of the best experts on this subject based on the ideXlab platform.
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efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs.
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Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs. © 2010 Elsevier B.V. and ECNP.
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Treatment of seasonal affective disorder (SAD) with Hypericum extract.
Pharmacopsychiatry, 1997Co-Authors: Siegfried KasperAbstract:: Seasonal affective disorder (SAD) is a subgroup of major depression and characterized by a regular occurrence of symptoms in autumn/winter and full remission or hypomania in spring/summer. Light therapy (LT) and recently pharmacotherapy with specific antidepressants have been shown to be beneficial. Within the array of pharmacotherapy Hypericum extract has also been found to be effective in a single-blind study (Martinez et al., 1994). In this 4 weeks treatment study 900 mg of Hypericum was associated with a significant reduction in the total score of the Hamilton Depression Rating Scale. There was no significant difference when bright light therapy was combined with Hypericum, compared to the situation without bright light therapy. Overall, Hypericum was well tolerated and therefore the data suggest that pharmacological treatment with Hypericum may be an efficient therapy in patients with SAD, which needs to be substantiated in further controlled studies.
Norman K. B. Robson - One of the best experts on this subject based on the ideXlab platform.
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Studies in the genus Hypericum L. (Clusiaceae). 1 Section 9. Hypericum sensu lato (part 3): Subsection 1. Hypericum series 2. Senanensia, subsection 2. Erecta and section 9b. Graveolentia
Systematics and Biodiversity, 2006Co-Authors: Norman K. B. RobsonAbstract:Abstract Part 4(3) of this monographic series of papers on the genus Hypericum is prefaced by an introduction to the genus and a summary of the aims and methods of the project. This is followed by treatments of the remaining parts of sect. 9. Hypericum sensu stricto and the last segregate section from the original sect. Hypericum, sect. 9b. Graveolentia. Both hitherto untreated parts of the reduced sect. Hypericum are mainly Japanese, but some species extend in distribution as far as Kamchatka, eastern Siberia, central China, and Sabah (Mt. Kinabalu). Sect. Graveolentia is North and Central American. Sect. Hypericum subsect. Hypericum series Senanensia contains seven species from northern Japan and adjacent areas, including H. pibairense (Miyabe & Y. Kimura) N. Robson, stat. nov., H. nakaii subsp. miyabei (Y. Kimura) N. Robson, comb. et stat. nov., H. nakaii subsp. tatewakii (S. Watanabe) N. Robson, comb. et stat. nov. and H. senanense subsp. mutiloides (R. Keller) N. Robson, comb. et stat. nov. Sect. Hyp...
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Studies in the genus Hypericum L. (Guttiferae) 4(2). Section 9. Hypericum sensu lato (part 2): subsection 1. Hypericum series 1. Hypericum
Bulletin of The Natural History Museum. Botany Series, 2002Co-Authors: Norman K. B. RobsonAbstract:Introduction 61 Sect. 9. Hypericum 61 Subdivision 61 Characters and variation 61 Distribution and evolution 62 Sect. 9. Hypericum subsect. 1. Hypericum series 1. Hypericum 62 Characters and variation 62 Hybrids 64 Distribution and evolution 65 Systematic treatment 66 Sect. 9. Hypericum 66 Sect. 9. Hypericum subsect. 1. Hypericum series 1. Hypericum 67 References 119 Systematic index 121 The subdivision of the large sect. 9. Hypericum and four of its segregated sections having been treated in Part 4(1), Part 4(2) is concerned with those members of sect. 9, viz. Hypericum sensu stricto, in which the stem internodes have glandiferous raised lines – subsect. Hypericum series Hypericum . The series comprises 11 species and can be divided into (i) a group centred in Europe and the Mediterranean (4 species) and (ii) one centred in north-east Asia (6 species), one species of which is confined to western North America and another has spread westward into Europe. The remaining species ( H. perforatum ) is morphologically and geographically intermediate between two taxa, one from each group, and behaves as an allotetraploid hybrid. It is divided into four subspecies: subspp. perforatum , songaricum (Ledeb. ex Rchb.) N. Robson stat. nov. , veronense (Schrank) H. Lindb. and chinense N. Robson subsp. nov. The hybrids of H. perforatum are treated in detail and include H. × desetangsii nothosubsp. balcanicum N. Robson, nothosubsp. nov. ( H. maculatum subsp. immaculatum × perforatum ). Other new hybrids proposed are: H. × laschii nothoforma froelichii N. Robson, nothoforma nov. ( H. maculatum subsp. obtusiusculum × tetrapterum ), H. undulatum × tetrapterum and H. elegans × perforatum .
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Plate 337. Hypericum subsessile
Curtis's Botanical Magazine, 1998Co-Authors: Norman K. B. RobsonAbstract:Hypericum subsessile N. Robson (Clusiaceae/Guttiferae) belongs to section Ascyreia, the basic Asian section of Hypericum. Although first collected (from Yunnan and Sichuan respectively) in 1928 and 1929, it was not described until 1985, after its rediscovery in 1981. It has a relatively primitive position among the Chinese members of section Ascyreia, as is shown by, for example, its subsessile leaves and disjunct distribution. Hypericum subsessile has already proved to be a hardy garden plant with noteworthy fruits.
Bruno Forti - One of the best experts on this subject based on the ideXlab platform.
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efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs.
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Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs. © 2010 Elsevier B.V. and ECNP.
Filippo Drago - One of the best experts on this subject based on the ideXlab platform.
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efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs.
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Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
European Neuropsychopharmacology, 2010Co-Authors: Siegfried Kasper, Bruno Forti, Filippo Caraci, Filippo Drago, Eugenio AgugliaAbstract:Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials and meta-analyses have demonstrated the efficacy and tolerability of Hypericum extract for mild to moderate depression. Recent comparative trials of Hypericum extract and other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), provide support for Hypericum extract efficacy. However, since the constituents of Hypericum extract differ between the individual manufacturers, the efficacy cannot be extrapolated from one extract to another. In this review, WS 5572, LI 160, WS 5570 and ZE 117 Hypericum extracts have been shown to be significantly more effective than placebo with at least similar efficacy and better tolerability compared to standard antidepressant drugs. © 2010 Elsevier B.V. and ECNP.